Inhibition of microRNA-10b-5p up-regulates HOXD10 to attenuate Alzheimer’s disease in rats via the Rho/ROCK signalling pathway

References

• Li S, Wang C, Wang W, et al. Trait anxiety, a personality risk factor associated with Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatry. 2021;105:110124.
   PubMed Web of Science ®Google Scholar
• Zhao J, O'Connor T, Vassar R. The contribution of activated astrocytes to Abeta production: implications for Alzheimer’s disease pathogenesis. J Neuroinflammation. 2011;8:150.
   PubMed Web of Science ®Google Scholar
• Ma L, Wang R, Han Y, et al. Development of a novel urine Alzheimer-associated neuronal thread protein ELISA kit and its potential use in the diagnosis of Alzheimer’s disease. J Clin Lab Anal. 2016;30:308–314.
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang Y, Liu P, et al. MicroRNA-128 knockout inhibits the development of Alzheimer’s disease by targeting PPARγ in mouse models. Eur J Pharmacol. 2019;843:134–144.
   PubMed Web of Science ®Google Scholar
• Wu BW, Wu MS, Guo JD. Effects of microRNA-10a on synapse remodeling in hippocampal neurons and neuronal cell proliferation and apoptosis through the BDNF-TrkB signaling pathway in a rat model of Alzheimer’s disease. J Cell Physiol. 2018;233:5281–5292.
   PubMed Web of Science ®Google Scholar
• Muller M, et al. MicroRNA-29a is a candidate biomarker for Alzheimer’s disease in cell-free cerebrospinal fluid. Mol Neurobiol. 2016;53:2894–2899.
   PubMed Web of Science ®Google Scholar
• Li W, Li C, Xiong Q, et al. MicroRNA-10b-5p downregulation inhibits the invasion of glioma cells via modulating homeobox B3 expression. Exp Ther Med. 2019;17:4577–4585.
   PubMed Web of Science ®Google Scholar
• Hoss AG, Labadorf A, Latourelle JC, et al. miR-10b-5p expression in Huntington’s disease brain relates to age of onset and the extent of striatal involvement. BMC Med Genomics. 2015;8:10.
   PubMed Web of Science ®Google Scholar
• Luan L, Ma Y, Zhang L. HOXD10 silencing suppresses human fibroblast-like synoviocyte migration in rheumatoid arthritis via downregulation of the p38/JNK pathway. Exp Ther Med. 2018;16:1621–1628.
   PubMed Web of Science ®Google Scholar
• Yachi K, Tsuda M, Kohsaka S, et al. miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition. Signal Transduct Target Ther. 2018;3:33.
   PubMed Web of Science ®Google Scholar
• Misra M, Shah V, Carpenter E, et al. Restricted patterns of Hoxd10 and Hoxd11 set segmental differences in motoneuron subtype complement in the lumbosacral spinal cord. Dev Biol. 2009;330:54–72.
   PubMed Web of Science ®Google Scholar
• Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007;449:682–688.
   PubMed Web of Science ®Google Scholar
• Liao CG, Kong LM, Zhou P, et al. miR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs. J Transl Med. 2014;12:234.
   PubMed Web of Science ®Google Scholar
• Liu Z, Zhu J, Cao H, et al. miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric in gastric cancer. Int J Oncol. 2012;40:1553–1560.
   PubMed Web of Science ®Google Scholar
• Liu J, Gao HY, Wang XF. The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system. Neural Regen Res. 2015;10:1892–1896.
   PubMed Web of Science ®Google Scholar
• Fujimura M, Usuki F, Kawamura M, et al. Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure. Toxicol Appl Pharmacol. 2011;250:1–9.
   PubMed Web of Science ®Google Scholar
• Tan HB, Zhong YS, Cheng Y, et al. Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage. Int J Ophthalmol. 2011;4:652–657.
   PubMed Web of Science ®Google Scholar
• Wen X, Wang L, Liu Z, et al. Intracranial injection of PEG-PEI/ROCK II-siRNA improves cognitive impairment in a mouse model of Alzheimer’s disease. Int J Neurosci. 2014;124:697–703.
   PubMed Web of Science ®Google Scholar
• Yang SH, Lee DK, Shin J, et al. Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice. EMBO Mol Med. 2017;9:61–77.
   PubMed Web of Science ®Google Scholar
• Kim B, Shin J, Kim YSoo, et al. Destruction of ERP responses to deviance in an auditory oddball paradigm in amyloid infusion mice with memory deficits. PLoS One. 2020;15:e0230277.
   PubMed Web of Science ®Google Scholar
• O'Hare E, Weldon DT, Mantyh PW, et al. Delayed behavioral effects following intrahippocampal injection of aggregated A beta (1-42). Brain Res. 1999;815:1–10.
   PubMed Web of Science ®Google Scholar
• Büttner-Ennever J. The Rat Brain in Stereotaxic Coordinates, 3rd edn. J Anat. 1997;191:315.
