α-Tocopherol as functional excipient for resveratrol and coenzyme Q10-loaded SNEDDS for improved bioavailability and prophylaxis of breast cancer

References

• Tong J, Zimmerman MC, Li S, et al. Neuronal uptake and intracellular superoxide scavenging of a fullerene (C60)-poly (2-oxazoline)s nanoformulation. Biomaterials 2011;32:3654–65.
   PubMed Web of Science ®Google Scholar
• Chitkara D, Nikalaje SK, Mittal A, et al. Development of quercetin nanoformulation and in vivo evaluation using streptozotocin induced diabetic rat model. Drug Deliv Transl Res 2012;2:112–23.
   PubMed Web of Science ®Google Scholar
• Liu Q, Zhang X, Zhang X, et al. C70-carboxyfullerenes as efficient antioxidants to protect cells against oxidative-induced stress. ACS Appl Mater Interfaces 2013;5:11101–7.
   PubMed Web of Science ®Google Scholar
• Yang J, Van Lith R, Baler K, et al. A thermoresponsive biodegradable polymer with intrinsic antioxidant properties. Biomacromolecules 2014;15:3942–52.
   PubMed Web of Science ®Google Scholar
• Richard PU, Duskey JT, Stolarov S, et al. New concepts to fight oxidative stress: nanosized three-dimensional supramolecular antioxidant assemblies. Expert Opin Drug Deliv 2015;12:1527–45.
   PubMed Web of Science ®Google Scholar
• Rogers E, Hsieh S, Organti N, et al. A high throughput in vitro analytical approach to screen for oxidative stress potential exerted by nanomaterials using a biologically relevant matrix: human blood serum. Toxicol In Vitro 2008;22:1639–47.
   PubMed Web of Science ®Google Scholar
• Hoennscheidt C, Margaritis A, Krull R. Novel applications of ubiquinone biopolymer nanocarriers for preventive and regenerative therapeutics: the Saccharomyces cerevisiae paradigm. Int J Pharm 2015;478:416–25.
   PubMed Web of Science ®Google Scholar
• Siddiqui IA, Sanna V, Ahmad N, et al. Resveratrol nanoformulation for cancer prevention and therapy. Ann N Y Acad Sci 2015;1348:20–31.
   PubMed Web of Science ®Google Scholar
• Perumal SS, Shanthi P, Sachdanandam P. Combined efficacy of tamoxifen and coenzyme Q10 on the status of lipid peroxidation and antioxidants in DMBA induced breast cancer. Mol Cell Biochem 2005;273:151–60.
   PubMed Web of Science ®Google Scholar
• Sakano K, Takahashi M, Kitano M, et al. Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats. Asian Pac J Cancer Prev 2006;7:599–603.
   PubMedGoogle Scholar
• Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997;275:218–20.
   PubMed Web of Science ®Google Scholar
• Rimando AM, Cuendet M, Desmarchelier C, et al. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J Agric Food Chem 2002;50:3453–7.
   PubMed Web of Science ®Google Scholar
• Lin JK, Tsai SH. Chemoprevention of cancer and cardiovascular disease by resveratrol. Proc Natl Sci Counc Repub China B 1999;23:99–106.
   PubMedGoogle Scholar
• Bhat KP, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Ann N Y Acad Sci 2002;957:210–29.
   PubMed Web of Science ®Google Scholar
• Singal PK, Siveski-Iliskovic N, Hill M, et al. Combination therapy with probucol prevents adriamycin-induced cardiomyopathy. J Mol Cell Cardiol 1995;27:1055–63.
   PubMed Web of Science ®Google Scholar
• Potgieter M, Pretorius E, Van Der Merwe CF, et al. Histological assessment of SJL/J mice treated with the antioxidants coenzyme Q10 and resveratrol. Micron 2011;42:275–82.
   PubMed Web of Science ®Google Scholar
• Bansal SS, Goel M, Aqil F, et al. Advanced drug delivery systems of curcumin for cancer chemoprevention. Cancer Prev Res (Phila) 2011;4:1158–71.
   PubMed Web of Science ®Google Scholar
• Ozawa Y, Mizushima Y, Koyama I, et al. Intestinal absorption enhancement of coenzyme Q10 with a lipid microsphere. Arzneimittelforschung 1986;36:689–90.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang S. Topical use of Coenzyme Q 10-loaded liposomes coated with trimethyl chitosan: tolerance, precorneal retention and anti-cataract effect. Int J Pharm 2009;372:66–75.
   PubMed Web of Science ®Google Scholar
• Teskač K, Kristl J. The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Int J Pharm 2010;390:61–9.
