Cigarette Smoke-Induced Alterations in Endothelial Nitric Oxide Synthase Phosphorylation: Role of Protein Kinase C

REFERENCES

• Bae S. W., Kim H. S., Cha Y. N., Park Y. S., Jo S. A., Jo I. Rapid increase in endothelial nitric oxide production by bradykinin is mediated by protein kinase A signaling pathway. Biochemical and Biophysical Research Communications 2003; 306: 981–987
   PubMed Web of Science ®Google Scholar
• Barua R. S., Ambrose J. A., Eales-Reynolds L. J., De Voe M. C., Zervas J. G., Saha D. C. Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilation. Circulation 2001; 104: 1905–1910
   PubMed Web of Science ®Google Scholar
• Barua R. S., Ambrose J. A., Srivastava S., De Voe M. C., Eales-Reynolds L. J. Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase. An in vitro demonstration in human coronary artery endothelial cells. Circulation 2003; 107: 2342–2347
   PubMed Web of Science ®Google Scholar
• Baylis C. Arginine, arginine analogs and nitric oxide production in chronic kidney disease. Nature Clinical Practice. Nephrology 2006; 2: 209–220
   PubMedGoogle Scholar
• Beckman J. A., Goldfine A. B., Gordon M. B., Garett L. A., Craeger M. A. Inhibition of protein kinase Cβ prevents impaired endothelium-dependent vasodilation caused by hyperglycaemia in humans. Circulation Research 2002; 90: 107–111
   PubMed Web of Science ®Google Scholar
• Boo Y. C., Soerscu G., Boyd N., Shiojimas I., Walsh K., Du J., Jo H. Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms. Role of protein kinase A. The Journal of Biological Chemistry 2002; 277: 3388–3396
   PubMed Web of Science ®Google Scholar
• Carnevali S., Petruzelli S., Longoni B., Vanacore R., Barale R., Cipollini M., Scatena F., Paggiaro P., Celi A., Giuntini C. Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. American Journal of Physiology. Lung Cellular and Molecular Physiology 2003; 284: L955–L963
   PubMed Web of Science ®Google Scholar
• Celermajer D. S., Sorensen K. E., Georgakopoulos D., Bull C., Thomas O., Robinson J., Deanfield J. E. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 1993; 88: 2149–2155
   PubMed Web of Science ®Google Scholar
• Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., Zeiher A. M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601–605
   PubMed Web of Science ®Google Scholar
• Dimmeler S., Zeiher A. M. Exercise and cardiovascular health: Get active to “AKTivate” your endothelial nitric oxide synthase. Circulation 2003; 107: 3118–3120
   PubMed Web of Science ®Google Scholar
• Feletou M., Vanhoutte P. M. Endothelial dysfunction: A multifaceted disorder (The Wiggers Award Lecture). American Journal of Physiology. Heart and Circulatory Physiology 2006; 291: H985–H1002
   PubMed Web of Science ®Google Scholar
• Fleming I., Fisslthaler B., Dimmeler S., Kemp B. E., Busse R. Phosphorylation of Thr495 regulates Ca2 +/calmodulin-dependent endothelial nitric oxide synthase activity. Circulation Research 2001; 88: 68–75
   PubMed Web of Science ®Google Scholar
• Fulton D., Gratton J. P., McCabe T. J., Fontana J., Fujio Y., Walsh K., Franke T. F., Papapetropoulos A., Sessa W. C. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999; 399: 597–601
   PubMed Web of Science ®Google Scholar
• Harris M. B., Ju H., Venema V. J., Liang H., Zou R., Michell B. J., Chen Z. P., Kemp B. E., Venema R. C. Reciprocal phosphorylation and regulation of endothelial nitric oxide synthase in response to bradykinin stimulation. The Journal of Biological Chemistry 2001; 276: 16587–16591
