Targetting ferroptosis for blood cell-related diseases

References

• Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273–285.
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072.
   PubMed Web of Science ®Google Scholar
• Xie Y, Hou W, Song X, et al. Ferroptosis: process and function. Cell Death Differ. 2016;23(3):369–379.
   PubMed Web of Science ®Google Scholar
• Hirschhorn T, Stockwell BR. The development of the concept of ferroptosis. Free Radic Biol Med. 2019;133:130–143.
   PubMed Web of Science ®Google Scholar
• Peng Q, Peng G, Wu L, et al. Photo-reduction enables catalyst regeneration in Fenton reaction on an Fe2O3-decorated TiO2 nanotube-based photocatalyst. Dalton Trans. 2020;49(20):6730–6737.
   PubMed Web of Science ®Google Scholar
• Schaer DJ, Buehler PW, Alayash AI, et al. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood. 2013;121(8):1276–1284.
   PubMed Web of Science ®Google Scholar
• Ciciliano JC, Sakurai Y, Myers DR, et al. Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach. Blood. 2015;126(6):817–824.
   PubMed Web of Science ®Google Scholar
• Tarangelo A, Magtanong L, Bieging-Rolett KT, et al. p53 suppresses metabolic stress-induced ferroptosis in cancer cells. Cell Rep. 2018;22(3):569–575.
   PubMed Web of Science ®Google Scholar
• Friedmann Angeli JP, Schneider M, Proneth B, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16(12):1180–1191.
   PubMed Web of Science ®Google Scholar
• Hou W, Xie Y, Song X, et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 2016;12(8):1425–1428.
   PubMed Web of Science ®Google Scholar
• Sun X, Ou Z, Chen R, et al. Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 2016;63(1):173–184.
   PubMed Web of Science ®Google Scholar
• Ou Y, Wang SJ, Li D, et al. Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci USA. 2016;113(44):E6806–E6812.
   PubMed Web of Science ®Google Scholar
• Kagan VE, Mao G, Qu F, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017;13(1):81–90.
   PubMed Web of Science ®Google Scholar
• Qiu Y, Cao Y, Cao W, et al. The application of ferroptosis in diseases. Pharmacol Res. 2020;159:104919.
   PubMed Web of Science ®Google Scholar
• Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–331.
   PubMed Web of Science ®Google Scholar
• Devos D, Moreau C, Kyheng M, et al. A ferroptosis-based panel of prognostic biomarkers for amyotrophic lateral Sclerosis. Sci Rep. 2019;9(1):2918.
   PubMedGoogle Scholar
• Li X, Zou Y, Xing J, et al. Pretreatment with roxadustat (FG-4592) attenuates folic acid-induced kidney injury through antiferroptosis via Akt/GSK-3β/Nrf2 pathway. Oxid Med Cell Longev. 2020;2020:6286984.
   PubMed Web of Science ®Google Scholar
• Zhou Y. The protective effects of cryptochlorogenic acid on β-cells function in diabetes in vivo and vitro via inhibition of ferroptosis. Diabetes Metab Syndr Obes. 2020;13:1921–1931.
   PubMed Web of Science ®Google Scholar
• Yang Y, Tai W, Lu N, et al. lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis. Aging. 2020;12(10):9085–9102.
   PubMedGoogle Scholar
• Zhao X, Liu Z, Gao J, et al. Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice. Toxicology. 2020;440:152489.
   PubMed Web of Science ®Google Scholar
• Shen Q, Liang M, Yang F, et al. Ferroptosis contributes to developmental cell death in rice blast. New Phytol. 2020;227(6):1831–1846.
   PubMed Web of Science ®Google Scholar
• Camaschella C, Pagani A, Nai A, et al. The mutual control of iron and erythropoiesis. Int J Lab Hematol. 2016;38(Suppl. 1):20–26.
   PubMed Web of Science ®Google Scholar
• Yu Y, Jiang L, Wang H, et al. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood. 2020;136(6):726–739.
   PubMed Web of Science ®Google Scholar
• Altamura S, Vegi NM, Hoppe PS, et al. Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis. Haematologica. 2020;105(4):937–950.
