ZIF-8 nanoparticles coated with macrophage-derived microvesicles for sustained, targeted delivery of dexamethasone to arthritic joints

References

• Symmons D, Turner G, Webb R, et al. The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology. 2002;41(7):793–800.
   PubMed Web of Science ®Google Scholar
• Wong JB, Ramey DR, Singh G. Long-term morbidity, mortality, and economics of rheumatoid arthritis. Arthritis Rheum. 2001;44(12):2746–2749.
   PubMed Web of Science ®Google Scholar
• Veerapen K, Mangat G, Watt I, et al. The expression of rheumatoid arthritis in Malaysian and British patients: a comparative study. Br J Rheumatol. 1993;32(7):541–545.
   PubMedGoogle Scholar
• Kasahara A, Kida T, Hirano A, et al. Risk of adrenal insufficiency in patients with polymyalgia rheumatica versus patients with rheumatoid arthritis: a cross-sectional study. Mod Rheumatol. 2022;1439–7595.
   Web of Science ®Google Scholar
• Mohammed RHA, Bansal P. Hand and wrist rheumatoid arthritis. In: StatPearls. Treasure Island (FL): StatPearls Publishing LLC; 2022.
   Google Scholar
• Dolan-O'Keefe M, Nick HS. Inhibition of cytoplasmic phospholipase A2 expression by glucocorticoids in rat intestinal epithelial cells. Gastroenterology. 2019;4:855–864.
   Google Scholar
• Filippa MG, Tektonidou MG, Mantzou A, et al. Adrenocortical dysfunction in rheumatoid arthritis: a narrative review and future directions. Eur J Clin Invest. 2022;52(1):e13635.
   PubMed Web of Science ®Google Scholar
• Ruiz-Irastorza G, Danza A, Khamashta M. Glucocorticoid use and abuse in SLE. Rheumatology. 2012;51(7):1145–1153.
   PubMed Web of Science ®Google Scholar
• Petta I, Bougarne N, Vandewalle J, et al. Glucocorticoid receptor-mediated transactivation is hampered by striatin-3, a novel interaction partner of the receptor. Sci Rep. 2017;7(1):8941.
   PubMedGoogle Scholar
• Kavanaugh A, Wells AF. Benefits and risks of low-dose glucocorticoid treatment in the patient with rheumatoid arthritis. Rheumatology. 2014;53(10):1742–1751.
   PubMed Web of Science ®Google Scholar
• Jadhav D, Vavia P. Dexamethasone sodium phosphate loaded modified cyclodextrin based nanoparticles: an efficient treatment for rheumatoid arthritis. J Pharm Sci. 2021;110(3):1206–1218.
   PubMed Web of Science ®Google Scholar
• Yan F, Zhong Z, Wang Y, et al. Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis. J Nanobiotechnol. 2020;18(1):115.
   PubMed Web of Science ®Google Scholar
• Silvagni E, Di Battista M, Bonifacio AF, et al. One year in review 2019: novelties in the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2019;37(4):519–534.
   PubMed Web of Science ®Google Scholar
• Rodríguez Villanueva J, Rodríguez Villanueva L, Guzmán Navarro M. Pharmaceutical technology can turn a traditional drug, dexamethasone into a first-line ocular medicine. A global perspective and future trends. Int J Pharm. 2017;516(1–2):342–351.
   PubMedGoogle Scholar
• Gambaro FM, Ummarino A, Torres Andón F, et al. Drug delivery systems for the treatment of knee osteoarthritis: a systematic review of in vivo studies. Int J Mol Sci. 2021;22(17):9137.
   Google Scholar
• Liang N, Ren N, Feng Z, et al. Biomimetic metal-organic frameworks as targeted vehicles to enhance osteogenesis. Adv Healthc Mater. 2022:e2102821.
   PubMed Web of Science ®Google Scholar
• Geng S, Lou R, Yin Q, et al. Reshaping the tumor microenvironment for increasing the distribution of glucose oxidase in tumor and inhibiting metastasis. J Mater Chem B. 2021;9(5):1424–1431.
   PubMed Web of Science ®Google Scholar
• Liu J, Wen Q, Zhou B, et al. “Clickable” ZIF-8 for cell-type-specific delivery of functional proteins. ACS Chem Biol. 2022;17(1):32–38.
   PubMed Web of Science ®Google Scholar
• Gao J, Yuheng L, Liu J, et al. A photoresponsive and metal-organic framework encapsulated DNA tetrahedral entropy-driven amplifier for high-performance imaging intracellular microRNA. Anal Chem. 2021;93(49):16638–16645.
