Tissue engineering approaches and generation of insulin-producing cells to treat type 1 diabetes

References

• van de Vyver M. Intrinsic mesenchymal stem cell dysfunction in diabetes mellitus: implications for autologous cell therapy. Stem Cells Dev. 2017;26(14):1042–1053.
   PubMed Web of Science ®Google Scholar
• Nazarian-Samani Z, Sewell RD, Lorigooini Z, et al. Medicinal plants with multiple effects on diabetes mellitus and its complications: a systematic review. Curr Diab Rep. 2018;18(10):72.
   PubMed Web of Science ®Google Scholar
• Wartchow KM, Rodrigues L, Lissner LJ, et al. Insulin-producing cells from mesenchymal stromal cells: protection against cognitive impairment in diabetic rats depends upon implant site. Life Sci. 2020;251:117587.
   PubMed Web of Science ®Google Scholar
• Khazaei MR, Makalani F, Ghanbari E, et al. An overview of effective herbal and antioxidant compounds on diabetes. J Contemp Med Sci. 2018;4(3):126–133.
   Web of Science ®Google Scholar
• Porat S, Dor Y. New sources of pancreatic beta cells. Curr Diab Rep. 2007;7(4):304–308.
   PubMedGoogle Scholar
• Shapiro AJ, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006;355(13):1318–1330.
   PubMed Web of Science ®Google Scholar
• Brennan DC, Kopetskie H, Sayre P, et al. Long-term follow-up of the Edmonton protocol of islet transplantation in the United States. Am J Transplant. 2016;16(2):509–517.
   PubMed Web of Science ®Google Scholar
• Stabler CL, Giraldo JA, Berman DM, et al. Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model. Am J Transplant. 2020;20(3):689–700.
   PubMed Web of Science ®Google Scholar
• Salg GA, Giese NA, Schenk M, et al. The emerging field of pancreatic tissue engineering: a systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells. J Tissue Eng. 2019;10:2041731419884708.
   Web of Science ®Google Scholar
• Nalbach L, Roma LP, Schmitt BM, et al. Improvement of islet transplantation by the fusion of islet cells with functional blood vessels. EMBO Mol Med. 2021;13(1):e12616.
   PubMed Web of Science ®Google Scholar
• Mobarra N, Soleimani M, Pakzad R, et al. Three-dimensional nanofiberous PLLA/PCL scaffold improved biochemical and molecular markers hiPS cell-derived insulin-producing islet-like cells. Artif Cells Nanomed Biotechnol. 2018;46(Suppl 3):S685–S692.
   PubMedGoogle Scholar
• Herberts CA, Kwa MS, Hermsen HP. Risk factors in the development of stem cell therapy. J Transl Med. 2011;9(1):1–14.
   Google Scholar
• Montanucci P, Pescara T, Greco A, et al. Co-microencapsulation of human umbilical cord-derived mesenchymal stem and pancreatic islet-derived insulin producing cells in experimental type 1 diabetes. Diabetes/Metab Res Rev. 2020;37(2):e3372.
   PubMed Web of Science ®Google Scholar
• Lee M, Jeong SY, Ha J, et al. Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo. Biochem Biophys Res Commun. 2014;446(4):983–989.
   PubMed Web of Science ®Google Scholar
• Lohan P, Treacy O, Griffin MD, et al. Anti-donor immune responses elicited by allogeneic mesenchymal stem cells and their extracellular vesicles: are we still learning? Front Immunol. 2017;8:1626.
   PubMed Web of Science ®Google Scholar
• Mohammadi N, Mardomi A, Hassannia H, et al. Mouse bone marrow-derived mesenchymal stem cells acquire immunogenicity concurrent with differentiation to insulin-producing cells. Immunobiology. 2020;225(5):151994.
   PubMed Web of Science ®Google Scholar
• Xu B, Fan D, Zhao Y, et al. Three-dimensional culture promotes the differentiation of human dental pulp mesenchymal stem cells into insulin-producing cells for improving the diabetes therapy. Front Pharmacol. 2019;10:1576.
   PubMed Web of Science ®Google Scholar
• Marappagounder D, Somasundaram I, Dorairaj S, et al. Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro. Cell Mol Biol Lett. 2013;18(1):75–88.
   PubMed Web of Science ®Google Scholar
• Magisson J, Sassi A, Xhema D, et al. Safety and function of a new pre-vascularized bioartificial pancreas in an allogeneic rat model. J Tissue Eng. 2020;11:2041731420924818.
   Web of Science ®Google Scholar
• Zhu Y, Wang D, Yao X, et al. Biomimetic hybrid scaffold of electrospun silk fibroin and pancreatic decellularized extracellular matrix for islet survival. J Biomater Sci Polym Ed. 2021;32(2):151–165.
   PubMed Web of Science ®Google Scholar
• Green JJ, Elisseeff JH. Mimicking biological functionality with polymers for biomedical applications. Nature. 2016;540(7633):386–394.
   PubMed Web of Science ®Google Scholar
• Mansour RN, Barati G, Soleimani M, et al. Generation of high-yield insulin producing cells from human-induced pluripotent stem cells on polyethersulfone nanofibrous scaffold. Artif Cells Nanomed Biotechnol. 2018;46(Suppl 1):733–739.
