Recent progress in drug delivery of pluronic P123: pharmaceutical perspectives

References

• Sastry NV, Hoffmann H. Interaction of amphiphilic block copolymer micelles with surfactants. Colloids Surf A Physicochem Eng Asp 2004;250:247–61.
   Web of Science ®Google Scholar
• Akash MS, Rehman K, Chen S. Pluronic F127-based thermosensitive gels for delivery of therapeutic proteins and peptides. Polym Rev 2014;54:573–97.
   Web of Science ®Google Scholar
• Akash MS, Rehman K, Chen S. Natural and synthetic polymers as drug carriers for delivery of therapeutic proteins. Polym Rev 2015;55:371–406.
   Web of Science ®Google Scholar
• Akash MS, Rehman K, Chen S. Polymeric-based particulate systems for delivery of therapeutic proteins. Pharm Dev Technol 2016;21:367–78.
   PubMed Web of Science ®Google Scholar
• Akash MS, Rehman K. Recent progress in biomedical applications of Pluronic (PF127): Pharmaceutical perspectives. J Control Release 2015;209:120–38.
   PubMed Web of Science ®Google Scholar
• Parmar A, Singh K, Bahadur A, et al. Interaction and solubilization of some phenolic antioxidants in Pluronic® micelles. Colloids Surf B Biointerfaces 2011;86:319–26.
   PubMed Web of Science ®Google Scholar
• Batrakova EV, Kabanov AV. Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers. J Control Release 2008;130:98–106.
   PubMed Web of Science ®Google Scholar
• Zhao L, Shi Y, Zou S, et al. Formulation and in vitro evaluation of quercetin loaded polymeric micelles composed of pluronic P123 and D-a-tocopheryl polyethylene glycol succinate. J Biomed Nanotechnol 2011;7:358–65.
   PubMed Web of Science ®Google Scholar
• Jindal N, Mehta SK. Nevirapine loaded Poloxamer 407/Pluronic P123 mixed micelles: optimization of formulation and in vitro evaluation. Colloids Surf B Biointerfaces 2015;129:100–6.
   PubMed Web of Science ®Google Scholar
• Sakai T, Kurosawa H, Okada T, et al. Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water. Colloids Surf A Physicochem Eng Asp 2011;389:82–9.
   Web of Science ®Google Scholar
• Chen S, Yang B, Guo C, et al. Spontaneous vesicle formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer. J Phys Chem B 2008;112:15659–65.
   PubMed Web of Science ®Google Scholar
• Han LM, Guo J, Zhang LJ, et al. Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with Pluronic P123. Acta Pharmacol Sin 2006;27:747–53.
   PubMed Web of Science ®Google Scholar
• Liu Z, Liu D, Wang L, et al. Docetaxel-loaded pluronic p123 polymeric micelles: in vitro and in vivo evaluation. Int J Mol Sci 2011;12:1684–96.
   PubMed Web of Science ®Google Scholar
• Wei Z, Hao J, Yuan S, et al. Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization. Int J Pharm 2009;376:176–85.
   PubMed Web of Science ®Google Scholar
• Zhang W, Shi Y, Chen Y, et al. Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance. Eur J Pharm Biopharm 2010;75:341–53.
   PubMed Web of Science ®Google Scholar
• Abdelbary GA, Tadros MI. Brain targeting of olanzapine via intranasal delivery of core-shell difunctional block copolymer mixed nanomicellar carriers: in vitro characterization, ex vivo estimation of nasal toxicity and in vivo biodistribution studies. Int J Pharm 2013;452:300–10.
   PubMed Web of Science ®Google Scholar
• Zhao L, Du J, Duan Y, et al. Curcumin loaded mixed micelles composed of Pluronic P123 and F68: preparation, optimization and in vitro characterization. Colloids Surf B Biointerfaces 2012;97:101–8.
   PubMed Web of Science ®Google Scholar
• Wang G, Wang JJ, Tang XJ, et al. In vitro and in vivo evaluation of functionalized chitosan-Pluronic micelles loaded with myricetin on glioblastoma cancer. Nanomedicine 2016;12:1263–78.