   PubMed Web of Science ®Google Scholar
• Alizadeh M, Azar PA, Mozaffari SA, et al. A DNA based biosensor amplified with ZIF-8/ionic liquid composite for determination of mitoxantrone anticancer drug: an experimental/docking investigation. Front Chem. 2020;8:814.
   PubMed Web of Science ®Google Scholar
• Tolentino MQ, Hartmann AK, Loe DT, et al. Controlled release of small molecules and proteins from DNA-surfactant stabilized metal organic frameworks. J Mater Chem B. 2020;8(26):5627–5635.
   PubMed Web of Science ®Google Scholar
• Zhao G, Wu H, Feng R, et al. Bimetallic zeolitic imidazolate framework as an intrinsic two-photon fluorescence and pH-Responsive MR imaging agent. ACS Omega. 2018;3(8):9790–9797.
   PubMed Web of Science ®Google Scholar
• Zhou Z, Gao Z, Shen H, et al. Metal-organic framework in situ post-encapsulating DNA-enzyme composites on a magnetic carrier with high stability and reusability. ACS Appl Mater Interfaces. 2020;12(6):7510–7517.
   PubMed Web of Science ®Google Scholar
• Chen Y, Wu H, Yang T, et al. Biomimetic nucleation of metal-organic frameworks on silk fibroin nanoparticles for designing core-shell-structured pH-responsive anticancer drug carriers. ACS Appl Mater Interfaces. 2021;13(40):47371–47381.
   PubMed Web of Science ®Google Scholar
• Belov L, Matic KJ, Hallal S, et al. Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples. J Extracell Vesicles. 2016;5:25355.
   PubMed Web of Science ®Google Scholar
• Gould SJ, Schaffer JE. Exosomes and microvesicles. Encyclopedia of Biological Chemistry III. 2021;5:455–458.
   Google Scholar
• Joshi B, Youssef S, Bron R, et al. DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease. iScience. 2021;24(11):103282.
   PubMed Web of Science ®Google Scholar
• Malys MSS, Aigner C, Schulz SMM, et al. Isolation of small extracellular vesicles from human sera. Int J Mol Sci. 2021;22(9):4653.
   PubMed Web of Science ®Google Scholar
• Chistiakov DA, Chekhonin VP. Extracellular vesicles shed by glioma cells: pathogenic role and clinical value. Tumour Biol. 2014;35(9):8425–8438.
   PubMedGoogle Scholar
• Liu C, Zhang W, Li Y, et al. Microfluidic sonication to assemble exosome membrane-coated nanoparticles for immune Evasion-Mediated targeting. Nano Lett. 2019;19(11):7836–7844.
   PubMed Web of Science ®Google Scholar
• Patel DB, Luthers CR, Lerman MJ, et al. Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system. Acta Biomater. 2019;95:236–244.
   PubMed Web of Science ®Google Scholar
• Garcia-Manero G, Daver NG, Xu J, et al. Magrolimab + azacitidine versus azacitidine + placebo in untreated higher risk (HR) myelodysplastic syndrome (MDS): the phase 3, randomized, ENHANCE study. J Clin Oncol. 2021;39(15_suppl):TPS7055.
   Web of Science ®Google Scholar
• Cheng L, Zhang X, Tang J, et al. Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy. Biomaterials. 2021;275:120964.
   PubMed Web of Science ®Google Scholar
• Du J, Wan Z, Wang C, et al. Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy. Theranostics. 2021;11(17):8185–8196.
   PubMed Web of Science ®Google Scholar
• Li R, He Y, Zhu Y, et al. Route to rheumatoid arthritis by macrophage-derived microvesicle-coated nanoparticles. Nano Lett. 2019;19(1):124–134.
   PubMed Web of Science ®Google Scholar
• Xu X, Zhao Y, Tan H, et al. In situ encapsulation of horseradish peroxidase in zeolitic imidazolate framework-8 enables catalyzing luminol reaction under near-neutral conditions for sensitive chemiluminescence determination of cholesterol. Mikrochim Acta. 2020;187(6):346.
   PubMed Web of Science ®Google Scholar
• Zielińska A, Ferreira NR, Feliczak-Guzik A, et al. Loading, release profile and accelerated stability assessment of monoterpenes-loaded solid lipid nanoparticles (SLN). Pharm Dev Technol. 2020;25(7):832–844.