   PubMedGoogle Scholar
• Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013;93(1):137–188.
   PubMed Web of Science ®Google Scholar
• Ghanbari E, Nejati V, Khazaei M, et al. Antioxidant and protective effects of royal jelly on histopathological changes in testis of diabetic rats. Int J Reprod Biomed. 2016;14(8):519–526.
   PubMedGoogle Scholar
• Otto-Buczkowska E, Jainta N. Pharmacological treatment in diabetes mellitus type 1-insulin and what else? Int J Endocrinol Metab. 2018;16(1):e13008.
   PubMed Web of Science ®Google Scholar
• Witkowski P, Philipson LH, Kaufman DB, et al. The demise of islet allotransplantation in the United States: a call for an urgent regulatory update. Am J Transplant. 2021;21(4):1365–1375.
   PubMed Web of Science ®Google Scholar
• Ghanbari E, Nejati V, Khazaei M. Improvement in serum biochemical alterations and oxidative stress of liver and pancreas following use of royal jelly in streptozotocin-induced diabetic rats. Cell J (Yakhteh). 2016;18(3):362.
   PubMed Web of Science ®Google Scholar
• Aathira R, Jain V. Advances in management of type 1 diabetes mellitus. World J Diabetes. 2014;5(5):689–696.
   PubMedGoogle Scholar
• Bruni A, Gala-Lopez B, Pepper AR, et al. Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges. Diabetes Metab Syndr Obes. 2014;7:211.
   PubMedGoogle Scholar
• Gregory JM, Cherrington AD, Moore DJ. The peripheral peril: Injected insulin induces insulin insensitivity in type 1 diabetes. Diabetes. 2020;69(5):837–847.
   PubMed Web of Science ®Google Scholar
• Smail HO. The role of gene therapy in the treatments of type 1 diabetes mellitus: a review. Bio Med Nat Prod Chem. 2020;9(2):57–64.
   Google Scholar
• Ludvigsson J. Combination therapy for preservation of beta cell function in type 1 diabetes: new attitudes and strategies are needed!. Immunol Lett. 2014;159(1-2):30–35.
   PubMed Web of Science ®Google Scholar
• Dias I, Pinheiro D, Silva KR, et al. Secretome effect of adipose tissue-derived stem cells cultured two-dimensionally and three-dimensionally in mice with streptozocin induced type 1 diabetes. Curr Res Pharmacol Drug Discov. 2021;2:100069.
   PubMedGoogle Scholar
• Poy MN, Eliasson L, Krutzfeldt J, et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 2004;432(7014):226–230.
   PubMed Web of Science ®Google Scholar
• Piran M, Enderami SE, Piran M, et al. Insulin producing cells generation by overexpression of miR-375 in adipose-derived mesenchymal stem cells from diabetic patients. Biologicals. 2017;46:23–28.
   PubMed Web of Science ®Google Scholar
• Mo Y, Wang Z, Gao J, et al. Comparative study of three types of mesenchymal stem cell to differentiate into pancreatic β-like cells in vitro. Exp Ther Med. 2021;22(3):1–11.
   Web of Science ®Google Scholar
• Hashemi J, Pasalar P, Soleimani M, et al. Application of a novel bioreactor for in vivo engineering of pancreas tissue. J Cell Physiol. 2018;233(5):3805–3816.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Park J-S. Usage of human mesenchymal stem cells in cell-based therapy: advantages and disadvantages. Dev Reprod. 2017;21(1):1–10.
   PubMedGoogle Scholar
• Pileggi A. Mesenchymal stem cells for the treatment of diabetes. Diabetes. 2012;61(6):1355–1356.
   PubMed Web of Science ®Google Scholar
• Cho J, D’Antuono M, Glicksman M, et al. A review of clinical trials: mesenchymal stem cell transplant therapy in type 1 and type 2 diabetes mellitus. Am J Stem Cells. 2018;7(4):82–93.
   PubMed Web of Science ®Google Scholar
• Wu H, Mahato RI. Mesenchymal stem cell-based therapy for type 1 diabetes. Discov Med. 2014;17(93):139–143.
   PubMed Web of Science ®Google Scholar
• Khatri R, Mazurek S, Petry SF, et al. Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway. Stem Cell Res Ther. 2020;11(1):497.
   PubMed Web of Science ®Google Scholar
• Khatri R, Petry SF, Linn T. Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration. Stem Cell Res Ther. 2021;12(1):1–14.
   PubMed Web of Science ®Google Scholar
• Izadi M, Nejad ASH, Moazenchi M, et al. Mesenchymal stem cells transplantation in newly diagnosed type-1 diabetes patients: a phase I/II randomized controlled trial. Cytotherapy. 2020;22(5):S85–S86.
   Web of Science ®Google Scholar
• Razavi M, Ren T, Zheng F, et al. Facilitating islet transplantation using a three-step approach with mesenchymal stem cells, encapsulation, and pulsed focused ultrasound. Stem Cell Res Ther. 2020;11(1):405.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang R, Qiao H, et al. Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells. J Cell Physiol. 2007;211(1):36–44.
