Role of exosomes in tumour growth, chemoresistance and immunity: state-of-the-art

References

• Senapati S, Mahanta AK, Kumar S, et al. Controlled drug delivery vehicles for cancer treatment and their performance. Signal Transduct Target Ther. 2018;3(1):7.
   PubMed Web of Science ®Google Scholar
• Singh AP, Biswas A, Shukla A, et al. Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles. Sig Transduct Target Ther. 2019;4(1):1–21.
   PubMedGoogle Scholar
• Burnouf T, Agrahari V, Agrahari V. Extracellular vesicles as nanomedicine: hopes and hurdles in clinical translation. Int J Nanomed. 2019;14:8847–8859.
   PubMed Web of Science ®Google Scholar
• Bobrie A, Colombo M, Raposo G, et al. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic. 2011;12(12):1659–1668.
   PubMed Web of Science ®Google Scholar
• Raposo G, Nijman HW, Stoorvogel W, et al. B lymphocytes secrete antigen-presenting vesicles. J Exp Med. 1996;183(3):1161–1172.
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Regnault A, Lozier A, et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes. Nat Med. 1998;4(5):594–600.
   PubMed Web of Science ®Google Scholar
• Janowska-Wieczorek A, Majka M, Kijowski J, et al. Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. Blood. 2001;98(10):3143–3149.
   PubMed Web of Science ®Google Scholar
• Dashevsky O, Varon D, Brill A. Platelet-derived microparticles promote invasiveness of prostate cancer cells via upregulation of MMP-2 production. Int J Cancer. 2009;124(8):1773–1777.
   PubMed Web of Science ®Google Scholar
• Maia J, Caja S, Strano Moraes MC, et al. Exosome-based cell-cell communication in the tumor microenvironment. Front Cell Dev Biol. 2018;6:18.
   PubMed Web of Science ®Google Scholar
• Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373–383.
   PubMed Web of Science ®Google Scholar
• Mirzaei H, Sahebkar A, Jaafari MR, et al. Diagnostic and therapeutic potential of exosomes in cancer: the beginning of a new tale? J Cell Physiol. 2017;232(12):3251–3260.
   PubMed Web of Science ®Google Scholar
• Karimzadeh MR, Seyedtaghia MR, Soudyab M, et al. Exosomal long noncoding RNAs: insights into emerging diagnostic and therapeutic applications in lung cancer. J Oncol. 2020;2020:7630197.
   PubMed Web of Science ®Google Scholar
• Nam G, Choi Y, Kim GB, et al. Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy. Adv Mater. 2020;32(51):2002440.
   Web of Science ®Google Scholar
• Elsharkasy OM, Nordin JZ, Hagey DW, et al. Extracellular vesicles as drug delivery systems: why and how? Adv Drug Deliv Rev. 2020;159:332–343.
   PubMed Web of Science ®Google Scholar
• Armstrong J, Stevens M. Strategic design of extracellular vesicle drug delivery systems. Adv Drug Deliv Rev. 2018;130:12–16.
   PubMed Web of Science ®Google Scholar
• Buzas EI, György B, Nagy G, et al. Emerging role of extracellular vesicles in inflammatory diseases. Nat Rev Rheumatol. 2014;10(6):356–364.
   PubMed Web of Science ®Google Scholar
• Seo N, Akiyoshi K, Shiku H. Exosome-mediated regulation of tumor immunology. Cancer Sci. 2018;109(10):2998–3004.
   PubMed Web of Science ®Google Scholar
• Veerman RE, Güçlüler Akpinar G, Eldh M, et al. Immune cell-derived extracellular vesicles-functions and therapeutic applications. Trends Mol Med. 2019;25(5):382–394.
   PubMed Web of Science ®Google Scholar
• He C, Zheng S, Luo Y, et al. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8(1):237–255.
   PubMed Web of Science ®Google Scholar
• Hu Q, Su H, Li J, et al. Clinical applications of exosome membrane proteins. Precis Clin Med. 2020;3(1):54–66.
   PubMedGoogle Scholar
• Tai Y-L, Chen K-C, Hsieh J-T, et al. Exosomes in cancer development and clinical applications. Cancer Sci. 2018;109(8):2364–2374.