   PubMed Web of Science ®Google Scholar
• Xie R, Yang P, Peng S, et al. A phosphorylcholine-based zwitterionic copolymer coated ZIF-8 nanodrug with a long circulation time and charged conversion for enhanced chemotherapy. J Mater Chem B. 2020;8(28):6128–6138.
   PubMed Web of Science ®Google Scholar
• Bosch S, de Beaurepaire L, Allard M, et al. Trehalose prevents aggregation of exosomes and cryodamage. Sci Rep. 2016;6:36162.
   PubMed Web of Science ®Google Scholar
• Ke Y, Fan X, Hao R, et al. Human embryonic stem cell-derived extracellular vesicles alleviate retinal degeneration by upregulating Oct4 to promote retinal Müller cell retrodifferentiation via HSP90. Stem Cell Res Ther. 2021;12(1):21.
   PubMed Web of Science ®Google Scholar
• Tan KL, Chia WC, How CW, et al. Benchtop isolation and characterisation of small extracellular vesicles from human mesenchymal stem cells. Mol Biotechnol. 2021;63(9):780–791.
   PubMed Web of Science ®Google Scholar
• Segura-Benítez M, Carbajo-García M, Corachán A, et al. Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantation. Reprod Biol Endocrinol. 2022;20(1):3.
   PubMed Web of Science ®Google Scholar
• Warnier G, De Groote E, Britto F, et al. Effects of an acute exercise bout in hypoxia on extracellular vesicle release in healthy and prediabetic subjects. Am J Physiol Regul Integr Compar Physiol. 2021;322(2):R112–R122.
   PubMed Web of Science ®Google Scholar
• Li H, Feng Y, Zheng X, et al. M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization. J Control Release. 2022;341:16–30.
   PubMed Web of Science ®Google Scholar
• Min H, Wang J, Qi Y, et al. Biomimetic metal-organic framework nanoparticles for cooperative combination of antiangiogenesis and photodynamic therapy for enhanced efficacy. Adv Mater. 2019;31(15):e1808200.
   PubMed Web of Science ®Google Scholar
• Zhang L, Wang Z, Zhang Y, et al. Erythrocyte membrane cloaked metal-organic framework nanoparticle as biomimetic nanoreactor for starvation-activated colon cancer therapy. ACS Nano. 2018;12(10):10201–10211.
   PubMed Web of Science ®Google Scholar
• Gong T, Tan T, Zhang P, et al. Palmitic acid-modified bovine serum albumin nanoparticles target scavenger receptor-A on activated macrophages to treat rheumatoid arthritis. Biomaterials. 2020;258:120296.
   PubMed Web of Science ®Google Scholar
• Cheng G, Li W, Ha L, et al. Self-assembly of extracellular vesicle-like metal-organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins. J Am Chem Soc. 2018;140(23):7282–7291.
   PubMed Web of Science ®Google Scholar
• Li S, Wu Y, Ding F, et al. Engineering macrophage-derived exosomes for targeted chemotherapy of triple-negative breast cancer. Nanoscale. 2020;12(19):10854–10862.
   PubMed Web of Science ®Google Scholar
• Rho J, Chung J, Im H, et al. Magnetic nanosensor for detection and profiling of erythrocyte-derived microvesicles. ACS Nano. 2013;7(12):11227–11233.
   PubMed Web of Science ®Google Scholar
• Deng C, Zhang Q, He P, et al. Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis. Nat Commun. 2021;12(1):2174.
   PubMed Web of Science ®Google Scholar
• Wenqi YXueqin, et al. Sequentially responsive biomimetic nanoparticles with optimal size in combination with checkpoint blockade for cascade synergetic treatment of breast cancer and lung metastasis. Biomaterials. 2019;217:119309.
   Web of Science ®Google Scholar
• Boushehri M, Dietrich D, Lamprecht A. Nanotechnology as a platform for the development of injectable parenteral formulations: a comprehensive review of the know-hows and state of the art. Pharmaceutics. 2020;12(6):510.
   Web of Science ®Google Scholar
• Ishida T, Kiwada H. Accelerated blood clearance (ABC) phenomenon induced by administration of PEGylated liposome. Yakugaku Zasshi. 2008;128(2):233–243.
   PubMed Web of Science ®Google Scholar
• Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles. 2013;2:20360.
   PubMedGoogle Scholar
• Lima Correa B, El Harane N, Gomez I, et al. Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts. Cardiovasc Res. 2021;117(1):292–307.
   PubMed Web of Science ®Google Scholar
• Shimizu A, Sawada K, Kobayashi M, et al. Exosomal CD47 plays an essential role in immune evasion in ovarian cancer. Mol Cancer Res. 2021;19(9):1583–1595.