   PubMed Web of Science ®Google Scholar
• Domouky AM, Hegab AS, Al-Shahat A, et al. Mesenchymal stem cells and differentiated insulin producing cells are new horizons for pancreatic regeneration in type I diabetes mellitus. Int J Biochem Cell Biol. 2017;87:77–85.
   PubMed Web of Science ®Google Scholar
• Rekittke NE, Ang M, Rawat D, et al. Regenerative therapy of type 1 diabetes mellitus: from pancreatic islet transplantation to mesenchymal stem cells. Stem Cells Int. 2016;2016:1–22.
   Web of Science ®Google Scholar
• Lysy PA, Weir GC, Bonner-Weir S. Concise review: pancreas regeneration: recent advances and perspectives. Stem Cells Transl Med. 2012;1(2):150–159.
   PubMed Web of Science ®Google Scholar
• Chen S, Du K, Zou C. Current progress in stem cell therapy for type 1 diabetes mellitus. Stem Cell Res Ther. 2020;11(1):275.
   PubMed Web of Science ®Google Scholar
• Nadri S, Barati G, Mostafavi H, et al. Differentiation of conjunctiva mesenchymal stem cells into secreting islet beta cells on plasma treated electrospun nanofibrous scaffold. Artif Cells Nanomed Biotechnol. 2018;46(Suppl 1):178–187.
   PubMedGoogle Scholar
• Warshauer JT, Bluestone JA, Anderson MS. New frontiers in the treatment of type 1 diabetes. Cell Metab. 2020;31(1):46–61.
   PubMed Web of Science ®Google Scholar
• Han Y, Li X, Zhang Y, et al. Mesenchymal stem cells for regenerative medicine. Cells. 2019;8(8):886.
   PubMed Web of Science ®Google Scholar
• Xin Y, Jiang X, Wang Y, et al. Insulin-producing cells differentiated from human bone marrow mesenchymal stem cells in vitro ameliorate streptozotocin-induced diabetic hyperglycemia. PLoS One. 2016;11(1):e0145838.
   PubMed Web of Science ®Google Scholar
• Chhabra P, Brayman KL. Stem cell therapy to cure type 1 diabetes: from hype to hope. Stem Cells Transl Med. 2013;2(5):328–336.
   PubMed Web of Science ®Google Scholar
• Aghazadeh Y, Nostro MC. Cell therapy for type 1 diabetes: current and future strategies. Curr Diab Rep. 2017;17(6):37.
   PubMed Web of Science ®Google Scholar
• Pagliuca FW, Millman JR, Gürtler M, et al. Generation of functional human pancreatic β cells in vitro. Cell. 2014;159(2):428–439.
   PubMed Web of Science ®Google Scholar
• Schulz TC. Concise review: manufacturing of pancreatic endoderm cells for clinical trials in type 1 diabetes. Stem Cells Transl Med. 2015;4(8):927–931.
   PubMed Web of Science ®Google Scholar
• D’Amour KA, Bang AG, Eliazer S, et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol. 2006;24(11):1392–1401.
   PubMed Web of Science ®Google Scholar
• Rezania A, Bruin JE, Arora P, et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol. 2014;32(11):1121–1133
   PubMed Web of Science ®Google Scholar
• Zhang D, Jiang W, Liu M, et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res. 2009;19(4):429–438.
   PubMed Web of Science ®Google Scholar
• Russ HA, Parent AV, Ringler JJ, et al. Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. EMBO J. 2015;34(13):1759–1772.
   PubMed Web of Science ®Google Scholar
• Mu XP, Ren LQ, Yan HW, et al. Enhanced differentiation of human amniotic fluid-derived stem cells into insulin-producing cells in vitro. J Diabetes Investig. 2017;8(1):34–43.
   PubMed Web of Science ®Google Scholar
• Päth G, Perakakis N, Mantzoros CS, et al. Stem cells in the treatment of diabetes mellitus—focus on mesenchymal stem cells. Metabolism. 2019;90:1–15.
   PubMed Web of Science ®Google Scholar
• Tao T, Wang Y, Chen W, et al. Engineering human islet organoids from iPSCs using an organ-on-chip platform. Lab Chip. 2019;19(6):948–958.
   PubMed Web of Science ®Google Scholar
• Ghoneim MA, Refaie AF, Elbassiouny BL, et al. From mesenchymal stromal/stem cells to insulin-producing cells: progress and challenges. Stem Cell Rev Rep. 2020;16(6):1156–1172.
   PubMed Web of Science ®Google Scholar
• Wu L-F, Wang N-N, Liu Y-S, et al. Differentiation of Wharton’s jelly primitive stromal cells into insulin-producing cells in comparison with bone marrow mesenchymal stem cells. Tissue Eng Part A. 2009;15(10):2865–2873.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Dou Z. Under a nonadherent state, bone marrow mesenchymal stem cells can be efficiently induced into functional islet-like cell clusters to normalize hyperglycemia in mice: a control study. Stem Cell Res Ther. 2014;5(3):1–13.
   PubMedGoogle Scholar
• Strem BM, Hicok KC, Zhu M, et al. Multipotential differentiation of adipose tissue-derived stem cells. Keio J Med. 2005;54(3):132–141.