   PubMed Web of Science ®Google Scholar
• Canli Ö, Alankuş YB, Grootjans S, et al. Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors. Blood. 2016;127(1):139–148.
   PubMed Web of Science ®Google Scholar
• Ouled-Haddou H, Messaoudi K, Demont Y, et al. A new role of glutathione peroxidase 4 during human erythroblast enucleation. Blood Adv. 2020;4(22): 5666–5680.
   PubMed Web of Science ®Google Scholar
• Gao M, Monian P, Pan Q, et al. Ferroptosis is an autophagic cell death process. Cell Res. 2016;26(9):1021–1032.
   PubMed Web of Science ®Google Scholar
• Weber GJ, Choe SE, Dooley KA, et al. Mutant-specific gene programs in the zebrafish. Blood. 2005;106(2):521–530.
   PubMed Web of Science ®Google Scholar
• Tang M, Chen Z, Wu D, et al. Ferritinophagy/ferroptosis: iron-related newcomers in human diseases. J Cell Physiol. 2018;233(12):9179–9190.
   PubMed Web of Science ®Google Scholar
• Gao X, Lee HY, Li W, et al. Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. Proc Natl Acad Sci USA. 2017;114(38):10107–10112.
   PubMed Web of Science ®Google Scholar
• Mancias JD, Pontano Vaites L, Nissim S, et al. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Elife. 2015;4:e10308.
   PubMed Web of Science ®Google Scholar
• Bellelli R, Federico G, Matte A, et al. NCOA4 deficiency impairs systemic iron homeostasis. Cell Rep. 2016;14(3):411–421.
   PubMed Web of Science ®Google Scholar
• Ryu MS, Duck KA, Philpott CC. Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells. Blood Cells Mol Dis. 2018;69:75–81.
   PubMed Web of Science ®Google Scholar
• Ryu MS, Zhang D, Protchenko O, et al. PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis. J Clin Invest. 2017;127(5):1786–1797.
   PubMed Web of Science ®Google Scholar
• Criscitiello MF, Kraev I, Lange S. Post-translational protein deimination signatures in serum and serum-extracellular vesicles of Bos taurus reveal immune, anti-pathogenic, anti-viral, metabolic and cancer-related pathways for deimination. Int J Mol Sci. 2020;21(8):2861.
   Web of Science ®Google Scholar
• NaveenKumar SK, Thushara RM, Sundaram MS, et al. Unconjugated bilirubin exerts pro-apoptotic effect on platelets via p38-MAPK activation. Sci Rep. 2015;5:15045.
   PubMed Web of Science ®Google Scholar
• Nebie O, Devos D, Vingtdeux V, et al. The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates. J Biomed Sci. 2019;26(1):89.
   PubMed Web of Science ®Google Scholar
• Gouel F, Do Van B, Chou ML, et al. The protective effect of human platelet lysate in models of neurodegenerative disease: involvement of the Akt and MEK pathways. J Tissue Eng Regen Med. 2017;11(11):3236–3240.
   PubMed Web of Science ®Google Scholar
• D'Herde K, Krysko DV. Ferroptosis: oxidized PEs trigger death. Nat Chem Biol. 2017;13(1):4–5.
   PubMed Web of Science ®Google Scholar
• NaveenKumar SK, SharathBabu BN, Hemshekhar M, et al. The role of reactive oxygen species and ferroptosis in heme-mediated activation of human platelets. ACS Chem Biol. 2018;13(8):1996–2002.
   PubMed Web of Science ®Google Scholar
• Kumar S, Bandyopadhyay U. Free heme toxicity and its detoxification systems in human. Toxicol Lett. 2005;157(3):175–188.
   PubMed Web of Science ®Google Scholar
• NaveenKumar SK, Hemshekhar M, Kemparaju K, et al. Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: protection by melatonin. Biochim Biophys Acta Mol Basis Dis. 2019;1865(9):2303–2316.
   PubMed Web of Science ®Google Scholar
• Gout PW, Buckley AR, Simms CR, et al. Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug. Leukemia. 2001;15(10):1633–1640.
   PubMed Web of Science ®Google Scholar
• Jiang Q, Wang K, Zhang X, et al. Platelet membrane-camouflaged magnetic nanoparticles for ferroptosis-enhanced cancer immunotherapy. Small. 2020;16(22):e2001704.