   PubMed Web of Science ®Google Scholar
• Duan Y, Cai X, Du H, et al. Novel in situ gel systems based on P123/TPGS mixed micelles and gellan gum for ophthalmic delivery of curcumin. Colloids Surf B Biointerfaces 2015;128:322–30.
   PubMed Web of Science ®Google Scholar
• Yang R, Zhang X, Li F, et al. Role of phospholipids and copolymers in enhancing stability and controlling degradation of intravenous lipid emulsions. Colloids Surf A Physicochem Eng Asp 2013;436:434–42.
   Web of Science ®Google Scholar
• Cai X, Liu M, Zhang C, et al. pH-responsive copolymers based on pluronic P123-poly(beta-amino ester): synthesis, characterization and application of copolymer micelles. Colloids Surf B Biointerfaces 2016;142:114–22.
   PubMed Web of Science ®Google Scholar
• Kabanov AV, Batrakova EV, Miller DW. Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Adv Drug Deliv Rev 2003;55:151–64.
   PubMed Web of Science ®Google Scholar
• Sun H, Meng Q, Tang S, et al. Inhibition of breast cancer metastasis by Pluronic copolymers with moderate hydrophilic-lipophilic balance. Mol Pharm 2015;12:3323–31.
   PubMed Web of Science ®Google Scholar
• Singh K, Marangoni DG. Synergistic interactions in the mixed micelles of cationic gemini with zwitterionic surfactants: the pH and spacer effect. J Colloid Interface Sci 2007;315:620–6.
   PubMed Web of Science ®Google Scholar
• John F, George J, Vartak SV, et al. Enhanced efficacy of pluronic copolymer micelle encapsulated SCR7 against cancer cell proliferation. Macromol Biosci 2015;15:521–34.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li Y, Zhang L, et al. Pharmacokinetics and biodistribution of paclitaxel-loaded pluronic P105 polymeric micelles. Arch Pharm Res 2008;31:530–8.
   PubMed Web of Science ®Google Scholar
• Wang Y, Yu L, Han L, et al. Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines. Int J Pharm 2007;337:63–73.
   PubMed Web of Science ®Google Scholar
• Yang L, Wu X, Liu F, et al. Novel biodegradable polylactide/poly(ethylene glycol) micelles prepared by direct dissolution method for controlled delivery of anticancer drugs. Pharm Res 2009;26:2332–42.
   PubMed Web of Science ®Google Scholar
• Yoo HS, Park TG. Folate receptor targeted biodegradable polymeric doxorubicin micelles. J Control Release 2004;96:273–83.
   PubMed Web of Science ®Google Scholar
• Bhattacharjee J, Verma G, Aswal VK, et al. Microstructure, drug binding and cytotoxicity of Pluronic P123–aerosol OT mixed micelles. RSC Adv 2013;3:23080–9.
   Web of Science ®Google Scholar
• Kabanov AV, Batrakova EV, Alakhov VY. An essential relationship between ATP depletion and chemosensitizing activity of Pluronic block copolymers. J Control Release 2003;91:75–83.
   PubMed Web of Science ®Google Scholar
• Chaibundit C, Ricardo NM, Costa Fde M, et al. Micellization and gelation of mixed copolymers P123 and F127 in aqueous solution. Langmuir 2007;23:9229–36.
   PubMed Web of Science ®Google Scholar
• Mohanty ME, Rao VJ, Mishra AK. A fluorescence study on the interaction of telmisartan in triblock polymers pluronic P123 and F127. Spectrochim Acta A Mol Biomol Spectrosc 2014;121:330–8.
   PubMed Web of Science ®Google Scholar
• Zhang W, Shi Y, Chen Y, et al. The potential of Pluronic polymeric micelles encapsulated with paclitaxel for the treatment of melanoma using subcutaneous and pulmonary metastatic mice models. Biomaterials 2011;32:5934–44.