   PubMed Web of Science ®Google Scholar
• Hirata K., Kuroda R., Sakoda T., Katayama M., Inoue N., Suematsu M., Kawashima S., Yokoyama M. Inhibition of endothelial nitric-oxide synthase activity by protein kinase C. Hypertension 1995; 25: 180–185
   PubMed Web of Science ®Google Scholar
• Ijzerman R. G., Serne E. H., van Weissenbruch M. M., de Jongh R. T., Stehouwer C. D. Cigerette smoking is associated with an acute impairment of microvascular function in humans. Clinical Science 2003; 104: 247–252
   PubMed Web of Science ®Google Scholar
• Kuboki K., Jiang Z. Y., Takahara N., Ha S. W., Igarashi M., Yamauchi T., Feener E. P., Herbert T. P., Rhodes C. J., King G. L. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo. A specific vascular action of insulin. Circulation 2000; 101: 676–681
   PubMed Web of Science ®Google Scholar
• Kugiyama K., Yasue H., Ohgushi M., Motoyama T., Kawano H., Inobe Y., Hirashima O., Sugiyama S. Deficiency in nitric oxide bioactivity in epicardial coronary arteries of cigarette smokers. Journal of the American College of Cardiology 1998; 31: 811–815
   PubMedGoogle Scholar
• Lawlor M. A., Alessi D. R. PKB/Akt: a key mediator of cell cell proliferation, survival and insulin responses?. Journal of Cell Science 2001; 114: 2903–2910
   PubMed Web of Science ®Google Scholar
• Li H., Förstermann U. Nitric oxide in the pathogenesis of vascular disease. The Journal of Pathology 2000; 190: 244–254
   PubMed Web of Science ®Google Scholar
• Lusher T. F., Noll G. Endothelial function as an end-point in interventional trials: concepts, methods and current data. Journal of Hypertension 1996; 14: S111–S119
   Google Scholar
• Matsubara M., Hayashi N., Jing T., Titani K. Regulation of endothelial nitric oxide synthase by protein kinase C. Journal of Biochemistry 2003; 133: 773–781
   PubMed Web of Science ®Google Scholar
• Mayhan W. G., Sharpe G. M. Effect of cigarette smoke extract on arteriolar dilatation in vivo. Journal of Applied Physiology 1997; 272: H2337–H2342
   Google Scholar
• Mazak I., Wittmann I., Wagner L., Wagner Z., Degrell P., Vas T., Molnar G. A., Nagy J. Cigarette smoke and its formaldehyde component inhibit bradykinin-induced calcium increase in pig aortic endothelial cells. Endothelium 2002; 9: 103–108
   PubMed Web of Science ®Google Scholar
• Mellor H., Parker P. J. The extended protein kinase C superfamily. The Biochemical Journal 1998; 332: 281–291
   PubMed Web of Science ®Google Scholar
• Michaud S. É., Dussault S., Groleau J., Haddad P., Rivard A. Cigarette smoke impairs VEGF-induced endothelial cell migration: Role of NO and reactive oxygen species. Journal of Molecular and Cellular Cardiology 2006; 41: 275–284
   PubMed Web of Science ®Google Scholar
• Michell B. J., Chen Z., Tiganis T., Stapleton D., Katsis F., Power D. A., Sim A. T., Kemp B. E. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. The Journal of Biological Chemistry 2001; 276: 17625–17628
   PubMed Web of Science ®Google Scholar
• Michell B. J., Griffiths J. E., Mitchelhill K. I., Rodriguez-Crespo I., Tiganis T., Bozinovski S., Ortiz de Montellano P. R., Kemp B. E., Pearson R. B. The Akt kinase signals directly to endothelial nitric oxide synthase. Current Biology 1999; 9: 845–848
   PubMed Web of Science ®Google Scholar
• Montagnani M., Chen H., Barr V. A., Quon M. J. Insulin-stimulated activaion of eNOS is independent of Ca2 + but requires phospyorylation by Akt at Ser1179. The Journal of Biological Chemistry 2001; 276: 30392–30398
   PubMed Web of Science ®Google Scholar
