270
Views
57
CrossRef citations to date
0
Altmetric
Research Article

Limited P-glycoprotein mediated efflux for anti-epileptic drugs

&
Pages 291-300 | Received 17 Jan 2006, Accepted 28 Mar 2006, Published online: 08 Oct 2008

References

  • Alsenz J, Steffen H, Alex R. Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers. Pharm Res 1998; 15: 423–428
  • Aronica E, Gorter JA, Jansen GH, Van Veelen CWM, Van Rijen PC, Leenstra S, Ramkema M, Scheffer GL, Scheper RJ, Troost D. Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: Focal cortical dysplasia and glioneuronal tumors. Neuroscience 2003; 118: 417–429
  • Artursson P. Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorbtive (Caco-2) cells. J Pharm Sci 1990; 79: 476–482
  • Artursson P, Palm K, Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Del Rev 1996; 22: 67–84
  • Belal F, Abdine H, Al-Majed A, Khalil NY. Spectrofluorimetric determination of vigabatrin and gabapentin in urine and dosage forms through derivatization with fluorescamine. J Pharm Biomed Anal 2002; 27: 253–260
  • Burton P, Goodwin J, Conradi R, Ho N, Hilgers R. In vitro permeability of peptidomimetic drugs: The role of polarized efflux pathways as additional barriers to absorption. Adv Drug Del Rev 1997; 23: 143–156
  • Chen S, Carvey PM. Rapid approach to the quantitative determination of topiramate (2,3:4,5-bis-O-(1-methylethylidene)-beta d fructopyranose sulfamate) in human plasma by liquid–liquid extraction and flow-injection negative-ion electrospray mass spectrometry. Rapid Commun Mass Spectrom 1999; 13: 1980–1984
  • Crowe A. The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel. Eur J Pharmacol 2002; 440: 7–16
  • Crowe A, Lemaire M. In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: Comparison with rapamycin. Pharm Res 1998; 15: 1666–1672
  • Deckers CLP, Genton P, Sills GJ, Schmidt D. Current limitations of antiepileptic drug therapy: A conference review. Epilepsy Res 2003; 53: 1–17
  • Didziapetris R, Japertas P, Avdeef A, Petrauskas A. Classification analysis of P-glycoprotein substrate specificity. J Drug Target 2003; 11: 391–406
  • Dimitrijevic D, Whitton PS, Domin M, Welham K, Florence AT. Increased vigabatrin entry into the brain by polysorbate 80 and sodium caprate. J Pharm Pharmacol 2001; 53: 149–154
  • Horie K, Tang F, Borchardt R. Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharm Res 2003; 20: 161–168
  • Hosoya K, Kim K, Lee V. Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers. Pharm Res 1996; 13: 885–890
  • Ingels F, Deferme S, Destexhe E, Oth M, Van den Mooter G, Augustijns P. Simulated intestinal fluid as transport medium in the Caco-2 Cell culture model. Int J Pharm 2002; 232: 183–192
  • Kazuhiro K, Lee R, Xu H, Harper P, Ito S. Effects of human milk and formula on expression MDR1, MRP2 and CYP3A in the C2BBE1 intestinal cell model. Clin Pharmacol Ther 2004; 75: P51
  • Kwan P, Sills GJ, Butler E, Gant TW, Brodie MJ. Differential expression of multidrug resistance genes in Maive rat brain. Neurosci Lett 2003; 339: 33–36
  • Lin JH, Yamazaki M. Role of P-glycoprotein in pharmacokinetics: Clinical implications. Clin Pharmacokinet 2003; 42: 59–98
  • Luer MS, Hamani C, Dujovny M, Gidal B, Cwik M, Deyo K, Fischer JH. Saturable transport of gabepentin at the blood–brain barrier. Neurol Res 1999; 21: 559–562
  • Löscher W, Potschka H. Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther 2002; 301: 7–14
  • Marchi N, Hallene KL, Kight KM, Cucullo L, Moddel G, Bingaman W, Dini G, Vessani A, Janigro D. 2004. Significance of MDR1 and multiple drug resistance in refractory human epileptic brain, BMC Medicine 2: Http://www.biomedcentral.com/1741-7015/2/37
  • Marroni M, Agrawal ML, Kight K, Hallene KL, Hossain M, Cucullo L, Signorelli K, Namura S, Bingaman W, Janigro D. Relationship between expression of multiple drug resistance proteins and p53 tumor suppressor gene proteins in human brain astrocytes. Neuroscience 2003; 121: 605–617
  • Marzolini C, Paus E, Buclin T, Kim RB. Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance. Pers Clin Pharm 2004; 75: 13–33