   PubMed Web of Science ®Google Scholar
• Xu L, Wu L, Deng F. Exosome: an emerging source of biomarkers for human diseases. Curr Mol Med. 2019;19(6):387–394.
   PubMed Web of Science ®Google Scholar
• Peng H, Ji W, Zhao R, et al. Exosome: a significant nano-scale drug delivery carrier. J Mater Chem B. 2020;8(34):7591–7608.
   PubMed Web of Science ®Google Scholar
• Sawada S-I, Sato YT, Kawasaki R, et al. Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering. Biomater Sci. 2020;8(2):619–630.
   PubMed Web of Science ®Google Scholar
• Yong T, Zhang X, Bie N, et al. Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy. Nat Commun. 2019;10(1):3838.
   PubMed Web of Science ®Google Scholar
• Wang J, Zheng Y, Zhao M. Exosome-based cancer therapy: implication for targeting cancer stem cells. Front Pharmacol. 2016;7:533.
   PubMed Web of Science ®Google Scholar
• Arrighetti N, Corbo C, Evangelopoulos M, et al. Exosome-like nanovectors for drug delivery in cancer. Curr Med Chem. 2019;26(33):6132–6148.
   PubMed Web of Science ®Google Scholar
• Lim W, Kim H-S. Exosomes as therapeutic vehicles for cancer. Tissue Eng Regen Med. 2019;16(3):213–223.
   PubMed Web of Science ®Google Scholar
• Wang H-X, Gires O. Tumor-derived extracellular vesicles in breast cancer: from bench to bedside. Cancer Lett. 2019;460:54–64.
   PubMed Web of Science ®Google Scholar
• Liu C, Su C. Design strategies and application progress of therapeutic exosomes. Theranostics. 2019;9(4):1015–1028.
   PubMed Web of Science ®Google Scholar
• Alenquer M, Amorim MJ. Exosome biogenesis, regulation, and function in viral infection. Viruses. 2015;7(9):5066–5083.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Xie L. Potential role of exosomes in cancer therapy. Prec Radiat Oncol. 2019;3(2): :59–64.
   Google Scholar
• Hwang I. Cell-cell communication via extracellular membrane vesicles and its role in the immune response. Mol Cells. 2013;36(2):105–111.
   PubMed Web of Science ®Google Scholar
• Chan BD, Wong W, Lee MM, et al. Exosomes in inflammation and inflammatory disease. Proteomics. 2019;19(8):1800149.
   PubMed Web of Science ®Google Scholar
• Wang J, Dong Y, Li Y, et al. Designer exosomes for active targeted chemo-photothermal synergistic tumor therapy. Adv Funct Mater. 2018;28(18):1707360.
   Web of Science ®Google Scholar
• Hu JL, Wang W, Lan XL, et al. CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer. Mol Cancer. 2019;18(1):91.
   PubMed Web of Science ®Google Scholar
• Mahmoudi A, Butler AE, Jamialahmadi T, et al. The role of exosomal miRNA in nonalcoholic fatty liver disease. J Cell Physiol. 2022;237(4):2078–2094.
   PubMed Web of Science ®Google Scholar
• Shahabipour F, Barati N, Johnston TP, et al. Exosomes: nanoparticulate tools for RNA interference and drug delivery. J Cell Physiol. 2017;232(7):1660–1668.
   PubMed Web of Science ®Google Scholar
• Samanta S, Rajasingh S, Drosos N, et al. Exosomes: new molecular targets of diseases. Acta Pharmacol Sin. 2018;39(4):501–513.
   PubMed Web of Science ®Google Scholar
• Cheng L, Wu S, Zhang K, et al. A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies. J Ovarian Res. 2017;10(1):73.
   PubMedGoogle Scholar
• Zhang Z, Dombroski JA, King MR. Engineering of exosomes to target cancer metastasis. Cell Mol Bioeng. 2020;13(1):1–16.
   PubMed Web of Science ®Google Scholar
• Keklikoglou I, Cianciaruso C, Güç E, et al. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nat Cell Biol. 2019;21(2):190–202.