   PubMed Web of Science ®Google Scholar
• Wei Z, Yuan S, Hao J, et al. Mechanism of inhibition of P-glycoprotein mediated efflux by Pluronic P123/F127 block copolymers: relationship between copolymer concentration and inhibitory activity. Eur J Pharm Biopharm 2013;83:266–74.
   PubMed Web of Science ®Google Scholar
• Guan Y, Huang J, Zuo L, et al. Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism. Arch Pharm Res 2011;34:1719–28.
   PubMed Web of Science ®Google Scholar
• Lee ES, Oh YT, Youn YS, et al. Binary mixing of micelles using Pluronics for a nano-sized drug delivery system. Colloids Surf B Biointerfaces 2011;82:190–5.
   PubMed Web of Science ®Google Scholar
• Cha MH, Choi J, Choi BG, et al. Synthesis and characterization of novel thermo-responsive F68 block copolymers with cell-adhesive RGD peptide. J Colloid Interface Sci 2011;360:78–85.
   PubMed Web of Science ®Google Scholar
• Wulff-Pérez M, Torcello-Gómez A, Gálvez-Ruíz MJ, et al. Stability of emulsions for parenteral feeding: Preparation and characterization of o/w nanoemulsions with natural oils and Pluronic f68 as surfactant. Food Hydrocolloids 2009;23:1096–102.
   Web of Science ®Google Scholar
• Yan A, Von Dem Bussche A, Kane AB, et al. Tocopheryl polyethylene glycol succinate as a safe, antioxidant surfactant for processing carbon nanotubes and fullerenes. Carbon N Y 2007;45:2463–70.
   PubMed Web of Science ®Google Scholar
• Gao Y, Li LB, Zhai G. Preparation and characterization of Pluronic/TPGS mixed micelles for solubilization of camptothecin. Colloids Surf B Biointerfaces 2008;64:194–9.
   PubMed Web of Science ®Google Scholar
• Bansal T, Akhtar N, Jaggi M, et al. Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation. Drug Discov Today 2009;14:1067–74.
   PubMed Web of Science ®Google Scholar
• Zhao H, Yung LY. Addition of TPGS to folate-conjugated polymer micelles for selective tumor targeting. J Biomed Mater Res A 2009;91:505–18.
   PubMed Web of Science ®Google Scholar
• Collnot EM, Baldes C, Wempe MF, et al. Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. J Control Release 2006;111:35–40.
   PubMed Web of Science ®Google Scholar
• Mandal AK, Sen Mojumdar S, Kumar Das A, et al. Effect of ionic liquid on diffusion in P123 gel: fluorescence correlation spectroscopy. Chemphyschem 2012;13:1942–8.
   PubMed Web of Science ®Google Scholar
• Hwang YJ, Oh C, Oh SG. Controlled release of retinol from silica particles prepared in O/W/O emulsion: the effects of surfactants and polymers. J Control Release 2005;106:339–49.
   PubMed Web of Science ®Google Scholar
• El-Setouhy DA, Basalious EB, Abdelmalak NS. Bioenhanced sublingual tablet of drug with limited permeability using novel surfactant binder and microencapsulated polysorbate: in vitro/in vivo evaluation. Eur J Pharm Biopharm 2015;94:386–92.
   PubMed Web of Science ®Google Scholar
• Liu Y, Feng L, Liu T, et al. Multifunctional pH-sensitive polymeric nanoparticles for theranostics evaluated experimentally in cancer. Nanoscale 2014;6:3231–42.
   PubMed Web of Science ®Google Scholar
• Lee ES, Oh KT, Kim D, et al. Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine). J Control Release 2007;123:19–26.
   PubMed Web of Science ®Google Scholar
• Yin H, Lee ES, Kim D, et al. Physicochemical characteristics of pH-sensitive poly(L-histidine)-b-poly(ethylene glycol)/poly(L-lactide)-b-poly(ethylene glycol) mixed micelles. J Control Release 2008;126:130–8.
   PubMed Web of Science ®Google Scholar
• Kost J, Langer R. Responsive polymeric delivery systems. Adv Drug Deliv Rev 2001;46:125–48.
