Curcumin synergistically increases effects of β-interferon and retinoic acid on breast cancer cells in vitro and in vivo by up-regulation of GRIM-19 through STAT3-dependent and STAT3-independent pathways

References

• de Santis CE, Bray F, Ferlay J, et al. International variation in female breast cancer incidence and mortality rates. Cancer Epidemiol Biomarkers Prev 2015;24:1495–506.
   PubMed Web of Science ®Google Scholar
• Wang X, Yuan S, Wang J, et al. Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo. Toxicol Appl Pharmacol 2006;215:168–78.
   PubMed Web of Science ®Google Scholar
• Anan P, Sundaram C, Jhurani S, et al. Curcumin and cancer: an “old-age” disease with an “age-old” solution. Cancer Lett 2008;267:133–64.
   PubMed Web of Science ®Google Scholar
• Mehrabian Z, Chandrasekaran K, Kalakonda S, et al. The IFN-beta and retinoic acid-induced cell death regulator GRIM-19 is upregulated during focal cerebral ischemia. J Interferon Cytokine Res 2007;27:383–92.
   PubMed Web of Science ®Google Scholar
• Nallar SC, Lin L, Srivastava V, et al. GRIM-1, a novel growth suppressor, inhibits rRNA maturation by suppressing small nucleolar RNAs. PLoS One 2011;6:e24082.
   Google Scholar
• Alchanati I, Nallar SC, Sun P, et al. A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Oncogene 2006;25:7138–47.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Li M, Wei Y, et al. Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers. J Interferon Cytokine Res 2009;29:695–703.
   PubMed Web of Science ®Google Scholar
• Lufei C, Ma J, Huang G, et al. GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction. EMBO J 2003;22:1325–35.
   PubMed Web of Science ®Google Scholar
• Zhang J, Yang J, Roy SK, et al. The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci USA 2003;100:9342–7.
   PubMed Web of Science ®Google Scholar
• Brantley EC, Benveniste EN. Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol Cancer Res 2008;6:675–84.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Hao H, Zhao S, et al. Downregulation of GRIM-19 promotes growth and migration of human glioma cells. Cancer Sci 2011;102:1991–9.
   PubMed Web of Science ®Google Scholar
• Schaffer M, Schaffer PM, Bar-Sela G. An update on Curcuma as a functional food in the control of cancer and inflammation. Curr Opin Clin Nutr Metab Care 2015;18:605.
   PubMed Web of Science ®Google Scholar
• Lv ZD, Liu XP, Zhao WJ, et al. Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivo. Int J Clin Exp Pathol 2014;7:2818–24.
   PubMed Web of Science ®Google Scholar
• Khaw AK, Hande MP, Kalthur G, et al. Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells. J Cell Biochem 2013;114:1257–70.
   PubMed Web of Science ®Google Scholar
• Lee DS, Lee MK, Kim JH. Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. Anticancer Res 2009;29:5039–44.
   PubMed Web of Science ®Google Scholar
• Vafaiyan Z, Gharaei R, Asadi J. The correlation between telomerase activity and Bax/Bcl-2 ratio in valproic acid-treated MCF-7 breast cancer cell line. Iran J Basic Med Sci 2015;18:700–4.
   PubMed Web of Science ®Google Scholar
• Seo T, Lee D, Shim YS, et al. Viral interferon regulatory factor 1 of Kaposi’s sarcoma-associated herpes virus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death. J Virol 2002;76:8797–807.
   PubMed Web of Science ®Google Scholar
• Zhang J, Gill A, Atmore B, et al. Upregulation of the signal transducers and activators of transcription 3 (STAT3) pathway in lymphatic metastases of papillary thyroid cancer. Int J Clin Exp Pathol 2011;4:356–62.
   PubMed Web of Science ®Google Scholar
• Walker SR, Nelson EA, Zou L, et al. Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol Cancer Res 2009;7:966–76.
   PubMed Web of Science ®Google Scholar
• Ranger JJ, Levy DE, Shahalizadeh S, et al. Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression. Cancer Res 2009;69:6823–30.
   PubMed Web of Science ®Google Scholar
• Diaz N, Minton S, Cox C, et al. Activation of stat3 in primary tumours from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res 2006;12:20–8.
   PubMed Web of Science ®Google Scholar
• Dien J, Amin HM, Chiu N, et al. Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer. Am J Pathol 2006;169:633–42.
   PubMed Web of Science ®Google Scholar
• Haura EB, Turkson J, Jove R. Mechanisms of disease: insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2005;2:315–24.
   PubMedGoogle Scholar
• Zhao X, Yang W, Pei F, et al. Downregulation of matrix metalloproteinases contributes to the inhibition of cell migration and invasion in HepG2 cells by sodium valproate. Oncol Lett 2015;10:531–5.
   PubMed Web of Science ®Google Scholar
• Nakada M, Okada Y, Yamashita J. The role of matrix metalloproteinases in glioma invasion. Front Biosci 2003;8:e261–9.
   PubMed Web of Science ®Google Scholar
• Lim YS, Kwon SK, Park JH, et al. Enhanced mucosal healing with curcumin in animal oral ulcer model. Laryngoscope 2016;126:E68–73.
   PubMed Web of Science ®Google Scholar
• Zhang Y, McClain SA, Lee HM, et al. A novel chemically modified curcumin “normalizes” wound-healing in rats with experimentally induced type i diabetes: initial studies. J Diabetes Res 2016;2016:5782904.
   PubMed Web of Science ®Google Scholar
• Wang L, Ye X, Cai X, et al. Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells. Oncotarget 2015;6:18027–37.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Krauthauser C, Maduskuie V, et al. Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo. BMC Cancer 2011;11:144.
   PubMed Web of Science ®Google Scholar
• Kim SH, Hwang CI, Juhnn YS, et al. GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells. Carcinogenesis 2007;28:223–31.
   PubMedGoogle Scholar
• Li S, Gu Z, Xiao Z, et al. Anti-tumor effect and mechanism of cyclooxygenase-2 inhibitor through matrix metalloproteinase 14 pathway in PANC-1 cells. Int J Clin Exp Pathol 2015;8:1737–42.
   PubMed Web of Science ®Google Scholar