   PubMed Web of Science ®Google Scholar
• Oves M, Qari HA, Felemban NM, et al. Exosomes: a paradigm in drug development against cancer and infectious diseases. J Nanomater. 2018;2018:1–17.
   Web of Science ®Google Scholar
• Ahadi A, Brennan S, Kennedy PJ, et al. Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes. Sci Rep. 2016;6:24922.
   PubMed Web of Science ®Google Scholar
• Chiodoni C, Di Martino MT, Zazzeroni F, et al. Cell communication and signaling: how to turn bad language into positive one. J Exp Clin Cancer Res. 2019;38(1):128.
   PubMed Web of Science ®Google Scholar
• Ludwig N, Whiteside TL. Potential roles of tumor-derived exosomes in angiogenesis. Expert Opin Ther Targets. 2018;22(5):409–417.
   PubMed Web of Science ®Google Scholar
• Tavasolian F, Hosseini AZ, Rashidi M, et al. The impact of immune cell-derived exosomes on immune response initiation and immune system function. Curr Pharm Des. 2021;27(2):197–205.
   PubMed Web of Science ®Google Scholar
• Nair S, Tang KD, Kenny L, et al. Salivary exosomes as potential biomarkers in cancer. Oral Oncol. 2018;84:31–40.
   PubMed Web of Science ®Google Scholar
• Milane L, Singh A, Mattheolabakis G, et al. Exosome mediated communication within the tumor microenvironment. J Control Release. 2015;219:278–294.
   PubMed Web of Science ®Google Scholar
• Knox MC, Ni J, Bece A, et al. A clinician’s guide to cancer-derived exosomes: immune interactions and therapeutic implications. Front Immunol. 2020;11:1612.
   PubMed Web of Science ®Google Scholar
• Salimu J, Webber J, Gurney M, et al. Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes. J Extracell Vesicles. 2017;6(1):1368823.
   PubMed Web of Science ®Google Scholar
• Ning Y, Shen K, Wu Q, et al. Tumor exosomes block dendritic cells maturation to decrease the T cell immune response. Immunol Lett. 2018;199:36–43.
   PubMed Web of Science ®Google Scholar
• Kobie JJ, Wu RS, Kurt RA, et al. Transforming growth factor β inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines. Cancer Res. 2003;63(8):1860–1864.
   PubMed Web of Science ®Google Scholar
• Clayton A, Mitchell J, Court J, et al. Human tumor-derived exosomes down-modulate NKG2D expression. J Immunol. 2008;180(11):7249–7258.
   PubMed Web of Science ®Google Scholar
• Saleem SN, Abdel-Mageed AB. Tumor-derived exosomes in oncogenic reprogramming and cancer progression. Cell Mol Life Sci. 2015;72(1):1–10.
   PubMed Web of Science ®Google Scholar
• Berchem G, Noman MZ, Bosseler M, et al. Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer. Oncoimmunology. 2016;5(4):e1062968.
   PubMed Web of Science ®Google Scholar
• Chow A, Zhou W, Liu L, et al. Macrophage immunomodulation by breast cancer-derived exosomes requires toll-like receptor 2-mediated activation of NF-κB. Sci Rep. 2014;4(1):5750.
   PubMedGoogle Scholar
• Bretz NP, Ridinger J, Rupp A-K, et al. Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via toll-like receptor signaling. J Biol Chem. 2013;288(51):36691–36702.
   PubMed Web of Science ®Google Scholar
• Ye L, Zhang Q, Cheng Y, et al. Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion. J Immunother Cancer. 2018;6(1):145.
   PubMedGoogle Scholar
• Capello M, et al. Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity. Nat Commun. 2019;10(1):254.
   PubMed Web of Science ®Google Scholar
• Zhang X, Yuan X, Shi H, et al. Exosomes in cancer: small particle, big player. J Hematol Oncol. 2015;8(1):83.
   PubMedGoogle Scholar
• Yue S, Mu W, Erb U, et al. The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding. Oncotarget. 2015;6(4):2366–2384.
   PubMedGoogle Scholar
• Steinbichler TB, Dudás J, Skvortsov S, et al. Therapy resistance mediated by exosomes. Mol Cancer. 2019;18(1):58.