   PubMedGoogle Scholar
• Ranjbaran H, Abediankenari S, Khalilian A, et al. Differentiation of Wharton’s jelly derived mesenchymal stem cells into insulin producing cells. Int J Hematol Oncol Stem Cell Res. 2018;12(3):220–229.
   PubMedGoogle Scholar
• Kamal MM, Kassem DH. Therapeutic potential of Wharton’s jelly mesenchymal stem cells for diabetes: achievements and challenges. Front Cell Dev Biol. 2020;8:16.
   PubMed Web of Science ®Google Scholar
• Chao KC, Chao KF, Fu YS, et al. Islet-like clusters derived from mesenchymal stem cells in Wharton’s jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS One. 2008;3(1):e1451.
   PubMed Web of Science ®Google Scholar
• Qu H, Liu X, Ni Y, et al. Laminin 411 acts as a potent inducer of umbilical cord mesenchymal stem cell differentiation into insulin-producing cells. J Transl Med. 2014;12(1):135–112.
   PubMedGoogle Scholar
• Manaph NPA, Sivanathan KN, Nitschke J, et al. An overview on small molecule-induced differentiation of mesenchymal stem cells into beta cells for diabetic therapy. Stem Cell Res Ther. 2019;10(1):1–18.
   PubMed Web of Science ®Google Scholar
• Al Madhoun A, Ali H, AlKandari S, et al. Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord wharton’s jelly mesenchymal stem cells. Stem Cell Res Ther. 2016;7(1):165.
   PubMedGoogle Scholar
• Rezania A, Bruin JE, Riedel MJ, et al. Maturation of human embryonic stem cell–derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes. 2012;61(8):2016–2029.
   PubMed Web of Science ®Google Scholar
• Narayanan K, Lim VY, Shen J, et al. Extracellular matrix-mediated differentiation of human embryonic stem cells: differentiation to insulin-secreting beta cells. Tissue Eng Part A. 2014;20(1–2):424–433.
   PubMed Web of Science ®Google Scholar
• Santos T, Percegona L, Gonzalez P, et al. Expression of ­pancreatic endocrine markers by mesenchymal stem cells from human umbilical cord vein. Transplant Proc. 2010;42(2):563–565.
   PubMed Web of Science ®Google Scholar
• Tang D-Q, Wang Q, Burkhardt BR, et al. In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation. Am J Stem Cells. 2012;1(2):114–127.
   PubMedGoogle Scholar
• Gabr MM, Zakaria MM, Refaie AF, et al. Insulin-producing cells from adult human bone marrow mesenchymal stem cells control streptozotocin-induced diabetes in nude mice. Cell Transplant. 2013;22(1):133–145.
   PubMed Web of Science ®Google Scholar
• Gabr MM, Zakaria MM, Refaie AF, et al. Generation of insulin-producing cells from human bone marrow-derived mesenchymal stem cells: comparison of three differentiation protocols. Biomed Res Int. 2014;2014:1–9.
   Web of Science ®Google Scholar
• Xie R, Everett LJ, Lim H-W, et al. Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell. 2013;12(2):224–237.
   PubMed Web of Science ®Google Scholar
• Shibata T, Naruse K, Kamiya H, et al. Transplantation of bone marrow–derived mesenchymal stem cells improves diabetic polyneuropathy in rats. Diabetes. 2008;57(11):3099–3107.
   PubMed Web of Science ®Google Scholar
• Ikemoto T, Feng R, Iwahashi S-I, et al. In vitro and in vivo effects of insulin-producing cells generated by xeno-antigen free 3D culture with RCP piece. Sci Rep. 2019;9(1):10759.
   PubMedGoogle Scholar
• Wada Y, Ikemoto T, Morine Y, et al. The differences in the characteristics of insulin-producing cells using human adipose-tissue derived mesenchymal stem cells from subcutaneous and visceral tissues. Sci Rep. 2019;9(1):13204.
   PubMedGoogle Scholar
• Kim H-S, Hong S-H, Oh S-H, et al. Activin A, exendin-4, and glucose stimulate differentiation of human pancreatic ductal cells. J Endocrinol. 2013;217(3):241–252.
   PubMed Web of Science ®Google Scholar
• Otonkoski T, Beattie GM, Mally MI, et al. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest. 1993;92(3):1459–1466.
   PubMed Web of Science ®Google Scholar
• Mashima H, Shibata H, Mine T, et al. Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor. Endocrinology. 1996;137(9):3969–3976.
   PubMed Web of Science ®Google Scholar
• Oliveira AG, Araújo TG, Carvalho B, et al. The role of hepatocyte growth factor (HGF) in insulin resistance and diabetes. Front Endocrinol (Lausanne). 2018;9:503.
   PubMed Web of Science ®Google Scholar
• Xu G, Stoffers DA, Habener JF, et al. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes. 1999;48(12):2270–2276.
   PubMed Web of Science ®Google Scholar
• Yang Z, Chen M, Carter JD, et al. Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. Biochem Biophys Res Commun. 2006;344(3):1017–1022.
