MS-818 Accelerates Mobilization of Endothelial Progenitor Cells and Differentiation to Endothelial Cells

REFERENCES

• Asahara T., Masuda H., Takahashi T., Kalka C., Pastore C., Silver M., Kearne M., Magner M., Isner J M. 1999. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circulation Research. 85: 221–228. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Asahara T., Murohara T., Sullivan A., Silver M., van der, Zee R., Li T., Witzenbichler B., Schatteman G., Isner J. M.. 1997. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 275: 964–967. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Asahara T., Takahashi T., Masuda H., Kalka C., Chen D., Iwaguro H., Inai Y., Silver M., Isner J. M.. 1999. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO Journal. 18: 3964–3972. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Awaya A., Kobayashi H., Horikomi K., Tanaka S., Kabir A., Yokoyama K., Ohno H., Kato K., Kitahara T., Tomino I., Isayama S., Nakamura S. 1993. Neurotropic pyrimidine heterocyclic compounds. I. The new synthesized pyrimidine compounds promote neurite outgrowth of GOTO and Neuro 2a neuroblastoma cell lines, and potentiate nerve growth factor (NGF)-induced neurite sprouting of PC 12 cells. Biological Pharmceutical Bulletin. 16: 248–253
   PubMed Web of Science ®Google Scholar
• Baumann C. I., Bailey A. S., Li W., Ferkowicz M. J., Yoder M. C., Fleming W. H.. 2004. PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors. Blood. 104: 1010–1016. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Beck L, Jr., D'Amore P. A.. 1997. Vascular development: Cellular and molecular regulation. FASEB Journal. 11: 365–373. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Bussolino F., Mantovani A., Persico G. 1997. Molecular mechanisms of blood vessel formation. Trends in Biochemical Sciences. 22: 251–256. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Carmeliet P. 2003. Blood vessels and nerves: Common signals, pathways and diseases. Nature Reviews Genetics. 4: 710–720. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Choi K., Kennedy M., Kazarov A., Papadimitriou J. C., Keller G. 1998. A common precursor for hematopoietic and endothelial cells. Development. 125: 725–732. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Dimmeler S., Aicher A., Vasa M., Mildner-Rihm C., Adler K., Tiemann M., Rutten H., Fichtlscherer S., Martin H., Zeiher A. M.. 2001. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. Journal of Clinical Investigation. 108: 391–397. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Endoh M., Ogawa M., Orkin S., Nishikawa S. 2002. SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation. EMBO Journal. 21: 6700–6708. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Folkman J., Shing Y. 1992. Angiogenesis. Journal of Biological Chemistry. 267: 10931–10934. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Fukuyama R., Ohta M., Ohta K., Saiwaki T., Fushiki S., Awaya A. 2000. A synthesized pyrimidine compound, MS-818, promotes walking function recovery from crush injury of the sciatic nerve through its indirect stimulation of Schwann cells. Restorative Neurology and Neuroscience. 17: 9–16. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Gassmann M., Donoho G., Berg P. 1995. Maintenance of an extrachromosomal plasmid vector in mouse embryonic stem cells. Proceedings of National Academy of Science of the United States of America. 92: 1292–1296
   PubMed Web of Science ®Google Scholar
• Heeschen C., Aicher A., Lehmann R., Fichtlscherer S., Vasa M., Urbich C., Mildner-Rihm C., Martin H., Zeiher A. M., Dimmeler S. 2003. Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood. 102: 1340–1346. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Itoh S., Samejima H., Shinomiya K., Awaya A. 1999. The effect of neurotrophic pyrimidine heterocyclic compounds, MS-818 and MS-430, on the regeneration of injured peripheral nerves. Restorative Neurology and Neuroscience. 14: 265–273. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Iwasaka C., Tanaka K., Abe M., Sato Y. 1996. Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells. Journal of Cellular Physiology. 169: 522–531. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Jiang X. M., Ohnishi A., Yamamoto T., Murai Y., Awaya A., Ikeda M. 1995. The effect of MS-818, a pyrimidine compound, on the regeneration of peripheral nerve fibers of mice after a crush injury. Acta Neuropathologica (Berlin). 90: 130–134
   PubMed Web of Science ®Google Scholar
• Kalka C., Masuda H., Takahashi T., Gordon R., Tepper O., Gravereaux E., Pieczek A., Iwaguro H., Hayashi S. I., Isner J. M., Asahara T. 2000. Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects. Circulation Research. 86: 1198–1202. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kim I., Kim H. G., So J. N., Kim J. H., Kwak H. J., Koh G. Y.. 2002. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Circulation Research. 86: 24–29