   PubMed Web of Science ®Google Scholar
• Nakamura R, Ishii H, Endo K, et al. Reciprocal expression of slug and snail in human oral cancer cells. PLoS One. 2018;13(7):e0199442.
   PubMed Web of Science ®Google Scholar
• Bandari SK, Purushothaman A, Ramani VC, et al. Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior. Matrix Biol. 2018;65:104–118.
   PubMed Web of Science ®Google Scholar
• Yu D-D, Wu Y, Zhang X-H, et al. Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222. Tumour Biol. 2016;37(3):3227–3235.
   PubMedGoogle Scholar
• Levchenko A, Mehta BM, Niu X, et al. Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells. Proc Natl Acad Sci U S A. 2005;102(6):1933–1938.
   PubMed Web of Science ®Google Scholar
• Jiang L, Gu Y, Du Y, et al. Exosomes: diagnostic biomarkers and therapeutic delivery vehicles for cancer. Mol Pharm. 2019;16(8):3333–3349.
   PubMedGoogle Scholar
• Chen R, Xu X, Tao Y, et al. Exosomes in hepatocellular carcinoma: a new horizon. Cell Commun Signal. 2019;17(1):1–11.
   PubMedGoogle Scholar
• Zhao W, Liu Y, Zhang C, et al. Multiple roles of exosomal long noncoding RNAs in cancers. Biomed Res Int. 2019;2019:1460572.
   PubMed Web of Science ®Google Scholar
• Wei F, Ma C, Zhou T, et al. Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p. Mol Cancer. 2017;16(1):132.
   PubMedGoogle Scholar
• Guan X-W, Zhao F, Wang J-Y, et al. Tumor microenvironment interruption: a novel anti-cancer mechanism of proton-pump inhibitor in gastric cancer by suppressing the release of microRNA-carrying exosomes. Am J Cancer Res. 2017;7(9):1913–1925.
   PubMed Web of Science ®Google Scholar
• Qu J-L, Qu X-J, Zhao M-F, et al. Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation. Dig Liver Dis. 2009;41(12):875–880.
   PubMedGoogle Scholar
• Fu M, Gu J, Jiang P, et al. Exosomes in gastric cancer: roles, mechanisms, and applications. Mol Cancer. 2019;18(1):41.
   PubMed Web of Science ®Google Scholar
• Yoon JH, Ham I-H, Kim O, et al. Gastrokine 1 protein is a potential theragnostic target for gastric cancer. Gastric Cancer. 2018;21(6):956–967.
   PubMed Web of Science ®Google Scholar
• Mao W, et al. Current status of research on exosomes in general, and for the diagnosis and treatment of kidney cancer in particular. J Exp Clin Cancer Res. 2021;40(1):1–13.
   Google Scholar
• Xia Y, Zhang Q, Zhen Q, et al. Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway. Oncotarget. 2017;8(23):37783–37795.
   PubMedGoogle Scholar
• Wang L, et al. CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p. Mol Cancer. 2019;18(1):1–15.
   Google Scholar
• Hou Y, Fan L, Li H-NA. Oncogenic miR-27a delivered by exosomes binds to SFRP1 and promotes angiogenesis in renal clear cell carcinoma. Mol Ther Nucleic Acids. 2021;24:92–103.
   PubMedGoogle Scholar
• Karami Fath M, et al. Exosome application in tumorigenesis: diagnosis and treatment of melanoma. Med Oncol. 2022;39(2):1–18.
   Google Scholar
• Tucci M, Mannavola F, Passarelli A, et al. Exosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity. Oncotarget. 2018;9(29):20826–20837.
   PubMedGoogle Scholar
• Peinado H, Alecˇković M, Lavotshkin S, et al. Correction: corrigendum: melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2016;22(12):1502–1502.
   PubMed Web of Science ®Google Scholar
• Yoshioka Y, Konishi Y, Kosaka N, et al. Comparative marker analysis of extracellular vesicles in different human cancer types. J Extracell Vesicles. 2013;2(1):20424.
   PubMedGoogle Scholar
• Jang SC, Crescitelli R, Cvjetkovic A, et al. Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma. J Extracell Vesicles. 2019;8(1):1635420.