   PubMed Web of Science ®Google Scholar
• Chan A, Orme RP, Fricker RA, et al. Remote and local control of stimuli responsive materials for therapeutic applications. Adv Drug Deliv Rev 2013;65:497–514.
   PubMed Web of Science ®Google Scholar
• Fan J, Zeng F, Wu S, et al. Polymer micelle with pH-triggered hydrophobic-hydrophilic transition and de-cross-linking process in the core and its application for targeted anticancer drug delivery. Biomacromolecules 2012;13:4126–37.
   PubMed Web of Science ®Google Scholar
• Yang YQ, Zhao B, Li ZD, et al. pH-sensitive micelles self-assembled from multi-arm star triblock co-polymers poly(epsilon-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery. Acta Biomater 2013;9:7679–90.
   PubMed Web of Science ®Google Scholar
• Min KH, Kim JH, Bae SM, et al. Tumoral acidic pH-responsive MPEG-poly(beta-amino ester) polymeric micelles for cancer targeting therapy. J Control Release 2010;144:259–66.
   PubMed Web of Science ®Google Scholar
• Little SR, Lynn DM, Ge Q, et al. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci USA 2004;101:9534–9.
   PubMed Web of Science ®Google Scholar
• Lai TC, Kataoka K, Kwon GS. Pluronic-based cationic block copolymer for forming pDNA polyplexes with enhanced cellular uptake and improved transfection efficiency. Biomaterials 2011;32:4594–603.
   PubMed Web of Science ®Google Scholar
• Kabanov AV, Lemieux P, Vinogradov S, et al. Pluronic block copolymers: novel functional molecules for gene therapy. Adv Drug Deliv Rev 2002;54:223–33.
   PubMed Web of Science ®Google Scholar
• Shen J, Yin Q, Chen L, et al. Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer. Biomaterials 2012;33:8613–24.
   PubMed Web of Science ®Google Scholar
• Ochietti B, Guerin N, Vinogradov SV, et al. Altered organ accumulation of oligonucleotides using polyethyleneimine grafted with poly(ethylene oxide) or pluronic as carriers. J Drug Target 2002;10:113–21.
   PubMed Web of Science ®Google Scholar
• Gaymalov ZZ, Yang Z, Pisarev VM, et al. The effect of the nonionic block copolymer pluronic P85 on gene expression in mouse muscle and antigen-presenting cells. Biomaterials 2009;30:1232–45.
   PubMed Web of Science ®Google Scholar
• Lemieux P, Guerin N, Paradis G, et al. A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle. Gene Ther 2000;7:986–91.
   PubMed Web of Science ®Google Scholar
• Vinogradov SV, Batrakova EV, Li S, et al. Mixed polymer micelles of amphiphilic and cationic copolymers for delivery of antisense oligonucleotides. J Drug Target 2004;12:517–26.
   PubMed Web of Science ®Google Scholar
• Gu J, Hao J, Fang X, et al. Factors influencing the transfection efficiency and cellular uptake mechanisms of Pluronic P123-modified polypropyleneimine/pDNA polyplexes in multidrug resistant breast cancer cells. Colloids Surf B Biointerfaces 2016;140:83–93.
   PubMed Web of Science ®Google Scholar
• Kopecek J. Polymer-drug conjugates: origins, progress to date and future directions. Adv Drug Deliv Rev 2013;65:49–59.
   PubMed Web of Science ®Google Scholar
• Ringsdorf H. Structure and properties of pharmacologically active polymers. Journal of Polymer Science: Polymer Symposia 1975;51:135–53.
   Google Scholar
• Li C, Wallace S. Polymer-drug conjugates: recent development in clinical oncology. Adv Drug Deliv Rev 2008;60:886–98.
   PubMed Web of Science ®Google Scholar
• Posey JA, Saif MW, Carlisle R, et al. Phase 1 study of weekly polyethylene glycol-camptothecin in patients with advanced solid tumors and lymphomas. Clin Cancer Res 2005;11:7866–71.