   PubMed Web of Science ®Google Scholar
• Sanna V, Roggio AM, Siliani S, et al. Development of novel cationic chitosan-and anionic alginate-coated poly(d,l-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol. Int J Nanomed 2012;7:5501–16.
   PubMed Web of Science ®Google Scholar
• Agrawal AK, Urimi D, Jain S. Multifunctional polymeric nano-carriers in targeted drug delivery. In: Devarajan PV, Jain S, eds. Targeted drug delivery: concepts and design. New York: Springer; 2015:461–500.
   Google Scholar
• Jain AK, Thanki K, Jain S. Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: part I. Formulation development, statistical optimization, and in vitro characterization. Pharm Res 2014;31:923–45.
   PubMed Web of Science ®Google Scholar
• Beg S, Sharma G, Thanki K, et al. Positively charged self-nanoemulsifying oily formulations of olmesartan medoxomil: systematic development, in vitro, ex vivo and in vivo evaluation. Int J Pharm 2015;493:466–82.
   PubMed Web of Science ®Google Scholar
• Nazzal S, Smalyukh I, Lavrentovich OD, Khan MA. Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. Int J Pharm 2002;235:247–65.
   PubMed Web of Science ®Google Scholar
• Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev 1997;25:47–58.
   Web of Science ®Google Scholar
• Jain S, Jain AK, Pohekar M, Thanki K. Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: implications for drug-induced cardiotoxicity and nephrotoxicity. Free Radic Biol Med 2013b;65:117–30.
   PubMed Web of Science ®Google Scholar
• Date AA, Nagarsenker M. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int J Pharm 2007;329:166–72.
   PubMed Web of Science ®Google Scholar
• Jain S, Kambam S, Thanki K, Jain AK. Cyclosporine A Loaded Self-nanoemulsifying Drug Delivery System (SNEDDS): implication of functional excipient based co-encapsulation strategy on oral bioavailability and nephrotoxicity. RSC Adv 2015;5:49633–42.
   Web of Science ®Google Scholar
• Jain S, Patil SR, Swarnakar NK, Agrawal AK. Oral delivery of doxorubicin using novel polyelectrolyte-stabilized liposomes (layersomes). Mol Pharm 2012;9:2626–35.
   PubMed Web of Science ®Google Scholar
• Dora CP, Trotta F, Kushwah V, et al. Potential of erlotinib cyclodextrin nanosponge complex to enhance solubility, dissolution rate, in vitro cytotoxicity and oral bioavailability. Carbohydr Polym 2016;137:339–49.
   PubMed Web of Science ®Google Scholar
• Agrawal AK, Harde H, Thanki K, Jain S. Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration. Biomacromolecules 2014;15:350–60.
   PubMed Web of Science ®Google Scholar
• Agrawal AK, Urimi D, Harde H, et al. Folate appended chitosan nanoparticles augment the stability, bioavailability and efficacy of insulin in diabetic rats following oral administration. RSC Adv 2015a;5:105179–93.
   Web of Science ®Google Scholar
• Jain AK, Thanki K, Jain S. Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. Mol Pharm 2013a;10:3459–74.
   PubMed Web of Science ®Google Scholar
• Jain AK, Swarnakar NK, Godugu C, et al. The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen. Biomaterials 2011;32:503–15.
   PubMed Web of Science ®Google Scholar
• Tripathi S, Kushwah V, Thanki K, Jain S. Triple antioxidant SNEDDS formulation with enhanced oral bioavailability: implication of chemoprevention of breast cancer. Nanomedicine 2016;12:1431–43.
   PubMed Web of Science ®Google Scholar
• Kaukonen AM, Boyd BJ, Porter CJ, Charman WN. Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations. Pharm Res 2004;21:245–53.
   PubMed Web of Science ®Google Scholar
• Li P, Ghosh A, Wagner RF, et al. Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions. Int J Pharm 2005;288:27–34.
   PubMed Web of Science ®Google Scholar
• Nepal PR, Han H-K, Choi H-K. Preparation and in vitro–in vivo evaluation of Witepsol H35 based self-nanoemulsifying drug delivery systems (SNEDDS) of coenzyme Q(10). Eur J Pharm Sci 2010;39:224–32.
   PubMed Web of Science ®Google Scholar
• Dahan A, Hoffman A. Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs. Eur J Pharm Sci 2005;24:381–8.
   PubMed Web of Science ®Google Scholar
• Fatouros DG, Walrand I, Bergenstahl B, Müllertz A. Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis products. Pharm Res 2009;26:361–74.
   PubMed Web of Science ®Google Scholar
• Joshi RP, Negi G, Kumar A, et al. SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection. Nanomedicine: Nanotechnol Biol Med2013;9:776–85.
   PubMed Web of Science ®Google Scholar