   PubMed Web of Science ®Google Scholar
• Peinado H, Alečković M, Lavotshkin S, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012;18(6):883–891.
   PubMed Web of Science ®Google Scholar
• Si Y, Kim S, Zhang E, et al. Targeted exosomes for drug delivery: biomanufacturing, surface tagging, and validation. Biotechnol J. 2020;15(1):1900163.
   Web of Science ®Google Scholar
• An T, Qin S, Xu Y, et al. Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis. J Extracell Vesicles. 2015;4(1):27522.
   PubMed Web of Science ®Google Scholar
• Zhao L, Gu C, Gan Y, et al. Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis. J Control Release. 2020;318:1–15.
   PubMed Web of Science ®Google Scholar
• Alvarez-Erviti L, Seow Y, Yin H, et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29(4):341–345.
   PubMed Web of Science ®Google Scholar
• Zhang H, Wang Y, Bai M, et al. Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor siRNA. Cancer Sci. 2018;109(3):629–641.
   PubMed Web of Science ®Google Scholar
• Srivastava A, Amreddy N, Babu A, et al. Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells. Sci Rep. 2016;6:38541.
   PubMed Web of Science ®Google Scholar
• Ohno S-i, Takanashi M, Sudo K, et al. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther. 2013;21(1):185–191.
   PubMed Web of Science ®Google Scholar
• Nie H, Xie X, Zhang D, et al. Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer. Nanoscale. 2020;12(2):877–887.
   PubMed Web of Science ®Google Scholar
• Sun D, Zhuang X, Xiang X, et al. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol Ther. 2010;18(9):1606–1614.
   PubMed Web of Science ®Google Scholar
• Druzhkova T, Yakovlev A. Exosome drug delivery through the blood–brain barrier: experimental approaches and potential applications. Neurochem J. 2018;12(3):195–204.
   Google Scholar
• Gao J, Sun J, Li H, et al. Lyophilized HER2-specific PEGylated immunoliposomes for active siRNA gene silencing. Biomaterials. 2010;31(9):2655–2664.
   PubMed Web of Science ®Google Scholar
• Kenari AN, Cheng L, Hill AF. Methods for loading therapeutics into extracellular vesicles and generating extracellular vesicles mimetic-nanovesicles. Methods. 2020;177:103–113.
   PubMed Web of Science ®Google Scholar
• Tarasov VV, Svistunov AA, Chubarev VN, et al. Extracellular vesicles in cancer nanomedicine. Semin Cancer Biol. 2021;69:212–225.
   PubMed Web of Science ®Google Scholar
• Sato YT, Umezaki K, Sawada S, et al. Engineering hybrid exosomes by membrane fusion with liposomes. Sci Rep. 2016;6:21933.
   PubMed Web of Science ®Google Scholar
• Kim HJ, Kim A, Miyata K, et al. Recent progress in development of siRNA delivery vehicles for cancer therapy. Adv Drug Deliv Rev. 2016;104:61–77.
   PubMed Web of Science ®Google Scholar
• Fuhrmann G, Serio A, Mazo M, et al. Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. J Control Release. 2015;205:35–44.
   PubMed Web of Science ®Google Scholar
• Luan X, Sansanaphongpricha K, Myers I, et al. Engineering exosomes as refined biological nanoplatforms for drug delivery. Acta Pharmacol Sin. 2017;38(6):754–763.
   PubMed Web of Science ®Google Scholar
• Pascucci L, Coccè V, Bonomi A, et al. Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery. J Control Release. 2014;192:262–270.
   PubMed Web of Science ®Google Scholar
• Monopoli MP, Zendrini A, Wu D, et al. Endogenous exosome labelling with an amphiphilic NIR-fluorescent probe. Chem Commun (Camb). 2018;54(52):7219–7222.
   PubMed Web of Science ®Google Scholar
• Tauro BJ, Greening DW, Mathias RA, et al. Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human Colon cancer cell line LIM1863-derived exosomes. Methods. 2012;56(2):293–304.
   PubMed Web of Science ®Google Scholar
• Yoo CE, Kim G, Kim M, et al. A direct extraction method for microRNAs from exosomes captured by immunoaffinity beads. Anal Biochem. 2012;431(2):96–98.
