Metformin protects cardiomyocytes against oxygen-glucose deprivation injury by promoting autophagic flux through AMPK pathway

References

• Ford TJ, Berry C. Angina: contemporary diagnosis and management. Heart. 2020;106(5):387–398.
   PubMed Web of Science ®Google Scholar
• Henry TD, Satran D, Hodges JS, et al. Long-term survival in patients with refractory angina. Euro Heart J. 2013;34(34):2683–2688.
   PubMed Web of Science ®Google Scholar
• Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004;6(4):463–477.
   PubMed Web of Science ®Google Scholar
• Lavandero S, Chiong M, Rothermel BA, et al. Autophagy in cardiovascular biology. J Clin Invest. 2015;125(1):55–64.
   PubMed Web of Science ®Google Scholar
• Woodall BP, Gustafsson AB. Autophagy-A key pathway for cardiac health and longevity. Acta Physiol. 2018;223(4):e13074.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011;147(4):728–741.
   PubMed Web of Science ®Google Scholar
• Nishida K, Taneike M, Otsu K. The role of autophagic degradation in the heart. J Mol Cell Cardiol. 2015;78:73–79.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Li H, Chen S, et al. Knockdown of microRNA-122 protects H9c2 cardiomyocytes from hypoxia-induced apoptosis and promotes autophagy. Med Sci Monit. 2017;23:4284–4290.
   PubMed Web of Science ®Google Scholar
• Chiang MH, Liang CJ, Liu CW, et al. Aliskiren improves ischemia- and oxygen glucose deprivation-induced cardiac injury through activation of autophagy and AMP-activated protein kinase. Front Pharmacol. 2017;8:819.
   PubMed Web of Science ®Google Scholar
• Du L, Shen T, Liu B, et al. Shock wave therapy promotes cardiomyocyte autophagy and survival during hypoxia. Cell Physiol Biochem. 2017;42(2):673–684.
   PubMedGoogle Scholar
• Wu X, Qin Y, Zhu X, et al. Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux. J Mol Cell Cardiol. 2018;124:70–82.
   PubMed Web of Science ®Google Scholar
• Gu Y, Gao L, Chen Y, et al. Sanggenon C protects against cardiomyocyte hypoxia injury by increasing autophagy. Mol Med Rep. 2017;16(6):8130–8136.
   PubMed Web of Science ®Google Scholar
• Hu M, Ye P, Liao H, et al. Metformin protects H9C2 cardiomyocytes from high-glucose and hypoxia/reoxygenation injury via inhibition of reactive oxygen species generation and inflammatory responses: role of AMPK and JNK. J Diabetes Res. 2016;2016:2961954.
   PubMed Web of Science ®Google Scholar
• Du Y, Xhang J, Fang F, et al. Metformin ameliorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis based on the SIRT3 signaling pathway. Gene. 2017;626:182–188.
   PubMed Web of Science ®Google Scholar
• Wang Y, Yang Z, Zheng G, et al. Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways. Life Sci. 2019;225:64–71.
   PubMed Web of Science ®Google Scholar
• Zhang C-S, Li M, Ma T, et al. Metformin activates AMPK through the lysosomal pathway. Cell Metab. 2016;24(4):521–522.
   PubMed Web of Science ®Google Scholar
• Amara VR, Surapaneni SK, Tikoo K. Metformin attenuates cardiovascular and renal injury in uninephrectomized rats on DOCA-salt: involvement of AMPK and miRNAs in cardioprotection. Toxicol Appl Pharmacol. 2019;362:95–104.
   PubMed Web of Science ®Google Scholar
• Bai F, Liu Y, Tu T, et al. Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway. Lipids Health Dis. 2019;18(1):109.
   PubMedGoogle Scholar
• Li K, Zhang TT, Hua F, et al. Metformin reduces TRIB3 expression and restores autophagy flux: an alternative antitumor action. Autophagy. 2018;14(7):1278–1279.
   PubMed Web of Science ®Google Scholar
• Zilinyi R, Czomap A, Czegledi A, et al. The cardioprotective effect of metformin in doxorubicin-induced cardiotoxicity: the role of autophagy. Molecules. 2018;23(5):1184.
   Web of Science ®Google Scholar
• You G, Long X, Song F, et al. Metformin activates the AMPK-mTOR pathway by modulating lncRNA TUG1 to induce autophagy and inhibit atherosclerosis. Drug Design, Devel Ther. 2020;14:457–468.
   PubMed Web of Science ®Google Scholar
• Wu S, Chang G, Gao L, et al. Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy. J Mol Med. 2018;96(8):791–806.
   PubMed Web of Science ®Google Scholar
• Wang X-F, Zhang J-Y, Li L, et al. Metformin improves cardiac function in rats via activation of AMP-activated protein kinase. Clin Exp Pharmacol Physiol. 2011;38(2):94–101.
   PubMed Web of Science ®Google Scholar
• Al-Rasheed NM, Al-Rasheed NM, AL-Rabeeah DA, et al. Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury. J Cell Biochem. 2018;119(5):3903–3912.
   PubMed Web of Science ®Google Scholar
• Sciarretta S, Maejima Y, Zablocki D, et al. The role of autophagy in the heart. Annual Rev Physiol. 2017;80:1–26.
   PubMed Web of Science ®Google Scholar
• Gustafsson AB, Gottlieb RA. Autophagy in ischemic heart disease. Circ Res. 2009;104(2):150–158.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature. 2008;451(7182):1069–1075.
   PubMed Web of Science ®Google Scholar
• Matsui Y, Takagi H, Qu X, et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 2007;100(6):914–922.
   PubMed Web of Science ®Google Scholar
• Sadoshima J. The role of autophagy during ischemia/reperfusion. Autophagy. 2008;4(4):402–403.
   PubMed Web of Science ®Google Scholar
• Kroemer G, Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol. 2008;9(12):1004–1010.
   PubMed Web of Science ®Google Scholar
• Zhu H, Tannous P, Johnstone JL, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007;117(7):1782–1793.
   PubMed Web of Science ®Google Scholar
• Marzetti E, Csiszar A, Dutta D, et al. Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol. 2013;305(4):H459–H476.
   PubMed Web of Science ®Google Scholar
• Riquelme JA, Chavez MN, Mondaca-Ruff D, et al. Therapeutic targeting of autophagy in myocardial infarction and heart failure. Expert Rev Cardiovasc Ther. 2016;14(9):1007–1019.
   PubMed Web of Science ®Google Scholar
• Chang J-C, Hu W-F, Lee W-S, et al. Intermittent hypoxia induces autophagy to protect cardiomyocytes from endoplasmic reticulum stress and apoptosis. Front Physiol. 2019;10:995.
   PubMed Web of Science ®Google Scholar
• Zhu H-H, Wang X-T, Sun Y-H, et al. Pim1 overexpression prevents apoptosis in cardiomyocytes after exposure to hypoxia and oxidative stress via upregulating cell autophagy. Cell Physiol Biochem. 2018;49(6):2138–2150.
   PubMedGoogle Scholar
• González A, Hall MN, Lin S-C, et al. AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control. Cell Metab. 2020;31(3):472–492.
   PubMed Web of Science ®Google Scholar
• Xie Z, Lau K, Eby B, et al. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes. 2011;60(6):1770–1778.
   PubMed Web of Science ®Google Scholar