Prolonged Local Forearm Hyperinsulinemia Induces Sustained Enhancement of Nitric Oxide–Dependent Vasodilation in Healthy Subjects

REFERENCES

• Anderson E. A., Hoffman R. P., Balon T. W., Sinkey C. A., Mark A. L.. 1991. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. Journal of Clinical Investigation. 87: 2246–2252. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Arcaro G., Cretti A., Balzano S., Lechi A., Muggeo M., Bonora E., Bonadonna R. C.. 2002. Insulin causes endothelial dysfunction in humans: Sites and mechanisms. Circulation. 105: 576–582. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Baron A. D., Steinberg H. O., Chaker H., Leaming R., Johnson A., Brechtel G. 1995. Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. Journal of Clinical Investigation. 96: 786–792. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Beckman J. A., Creager M. A., Libby P. 2002. Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management. Journal of the American Medical Association. 287: 2570–2581. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bruning T. A., Chang P. C., Blauw G. J., Vermeij P., van, Zwieten P. A.. 1993. Serotonin-induced vasodilatation in the human forearm is mediated by the “nitric oxide-pathway”: No evidence for involvement of the 5-HT3-receptor. Journal of Cardiovascular Pharmacology. 22: 44–51. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Campia U., Sullivan G., Bryant M. B., Waclawiw M. A., Quon M. J., Panza J. A.. 2003. Insulin impairs endothelium-dependent vasodilation independent of insulin sensitivity or lipid profile. American Journal of Physiology Heart and Circulatory Physiology. 286: H76–82. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Cardillo C., Campia U., Bryant M. B., Panza J. A.. 2002. Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation. 106: 1783–1787. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Cardillo C., Kilcoyne C. M., Nambi S. S., Cannon R. O., III, Quon M. J., Panza J. A.. 1998. Vasodilator response to systemic but not to local hyperinsulinemia in the human forearm. Hypertension. 32: 740–745. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Cardillo C., Nambi S. S., Kilcoyne C. M., Choucair W. K., Katz A., Quon M. J., Panza J. A.. 1999. Insulin stimulates both endothelin and nitric oxide activity in the human forearm. Circulation. 100: 820–825. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Cleland S. J., Petrie J. R., Ueda S., Elliott H. L., Connell J. M.. 1999. Insulin-mediated vasodilation and glucose uptake are functionally linked in humans. Hypertension. 33: 554–558. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Dawson D., Vincent M. A., Barrett E. J., Kaul S., Clark A., Leong-Poi H., Lindner J. R.. 2002. Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound. American Journal of Physiology-Endocrinology and Metabolism. 282: E714–E720. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Dela F., Larsen J. J., Mikines K. J., Galbo H. 1995. Normal effect of insulin to stimulate leg blood flow in NIDDM. Diabetes. 44: 221–226. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Eskurza I., Seals D. R., DeSouza C. A., Tanaka H. 2001. Pharmacologic versus flow-mediated assessments of peripheral vascular endothelial vasodilatory function in humans. American Journal of Cardiology. 88: 1067–1069. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ferri C., Carlomagno A., Coassin S., Baldoncini R., Cassone Faldetta M. R., Laurenti O., Properzi G., Santucci A., De, Mattia G. 1995. Circulating endothelin-1 levels increase during euglycemic hyperinsulinemic clamp in lean NIDDM men. Diabetes Care. 18: 226–233. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Gaede P., Vedel P., Larsen N., Jensen G. V., Parving H. H., Pedersen O. 2003. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. New England Journal of Medicine. 348: 383–393. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hausberg M., Hoffman R. P., Somers V. K., Sinkey C. A., Mark A. L., Anderson E. A.. 1997. Contrasting autonomic and hemodynamic effects of insulin in healthy elderly versus young subjects. Hypertension. 29: 700–705. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hermann T. S., Rask-Madsen C., Ihlemann N., Dominguez H., Jensen C. B., Storgaard H., Vaag A. A., Kober L., Torp-Pedersen C. 2003. Normal insulin-stimulated endothelial function and impaired insulin-stimulated muscle glucose uptake in young adults with low birth weight. Journal of Clinical Endocrinology and Metabolism. 88: 1252–1257. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hijmering M. L., Stroes E. S., Olijhoek J., Hutten B. A., Blankestijn P. J., Rabelink T. J.. 2002. Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. Journal of the American College of Cardiology. 39: 683–688. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ihlemann N., Rask-Madsen C., Kober L., Torp-Pedersen C. 2004. Vascular insulin response is preserved in non-diabetic patients with coronary artery disease, despite endothelial dysfunction. Scandinavian Cardiovascular Journal. 38: 22–27. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Laakso M., Edelman S. V., Brechtel G., Baron A. D.. 1990. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. Journal of Clinical Investigation. 85: 1844–1852. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Laakso M., Edelman S. V., Brechtel G., Baron A. D.. 1992. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes. 41: 1076–1083. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Lembo G., Iaccarino G., Vecchione C., Barbato E., Izzo R., Fontana D., Trimarco B. 1997. Insulin modulation of an endothelial nitric oxide component present in the alpha2- and beta-adrenergic responses in human forearm. Journal of Clinical Investigation. 100: 2007–2014. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Lind L., Eriksson M. 2003. Influence of nervous blockade on insulin-mediated glucose uptake in the human forearm. Metabolism. 52: 413–417. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Malmberg K., McGuire D. K.. 1999. Diabetes and acute myocardial infarction: The role of insulin therapy. American Heart Journal. 138: S381–S386. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Natali A., Buzzigoli G., Taddei S., Santoro D., Cerri M., Pedrinelli R., Ferrannini E. 1990. Effects of insulin on hemodynamics and metabolism in human forearm. Diabetes. 39: 490–500. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Pyorala K., Uusitupa M., Laakso M., Siitonen O., Niskanen L., Ronnemaa T. 1987. Macrovascular complications in relation to hyperinsulinaemia in non-insulin-dependent diabetes mellitus. Diabete & Metabolisme. 13: 345–349