   PubMed Web of Science ®Google Scholar
• Kassem DH, Kamal MM, El-Kholy AE-LG, et al. Exendin-4 enhances the differentiation of wharton’s jelly mesenchymal stem cells into insulin-producing cells through activation of various β-cell markers. Stem Cell Res Ther. 2016;7(1):108.
   PubMedGoogle Scholar
• Gan J, Wang Y, Zhou X. Stem cell transplantation for the treatment of patients with type 1 diabetes mellitus: a meta-analysis. Exp Ther Med. 2018;16(6):4479–4492.
   PubMed Web of Science ®Google Scholar
• Katuchova J, Harvanova D, Spakova T, et al. Mesenchymal stem cells in the treatment of type 1 diabetes mellitus. Endocr Pathol. 2015;26(2):95–103.
   PubMed Web of Science ®Google Scholar
• Jiang W, Shi Y, Zhao D, et al. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res. 2007;17(4):333–344.
   PubMed Web of Science ®Google Scholar
• Choi KS, Shin J-S, Lee J-J, et al. In vitro trans-differentiation of rat mesenchymal cells into insulin-producing cells by rat pancreatic extract. Biochem Biophys Res Commun. 2005;330(4):1299–1305.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418(6893):41–49.
   PubMed Web of Science ®Google Scholar
• Kroon E, Martinson LA, Kadoya K, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008;26(4):443–452.
   PubMed Web of Science ®Google Scholar
• Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science. 2001;292(5520):1389–1394.
   PubMed Web of Science ®Google Scholar
• Russ HA, Sintov E, Anker-Kitai L, et al. Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One. 2011;6(9):e25566.
   PubMed Web of Science ®Google Scholar
• Jeon K, Lim H, Kim J-H, et al. Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model. Stem Cells Dev. 2012;21(14):2642–2655.
   PubMed Web of Science ®Google Scholar
• Shin L, Peterson DA. Impaired therapeutic capacity of autologous stem cells in a model of type 2 diabetes. Stem Cells Transl Med. 2012;1(2):125–135.
   PubMed Web of Science ®Google Scholar
• Burt RK, Oyama Y, Traynor A, et al. Hematopoietic stem cell therapy for type 1 diabetes: induction of tolerance and islet cell neogenesis. Autoimmun Rev. 2002;1(3):133–138.
   PubMedGoogle Scholar
• Banakh I, Gonez LJ, Sutherland RM, et al. Adult pancreas side population cells expand after β cell injury and are a source of insulin-secreting cells. PLoS One. 2012;7(11):e48977.
   PubMed Web of Science ®Google Scholar
• Machado C, Telles P, Nascimento ILO. Immunological characteristics of mesenchymal stem cells. Rev Bras Hematol Hemoter. 2013;35(1):62–67.
   PubMedGoogle Scholar
• Rodriguez-Fernandez S, Almenara-Fuentes L, Perna-Barrull D, et al. A century later, still fighting back: antigen-specific immunotherapies for type 1 diabetes. Immunol Cell Biol. 2021;99(5):461–474.
   PubMed Web of Science ®Google Scholar
• Hwa AJ, Weir GC. Transplantation of macroencapsulated insulin-producing cells. Curr Diab Rep. 2018;18(8):50.
   PubMed Web of Science ®Google Scholar
• Sharon N, Chawla R, Mueller J, et al. A peninsular structure coordinates asynchronous differentiation with morphogenesis to generate pancreatic islets. Cell. 2019;176(4):790–804.e13.
   PubMed Web of Science ®Google Scholar
• Lysy PA, Weir GC, Bonner-Weir S. Making β cells from adult cells within the pancreas. Curr Diab Rep. 2013;13(5):695–703.
   PubMed Web of Science ®Google Scholar
• Ramiya VK, Maraist M, Arfors KE, et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med. 2000;6(3):278–282.
   PubMed Web of Science ®Google Scholar
• Xie L, Zeng X, Hu J, et al. Characterization of nestin, a selective marker for bone marrow derived mesenchymal stem cells. Stem Cells Int. 2015;2015:762098.
   PubMed Web of Science ®Google Scholar
• Bernal A, Arranz L. Nestin-expressing progenitor cells: function, identity and therapeutic implications. Cell Mol Life Sci. 2018;75(12):2177–2195.
   PubMed Web of Science ®Google Scholar
• Herrera MB, Bruno S, Buttiglieri S, et al. Isolation and characterization of a stem cell population from adult human liver. Stem Cells. 2006;24(12):2840–2850.
   PubMed Web of Science ®Google Scholar
• Sapir T, Shternhall K, Meivar-Levy I, et al. Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci USA. 2005;102(22):7964–7969.
   PubMed Web of Science ®Google Scholar
• Zalzman M, Anker-Kitai L, Efrat S. Differentiation of human liver-derived, insulin-producing cells toward the β-cell phenotype. Diabetes. 2005;54(9):2568–2575.
   PubMed Web of Science ®Google Scholar
• Meivar-Levy I, Ferber S. Reprogramming of liver cells into insulin-producing cells. Best Pract Res Clin Endocrinol Metab. 2015;29(6):873–882.
   PubMed Web of Science ®Google Scholar
• Cerdá-Esteban N, Naumann H, Ruzittu S, et al. Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2. Nat Commun. 2017;8(1):14127–14113.