   PubMed Web of Science ®Google Scholar
• Mathivanan S, Lim JWE, Tauro BJ, et al. Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human Colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol Cell Proteomics. 2010;9(2):197–208.
   PubMed Web of Science ®Google Scholar
• Kanwar SS, Dunlay CJ, Simeone DM, et al. Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes. Lab Chip. 2014;14(11):1891–1900.
   PubMed Web of Science ®Google Scholar
• Duskey JT, Rice KG. Nanoparticle ligand presentation for targeting solid tumors. Int J Emerg Med. 2014;15(5):1345–1354.
   Google Scholar
• Maguire CA, Balaj L, Sivaraman S, et al. Microvesicle-associated AAV vector as a novel gene delivery system. Mol Ther. 2012;20(5):960–971.
   PubMed Web of Science ®Google Scholar
• Tian Y, Li S, Song J, et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials. 2014;35(7):2383–2390.
   PubMed Web of Science ®Google Scholar
• Munagala R, Aqil F, Jeyabalan J, et al. Bovine milk-derived exosomes for drug delivery. Cancer Lett. 2016;371(1):48–61.
   PubMed Web of Science ®Google Scholar
• Wang Q-L, Zhuang X, Sriwastva MK, et al. Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways. Theranostics. 2018;8(18):4912–4924.
   PubMed Web of Science ®Google Scholar
• Agrawal AK, Aqil F, Jeyabalan J, et al. Milk-derived exosomes for oral delivery of paclitaxel. Nanomed Nanotechnol Biol Med. 2017;13(5):1627–1636.
   PubMed Web of Science ®Google Scholar
• Lamichhane TN, Raiker RS, Jay SM. Exogenous DNA loading into extracellular vesicles via electroporation is size-dependent and enables limited gene delivery. Mol Pharm. 2015;12(10):3650–3657.
   PubMed Web of Science ®Google Scholar
• Pan Q, Ramakrishnaiah V, Henry S, et al. Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi). Gut. 2012;61(9):1330–1339.
   PubMed Web of Science ®Google Scholar
• Xin H, Li Y, Buller B, et al. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells. 2012;30(7):1556–1564.
   PubMed Web of Science ®Google Scholar
• Hadla M, Palazzolo S, Corona G, et al. Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models. Nanomedicine (Lond). 2016;11(18):2431–2441.
   PubMed Web of Science ®Google Scholar
• Yoshimura A, Sawada K, Nakamura K, et al. Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells. BMC Cancer. 2018;18(1):1–13.
   PubMedGoogle Scholar
• Kim MS, Haney MJ, Zhao Y, et al. Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations. Nanomed Nanotechnol Biol Med. 2018;14(1):195–204.
   PubMed Web of Science ®Google Scholar
• Li S-P, Lin Z-X, Jiang X-Y, et al. Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools. Acta Pharmacol Sin. 2018;39(4):542–551.
   PubMed Web of Science ®Google Scholar
• Parsamanesh N, Moossavi M, Bahrami A, et al. Therapeutic potential of curcumin in diabetic complications. Pharmacol Res. 2018;136:181–193.
   PubMed Web of Science ®Google Scholar
• Jyotirmayee B, Mahalik G. A review on selected pharmacological activities of curcuma longa L. Int J Food Prop. 2022;25(1):1377–1398.
   Web of Science ®Google Scholar
• Panahi Y, Khalili N, Sahebi E, et al. Curcuminoids modify lipid profile in type 2 diabetes mellitus: a randomized controlled trial. Complement Ther Med. 2017;33:1–5.
   PubMed Web of Science ®Google Scholar
• Farhood B, Mortezaee K, Goradel NH, et al. Curcumin as an anti-inflammatory agent: implications to radiotherapy and chemotherapy. J Cell Physiol. 2019;234(5):5728–5740.
   PubMed Web of Science ®Google Scholar
• Shakeri A, Cicero AFG, Panahi Y, et al. Curcumin: a naturally occurring autophagy modulator. J Cell Physiol. 2019;234(5):5643–5654.
   PubMed Web of Science ®Google Scholar
• Heidari Z, Daei M, Boozari M, et al. Curcumin supplementation in pediatric patients: a systematic review of current clinical evidence. Phytother Res. 2022;36(4):1442–1458.