   PubMed Web of Science ®Google Scholar
• Liu Z, Wang Y, Zhang J, et al. Pluronic P123-docetaxel conjugate micelles: synthesis, characterization, and antitumor activity. J Biomed Nanotechnol 2013;9:2007–16.
   PubMed Web of Science ®Google Scholar
• William WN, Jr., Heymach JV, Kim ES, et al. Molecular targets for cancer chemoprevention. Nat Rev Drug Discov 2009;8:213–25.
   PubMed Web of Science ®Google Scholar
• Farokhzad OC, Cheng J, Teply BA, et al. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci USA 2006;103:6315–20.
   PubMed Web of Science ®Google Scholar
• Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449–65.
   PubMed Web of Science ®Google Scholar
• Powis G, Kirkpatrick L. Hypoxia inducible factor-1alpha as a cancer drug target. Mol Cancer Ther 2004;3:647–54.
   PubMed Web of Science ®Google Scholar
• Song H, He R, Wang K, et al. Anti-HIF-1alpha antibody-conjugated pluronic triblock copolymers encapsulated with Paclitaxel for tumor targeting therapy. Biomaterials 2010;31:2302–12.
   PubMed Web of Science ®Google Scholar
• Coradini D, Pellizzaro C, Abolafio G, et al. Hyaluronic-acid butyric esters as promising antineoplastic agents in human lung carcinoma: a preclinical study. Invest New Drugs 2004;22:207–17.
   PubMed Web of Science ®Google Scholar
• Miletti-González KE, Chen S, Muthukumaran N, et al. The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer. Cancer Res 2005;65:6660–7.
   PubMed Web of Science ®Google Scholar
• Gu J, Fang X, Hao J, et al. Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery. Biomaterials 2015;45:99–114.
   PubMed Web of Science ®Google Scholar
• Lee DE, Hong YD, Choi KH, et al. Preparation and evaluation of 99mTc-labeled cyclic arginine-glycine-aspartate (RGD) peptide for integrin targeting. Appl Radiat Isot 2010;68:1896–902.
   PubMed Web of Science ®Google Scholar
• Zhao W, Liu K, Chen S, et al. Polyethylenimine derivate conjugated with RGD-TAT-NLS as a novel gene vector. Biomed Mater Eng 2014;24:1933–9.
   PubMed Web of Science ®Google Scholar
• Hu J, Zhao W, Liu K, et al. Low-molecular weight polyethylenimine modified with Pluronic 123 and RGD- or chimeric RGD-NLS peptide: characteristics and transfection efficacy of their complexes with plasmid DNA. Molecules 2016;21:655?67.
   Web of Science ®Google Scholar
• Hartmann LC, Keeney GL, Lingle WL, et al. Folate receptor overexpression is associated with poor outcome in breast cancer. Int J Cancer 2007;121:938–42.
   PubMed Web of Science ®Google Scholar
• Iwakiri S, Sonobe M, Nagai S, et al. Expression status of folate receptor alpha is significantly correlated with prognosis in non-small-cell lung cancers. Ann Surg Oncol 2008;15:889–99.
   PubMed Web of Science ®Google Scholar
• Chen H, Ahn R, Van den Bossche J, et al. Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide. Mol Cancer Ther 2009;8:1955–63.
   PubMed Web of Science ®Google Scholar
• Zhao X, Li H, Lee RJ. Targeted drug delivery via folate receptors. Expert Opin Drug Deliv 2008;5:309–19.
   PubMed Web of Science ®Google Scholar
• Gabizon A, Tzemach D, Gorin J, et al. Improved therapeutic activity of folate-targeted liposomal doxorubicin in folate receptor-expressing tumor models. Cancer Chemother Pharmacol 2010;66:43–52.
   PubMed Web of Science ®Google Scholar
• Nichols B. Endocytosis of lipid-anchored proteins: excluding GEECs from the crowd. J Cell Biol 2009;186:457–9.