   PubMedGoogle Scholar
• Navarro-Tableros V, Gai C, Gomez Y, et al. Islet-like structures generated in vitro from adult human liver stem cells revert hyperglycemia in diabetic SCID mice. Stem Cell Rev Rep. 2019;15(1):93–111.
   PubMed Web of Science ®Google Scholar
• Wang X, Maxwell KG, Wang K, et al. A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes. Sci Transl Med. 2021;13(596):eabb4601.
   Web of Science ®Google Scholar
• Espona-Noguera A, Ciriza J, Cañibano-Hernández A, et al. Review of advanced hydrogel-based cell encapsulation systems for insulin delivery in type 1 diabetes mellitus. Pharmaceutics. 2019;11(11):597.
   PubMed Web of Science ®Google Scholar
• Vaithilingam V, Tuch BE. Islet transplantation and encapsulation: an update on recent developments. Rev Diabet Stud. 2011;8(1):51–67.
   PubMedGoogle Scholar
• Scharp DW, Marchetti P. Encapsulated islets for diabetes therapy: history, current progress, and critical issues requiring solution. Adv Drug Deliv Rev. 2014;67:35–73.
   PubMed Web of Science ®Google Scholar
• Soon-Shiong P, Heintz RE, Merideth N, et al. Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Lancet (London, England). 1994;343(8903):950–951.
   PubMed Web of Science ®Google Scholar
• Dang TT, Thai AV, Cohen J, et al. Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug. Biomaterials. 2013;34(23):5792–5801.
   PubMed Web of Science ®Google Scholar
• Vegas AJ, Veiseh O, Doloff JC, et al. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016;34(3):345–352.
   PubMed Web of Science ®Google Scholar
• Strand BL, Ryan L, Veld P, et al. Poly-l-lysine induces fibrosis on alginate microcapsules via the induction of cytokines. Cell Transplant. 2001;10(3):263–275.
   Web of Science ®Google Scholar
• Farina M, Alexander JF, Thekkedath U, et al. Cell encapsulation: overcoming barriers in cell transplantation in diabetes and beyond. Adv Drug Deliv Rev. 2019;139:92–115.
   PubMed Web of Science ®Google Scholar
• Kleinberger RM, Burke NA, Dalnoki-Veress K, et al. Systematic study of alginate-based microcapsules by micropipette aspiration and confocal fluorescence microscopy. Mater Sci Eng C Mater Biol Appl. 2013;33(7):4295–4304.
   PubMed Web of Science ®Google Scholar
• Song S, Roy S. Progress and challenges in macroencapsulation approaches for type 1 diabetes (T1D) treatment: cells, ­biomaterials, and devices. Biotechnol Bioeng. 2016;113(7):1381–1402.
   PubMed Web of Science ®Google Scholar
• Schweicher J, Nyitray C, Desai TA. Membranes to achieve immunoprotection of transplanted islets. Front Biosci (Landmark Ed). 2014;19(1):49–76.
   PubMedGoogle Scholar
• Kieffer TJ, Woltjen K, Osafune K, et al. Beta-cell replacement strategies for diabetes. J Diabetes Investig. 2018;9(3):457–463.
   Web of Science ®Google Scholar
• Omami M, McGarrigle JJ, Reedy M, et al. Islet microencapsulation: strategies and clinical status in diabetes. Curr Diab Rep. 2017;17(7):47.
   PubMed Web of Science ®Google Scholar
• Weaver JD, Headen DM, Aquart J, et al. Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites. Sci Adv. 2017;3(6):e1700184.
   PubMed Web of Science ®Google Scholar
• Rafael E, Wu G, Hultenby K, et al. Improved survival of macroencapsulated islets of langerhans by preimplantation of the immunoisolating device: a morphometric study. Cell Transplant. 2003;12(4):407–412.
   PubMed Web of Science ®Google Scholar
• Fraker CA, Cechin S, Álvarez-Cubela S, et al. A physiological pattern of oxygenation using perfluorocarbon-based culture devices maximizes pancreatic islet viability and enhances β-cell function. Cell Transplant. 2013;22(9):1723–1733.
   PubMed Web of Science ®Google Scholar
• Le Pape F, Cosnuau-Kemmat L, Richard G, et al. HEMOXCell, a new oxygen carrier usable as an additive for mesenchymal stem cell culture in platelet lysate-supplemented media. Artif Organs. 2017;41(4):359–371.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Brotons A, Bietiger W, Peronet C, et al. Comparison of perfluorodecalin and HEMOXCell as oxygen carriers for islet oxygenation in an in vitro model of encapsulation. Tissue Eng Part A. 2016;22(23–24):1327–1336.
   PubMed Web of Science ®Google Scholar
• Haller C, Piccand J, De Franceschi F, et al. Macroencapsulated human iPSC-derived pancreatic progenitors protect against STZ-induced hyperglycemia in mice. Stem Cell Rep. 2019;12(4):787–800.
   PubMed Web of Science ®Google Scholar
• Kumagai-Braesch M, Jacobson S, Mori H, et al. The TheraCyte™ device protects against islet allograft rejection in immunized hosts. Cell Transplant. 2013;22(7):1137–1146.