   PubMed Web of Science ®Google Scholar
• Garg AD, Agostinis P. Cell death and immunity in cancer: from danger signals to mimicry of pathogen defense responses. Immunol Rev. 2017;280(1):126–148.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Song J, Zhao Z, et al. Single-cell transcriptome analysis reveals tumor immune microenvironment heterogenicity and granulocytes enrichment in colorectal cancer liver metastases. Cancer Lett. 2020;470:84–94.
   PubMed Web of Science ®Google Scholar
• Ma XL, Tsao PS, Lefer AM. Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion. J Clin Invest. 1991;88(4):1237–1243.
   PubMed Web of Science ®Google Scholar
• McDonald B, Pittman K, Menezes GB, et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science. 2010;330(6002):362–366.
   PubMed Web of Science ®Google Scholar
• Li W, Feng G, Gauthier JM, et al. Ferroptotic cell death and TLR4/trif signaling initiate neutrophil recruitment after heart transplantation. J Clin Invest. 2019;129(6):2293–2304.
   PubMed Web of Science ®Google Scholar
• Sarhan M, Land WG, Tonnus W, et al. Origin and consequences of necroinflammation. Physiol Rev. 2018;98(2):727–780.
   PubMed Web of Science ®Google Scholar
• Allam R, Kumar SV, Darisipudi MN, et al. Extracellular histones in tissue injury and inflammation. J Mol Med. 2014;92(5):465–472.
   PubMed Web of Science ®Google Scholar
• Mulay SR, Kumar SV, Lech M, et al. How kidney cell death induces renal necroinflammation. Semin Nephrol. 2016;36(3):162–173.
   PubMed Web of Science ®Google Scholar
• Bosmann M, Grailer JJ, Ruemmler R, et al. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J. 2013;27(12):5010–5021.
   PubMed Web of Science ®Google Scholar
• Yotsumoto S, Muroi Y, Chiba T, et al. Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. Sci Rep. 2017;7(1):16026.
   PubMedGoogle Scholar
• Zou Y, Henry WS, Ricq EL, et al. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature. 2020;585(7826):603–608.
   PubMed Web of Science ®Google Scholar
• Spetz J, Presser AG, Sarosiek KA. T cells and regulated cell death: kill or be killed. Int Rev Cell Mol Biol. 2019;342:27–71.
   PubMed Web of Science ®Google Scholar
• Wang W, Green M, Choi JE, et al. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569(7755):270–274.
   PubMed Web of Science ®Google Scholar
• Haimovitz-Friedman A, Kan CC, Ehleiter D, et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med. 1994;180(2):525–535.
   PubMed Web of Science ®Google Scholar
• Lang X, Green MD, Wang W, et al. Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11. Cancer Discov. 2019;9(12):1673–1685.
   PubMed Web of Science ®Google Scholar
• Chen PH, Wu J, Ding CC, et al. Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism. Cell Death Differ. 2020;27(3):1008–1022.
   PubMed Web of Science ®Google Scholar
• Venkata Narayanan I, Paulsen MT, Bedi K, et al. Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53. Sci Rep. 2017;7:43598.
   PubMed Web of Science ®Google Scholar
• Matsushita M, Freigang S, Schneider C, et al. T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J Exp Med. 2015;212(4):555–568.
   PubMed Web of Science ®Google Scholar
• Kahn-Kirby AH, Amagata A, Maeder CI, et al. Targeting ferroptosis: a novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. PLOS One. 2019;14(3):e0214250.
   PubMed Web of Science ®Google Scholar
• Muri J, Thut H, Bornkamm GW, et al. B1 and marginal zone B cells but not follicular B2 cells require Gpx4 to prevent lipid peroxidation and ferroptosis. Cell Rep. 2019;29(9):2731–2744.e4.
   PubMed Web of Science ®Google Scholar
• Bertolotti M, Yim SH, Garcia-Manteiga JM, et al. B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses. Antioxid Redox Signal. 2010;13(8):1133–1144.
