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Original Articles

Quercetin inhibits human microvascular endothelial cells viability, migration and tube-formation in vitro through restraining microRNA-216a

, , , , , , & ORCID Icon show all
Pages 609-616 | Received 18 Sep 2019, Accepted 25 Nov 2019, Published online: 10 Dec 2019

Reference

  • Criqui MH, Aboyans V. Epidemiology of peripheral artery disease. Circ Res. 2015;116(9):1509–1526.
  • Song P, Rudan D, Wang M, et al. National and subnational estimation of the prevalence of peripheral artery disease (PAD) in China: a systematic review and meta-analysis. J Global Health. 2019;9(1):010601.
  • Benjamin EJ, Virani SS, Callaway CW, et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137(12):e67–e492.
  • Fowkes FG, Rudan D, Rudan I, et al. Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet. 2013;382(9901):1329–1340.
  • Aiman U, Haseen MA, Beg MH, et al. Profile of atherosclerotic risk factors and management in patients of peripheral arterial disease at a tertiary care teaching hospital of north India. Ind J Pharma Sci. 2014;76(6):504–509.
  • Dagher NN, Modrall JG. Pharmacotherapy before and after revascularization: anticoagulation, antiplatelet agents, and statins. Sem Vascular Surg. 2007;20(1):10–14.
  • Anand David AV, Arulmoli R, Parasuraman S. Overviews of biological importance of quercetin: a bioactive flavonoid. Phcog Rev. 2016;10(20):84–89.
  • Milackova I, Prnova MS, Majekova M, et al. 2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent. J Enzyme Inhib Med Chem. 2015;30(1):107–113.
  • Bjorkoy G, Lamark T, Pankiv S, et al. Monitoring autophagic degradation of p62/SQSTM1. Meth Enzymol. 2009;452:181–197.
  • Russo M, Spagnuolo C, Tedesco I, et al. The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol. 2012;83(1):6–15.
  • Bhaskar S, Sudhakaran PR, Helen A. Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-kappaB signaling pathway. Cell Immunol. 2016;310:131–140.
  • Huang DY, Dai ZR, Li WM, et al. Inhibition of EGF expression and NF-kappaB activity by treatment with quercetin leads to suppression of angiogenesis in nasopharyngeal carcinoma. Saudi J Biological Sciences. 2018;25(4):826–831.
  • Patel RV, Mistry BM, Shinde SK, et al. Therapeutic potential of quercetin as a cardiovascular agent. Eur J Med Chem. 2018;155:889–904.
  • Li YJ, Zhang ZY, Mao YY, et al. A genetic variant in MiR-146a modifies digestive system cancer risk: a meta-analysis. Asian Pac J Cancer Prev. 2014;15(1):145–150.
  • Ghorai A, Ghosh U. miRNA gene counts in chromosomes vary widely in a species and biogenesis of miRNA largely depends on transcription or post-transcriptional processing of coding genes. Front Genet. 2014;5:100.
  • Farooqi AA, Jabeen S, Attar R, et al. Quercetin-mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer. J Cell Biochem. 2018;119(12):9664–9674.
  • Du F, Feng Y, Fang J, et al. MicroRNA-143 enhances chemosensitivity of Quercetin through autophagy inhibition via target GABARAPL1 in gastric cancer cells. Biomed Pharmacother. 2015;74:169–177.
  • Tao SF, He HF, Chen Q. Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells. Mol Cell Biochem. 2015;402(1-2):93–100.
  • Budheswar D, Jagajjit S. Inferring Quercetin mediated miRNA-TF-gene Regulatory circuit using meta-analysis of Gene expression data. Int Res J Biol Sci. 2014;3(2):40–47.
  • Sonoki H, Sato T, Endo S, et al. Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells. Nutrients. 2015;7(6):4578–4592.
  • Greco S, Fasanaro P, Castelvecchio S, et al. MicroRNA dysregulation in diabetic ischemic heart failure patients. Diabetes. 2012;61(6):1633–1641.
  • Menghini R, Casagrande V, Marino A, et al. MiR-216a: a link between endothelial dysfunction and autophagy. Cell Death Dis. 2014;5:e1029.
  • Ish-Shalom S, Lichter A. Analysis of fungal gene expression by Real Time quantitative PCR. Methods Mol Biol. 2010;638:103–114.