   PubMed Web of Science ®Google Scholar
• Robert T, De Mesmaeker I, Stangé GM, et al. Functional beta cell mass from device-encapsulated hESC-derived pancreatic endoderm achieving metabolic control. Stem Cell Rep. 2018;10(3):739–750.
   PubMed Web of Science ®Google Scholar
• Nyitray CE, Chang R, Faleo G, et al. Polycaprolactone thin-film micro-and nanoporous cell-encapsulation devices. ACS Nano. 2015;9(6):5675–5682.
   PubMed Web of Science ®Google Scholar
• Chang R, Faleo G, Russ HA, et al. Nanoporous immunoprotective device for stem-cell-derived β-cell replacement therapy. ACS Nano. 2017;11(8):7747–7757.
   PubMed Web of Science ®Google Scholar
• Pepper AR, Gala-Lopez B, Pawlick R, et al. A prevascularized subcutaneous device-less site for islet and cellular transplantation. Nat Biotechnol. 2015;33(5):518–523.
   PubMed Web of Science ®Google Scholar
• Kozlovskaya V, Zavgorodnya O, Chen Y, et al. Ultrathin polymeric coatings based on hydrogen-bonded polyphenol for protection of pancreatic islet cells. Adv Funct Mater. 2012;22(16):3389–3398.
   PubMed Web of Science ®Google Scholar
• Zhi Z-L, Khan F, Pickup JC. Multilayer nanoencapsulation: a nanomedicine technology for diabetes research and management. Diabetes Res Clin Pract. 2013;100(2):162–169.
   PubMed Web of Science ®Google Scholar
• Krol S, Del Guerra S, Grupillo M, et al. Multilayer nanoencapsulation. New approach for immune protection of human pancreatic islets. Nano Lett. 2006;6(9):1933–1939.
   PubMed Web of Science ®Google Scholar
• Knobeloch T, Abadi SEM, Bruns J, et al. Injectable polyethylene glycol hydrogel for islet encapsulation: an in vitro and in vivo characterization. Biomed Phys Eng Express. 2017;3(3):035022.
   PubMed Web of Science ®Google Scholar
• Sakata N, Sumi S, Yoshimatsu G, et al. Encapsulated islets transplantation: past, present and future. World J Gastrointest Pathophysiol. 2012;3(1):19–26.
   PubMedGoogle Scholar
• Ravnic DJ, Leberfinger AN, Ozbolat IT. Bioprinting and cellular therapies for type 1 diabetes. Trends Biotechnol. 2017;35(11):1025–1034.
   PubMed Web of Science ®Google Scholar
• Desai T, Shea LD. Advances in islet encapsulation technologies. Nat Rev Drug Discov. 2017;16(5):338–350.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Lee JB, Park Y-W, et al. 3D bioprinting for artificial pancreas organ. Biomimetic Medical Materials. 2018;1064:355–374.
   Web of Science ®Google Scholar
• Kim J, Kang K, Drogemuller CJ, et al. Bioprinting an artificial pancreas for type 1 diabetes. Curr Diab Rep. 2019;19(8):1–10.
   PubMed Web of Science ®Google Scholar
• Wang N, Adams G, Buttery L, et al. Alginate encapsulation technology supports embryonic stem cells differentiation into insulin-producing cells. J Biotechnol. 2009;144(4):304–312.
   PubMed Web of Science ®Google Scholar
• Jafarian A, Taghikhani M, Abroun S, et al. Generation of high-yield insulin producing cells from human bone marrow mesenchymal stem cells. Mol Biol Rep. 2014;41(7):4783–4794.
   PubMed Web of Science ®Google Scholar
• Llacua LA, Faas MM, de Vos P. Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets. Diabetologia. 2018;61(6):1261–1272.
   PubMed Web of Science ®Google Scholar
• Ghahremani-Nasab M, Ghanbari E, Jahanbani Y, et al. Premature ovarian failure and tissue engineering. J Cell Physiol. 2020;235(5):4217–4226.
   PubMed Web of Science ®Google Scholar
• Hosseini M, Dadashi-Noshahr K, Islami M, et al. A novel silk/PES hybrid nanofibrous scaffold promotes the in vitro proliferation and differentiation of adipose-derived mesenchymal stem cells into insulin producing cells. Polym Adv Technol. 2020;31(8):1857–1864.
   Web of Science ®Google Scholar
• Amer LD, Mahoney MJ, Bryant SJ. Tissue engineering approaches to cell-based type 1 diabetes therapy. Tissue Eng Part B Rev. 2014;20(5):455–467.
   PubMed Web of Science ®Google Scholar
• Kumar N, Joisher H, Ganguly A. Polymeric scaffolds for pancreatic tissue engineering: a review. Rev Diabet Stud. 2018;14(4):334–353.
   PubMedGoogle Scholar
• Asghari F, Samiei M, Adibkia K, et al. Biodegradable and biocompatible polymers for tissue engineering application: a review. Artif Cells Nanomed Biotechnol. 2017;45(2):185–192.
   PubMed Web of Science ®Google Scholar
• Olabisi RM. Cell microencapsulation with synthetic polymers. J Biomed Mater Res A. 2015;103(2):846–859.