   PubMed Web of Science ®Google Scholar
• Gough SM, Goldberg L, Pineda M, et al. Progenitor B-1 B-cell acute lymphoblastic leukemia is associated with collaborative mutations in 3 critical pathways. Blood Adv. 2017;1(20):1749–1759.
   PubMed Web of Science ®Google Scholar
• Deng R, Zhang J, Chen J. lncRNA SNHG1 negatively regulates miRNA-101-3p to enhance the expression of ROCK1 and promote cell proliferation, migration and invasion in osteosarcoma. Int J Mol Med. 2019;43(3):1157–1166.
   PubMed Web of Science ®Google Scholar
• Kinowaki Y, Kurata M, Ishibashi S, et al. Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma. Lab Invest. 2018;98(5):609–619.
   PubMed Web of Science ®Google Scholar
• Li T, Liu X, Jiang L, et al. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging. Oncotarget. 2016;7(11):11838–11849.
   PubMedGoogle Scholar
• Xia X, Fan X, Zhao M, et al. The relationship between ferroptosis and tumors: a novel landscape for therapeutic approach. Curr Gene Ther. 2019;19(2):117–124.
   PubMed Web of Science ®Google Scholar
• Pramil E, Herbi Bastian L, Denefle T, et al. Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1-derived peptides overcomes drug resistance. Blood Adv. 2019;3(20):2920–2933.
   PubMed Web of Science ®Google Scholar
• Yanatori I, Richardson DR, Toyokuni S, et al. The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer. J Biol Chem. 2017;292(32):13205–13229.
   PubMed Web of Science ®Google Scholar
• Adamson JW. The relationship of erythropoietin and iron metabolism to red blood cell production in humans. Semin Oncol. 1994;2(Suppl. 3):9–15.
   Google Scholar
• Ludwig H, Muldur E, Endler G, et al. Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia. Ann Oncol. 2013;24(7):1886–1892.
   PubMed Web of Science ®Google Scholar
• Ludwig H, Evstatiev R, Kornek G, et al. Iron metabolism and iron supplementation in cancer patients. Wien Klin Wochenschr. 2015;127(23–24):907–919.
   PubMed Web of Science ®Google Scholar
• Pfeifhofer-Obermair C, Tymoszuk P, Petzer V, et al. Iron in the tumor microenvironment—connecting the dots. Front Oncol. 2018;8:549.
   PubMed Web of Science ®Google Scholar
• Willis J, Epperly MW, Fisher R, et al. Amelioration of head and neck radiation-Induced mucositis and distant marrow suppression in Fanca–/– and Fancg–/– mice by intraoral administration of GS-nitroxide (JP4-039). Radiat Res. 2018;189(6):560–578.
   PubMed Web of Science ®Google Scholar
• Thermozier S, Hou W, Zhang X, et al. Anti-ferroptosis drug enhances total-body irradiation mitigation by drugs that block apoptosis and necroptosis. Radiat Res. 2020;193(5):435–450.
   PubMed Web of Science ®Google Scholar
• Song X, Xie Y, Kang R, et al. FANCD2 protects against bone marrow injury from ferroptosis. Biochem Biophys Res Commun. 2016;480(3):443–449.
   PubMed Web of Science ®Google Scholar
• Santana-Codina N, Mancias JD. The role of NCOA4-mediated ferritinophagy in health and disease. Pharmaceuticals. 2018;11(4):114.
   Web of Science ®Google Scholar
• O'Donnell VB, Aldrovandi M, Murphy RC, et al. Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death. Sci Signal. 2019;12(574):eaau2293.
   PubMed Web of Science ®Google Scholar
• Brigelius-Flohe R, Flohe L. Regulatory phenomena in the glutathione peroxidase superfamily. Antioxid Redox Signal. 2020;33(7):498–516.
   PubMed Web of Science ®Google Scholar
• Jin RC, Mahoney CE, Anderson LC, et al. Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. Circulation. 2011;123(18):1963–1973.
   PubMed Web of Science ®Google Scholar
• Voetsch B, Jin RC, Bierl C, et al. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke. 2007;38(1):41–49.
   PubMed Web of Science ®Google Scholar
• Que X, Hung MY, Yeang C, et al. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018;558(7709):301–306.