   Google Scholar
• Wang L, Song L, Chen X, et al. microRNA-139-5p confers sensitivity to antiepileptic drugs in refractory epilepsy by inhibition of MRP1. CNS Neurosci Ther. 2020;26:465–474.
   PubMed Web of Science ®Google Scholar
• Lee ST, Chu K, Jung KH, et al. miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Ann Neurol. 2012;72:269–277.
   PubMed Web of Science ®Google Scholar
• Zhang Y, et al. Effects of resveratrol on learning and memory in rats with vascular dementia. Mol Med Rep. 2019;20:4587–4593.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang J, Du J, et al. TAT-Ngn2 enhances cognitive function recovery and regulates caspase-dependent and mitochondrial apoptotic pathways after experimental stroke. Front Cell Neurosci. 2018;12:475.
   PubMed Web of Science ®Google Scholar
• Liu AH, Wu YT, Wang YP. MicroRNA-129-5p inhibits the development of autoimmune encephalomyelitis-related epilepsy by targeting HMGB1 through the TLR4/NF-kB signaling pathway. Brain Res Bull. 2017;132:139–149.
   PubMed Web of Science ®Google Scholar
• Zhao N, Sun C, Zheng M, et al. Amentoflavone suppresses amyloid β1-42 neurotoxicity in Alzheimer’s disease through the inhibition of pyroptosis. Life Sci. 2019;239:117043.
   PubMed Web of Science ®Google Scholar
• Yu N, et al. Ganoderma lucidum triterpenoids (GLTs) reduce neuronal apoptosis via inhibition of ROCK signal pathway in APP/PS1 transgenic Alzheimer’s disease mice. Oxid Med Cell Longev. 2020;2020:9894037.
   PubMed Web of Science ®Google Scholar
• Asaad M, Lee JH. A guide to using functional magnetic resonance imaging to study Alzheimer’s disease in animal models. Dis Model Mech. 2018;11:dmm031724.
   PubMed Web of Science ®Google Scholar
• Eivani M, Alijanpour S, Arefian E, et al. Corticolimbic analysis of microRNAs and protein expressions in scopolamine-induced memory loss under stress. Neurobiol Learn Mem. 2019;164:107065.
   PubMed Web of Science ®Google Scholar
• Wang D, Wang W, Lin W, et al. Apoptotic cell induction of miR-10b in macrophages contributes to advanced atherosclerosis progression in ApoE-/- mice. Cardiovasc Res. 2018;114:1794–1805.
   PubMed Web of Science ®Google Scholar
• Li Q, Du X, Pan Z, et al. The transcription factor SMAD4 and miR-10b contribute to E2 release and cell apoptosis in ovarian granulosa cells by targeting CYP19A1. Mol Cell Endocrinol. 2018;476:84–95.
   PubMed Web of Science ®Google Scholar
• Yuan YH, Wang HY, Lai Y, et al. Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway. Cell Commun Signal. 2019;17:9.
   PubMed Web of Science ®Google Scholar
• Cao YM, Gu J, Zhang YS, et al. Aberrant hypermethylation of the HOXD10 gene in papillary thyroid cancer with BRAFV600E mutation. Oncol Rep. 2018;39:338–348.
   PubMed Web of Science ®Google Scholar
• Hu X, Chen D, Cui Y, et al. Targeting microRNA-23a to inhibit glioma cell invasion via HOXD10. Sci Rep. 2013;3:3423.
   PubMed Web of Science ®Google Scholar
• Klein S, Dieterich LC, Mathelier A, et al., FANTOM consortium. DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C. J Cell Sci. 2016;129:2573–2585.
   PubMed Web of Science ®Google Scholar
• Henderson BW, Gentry EG, Rush T, et al. Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer’s disease and ROCK1 depletion reduces amyloid-β levels in brain . J Neurochem. 2016;138:525–531.
   PubMed Web of Science ®Google Scholar
• Park JC, Baik SH, Han SH, et al. Annexin A1 restores Aβ1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway. Aging Cell. 2017;16:149–161.
   PubMed Web of Science ®Google Scholar
• Wang Y, et al. Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats. Mol Med Rep. 2018;18:4486–4498.
   PubMed Web of Science ®Google Scholar
• Chen J, Sun Z, Jin M, et al. Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway. J Neuroimmunol. 2017;305:108–114.
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang X, Yang W, et al. Effect of Simvastatin on the Intestinal Rho/ROCK Signaling Pathway in Rats With Sepsis. J Surg Res. 2018;232:531–538.
   PubMed Web of Science ®Google Scholar
• Hamano T, Shirafuji N, Yen SH, et al. Rho-kinase ROCK inhibitors reduce oligomeric tau protein. Neurobiol Aging. 2020;89:41–54.
   PubMed Web of Science ®Google Scholar