   PubMed Web of Science ®Google Scholar
• Enderami SE, Soleimani M, Mortazavi Y, et al. Generation of insulin-producing cells from human adipose-derived mesenchymal stem cells on PVA scaffold by optimized differentiation protocol. J Cell Physiol. 2018;233(5):4327–4337.
   PubMed Web of Science ®Google Scholar
• Karimi R, Barabadi Z, Larijani B, et al. Comparison of insulin secretion by transduced adipose-derived and endometrial-derived stem cells in 2D and 3D cultures on fibrin scaffold. J Biomed Mater Res Part A. 2020;109(6):1036–1044.
   PubMed Web of Science ®Google Scholar
• Dufour JM, Rajotte RV, Zimmerman M, et al. Development of an ectopic site for islet transplantation, using biodegradable scaffolds. Tissue Eng. 2005;11(9–10):1323–1331.
   PubMedGoogle Scholar
• Wang R, Rosenberg L. Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J Endocrinol. 1999;163(2):181–190.
   PubMed Web of Science ®Google Scholar
• Gibly RF, Zhang X, Graham ML, et al. Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models. Biomaterials. 2011;32(36):9677–9684.
   PubMed Web of Science ®Google Scholar
• Berman DM, O’Neil JJ, Coffey LC, et al. Long-term survival of nonhuman primate islets implanted in an omental pouch on a biodegradable scaffold. Am J Transplant. 2009;9(1):91–104.
   PubMed Web of Science ®Google Scholar
• Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol. 2014;32(8):773–785.
   PubMed Web of Science ®Google Scholar
• Yue Z, Liu X, Coates PT, et al. Advances in printing biomaterials and living cells: implications for islet cell transplantation. Curr Opin Organ Transplant. 2016;21(5):467–475.
   PubMed Web of Science ®Google Scholar
• Schubert C, Van Langeveld MC, Donoso LA. Innovations in 3D printing: a 3D overview from optics to organs. Br J Ophthalmol. 2014;98(2):159–161.
   PubMed Web of Science ®Google Scholar
• Ozbolat IT, Chen H, Yu Y. Development of ‘multi-arm bioprinter’for hybrid biofabrication of tissue engineering constructs. Rob Comput Integr Manuf. 2014;30(3):295–304.
   Web of Science ®Google Scholar
• Kolesky DB, Truby RL, Gladman AS, et al. 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Adv Mater. 2014;26(19):3124–3130.
   PubMed Web of Science ®Google Scholar
• Di Bella C, Duchi S, O’Connell CD, et al. In situ handheld three-dimensional bioprinting for cartilage regeneration. J Tissue Eng Regen Med. 2018;12(3):611–621.
   PubMed Web of Science ®Google Scholar
• Kesti M, Eberhardt C, Pagliccia G, et al. Bioprinting complex cartilaginous structures with clinically compliant biomaterials. Adv Funct Mater. 2015;25(48):7406–7417.
   Web of Science ®Google Scholar
• Derakhshanfar S, Mbeleck R, Xu K, et al. 3D bioprinting for biomedical devices and tissue engineering: a review of recent trends and advances. Bioact Mater. 2018;3(2):144–156.
   PubMed Web of Science ®Google Scholar
• Marchioli G, van Gurp L, Van Krieken P, et al. Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of langerhans transplantation. Biofabrication. 2015;7(2):025009.
   PubMed Web of Science ®Google Scholar
• Duin S, Schütz K, Ahlfeld T, et al. 3D bioprinting of functional islets of langerhans in an alginate/methylcellulose hydrogel blend. Adv Healthcare Mater. 2019;8(7):1801631.
   Web of Science ®Google Scholar
• Penko D, Mohanasundaram D, Sen S, et al. Incorporation of endothelial progenitor cells into mosaic pseudoislets. Islets. 2011;3(3):73–79.
   PubMed Web of Science ®Google Scholar
• Ma M, Chiu A, Sahay G, et al. Core–shell hydrogel microcapsules for improved islets encapsulation. Adv Healthc Mater. 2013;2(5):667–672.
   PubMed Web of Science ®Google Scholar
• Agrawal P, Pramanik K. Enhanced chondrogenic differentiation of human mesenchymal stem cells in silk fibroin/chitosan/glycosaminoglycan scaffolds under dynamic culture condition. Differentiation. 2019;110:36–48.
   PubMed Web of Science ®Google Scholar
• Afflerbach A-K, Kiri MD, Detinis T, et al. Mesenchymal stem cells as a promising cell source for integration in novel in vitro models. Biomolecules. 2020;10(9):1306.
   PubMed Web of Science ®Google Scholar
• Ojaghi M, Soleimanifar F, Kazemi A, et al. Electrospun poly-l-lactic acid/polyvinyl alcohol nanofibers improved insulin-producing cell differentiation potential of human adipose-derived mesenchymal stem cells. J Cell Biochem. 2019;120(6):9917–9926.
   PubMed Web of Science ®Google Scholar
• Hashemi J, Pasalar P, Soleimani M, et al. Decellularized pancreas matrix scaffolds for tissue engineering using ductal or arterial catheterization. Cells Tissues Organs. 2018;205(2):72–84.
   PubMed Web of Science ®Google Scholar