   PubMed Web of Science ®Google Scholar
• Ferretti G, Bacchetti T, Johnston TP, et al. Lipoprotein(a): a missing culprit in the management of athero-thrombosis? J Cell Physiol. 2018;233(4):2966–2981.
   PubMed Web of Science ®Google Scholar
• van der Valk FM, Bekkering S, Kroon J, et al. Oxidized phospholipids on lipoprotein(a) elicit arterial wall inflammation and an inflammatory monocyte response in humans. Circulation. 2016;134(8):611–624.
   PubMed Web of Science ®Google Scholar
• Imai H, Matsuoka M, Kumagai T, et al. Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis. Curr Top Microbiol Immunol. 2017;403:143–170.
   PubMed Web of Science ®Google Scholar
• Sharma RD, Katkar GD, Sundaram MS, et al. Oxidative stress-induced methemoglobinemia is the silent killer during snakebite: a novel and strategic neutralization by melatonin. J Pineal Res. 2015;59(2):240–254.
   PubMed Web of Science ®Google Scholar
• Medrano-Campillo P, Sarmiento-Soto H, Alvarez-Sanchez N, et al. Evaluation of the immunomodulatory effect of melatonin on the T-cell response in peripheral blood from systemic lupus erythematosus patients. J Pineal Res. 2015;58(2):219–226.
   PubMed Web of Science ®Google Scholar
• Katkar GD, Sundaram MS, Hemshekhar M, et al. Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress. J Pineal Res. 2014;56(3):295–312.
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Vitale I, Abrams JM, et al. Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death 2012. Cell Death Differ. 2012;19(1):107–120.
   PubMed Web of Science ®Google Scholar
• Semeraro F, Ammollo CT, Morrissey JH, et al. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood. 2011;118(7):1952–1961.
   PubMed Web of Science ®Google Scholar
• Roh H, Kim A, Kim N, et al. Multi-omics analysis provides novel insight into immuno-physiological pathways and development of thermal resistance in rainbow trout exposed to acute thermal stress. Int J Mol Sci. 2020;21(23):9198.
   Web of Science ®Google Scholar
• Li Z, Weng H, Su R, et al. FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase. Cancer Cell. 2017;31(1):127–141.
   PubMed Web of Science ®Google Scholar
• Callens C, Coulon S, Naudin J, et al. Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010;207(4):731–750.
   PubMed Web of Science ®Google Scholar
• Yu Y, Xie Y, Cao L, et al. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents. Mol Cell Oncol. 2015;2(4):e1054549.
   PubMed Web of Science ®Google Scholar
• Yusuf RZ, Saez B, Sharda A, et al. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. 2020;136(11):1303–1316.
   PubMed Web of Science ®Google Scholar
• Viswanathan VS, Ryan MJ, Dhruv HD, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017;547(7664):453–457.
   PubMed Web of Science ®Google Scholar
• Magtanong L, Ko PJ, To M, et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem Biol. 2019;26(3):420–432.e9.
   PubMed Web of Science ®Google Scholar
• Zhu HY, Huang ZX, Chen GQ, et al. Typhaneoside prevents acute myeloid leukemia (AML) through suppressing proliferation and inducing ferroptosis associated with autophagy. Biochem Biophys Res Commun. 2019;516(4):1265–1271.
   PubMed Web of Science ®Google Scholar
• Feng Y, Hua X, Niu R, et al. ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway. Biol Res. 2019;52(1):26.
   PubMedGoogle Scholar
• Sauer H, Wartenberg M, Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem. 2001;11(4):173–186.
   PubMed Web of Science ®Google Scholar
• Feng Y, Niu R, Cheng X, et al. ATPR-induced differentiation and G0/G1 phase arrest in acute promyelocytic leukemia by repressing EBP50/NCF1 complex to promote the production of ROS. Toxicol Appl Pharmacol. 2019;379:114638.
   PubMed Web of Science ®Google Scholar
• Du Y, Bao J, Zhang MJ, et al. Targeting ferroptosis contributes to ATPR-induced AML differentiation via ROS–autophagy–lysosomal pathway. Gene. 2020;755:144889.
   PubMed Web of Science ®Google Scholar
• Ishikawa C, Senba M, Mori N. Evaluation of artesunate for the treatment of adult T-cell leukemia/lymphoma. Eur J Pharmacol. 2020;872:172953.