   Web of Science ®Google Scholar
• Kirchmair R., Gander R., Egger M., Hanley A., Silver M., Ritsch A., Murayama T., Kaneider N., Sturm W., Kearny M., Fischer-Colbrie R., Kircher B., Gaenzer H., Wiedermann C. J., Ropper A. H., Losordo D. W., Patsch J. R., Schratzberger P. 2004. The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo. Circulation. 109: 777–783. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kodama H., Nose M., Niida S., Yamisaki A. 1991. Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by storomal cells. Journal of Experimental Medicine. 173: 1291–1294. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Koyama Y., Awaya A., Ishikawa N., Fujita S., Tomino I., Yokoyama K., Araki S., Takesue M., Kato K., Ishiguro M., Kitahara T., Kihara N., Baba A. 1997. Neurotrophic pyrimidine heterocyclic compounds. II. Effect of novel neurotrophic pyrimidine derivatives on astrocytic morphological differentiation. Biological Pharmceutical Bulletin. 20: 138–141
   PubMed Web of Science ®Google Scholar
• Kureishi Y., Luo Z., Shiojima I., Bialik A., Fulton D., Lefer D. J., Sessa W. C., Walsh K. 2000. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nature Medicine. 6: 1004–1010. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Llevadot J., Murasawa S., Kureishi Y., Uchida S., Masuda H., Kawamoto A., Walsh K., Isner J. M., Asahara T. 2001. HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells. Journal of Clinical Investigation. 108: 399–405. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Majka S. M., Jackson K. A., Kienstra K. A., Majesky M. W., Goodell M. A., Hirschi K. K.. 2003. Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. Journal of Clinical Investigation. 111: 71–79. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Matsumoto K., Haraguchi S., Miyoshi K., Awaya A., Sato E. 1997. Enhanced of number of ovulations by administration of a pyrimidine compound MS-818 with potentiating activity of angiogenesis in mice superovulated by PMSG and hCG. Journal of Reproduction and Development. 43: 137–141. [CROSSREF]
   Google Scholar
• Mitsuyama T., Kawamata T., Yamane F., Awaya A., Hori T. 2002. Role of a synthetic pyrimidine compound, MS-818, in reduction of infarct size and amelioration of sensorimotor dysfunction following permanent focal cerebral ischemia in rats. Journal of Neurosurgery. 96: 1072–1076. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Moore M. A., Hattori K., Heissig B., Shieh J. H., Dias S., Crystal R. G., Rafii S. 2001. Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF, and angiopoietin-1. Annals of the New York Academy of Science. 938: 36–45
   PubMed Web of Science ®Google Scholar
• Morales-Ruiz M., Fulton D., Sowa G., Languino L. R., Fujio Y., Walsh K., Sessa W. C.. 2000. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circulation Research. 86: 892–896. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Morales-Ruiz M., Lee M. J., Zollner S., Gratton J. P., Scotland R., Shiojima I., Walsh K., Hla T., Sessa W. C.. 2001. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. Journal of Biological Chemistry. 276: 19672–19677. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Nakagawa T., Abe M., Yamazaki T., Miyashita H., Niwa H., Kokubun S., Sato Y. 2003. HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro. Arteriosclerosis Thrombosis and Vascular Biology. 23: 231–237. [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Nieda M., Nicol A., Denning-Kendall P., Sweetenham J., Bradley B., Hows J. 1997. Endothelial cell precursors are normal components of human umbilical cord blood. British Journal of Haematology. 98: 775–777. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Nishikawa S.-I., Nishikawa S., Hirashima M., Matsuyoshi N., Kodama H. 1998. Progressive lineage analysis by cell sorting and culture identifies FLK1‘VE-cadherin’ cells at a diverging point of endothelial and hematopoietic lineages. Development. 125: 1747–1757. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Papapetropoulos A., Fulton D., Mahboubi K., Kalb R. G., O'Connor D. S., Li F., Altieri D. C., Sessa W. C.. 2000. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. Journal of Biological Chemistry. 275: 9102–9105. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Peichev M., Naiyer A. J., Pereira D., Zhu Z., Lane W. J., Williams M., Oz M. C., Hicklin D. J., Witte L., Moore M. A., Rafii S. 2000. Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood. 95: 952–958. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Quirici N., Soligo D., Caneva L., Servida F., Bossolasco P., Deliliers G. L.. 2001. Differentiation and expansion of endothelial cells from human bone marrow CD133(+) cells. British Journal of Haematology. 115: 186–194. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Reddy K. B., Nabha S. M., Atanaskova N. 2003. Role of MAP kinase in tumor progression and invasion. Cancer and Metastasis Reviews. 22: 395–403. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Reyes M., Dudek A., Jahagirdar B., Koodie L., Marker P. H., Verfaillie C. M.. 2002. Origin of endothelial progenitors in human postnatal bone marrow. Journal of Clinical Investigation. 109: 337–346. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Risau W., Flamme I. 1995. Vasculogenesis. Annual Review of Cell and Developmental Biology. 11: 73–91. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Risau W. 1995. Differentiation of endothelium. FASEB Journal. 9: 926–933. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Risau W. 1997. Mechanisms of angiogenesis. Nature. 386: 671–674. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Salven P., Mustjoki S., Alitalo R., Alitalo K., Rafii S. 2003. VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. Blood. 101: 168–172. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Sanjo N., Owada K., Kobayashi T., Mizusawa H., Awaya A., Michikawa M. 1998. A novel neurotrophic pyrimidine compound MS-818 enhances neurotrophic effects of basic fibroblast growth factor. Journal of Neuroscience Research. 54: 604–612. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sato Y., Rifkin D. B.. 1988. Autocrine activities of basic fibroblast growth factor: Regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. Journal of Cell Biology. 107: 1199–205. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sato Y., Okamura K., Morimoto A., Hamanaka R., Hamaguchi K., Shimada T., Ono M., Kohno K., Sakata T., Kuwano M. 1993. Indispensable role of tissue-type plasminogen activator in growth factor-dependent tube formation of human microvascular endothelial cells in vitro. Experimental Cell Research. 204: 223–229. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Shiojima I., Walsh K. 2002. Role of Akt signaling in vascular homeostasis and angiogenesis. Circulation Research. 90: 1243–1250. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sugiyama N., Yoshimura A., Fujitsuka C., Iwata H., Awaya A., Mori S., Yoshizato H., Fujitsuka N. 2002. Acceleration by MS-818 of early muscle regeneration and enhanced muscle recovery after surgical transection. Muscle and Nerve. 25: 218–229. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Takahashi T., Kalka C., Masuda H., Chen D., Silver M., Kearney M., Magner M., Isner J. M., Asahara T. 1999. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nature Medicine. 5: 434–438. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Torigoe K., Awaya A. 1998. A newly synthesized neurotropic pyrimidine compound, MS-818, may activate migratory schwann cells in peripheral nerve regeneration. Brain Research. 787: 337–340. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Vasa M., Fichtlscherer S., Adler K., Aicher A., Martin H., Zeiher A. M., Dimmeler S. 2001. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation. 103: 2885–2890. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Vittet D., Prandini M. H., Berthier R., Schweitzer A., Martin-Sisteron H., Uzan G., Dejana E. 1996. Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps. Blood. 88: 3424–3431. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Walter D. H., Rittig K., Bahlmann F. H., Kirchmair R., Silver M., Murayama T., Nishimura H., Losordo D. W., Asahara T., Isner J. M.. 2002. Statin therapy accelerates reendothelialization: A novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation. 105: 3017–3024. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wang Y., Sheibani N. 2002. Expression pattern of alternatively spliced PECAM-1 isoforms in hematopoietic cells and platelets. Journal of Cellular Biochemistry. 87: 424–438. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Watanabe S., Wang X. E., Hirose M., Osada T., Yoshizawa T., Tanaka H., Itatsu T., Nakajima M., Yamamoto J., Miwa H., Miyazaki A., Awaya A., Sato N. 1998. A neurotrophic pyrimidine compound, MS-818, enhances EGF-induced restoration of gastric epithelial wounds in vitro. Journal of Clinical Gastroenterology. 27: S105–S109. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yamaguchi T. P., Dumont D. J., Conlon R. A., Breitman M. L., Rossant J. 1993. Flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development. 118: 489–498. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Yasuhara S., Kashiwagi S., Ito H., Awaya A. 1995. The neurotrophic pyrimidine heterocyclic compound MS-818 promotes the angiogenesis induced by basic FGF. International Journal of Clinical Pharmacology Research. 15: 167–174. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Yoshikawa M., Saura R., Mizuno K., Awaya A. 2000. The effect of MS-818, newly synthesized pyrimidine compound, on fracture repair. Kobe Journal of Medical Science. 46: 265–282
   PubMedGoogle Scholar