   PubMed Web of Science ®Google Scholar
• Tomeh MA, Hadianamrei R, Zhao X. A review of curcumin and its derivatives as anticancer agents. IJMS. 2019;20(5):1033.
   Google Scholar
• Mohammed ES, El-Beih NM, El-Hussieny EA, et al. Effects of free and nanoparticulate curcumin on chemically induced liver carcinoma in an animal model. Arch Med Sci. 2021;17(1):218–227.
   PubMed Web of Science ®Google Scholar
• Afshari AR, Jalili-Nik M, Abbasinezhad-Moud F, et al. Anti-tumor effects of curcuminoids in glioblastoma multiforme: an updated literature review. Curr Med Chem. 2021;28(39):8116–8138.
   PubMed Web of Science ®Google Scholar
• Mohajeri M, Bianconi V, Ávila-Rodriguez MF, et al. Curcumin: a phytochemical modulator of estrogens and androgens in tumors of the reproductive system. Pharmacol Res. 2020;156:104765.
   PubMed Web of Science ®Google Scholar
• Ha D, Yang N, Nadithe V. Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges. Acta Pharm Sin B. 2016;6(4):287–296.
   PubMed Web of Science ®Google Scholar
• Zhang H-G, Kim H, Liu C, et al. Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. Biochim Biophys Acta. 2007;1773(7):1116–1123.
   PubMed Web of Science ®Google Scholar
• Floriano JF, Willis G, Catapano F, et al. Exosomes could offer new options to combat the Long-Term complications inflicted by gestational diabetes mellitus. Cells. 2020;9(3):675.
   PubMed Web of Science ®Google Scholar
• Center J, Louisville U. Study investigating the ability of plant exosomes to deliver curcumin to normal and colon cancer tissue. 2011. Available from: https://clinicaltrials.gov/ct2/show/NCT01294072.
   Google Scholar
• Bian Y, Wei J, Zhao C, et al. Natural polyphenols targeting senescence: a novel prevention and therapy strategy for cancer. IJMS. 2020;21(2):684.
   Google Scholar
• Takakura Y, Matsumoto A, Takahashi Y. Therapeutic application of small extracellular vesicles (sEVs): pharmaceutical and pharmacokinetic challenges. Biol Pharm Bull. 2020;43(4):576–583.
   PubMed Web of Science ®Google Scholar
• Boyiadzis M, Whiteside T. The emerging roles of tumor-derived exosomes in hematological malignancies. Leukemia. 2017;31(6):1259–1268.
   PubMed Web of Science ®Google Scholar
• Morse MA, Garst J, Osada T, et al. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J Transl Med. 2005;3(1):9.
   PubMed Web of Science ®Google Scholar
• Yu S, Cao H, Shen B, et al. Tumor-derived exosomes in cancer progression and treatment failure. Oncotarget. 2015;6(35):37151–37168.
   PubMedGoogle Scholar
• Kitagawa T, Taniuchi K, Tsuboi M, et al. Circulating pancreatic cancer exosomal RNA s for detection of pancreatic cancer. Mol Oncol. 2019;13(2):212–227.
   PubMed Web of Science ®Google Scholar
• Lin X-J, Fang J-H, Yang X-J, et al. Hepatocellular carcinoma cell-secreted exosomal microRNA-210 promotes angiogenesis in vitro and in vivo. Mol Ther Nucleic Acids. 2018;11:243–252.
   PubMedGoogle Scholar
• Yang Y-N, Zhang R, Du J-W, et al. Predictive role of UCA1-containing exosomes in cetuximab-resistant colorectal cancer. Cancer Cell Int. 2018;18(1):164.
   PubMedGoogle Scholar
• Rodríguez-Martínez A, de Miguel-Pérez D, Ortega FG, et al. Exosomal miRNA profile as complementary tool in the ­diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy. Breast Cancer Res. 2019;21(1):21.
   PubMedGoogle Scholar
• Lin Y, Dong H, Deng W, et al. Evaluation of salivary exosomal chimeric GOLM1-NAA35 RNA as a potential biomarker in esophageal carcinoma. Clin Cancer Res. 2019;25(10):3035–3045.