   PubMed Web of Science ®Google Scholar
• O'Neill PM, Barton VE, Ward SA. The molecular mechanism of action of artemisinin—the debate continues. Molecules. 2010;15(3):1705–1721.
   PubMed Web of Science ®Google Scholar
• Zhu S, Yu Q, Huo C, et al. Ferroptosis: a novel mechanism of artemisinin and its derivatives in cancer therapy. Curr Med Chem. 2021;28(2):329–345.
   PubMed Web of Science ®Google Scholar
• Tarangelo A, Dixon S. The p53–p21 pathway inhibits ferroptosis during metabolic stress. Oncotarget. 2018;9(37):24572–24573.
   PubMedGoogle Scholar
• Jiang L, Kon N, Li T, et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520(7545):57–62.
   PubMed Web of Science ®Google Scholar
• Edeas M, Saleh J, Peyssonnaux C. Iron: innocent bystander or vicious culprit in COVID-19 pathogenesis? Int J Infect Dis. 2020;97:303–305.
   PubMed Web of Science ®Google Scholar
• Fujita N, Sugimoto R, Urawa N, et al. Hepatic iron accumulation is associated with disease progression and resistance to interferon/ribavirin combination therapy in chronic hepatitis C. J Gastroenterol Hepatol. 2007;22(11):1886–1893.
   PubMed Web of Science ®Google Scholar
• Drakesmith H, Chen N, Ledermann H, et al. HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis. Proc Natl Acad Sci USA. 2005;102(31):11017–11022.
   PubMed Web of Science ®Google Scholar
• Traore HN, Meyer D. The effect of iron overload on in vitro HIV-1 infection. J Clin Virol. 2004;31:92–98.
   PubMed Web of Science ®Google Scholar
• Crowe WE, Maglova LM, Ponka P, et al. Human cytomegalovirus-induced host cell enlargement is iron dependent. Am J Physiol Cell Physiol. 2004;287(4):C1023–C1030.
   PubMed Web of Science ®Google Scholar
• Perricone C, Bartoloni E, Bursi R, et al. COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy. Immunol Res. 2020;68(4):213–224.
   PubMed Web of Science ®Google Scholar
• Liu W, Zhang S, Nekhai S, et al. Depriving iron supply to the virus represents a promising adjuvant therapeutic against viral survival. Curr Clin Microbiol Rep. 2020;1–7.
   Google Scholar
• Gordeuk VR, McLaren CE, MacPhail AP, et al. Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited. Blood. 1996;87(8):3470–3476.
   PubMed Web of Science ®Google Scholar
• Dragset MS, Poce G, Alfonso S, et al. A novel antimycobacterial compound acts as an intracellular iron chelator. Antimicrob Agents Chemother. 2015;59(4):2256–2264.
   PubMed Web of Science ®Google Scholar
• Amaral EP, Costa DL, Namasivayam S, et al. A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis. J Exp Med. 2019;216(3):556–570.
   PubMed Web of Science ®Google Scholar
• Cavezzi A, Troiani E, Corrao S. COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review. Clin Pract. 2020;10(2):1271.
   PubMed Web of Science ®Google Scholar
• Yang M, Lai CL. SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement? Cell Death Discov. 2020;6(1):130.
   PubMed Web of Science ®Google Scholar
• Hirayama M, Ito M, Minato T, et al. Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson's disease. Med Gas Res. 2018;8(4):144–149.
   PubMed Web of Science ®Google Scholar
• Jacobs W, Lammens M, Kerckhofs A, et al. Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID-19): autopsy reveals a ferroptosis signature. ESC Heart Fail. 2020.
   Google Scholar
• Tavakolpour S, Rakhshandehroo T, Wei EX, et al. Lymphopenia during the COVID-19 infection: what it shows and what can be learned. Immunol Lett. 2020;225:31–32.
   PubMed Web of Science ®Google Scholar
• Wang Y, Huang J, Sun Y, et al. SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis ER stress and DNA synthesis. Food Chem Toxicol. 2020;153:112286.
   Web of Science ®Google Scholar
• Lodigiani C, Iapichino G, Carenzo L, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191:9–14.