   PubMed Web of Science ®Google Scholar
• Rask-Madsen C., Dominguez H., Ihlemann N., Hermann T., Kober L., Torp-Pedersen C. 2003. Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation. 108: 1815–1821. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rask-Madsen C., Ihlemann N., Krarup T., Christiansen E., Kober L., Nervil Kistorp C., Torp-Pedersen C. 2001. Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease. Diabetes. 50: 2611–2618. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Steil G. M., Ader M., Moore D. M., Rebrin K., Bergman R. N.. 1996. Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process. Journal of Clinical Investigation. 97: 1497–1503. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Steinberg H. O., Brechtel G., Johnson A., Fineberg N., Baron A. D.. 1994. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. Journal of Clinical Investigation. 94: 1172–1179. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Steinberg H. O., Paradisi G., Hook G., Crowder K., Cronin J., Baron A. D.. 2000. Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production. Diabetes. 49: 1231–1238. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Steinberg H. O., Tarshoby M., Monestel R., Hook G., Cronin J., Johnson A., Bayazeed B., Baron A. D.. 1997. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. Journal of Clinical Investigation. 100: 1230–1239. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Stratton I. M., Adler A. I., Neil H. A., Matthews D. R., Manley S. E., Cull C. A., Hadden D., Turner R. C., Holman R. R.. 2000. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. British Medical Journal. 321: 405–412. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Stroes E. S., Koomans H. A. de B.T., Rabelink T. J.. 1995. Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet. 346: 467–471. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tack C. J., Heeremans M., Thien T., Lutterman J. A., Smits P. 1996a. Regional hyperinsulinemia induces vasodilation but does not modulate adrenergic responsiveness in humans. Journal of Cardiovascular Pharmacology. 28: 245–251. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tack C. J., Schefman A. E., Willems J. L., Thien T., Lutterman J. A., Smits P. 1996b. Direct vasodilator effects of physiological hyperinsulinaemia in human skeletal muscle. European Journal of Clinical Investigation. 26: 772–778. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tack C. J., Smits P., Willemsen J. J., Lenders J. W., Thien T., Lutterman J. A.. 1996c. Effects of insulin on vascular tone and sympathetic nervous system in NIDDM. Diabetes. 45: 15–22. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Taddei S., Virdis A., Mattei P., Natali A., Ferrannini E., Salvetti A. 1995. Effect of insulin on acetylcholine-induced vasodilation in normotensive subjects and patients with essential hypertension. Circulation. 92: 2911–2918. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Ueda S., Petrie J. R., Cleland S. J., Elliott H. L., Connell J. M.. 1998. The vasodilating effect of insulin is dependent on local glucose uptake: A double blind, placebo-controlled study. Journal of Clinical Endocrinololy and Metabolism. 83: 2126–2131. [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Utriainen T., Malmstrom R., Makimattila S., Yki-Jarvinen H. 1995. Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects. Diabetologia. 38: 555–564. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Vehkavaara S., Makimattila S., Schlenzka A., Vakkilainen J., Westerbacka J., Yki-Jarvinen H. 2000. Insulin therapy improves endothelial function in type 2 diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 545–550. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Vehkavaara S., Yki-Jarvinen H. 2004. 3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 325–330. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Vincent M. A., Dawson D., Clark A. D., Lindner J. R., Rattigan S., Clark M. G., Barrett E. J.. 2002. Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow. Diabetes. 51: 42–48. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Vollenweider P., Randin D., Tappy L., Jequier E., Nicod P., Scherrer U. 1994. Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans. Journal of Clinical Investigation. 93: 2365–2371. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Vollenweider P., Tappy L., Randin D., Schneiter P., Jequier E., Nicod P., Scherrer U. 1993. Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans. Journal of Clinical Investigation. 92: 147–154. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Westerbacka J., Bergholm R., Tiikkainen M., Yki-Jarvinen H. 2004. Glargine and regular human insulin similarly acutely enhance endothelium-dependent vasodilatation in normal subjects. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 320–324. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yki-Jarvinen H., Utriainen T. 1998. Insulin-induced vasodilatation: Physiology or pharmacology?. Diabetologia. 41: 369–379. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zierler K. L.. 1961. Theory of the use of arteriovenous concentration differences for measuring metabolism in steady and non-steady states. Journal of Clinical Investigation. 40: 2111–2125
   PubMed Web of Science ®Google Scholar