213
Views
47
CrossRef citations to date
0
Altmetric
Research Article

In vitro evaluation and pharmacokinetics in dogs of guar gum and Eudragit FS30D-coated colon-targeted pellets of indomethacin

, &
Pages 123-131 | Received 25 May 2006, Accepted 02 Oct 2006, Published online: 08 Oct 2008

References

  • Amighi K, Timmermans J, Puigdevall J, Baltes E, Moes AJ. Peroral sustained-release film-coated pellets as a means to overcome physicochemical and biological drug-related problems. I. In vitro development and evaluation. Drug Dev Ind Pharm 1998; 24: 509–515
  • Ashford M, Fell JT, Attwood D, Woodhead PJ. An in-vitro investigation into the suitability of pH dependent polymers for colonic targeting. Int J Pharm 1993a; 91: 241–245
  • Ashford M, Fell JT, Attwood D, Sharma H, Woodhead PJ. An in vivo investigation into the suitability of pH-dependent polymers for colonic targeting. Int J Pharm 1993b; 95: 193–199
  • Basit AW. Advances in colonic drug delivery. Drugs 2005; 65: 1991–2007
  • Bayliss CE, Houston AP. Degradation of guar gum by faecal bacterial. Appl Environ Microbiol 1986; 48: 626–632
  • Davis SS, Wilding EA, Wilding IR. Gastrointestinal transit of a matrix tablet formulation: Comparison of canine and human data. Int J Pharm 1993; 94: 235–238
  • Durig T, Fassihi R. Guar-based monolithic matrix systems: Effect of ionizable and non-ionizable substances and excipients on gel dynamics and release kinetics. J Control Release 2002; 80: 45–56
  • Gao C, Huang J, Jiao Y, Shan L, Liu Y, Li Y, Mei X. In vitro release and in vivo absorption in beagle dogs of meloxicam from Eudragit® FS 30 D-coated pellets. Int J Pharm 2006; 322: 104–112
  • Gliko-Kabir I, Yagen B, Penhasi A, Rubinstein A. Low swelling, crosslinked guar and its potential use as colon-specific drug carrier. Pharm Res 1998; 15: 1019–1025
  • Gliko-Kabir I, Yagen B, Baluom M, Rubinstein A. Phosphated crosslinked guar for colon-specific drug delivery: II. In vitro and in vivo evaluation in the rat. J Control Release 2000; 63: 129–134
  • Gupta VK, Beckert TE, Price JC. A novel pH- and time-based multi-unit potential colonic drug delivery system. I. Development. Int J Pharm 2001; 213: 83–91
  • Ibekwe VC, Fadda HM, Parsons GE, Basit AW. A comparative in vitro assessment of the drug release performance of pH-responsive polymers for ileo-colonic delivery. Int J Pharm 2006a; 308: 52–60
  • Ibekwe VC, Liu F, Fadda HM, Khela MK, Evans DF, Parsons GE, Basit AW. An investigation into the in vivo performance variability of pH responsive polymers for ileo-colonic drug delivery using gamma scintigraphy in humans. J Pharm Sci 2006b, in press, doi 10.1002/jps.20742
  • Ji C, Xu H, Wu W. A novel pH-, time- and enzyme-controlled colon-specific delivery system of 5-fluorouracil. Arch Pharm Res. 2006, Accepted for publication
  • Krishnaiah YSR, Styanarayana S, Rama Prasad YV. Evaluation of guar gum as a compression coat for drug targeting to colon. Int J Pharm 1998; 171: 137–146
  • Krishnaiah YSR, Veer Raju P, Dinesh Kumar B, Bhaskar P, Satyanarayana V. Development of colon targeted drug delivery systems for mebendazole. J Control Release 2001; 77: 87–95
  • Krishnaiah YSR, Styanarayana V, Dinesh Kumar B, Karthikeyan RS. In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of indomethacin. Eur J Pharm Sci 2002; 16: 185–192
  • Lee WW, Wilson CG, Mukherji G. Time-dependent systems for colonic delivery. Modified-release drug delivery technology, MJ Rathbone, J Hadgraft, MS Roberts. Marcel Dekker, New York 2003; 243–248
  • Leong CW, Newton JM, Basit AW, Podczeck F, Cummings JH, Ring SG. The formation of colonic digestible films of amylose and ethylcellulose from aqueous dispersions at temperatures below 37°C. Eur J Pharm Biopharm 2002; 54: 291–297