  • Simons M, Gordon E, Claesson-Welsh L. Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol. 2016;17(10):611–625.
  • Dugas TR, Brewer G, Longwell M, et al. Nanoentrapped polyphenol coating for sustained drug release from a balloon catheter. J Biomed Mater Res. 2019;107(3):646–651.
  • Chekalina N, Burmak Y, Petrov Y, et al. Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease. Indian Heart J. 2018;70(5):593–597.
  • Kabadere S, Oztopcu-Vatan P, Uyar R, et al. Quercetin both partially attenuates hydrogen peroxide-induced toxicity and decreases viability of rat glial cells. Acta Biologica Hungarica. 2011;62(3):221–227.
  • Min Y-D, Choi C-H, Bark H, et al. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line. Inflamm Res. 2007;56(5):210–215.
  • Casella M, Parody J, Ceballos M, et al. Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis. Mol Nutr Food Res. 2014;58(2):289–300. eng.
  • Wan L, Pantel K, Kang Y. Tumor metastasis: moving new biological insights into the clinic. Nat Med. 2013;19(11):1450–1464.
  • Lorenzon E, Colladel R, Andreuzzi E, et al. MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway. Oncogene. 2012;31(26):3136–3147.
  • Shen K, Ji L, Lu B, et al. Andrographolide inhibits tumor angiogenesis via blocking VEGFA/VEGFR2-MAPKs signaling cascade. Chem-Biol Interact. 2014;218:99–106.
  • Pratheeshkumar P, Budhraja A, Son YO, et al. Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PloS One. 2012;7(10):e47516.
  • Chou CC, Yang JS, Lu HF, et al. Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells. Arch Pharm Res. 2010;33(8):1181–1191.
  • Wang D, Sun-Waterhouse D. MicroRNAs as molecular targets of quercetin and its derivatives underlying their biological effects: a preclinical strategy. Crit Rev Food Sci Nutr. 2019;59(14):2189–2201.
  • Liu SC, Chuang SM, Hsu CJ, et al. CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression. Cell Death Dis. 2014;5:e1485.
  • Vasa-Nicotera M, Chen H, Tucci P, et al. miR-146a is modulated in human endothelial cell with aging. Atherosclerosis. 2011;217(2):326–330.
  • Ji Q, Xu X, Li L, et al. miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14. Cell Death Dis. 2017;8(10):e3103.
  • Zhang Y, Tang X, Shi M, et al. MiR-216a decreases MALAT1 expression, induces G2/M arrest and apoptosis in pancreatic cancer cells. Biochem Biophy Res Commun. 2017;483(2):816–822.
  • Hou BH, Jian ZX, Cui P, et al. miR-216a may inhibit pancreatic tumor growth by targeting JAK2. FEBS Letters. 2015;589(17):2224–2232.
  • Jeyapalan Z, Deng Z, Shatseva T, et al. Expression of CD44 3'-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis. Nucleic Acids Res. 2011;39(8):3026–3041.
  • Wang J, Ma XY, Feng YF, et al. Magnesium ions promote the biological behaviour of rat calvarial osteoblasts by activating the PI3K/Akt signalling pathway. Biol Trace Elem Res. 2017;179(2):284–293.
  • Tsurumi A, Zhao C, Li WX. Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes. BMC Genomics. 2017;18(1):718–718.
  • Muendlein A, Kinz E, Gasser K, et al. Occurrence of the JAK2 V617F mutation in patients with peripheral arterial disease. Am J Hematol. 2015;90(1):E17–21.
  • Wang Y, Wang S, Wier WG, et al. Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction rats via a PI3K/Akt/eNOS pathway-mediated mechanism. Am J Physiol Heart Circulatory Physiol. 2010;299(6):H2097–106.
  • Gong D, Cheng HP, Xie W, et al. Cystathionine gamma-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway. Biochem Biophy Res Commun. 2016;470(1):107–116.
  • Choi JS, Kang SW, Li J, et al. Blockade of oxidized LDL-triggered endothelial apoptosis by quercetin and rutin through differential signaling pathways involving JAK2. J Agric Food Chem. 2009;57(5):2079–2086.
  • Lu XL, Zhao CH, Yao XL, et al. Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathway. Biomed Pharmacother. 2017;85:658–671.
  • Xia H, Ooi LL, Hui KM. MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. Hepatology. 2013;58(2):629–641.

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