   PubMed Web of Science ®Google Scholar
• Hadadi A, Mortezazadeh M, Kolahdouzan K, et al. Does recombinant human erythropoietin administration in critically ill COVID-19 patients have miraculous therapeutic effects? J Med Virol. 2020;92(7):915–918.
   PubMed Web of Science ®Google Scholar
• Banchini F, Vallisa D, Maniscalco P, et al. Iron overload and hepcidin overexpression could play a key role in COVID infection, and may explain vulnerability in elderly, diabetics, and obese patients. Acta Biomed. 2020;91(3):e2020013.
   PubMedGoogle Scholar
• Lipinski B, Pretorius E. Novel pathway of iron-induced blood coagulation: implications for diabetes mellitus and its complications. Pol Arch Med Wewn. 2012;122(3):115–122.
   PubMed Web of Science ®Google Scholar
• Stegenga ME, van der Crabben SN, Levi M, et al. Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans. Diabetes. 2006;55(6):1807–1812.
   PubMed Web of Science ®Google Scholar
• Wang H, Li H, Jiang X, et al. Hepcidin is directly regulated by insulin and plays an important role in iron overload in streptozotocin-induced diabetic rats. Diabetes. 2014;63(5):1506–1518.
   PubMed Web of Science ®Google Scholar
• Zhao K, Huang J, Dai D, et al. Serum iron level as a potential predictor of coronavirus disease 2019 severity and mortality: a retrospective study. Open Forum Infect Dis. 2020;7(7):ofaa250.
   PubMed Web of Science ®Google Scholar
• Bellmann-Weiler R, Lanser L, Barket R, et al. Prevalence and predictive value of anemia and dysregulated iron homeostasis in patients with COVID-19 infection. J Clin Med. 2020;9(8):2429.
   PubMed Web of Science ®Google Scholar
• Daher R, Manceau H, Karim Z. Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease. Presse Med. 2017;46(12 Pt 2):e272–e278.
   PubMed Web of Science ®Google Scholar
• Kaneko Y, Miyajima H, Piperno A, et al. Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders. J Gastroenterol. 2010;45(11):1163–1171.
   PubMed Web of Science ®Google Scholar
• Kell DB, Pretorius E. Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics. 2014;6(4):748–773.
   PubMed Web of Science ®Google Scholar
• Zhang X, Cheng Y, Zhou Q, et al. The effect of Chinese traditional medicine Huaiqihuang (HQH) on the protection of nephropathy. Oxid Med Cell Longev. 2020;2020:2153912.
   PubMed Web of Science ®Google Scholar
• Cordoba-David G, Duro-Castano A, Castelo-Branco RC, et al. Effective nephroprotection against acute kidney injury with a star-shaped polyglutamate–curcuminoid conjugate. Sci Rep. 2020;10(1):2056.
   PubMed Web of Science ®Google Scholar
• Yamaguchi Y, Kasukabe T, Kumakura S. Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis. Int J Oncol. 2018;52(3):1011–1022.
   PubMed Web of Science ®Google Scholar
• Li X, Zeng J, Liu Y, et al. Inhibitory effect and mechanism of action of quercetin and quercetin Diels–Alder anti-dimer on erastin-induced ferroptosis in bone marrow-derived mesenchymal stem cells. Antioxidants. 2020;9(3):205.
   Web of Science ®Google Scholar
• Chen Y, Li N, Wang H, et al. Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma. Life Sci. 2020;247:117425.
   PubMed Web of Science ®Google Scholar
• Jiang T, Chu J, Chen H, et al. Gastrodin inhibits H2O2-induced ferroptosis through its antioxidative effect in rat glioma cell line C6. Biol Pharm Bull. 2020;43(3):480–487.
   PubMed Web of Science ®Google Scholar
• Yaseen A, Yang F, Zhang X, et al. Ferroptosis inhibitory constituents from the fruits of Cullen corylifolium. Nat Prod Res. 2020;1–5.
   Google Scholar
• Chen P, Wu Q, Feng J, et al. Erianin, a novel dibenzyl compound in dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis. Signal Transduct Target Ther. 2020;5(1):51.
   PubMed Web of Science ®Google Scholar