Enhanced transport of P-glycoprotein substrate saquinavir in presence of thiolated chitosan

References

• Abulrob AG, Mason M, Bryce R, Gumbleton M. The effect of fatty acids and analogues upon intracellular levels of doxorubicin in cells displaying P-glycoprotein mediated multidrug resistance. J Drug Target 2000; 8: 247–256
   PubMed Web of Science ®Google Scholar
• Al-Shawi MK, Senior AE. Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein. J Biol Chem 1993; 268: 4197–4206
   PubMed Web of Science ®Google Scholar
• Artursson P. Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J Pharm Sci 1990; 79: 476–482
   PubMed Web of Science ®Google Scholar
• Batrakova EV, Li S, Li Y, Alakhov VY, Kabanov AV. Effect of Pluronic P85 on ATPase activity of drug efflux transporters. Pharm Res 2004; 21: 2226–2233
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A, Schwarz V, Steininger S. Polymers with thiol groups: A new generation of mucoadhesive polymers?. Pharm Res 1999; 16: 876–881
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A, Zarti H, Walker GF. Thiolation of polycarbophil enhances its inhibition of soluble and intestinal brush border membrane bound aminopeptidase N. J Pharm Sci 2001; 90: 1907–1914
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A, Hornof M, Zoidl T. Thiolated polymers–thiomers: Synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. Int J Pharm 2003; 260: 229–237
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A, Hornof M, Guggi D. Thiolated chitosans. Eur J Pharm Biopharm 2004; 57: 9–17
   PubMed Web of Science ®Google Scholar
• Bogman K, Zysset Y, Degen L, Hopfgartner G, Gutmann H, Alsenz J, Drewe J. P-glycoprotein and surfactants: Effect on intestinal talinolol absorption. Clin Pharmacol Ther 2005; 77: 24–32
   PubMed Web of Science ®Google Scholar
• Bogman K, Erne-Brand F, Alsenz J, Drewe J. The role of surfactants in the reversal of active transport mediated by multidrug resistance proteins. J Pharm Sci 2003; 92: 1250–1261
   PubMed Web of Science ®Google Scholar
• Bromberg L, Alakhov V. Effects of polyether-modified poly(acrylic acid) microgels on doxorubicin transport in human intestinal epithelial Caco-2 cell layers. J Control Release 2003; 88: 11–22
   PubMed Web of Science ®Google Scholar
• Carreno-Gomez B, Duncan R. 2000. Compositions with enhanced oral bioavailability, US Patent 424/78.17.
   Google Scholar
• Clausen AE, Kast CE, Bernkop-Schnürch A. The role of glutathione in the permeation enhancing effect of thiolated polymers. Pharm Res 2002; 19: 602–608
   PubMed Web of Science ®Google Scholar
• Demina T, Grozdova I, Krylova O, Zhirnov A, Istratov V, Frey H, Kautz H, Melik-Nubarov N. Relationship between the structure of amphiphilic copolymers and their ability to disturb lipid bilayers. Biochemistry 2005; 44: 4042–4054
   PubMed Web of Science ®Google Scholar
• Demirbas S, Stavchansky S. Effects of citicholine and dimethylsulfoxide on transepithelial transport of passively diffused drugs in the Caco-2 cell culture model. Int J Pharm 2003; 251: 107–112
   PubMedGoogle Scholar
• Föger F, Schmitz T, Bernkop-Schnürch A. In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. Biomaterials 2006; 27: 4250–4255
   PubMed Web of Science ®Google Scholar
• Gerrard G, Payne E, Baker RJ, Jones DT, Potter M, Prentice HG, Ethell M, McCullough H, Burgess M, Mehta AB, Ganeshaguru K. Clinical effects and P-glycoprotein inhibition in patients with acute myeloid leukaemia treated with zosuquidar trihydrochloride, daunorubicin and cytarabine. Haematologica 2004; 89: 782–790