  • Morita Y, Sakaeda T, Horinouchi M, Nakamura T, Kuroda K, Miki I, Yoshimura K, Sakai T, Shirasaka D, Tamura T, Aoyama N, Kasuga M, Okumura K. MDR1 genotype-related duodenal absorption rate of digoxin in healthy Japanese subjects. Pharm Res 2003; 20: 552–556
  • Owen A, Pirmohamed M, Tettey JN, Morgan P, Chadwick D, Park BK. Carbamazepine is not a substrate for P-glycoprotein. Br J Clin Pharmacol 2001; 51: 345–349
  • Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL. No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Clin Pharmacol Ther 2003; 74: 487–498
  • Pendse S, Briscoe DM, Frank M. P-glycoprotein and alloimmune T-cell activation. Clin App Immuno Rev 2003; 4: 3–14
  • Potschka H, Loscher W. In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood–brain barrier of rats. Epilepsia 2001a; 42: 1231–1240
  • Potschka H, Loscher W. Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain. Neuroreport 2001b; 12: 2387–2389
  • Potschka H, Fedrowitz M, Löscher W. P-glycoprotein-mediated efflux of phenobarbital, lamotrigine and felbamate at the blood–brain barrier: Evidence from micridialysis experiments in rats. Neurosci Lett 2002; 327: 173–176
  • Raeissi SD, Hidalgo IJ, Segura-Aguilar J, Artursson P. Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers. Pharm Res 1999; 16: 625–632
  • Reiss WG, Oles KS. Acetazolamide in the treatment of seizures. Ann Pharmacother 1996; 30: 514–519
  • Rizzi M, Caccia S, Guiso G, Richichi C, Gorter JA, Aronica E, Aliprandi M, Bagnati R, Fanelli R, D'Incalci M, Samanin R, Vezzani A. Limbic seizures induce P-glycoprotein in rodent brain: Functional implications for pharmacoresistance. J Neurosci 2002; 22: 5833–5839
  • Sadeque AJM, Wandel C, He H, Shah S, Wood AJJ. Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther 2000; 68: 231–237
  • Schinkel AH. P-glycoprotein, a gatekeeper in the blood–brain barrier. Adv Drug Del Rev 1999; 36: 179–194
  • Schinkel AH, Wagenaar E, Mol CA, van Deemter L. P-glycoprotein in the blood–brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 1996; 97: 2517–2524
  • Schwab M, Eichelbaum M, Fromm MF. Genetic polymorphisms of the human MDR1 drug transporter. Ann Rev Pharmacol Toxicol 2003; 43: 285–307
  • Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, Wood NW, Sisodiya SM. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. NEJM 2003; 348: 1442–1448
  • Sills GJ, Kwan P, Butler E, de Lange ECM, van den Berg D, Brodie MJ. P-glycoprotein-mediated efflux of antiepileptic drugs: Preliminary studies in mdr1a knockout mice. Epilepsy Behav 2002; 3: 427–432
  • Sills GJ, Mohanraj R, Butler E, McCrindle S, Collier L, Wilson EA, Brodie MJ. Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia 2005; 46: 643–647
  • Sisodiya SM, Lin WR, Harding BN, Squier MV, Thom M. Drug resistance in epilepsy: Expression of drug resistance proteins in common causes of refractory epilepsy. Brain 2002; 125: 22–31
  • Tang PH, Miles MV, Glauser TA, Coletta L, Doughman N, Doose D, Frey M, DeGrauw A. An improved gas-chromatographic assay for topiramate monitoring in paediatric patients. Ther Drug Monit 2000; 22: 195–201
  • Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 1995; 36: 1–6
  • Tsuji A, Tamai I. Carrier-mediated or specialized transport of drugs across the blood–brain barrier. Adv Drug Del Rev 1999; 36: 277–290
  • Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R. Human P-glycoprotein transports cortisol, aldosterone and dexamethasone, but not progesterone. J Biol Chem 1992; 267: 24248–24252
  • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genom Biol 2002; 3(34)1–11
  • Volk H, Potschka H, Loscher W. Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables. J Histochem Cytochem 2005; 53: 517–531
  • Wacher V, Salphati L, Benet L. Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Del Rev 1996; 20: 99–112
  • Weiss J, Kerpen CJ, Lindenmaier H, Dormann SMG, Haefeli WE. Interaction of antiepileptic drugs with human P-glycoprotein in vitro. J Pharmacol Exp Ther 2003; 307: 262–267

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.