   PubMed Web of Science ®Google Scholar
• Yuan N, Ge Z, Ji WCE, et al. Exosomes secreted from hypoxia-preconditioned mesenchymal stem cells prevent steroid-induced osteonecrosis of the femoral head by promoting angiogenesis in rats. Biomed Res Int. 2021;2021:6655225.
   PubMed Web of Science ®Google Scholar
• Elsharkasy OM, Nordin JZ, Hagey DW, et al. Extracellular vesicles as drug delivery systems: why and how? Adv Drug Deliv Rev. 2020;159:332–343.
   PubMed Web of Science ®Google Scholar
• Sengupta V, Sengupta S, Lazo A, et al. Exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID-19. Stem Cells Dev. 2020;29(12):747–754.
   PubMed Web of Science ®Google Scholar
• Phinney DG, Pittenger MF. Concise review: MSC-derived exosomes for cell-free therapy. Stem Cells. 2017;35(4):851–858.
   PubMed Web of Science ®Google Scholar
• Keshtkar S, Azarpira N, Ghahremani MH. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine. Stem Cell Res Ther. 2018;9(1):63.
   PubMed Web of Science ®Google Scholar
• Ruan S, Erwin N, He M. Light-induced high-efficient cellular production of immune functional extracellular vesicles. J Extracell Vesicles. 2022;11(3):e12194.
   PubMed Web of Science ®Google Scholar
• Mendt M, Kamerkar S, Sugimoto H, et al. Generation and testing of clinical-grade exosomes for pancreatic cancer. JCI Insight. 2018;3(8):e99263.
   PubMed Web of Science ®Google Scholar
• Haraszti RA, Miller R, Stoppato M, et al. Exosomes produced from 3D cultures of MSCs by tangential flow filtration show higher yield and improved activity. Mol Ther. 2018;26(12):2838–2847.
   PubMed Web of Science ®Google Scholar
• Shyong YJ, Chang KC, Lin FH. Calcium phosphate particles stimulate exosome secretion from phagocytes for the enhancement of drug delivery. Colloids Surf B Biointerfaces. 2018;171:391–397.
   PubMed Web of Science ®Google Scholar
• Mohammadpour R, Dobrovolskaia MA, Cheney DL, et al. Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications. Adv Drug Deliv Rev. 2019;144:112–132.
   PubMed Web of Science ®Google Scholar
• Johari SA, Sarkheil M, Veisi S. Cytotoxicity, oxidative stress, and apoptosis in human embryonic kidney (HEK293) and colon cancer (SW480) cell lines exposed to nanoscale zeolitic imidazolate framework 8 (ZIF-8). Environ Sci Pollut Res. 2021;28(40):56772–56781.
   PubMed Web of Science ®Google Scholar
• Gao X, Xue Y, Zhu Z, et al. Nanoscale zeolitic imidazolate framework-8 activator of canonical MAPK signaling for bone repair. ACS Appl Mater Interfaces. 2021;13(1):97–111.
   PubMed Web of Science ®Google Scholar
• Cavalu S, Fritea L, Brocks M, et al. Novel hybrid composites based on PVA/SeTiO(2) nanoparticles and natural hydroxyapatite for orthopedic applications: Correlations between structural, morphological and biocompatibility properties. Materials. 2020;13(9):2077.
   Web of Science ®Google Scholar
• Zou F, Jiang J, Lv F, et al. Preparation of antibacterial and osteoconductive 3D-printed PLGA/Cu(I)@ZIF-8 nanocomposite scaffolds for infected bone repair. J Nanobiotechnol. 2020;18(1):39.
   PubMed Web of Science ®Google Scholar
• Ejeian F, Razmjou A, Nasr-Esfahani MH, et al. ZIF-8 modified polypropylene membrane: a biomimetic cell culture platform with a view to the improvement of guided bone regeneration. Int J Nanomedicine. 2020;15:10029–10043.
   PubMed Web of Science ®Google Scholar
• Warnecke A, Prenzler N, Harre J, et al. First-in-human intracochlear application of human stromal cell-derived extracellular vesicles. J Extracell Vesicles. 2021;10(8):e12094.
   PubMed Web of Science ®Google Scholar
• Crawford D, Casaban J, Haydon R, et al. Synthesis by extrusion: continuous, large-scale preparation of MOFs using little or no solvent. Chem Sci. 2015;6(3):1645–1649.
   PubMed Web of Science ®Google Scholar