  • Li SP, Feld KM, Kowarski CR. The effect of polymer coating systems on the preparation, tableting, and dissolution properties of sustained-release drug pellets. Drug Dev Ind Pharm 1997; 23: 623–631
  • Matsuda KI, Takaya T, Shimoji F, Muraoka M, Yoshikawa M, Takada K. Effect of food intake on the deliver of fluorescein as a model drug in colon delivery capsule after oral to beagle dogs. J Drug Target 1996; 4: 59–67
  • Milojevic S, Newton JM, Cummings JH, Gibson GR, Botham RL, Ring SG, Stockham M, Allwood MC. Amylose as a coating for drug delivery to the colon: Preparation and in vitro evaluation using 5-aminosalicylic acid pellets. J Control Release 1996; 38: 75–84
  • Mura P, Maestrelli F, Cirri M, González Rodríguez ML, Rabasco Alvarez AM. Development of enteric-coated pectin-based matrix tablets for colonic delivery of theophylline. J Drug Target 2003; 11: 365–371
  • Nováková L, Matysová L, Havlíková L, Solich P. Development and validation of HPLC method for determination of indomethacin and its two degradation products in topical gel. J Pharm Biomed Anal 2005; 37: 899–905
  • Pozzi F, Furlani P, Gazzaniga A, Davis SS, Wilding IR. The Time-Clock ® system: A new oral dosage form for fast and complete release of drug after predetermined lag time. J Control Release 1994; 31: 99–108
  • Rama Prasad YV, Krishnaiah YSR, Satyanarayana S. In vitro evaluation of guar gum as a carrier for colon-specific drug delivery. J Control Release 1998; 51: 281–287
  • Rubinstein A, Radai R, Ezra M, Pathak S, Rokem JS. In vitro evaluation of calcium pectinate: A potential colon-specific drug delivery carrier. Pharm Res 1993; 10: 258–263
  • Semdé R, Amighi K, Devleeschouwer MJ, Moës AJ. Studies of pectin HM/Eudragit® RL/Eudragit® NE film-coating formulations intended for colonic drug delivery. Int J Pharm 2000; 197: 181–192
  • Sinha VR, Kumria R. Polysaccharides in colon-specific drug delivery. Int J Pharm 2001; 224: 19–38
  • Sugimoto M, Okagaki T, Narisawa S, Koida Y, Nakajima K. Improvement of dissoluteion characteristics and bioavailability of poorly water-soluble drugs by novel cogrinding method using water-soluble polymer. Int J Pharm 1998; 160: 11–19
  • Tomlin J, Read NW, Edwards CA, Duerden BI. The degradation of guar gum by a faecal incubation system. Br J Nutr 1986; 55: 481–486
  • Tozaki H, Komoike J, Tada C, Maruyama T, Terabe A, Suzuki T, Yamamoto A, Muranishi S. Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon. J Pharm Sci 1997; 86: 1016–1021
  • Tugcu-Demiröz F, Acartürk F, Takka S, Konus-Boyunaga Ö. In-vitro and in-vivo evaluation of mesalazine–guar gum matrix tablets for colonic drug delivery. J Drug Target 2004; 12: 105–112
  • Turkoglu M, Ugurlu T. In vitro evaluation of pectin–HPMC compression coated 5-aminosalicylic acid tablets for colonic delivery. Eur J Pharm Biopharm 2002; 53: 65–73
  • Van den Mooter G. Colon drug delivery. Expert Opin Drug Deliv 2006; 3: 111–125
  • Wakerly Z, Felt J, Attwood D, Parkins D. Pectin/ethylcellulose film coating formulations for colonic drug delivery. Pharm Res 1996; 13: 1210–1212
  • Watts PJ, Barrow L, Streed KP, Wilson CG, Spiller RC, Melia CD, Davies MC. The transit rate of different-sized model dosage forms through the human colon and the effects of a lactulose-induced catharsis. Int J Pharm 1992; 87: 215–221
  • Wilson PJ, Basit AW. Exploiting gastrointestinal bacteria to target drugs to the colon: An in vitro study using amylose coated tablets. Int J Pharm 2005; 300: 89–94
  • Wong D, Larrabee S, Clifford K, Tremblay J, Friend DR. USP dissolution apparatus III (reciprocating cylinder) for screening of guar-based colonic delivery formulations. J Control Release 1997; 47: 173–179

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.