A dual-functional buformin-mimicking poly(amido amine) for efficient and safe gene delivery

References

• Tian G, Zhang X, Gu Z, et al. Recent advances in upconversion nanoparticles-based multifunctional nanocomposites for combined cancer therapy. Adv Mater. 2016;47:7692–7712.
   Google Scholar
• Xing H, Lu M, Yang T, et al. Structure-function relationships of nonviral gene vectors: lessons from antimicrobial polymers. Acta Biomater. 2019;86:15–40.
   PubMed Web of Science ®Google Scholar
• Mintzer MA, Simanek EE. Nonviral vectors for gene delivery. Chem Rev. 2009;109:259–302.
   PubMed Web of Science ®Google Scholar
• Davis ME. Non-viral gene delivery systems. Curr Opin Biotech. 2002;13:128–131.
   PubMed Web of Science ®Google Scholar
• Singha K, Namgung R, Kim WJ. Polymers in small-interfering RNA delivery. Nucl Acid Ther. 2011;21:133–147.
   PubMed Web of Science ®Google Scholar
• Mu LM, Ju RJ, Liu R, et al. Dual-functional drug liposomes in treatment of resistant cancers. Adv Drug Deliv Rev. 2017;115:46–56.
   PubMed Web of Science ®Google Scholar
• Kihoon N, Hye Yeong N, Pyung-Hwan K, et al. Paclitaxel-conjugated PEG and arginine-grafted bioreducible poly (disulfide amine) micelles for co-delivery of drug and gene. Biomaterials. 2012;33:8122–8130.
   PubMed Web of Science ®Google Scholar
• Vicent MJ, Duncan R. Polymer conjugates: nanosized medicines for treating cancer. Trends Biotechnol. 2006;24:39–47.
   PubMed Web of Science ®Google Scholar
• Yang R, Mondal G, Wen D, et al. Combination therapy of paclitaxel and cyclopamine polymer-drug conjugates to treat advanced prostate cancer. Nanomed Nanotechnol. 2017;13:391–401.
   PubMed Web of Science ®Google Scholar
• Kang Y, Lu L, Lan J, et al. Redox-responsive polymeric micelles formed by conjugating gambogic acid with bioreducible poly(amido amine)s for the co-delivery of docetaxel and MMP-9 shRNA. Acta Biomater. 2018;68:137–153.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Zhao Y, Miao L, et al. Co-delivery of polymeric metformin and cisplatin by self-assembled core-membrane nanoparticles to treat non-small cell lung cancer. J Control Release. 2016;244:63–73.
   PubMed Web of Science ®Google Scholar
• Dahee L, Eunji C, Jaewon L, et al. RAGE-binding peptide-conjugated polyethylenimine as a dual-functional carrier: a RAGE-mediated gene carrier and an anti-angiogenic reagent. J Ind Eng Chem. 2018;67:284–292.
   Web of Science ®Google Scholar
• Luo C, Miao L, Zhao Y, et al. A novel cationic lipid with intrinsic antitumor activity to facilitate gene therapy of TRAIL DNA. Biomaterials. 2016;102:239–248.
   PubMed Web of Science ®Google Scholar
• Shi K, Zhao Y, Miao L, et al. Dual functional lipoMET mediates envelope-type nanoparticles to combinational oncogene silencing and tumor growth inhibition. Mol Ther. 2017;25:1567–1579.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang W, Guo S, et al. PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery. Nat Commun. 2016;7:11822.
   PubMed Web of Science ®Google Scholar
• Matsuo J, Tsukumo Y, Saito S, et al. Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-induced cytotoxicity during glucose deprivation. Mol Cancer Ther. 2012;11:1082–1091.
   PubMed Web of Science ®Google Scholar
• Herrera-Martínez AD, Pedraza-Arevalo S, L-López F, et al. Type 2 diabetes in neuroendocrine tumors: are biguanides and statins part of the solution? J Clin Endocr Metab. 2019;104:57–73.