   PubMed Web of Science ®Google Scholar
• Hugger ED, Audus KL, Borchardt RT. Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers. J Pharm Sci 2002; 91: 1980–1990
   PubMed Web of Science ®Google Scholar
• Hunter J, Hirst BH. Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption. Adv Drug Deliv Rev 1997; 25: 129–157
   Web of Science ®Google Scholar
• Jain R, Agarwal S, Majumdar S, Zhu X, Pal D, Mitra AK. Evasion of P-gp mediated cellular efflux and permeability enhancement of HIV-protease inhibitor saquinavir by prodrug modification. Int J Pharm 2005; 303: 8–19
   PubMed Web of Science ®Google Scholar
• Kageyama M, Namiki H, Fukushima H, Ito Y, Shibata N, Takada K. In vivo effects of cyclosporine A and ketoconazole on the pharmacokinetics of representative substrates for P-glycoprotein and cytochrome P450 (CYP) 3A in rats. Biol Pharm Bull 2005; 28: 316–322
   PubMed Web of Science ®Google Scholar
• Kim RB. Drugs as P-glycoprotein substrates, inhibitors, and inducers. Drug Metab Rev 2002; 34: 47–54
   PubMed Web of Science ®Google Scholar
• Liu R, Sharom FJ. Site-directed fluorescence labelling of P-glycoprotein on cystein residues in the nucleotide binding domains. Biochemistry 1996; 35: 11865–11873
   PubMed Web of Science ®Google Scholar
• Lo YL, Huang JD. Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats. Biochem Pharmacol 2000; 59: 665–672
   PubMed Web of Science ®Google Scholar
• Luessen HL, De Leeuw BJ, Langemeyer MW, De Boer AB, Verhoef JC, Junginger HE. Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm Res 1996; 13: 1668–1672
   PubMed Web of Science ®Google Scholar
• Makhey VD, Guo A, Norris DA, Hu P, Yan J, Sinko PJ. Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells. Pharm Res 1998; 15: 1160–1167
   PubMed Web of Science ®Google Scholar
• Mouly SJ, Paine MF, Watkins PB. Contributions of CYP3A4, P-glycoprotein, and serum protein binding to the intestinal first-pass extraction of saquinavir. J Pharmacol Exp Ther 2003; 308: 941–948
   Web of Science ®Google Scholar
• Richter M, Gyemant N, Molnar J, Hilgeroth A. Comparative effect on intestinal absorption in situ by P-glycoprotein-modifying HIV protease inhibitors. Pharm Res 2004; 21: 1862–1866
   PubMed Web of Science ®Google Scholar
• Riley RG, Green KL, Smart JD, Tsibouklis J, Davis JA, Hampson F, Dettmar PW, Wilber WR. The gastrointestinal transit profile of 14C-labelled poly (acrylic acids): An in vivo study. Biomaterials 2001; 22: 1861–1867
   PubMed Web of Science ®Google Scholar
• Roldo M, Hornof M, Caliceti P, Bernkop-Schnürch A. Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: Synthesis and in vitro evaluation. Eur J Pharm Biopharm 2004; 57: 115–121
   PubMed Web of Science ®Google Scholar
• Senior AE, Gros P, Urbatsch IL. Residues in P-glycoprotein catalytic sites that react with the inhibitor 7-chloro-4-nitrobenzo-2-oxa-1, 3-diazole. Arch Biochem Biophys 1998; 357: 121–125
   PubMed Web of Science ®Google Scholar
• Troutman MD, Thakker DR. Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in CaCo-2 cells. Pharm Res 2003; 20: 1192–1199
   PubMed Web of Science ®Google Scholar
• Varma MVS, Ashokraj Y, Dey CS, Panchagnula R. P-glycoprotein inhibitors and their screening: A perspective from bioavailability enhancement. Pharm Res 2003; 48: 347–359
   Web of Science ®Google Scholar
• Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci 1998; 87: 1322–1330
   PubMed Web of Science ®Google Scholar
• Werle M, Hoffer M. Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine. J Control Release 2006; 111: 41–46
   PubMed Web of Science ®Google Scholar