   PubMed Web of Science ®Google Scholar
• Lakhan SE, Sabharanjak S, De A. Endocytosis of glycosylphosphatidylinositol-anchored proteins. J Biomed Sci 2009;16:93
   PubMed Web of Science ®Google Scholar
• Wei K, Peng X, Zou F. Folate-decorated PEG-PLGA nanoparticles with silica shells for capecitabine controlled and targeted delivery. Int J Pharm 2014;464:225–33.
   PubMed Web of Science ®Google Scholar
• Li Y, Bi Y, Xi Y, et al. Enhancement on oral absorption of paclitaxel by multifunctional pluronic micelles. J Drug Target 2013;21:188–99.
   PubMed Web of Science ®Google Scholar
• Xu W, Cui Y, Ling P, et al. Preparation and evaluation of folate-modified cationic pluronic micelles for poorly soluble anticancer drug. Drug Deliv 2012;19:208–19.
   PubMed Web of Science ®Google Scholar
• Li M, Liu Y, Feng L, et al. Polymeric complex micelles with double drug-loading strategies for folate-mediated paclitaxel delivery. Colloids Surf B Biointerfaces 2015;131:191–201.
   PubMed Web of Science ®Google Scholar
• Stockert RJ. The asialoglycoprotein receptor: relationships between structure, function, and expression. Physiol Rev 1995;75:591–609.
   PubMed Web of Science ®Google Scholar
• Kim EM, Jeong HJ, Park IK, et al. Asialoglycoprotein receptor targeted gene delivery using galactosylated polyethylenimine-graft-poly(ethylene glycol): in vitro and in vivo studies. J Control Release 2005;108:557–67.
   PubMed Web of Science ®Google Scholar
• Wu DQ, Lu B, Chang C, et al. Galactosylated fluorescent labeled micelles as a liver targeting drug carrier. Biomaterials 2009;30:1363–71.
   PubMed Web of Science ®Google Scholar
• Yang R, Meng F, Ma S, et al. Galactose-decorated cross-linked biodegradable poly(ethylene glycol)-b-poly(epsilon-caprolactone) block copolymer micelles for enhanced hepatoma-targeting delivery of paclitaxel. Biomacromolecules 2011;12:3047–55.
   PubMed Web of Science ®Google Scholar
• Wei W, Yue ZG, Qu JB, et al. Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation. Nanomedicine (Lond) 2010;5:589–96.
   PubMed Web of Science ®Google Scholar
• Morgan NY, English S, Chen W, et al. Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots. Acad Radiol 2005;12:313–23.
   PubMed Web of Science ®Google Scholar
• Zhang X, Guo S, Fan R, et al. Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells. Biomaterials 2012;33:7103–14.
   PubMed Web of Science ®Google Scholar
• Pardridge WM. Blood-brain barrier delivery. Drug Discov Today 2007;12:54–61.
   PubMed Web of Science ®Google Scholar
• Li J, Zhou L, Ye D, et al. Choline-derivate-modified nanoparticles for brain-targeting gene delivery. Adv. Mater. Weinheim 2011;23:4516–20.
   PubMed Web of Science ®Google Scholar
• Kanai Y, Segawa H, Miyamoto K, et al. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 1998;273:23629–32.
   PubMed Web of Science ®Google Scholar
• Hayashi K, Jutabha P, Endou H, et al. LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells. J Immunol 2013;191:4080–5.
   PubMed Web of Science ®Google Scholar
• Sinclair LV, Rolf J, Emslie E, et al. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol 2013;14:500–8.
   PubMed Web of Science ®Google Scholar
• Nii T, Segawa H, Taketani Y, et al. Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation. Biochem J 2001;358:693–704.
   PubMed Web of Science ®Google Scholar
• Huttunen KM, Huttunen J, Aufderhaar I, et al. L-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors. Int J Pharm 2016;498:205–16.
   PubMed Web of Science ®Google Scholar
• Liu J, He Y, Zhang J, et al. Functionalized nanocarrier combined seizure-specific vector with P-glycoprotein modulation property for antiepileptic drug delivery. Biomaterials 2016;74:64–76.
   PubMed Web of Science ®Google Scholar