   PubMed Web of Science ®Google Scholar
• Vazquez-Borrego MC, Fuentes-Fayos AC, Herrera-Martinez AD, et al. Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and -independent mechanisms. J Clin Endocr Metab. 2019;104:3501–3513.
   PubMed Web of Science ®Google Scholar
• Stefania O, Francesca R, Giovanna T, et al. The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells. Int J Cancer. 2015;136:E534–E544.
   PubMed Web of Science ®Google Scholar
• Kilgore J, Jackson AL, Clark LH, et al. Buformin exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells. Am J Transl Res. 2016;8:2705–2715.
   PubMed Web of Science ®Google Scholar
• Parris AB, Zhao Q, Howard EW, et al. Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice. J Exp Clin Canc Res. 2017;36:28.
   PubMed Web of Science ®Google Scholar
• Yu J, Zhang J, Xing H, et al. Guanidinylated bioresponsive poly(amido amine)s designed for intranuclear gene delivery. Int J Nanomedicine. 2016;11:4011–4024.
   PubMed Web of Science ®Google Scholar
• Yu J, Zhang J, Xing H, et al. Novel guanidinylated bioresponsive poly(amidoamine)s designed for short hairpin RNA delivery. Int J Nanomedicine. 2016;11:6651–6666.
   PubMed Web of Science ®Google Scholar
• Xing H, Mei L, Lei X, et al. Molecular weight determination of a newly synthesized guanidinylated disulfide-containing poly (amido amine) by gel permeation chromatography. Asian J Pharm Sci. 2017;12:292–298.
   PubMed Web of Science ®Google Scholar
• Xing H, Cheng L, Lu M, et al. A biodegradable poly(amido amine) based on the antimicrobial polymer polyhexamethylene biguanide for efficient and safe gene delivery. Colloid Surface B. 2019;182:110355.
   PubMed Web of Science ®Google Scholar
• Son S, Namgung R, Kim J, et al. Bioreducible polymers for gene silencing and delivery. Acc Chem Res. 2012;45:1100–1112.
   PubMed Web of Science ®Google Scholar
• Saczewski F, Balewski L. Biological activities of guanidine compounds. Expert Opin Ther Patents. 2009;19:1417–1448.
   PubMed Web of Science ®Google Scholar
• Yu C, Tan E, Xu Y, et al. A guanidinium-rich polymer for efficient cytosolic delivery of native proteins. Bioconjugate Chem. 2019;30:413–417.
   PubMed Web of Science ®Google Scholar
• Ou M, Wang X, Xu R, et al. Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity. Bioconjugate Chem. 2008;19:626–633.
   PubMed Web of Science ®Google Scholar
• Ullah I, Zhao J, Rukh S, et al. A PEG-b-poly(disulfide-L-lysine) based redox-responsive cationic polymer for efficient gene transfection. J Mater Chem B. 2019;7:1893–1905.
   PubMed Web of Science ®Google Scholar
• Grosse S, Aron Y, Thevenot G, et al. Potocytosis and cellular exit of complexes as cellular pathways for gene delivery by polycations. J Gene Med. 2005;7:1275–1286.
   PubMed Web of Science ®Google Scholar
• Mogaki R, Hashim PK, Okuro K, et al. Guanidinium-based “molecular glues’’ for modulation of biomolecular functions. Chem Soc Rev. 2017;46:6480–6491.
   PubMed Web of Science ®Google Scholar
• Lv HT, Zhang SB, Wang B, et al. Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release. 2006;114:100–109.
   PubMed Web of Science ®Google Scholar
• Kim TI, Ou M, Lee M, et al. Arginine-grafted bioreducible poly(disulfide amine) for gene delivery systems. Biomaterials. 2009;30:658–664.
   PubMed Web of Science ®Google Scholar
• Semple SC, Akin A, Jianxin C, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010;28:172–176.
   PubMed Web of Science ®Google Scholar
• Dowling RJO, Mahvash Z, I George F, et al. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res. 2007;67:10804–10812.
   PubMed Web of Science ®Google Scholar
• Kimura N, Tokunaga C, Dalal S, et al. A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells. 2003;8:65–79.
   PubMed Web of Science ®Google Scholar