   PubMed Web of Science ®Google Scholar
• Donoso-Quezada J, Ayala-Mar S, González-Valdez J. State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review. Crit Rev Biotechnol. 2020;40(6):804–820.
   PubMed Web of Science ®Google Scholar
• Emam SE, Ando H, Lila ASA, et al. Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways. Sci Rep. 2018;8(1):1–11.
   PubMedGoogle Scholar
• Tavasolian F, Moghaddam AS, Rohani F, et al. Exosomas: jugadores efectivos en la artritis reumatoide. Autoimmun Rev. 2020;19(6):102511.
   PubMed Web of Science ®Google Scholar
• Zamani P, Fereydouni N, Butler AE, et al. The therapeutic and diagnostic role of exosomes in cardiovascular diseases. Trends Cardiovasc Med. 2019;29(6):313–323.
   PubMed Web of Science ®Google Scholar
• Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol. 2008;110(1):13–21.
   PubMed Web of Science ®Google Scholar
• Jabbari N, Akbariazar E, Feqhhi M, et al. Breast cancer-derived exosomes: tumor progression and therapeutic agents. J Cell Physiol. 2020;235(10):6345–6356.
   PubMed Web of Science ®Google Scholar
• Hannafon BN, Carpenter KJ, Berry WL, et al. Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Mol Cancer. 2015;14(1):1–13.
   PubMedGoogle Scholar
• Li XJ, Ren ZJ, Tang JH, et al. Exosomal MicroRNA MiR-1246 promotes cell proliferation, invasion and drug resistance by targeting CCNG2 in breast cancer. Cell Physiol Biochem. 2017;44(5):1741–1748.
   PubMedGoogle Scholar
• Meng Y, Sun J, Wang X, et al. Exosomes: a promising avenue for the diagnosis of breast cancer. Technol Cancer Res Treat. 2019;18:153303381882142.
   Web of Science ®Google Scholar
• Moon P-G, Lee J-E, Cho Y-E, et al. Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer. Oncotarget. 2016;7(26):40189–40199.
   PubMedGoogle Scholar
• Ab Razak NS, Ab Mutalib NS, Mohtar MA, et al. Impact of chemotherapy on extracellular vesicles: understanding the Chemo-EVs. Front Oncol. 2019;9:1113.
   PubMed Web of Science ®Google Scholar
• Liao Z, Jaular LM, Soueidi E, et al. Acetylcholinesterase is not a generic marker of extracellular vesicles. J Extracell Vesicles. 2019;8(1):1628592.
   PubMed Web of Science ®Google Scholar
• Emam SE, Ando H, Abu Lila AS, et al. Doxorubicin expands in vivo secretion of circulating exosome in mice. Biol Pharm Bull. 2018;41(7):1078–1083.
   PubMed Web of Science ®Google Scholar
• Ludwig S, Floros T, Theodoraki M-N, et al. Suppression of lymphocyte functions by plasma exosomes correlates with disease activity in patients with head and neck cancer. Clinical Cancer Research. 2017;23(16):4843–4854.
   PubMed Web of Science ®Google Scholar
• Bunggulawa EJ, et al. Recent advancements in the use of exosomes as drug delivery systems. J Nanobiotechnol. 2018;16(1):1–13.
   PubMed Web of Science ®Google Scholar
• Panigrahi AR, Srinivas L, Panda J. Exosomes: insights and therapeutic applications in cancer. Transl Oncol. 2022;21:101439.
   PubMed Web of Science ®Google Scholar
• Yang D, Zhang W, Zhang H, et al. Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosome-based theranostics. Theranostics. 2020;10(8):3684–3707.
   PubMed Web of Science ®Google Scholar
• Maroto R, Zhao Y, Jamaluddin M, et al. Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses. J Extracell Vesicles. 2017;6(1):1359478.
   PubMed Web of Science ®Google Scholar
• Sarker S, et al. Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. J Transl Med. 2014;12(1):1–19.
   Google Scholar
• Dvorak HF, Quay SC, Orenstein NS, et al. Tumor shedding and coagulation. Science. 1981;212(4497):923–924.
   PubMed Web of Science ®Google Scholar