• Munzel T., Daiber A., Ullrich V., Mulsch A. Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl cyclase and the cGMP-dependent protein kinase. Arteriosclerosis, Thrombosis, and Vascular Biology 2005; 25: 1551–1557
   PubMed Web of Science ®Google Scholar
• Nagy J., Demaster E. G., Wittmann I., Shultz P., Raij L. Induction of endothelial cell injury by cigarette smoke. Endothelium 1997; 5: 251–263
   PubMed Web of Science ®Google Scholar
• Naruse K., Rask-Madsen C., Takahara N., Ha S. W., Suzuma K., Way K. J., Jacobs J. R.C., Clermont A. C., Ueki K., Ohshiro Y., Zhang J., Goldfine A. B., King G. L. Activation of vascular protein kinase C-β inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes 2006; 55: 691–698
   PubMed Web of Science ®Google Scholar
• Ndiaye M., Chataigneau M., Lobysheva I., Chataigneau T., Schini-Kerth V. B. Red wine polyphenols-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. The FASEB Journal 2004; 19: 455–467
   PubMedGoogle Scholar
• Ota Y., Kugiyama K., Sugiyama S., Ohgushi M., Matsumara T., Doi H., Ogata N., Oka H., Yasue H. Impairment of endothelium-dependent relaxation of rabbit aortas by cigarette smoke extract—Role of free radicals and attenuation by captopril. Atherosclerosis 1997; 131: 195–202
   PubMed Web of Science ®Google Scholar
• Ravi K., Brennan L. A., Snezena L., Ross P. A., Black S. M. S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity. Proceedings of the National Academy of Sciences of the United States of America 2004; 101: 2619–2624
   PubMed Web of Science ®Google Scholar
• Rodríguez-Crespo I., Gerber N. C., Ortiz de Montenello P. R. Endothelial nitric-oxide synthase. Expression in Escheria coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation. The Journal of Biological Chemistry 1996; 271: 11462–11467
   PubMed Web of Science ®Google Scholar
• Smith C. J., Fischer T. H. Particulate and vapour phase constituents of cigarette mainstream smoke and risk of myocardial infarction. Atherosclerosis 2001; 158: 257–267
   PubMed Web of Science ®Google Scholar
• Su Y., Han W., Giraldo C., De Li Y., Block E. R. Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells. American Journal of Respiratory Cell and Molecular Biology 1998; 19: 819–825
   PubMed Web of Science ®Google Scholar
• Thomas S. R., Chen K., Keaney J. F. Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. The Journal of Biological Chemistry 2002; 277: 6017–6024
   PubMed Web of Science ®Google Scholar
• Venema R. C., Ju H., Zou R., Ryan J. W., Venema V. J. Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms. The Journal of Biological Chemistry 1997; 272: 1276–1282
   PubMed Web of Science ®Google Scholar
• Wagner L., Wittmann I., Kátai J., Melegh B., Nagy J. Does cigarette smoke affect the protein components of endothelial cells?. Nephrology, Dialysis, Transplantation 1999; 14: A10
   Google Scholar
• Xu J., Xie Z., Reece R., Pimental D., Zou M. H. Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid. Role of NAD(P)H oxidase-derived superoxide and peroxynitrite. Arteriosclerosis, Thrombosis, and Vascular Biology 2006; 26: 2688–2695
   PubMed Web of Science ®Google Scholar
• Zhang W. Z., Venardos K., Chin-Dusting J., Kaye D. M. Adverse effects of cigarette smoke on NO bioavailability. Role of arginine metabolism and oxidative stress. Hypertension 2006; 48: 278–285
   PubMed Web of Science ®Google Scholar
• Zou M. H., Hou X. Y., Shi C. M., Nagata D., Walsh K., Cohen R. A. Modulation by peroxynitrite of Akt- and AMPK-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. The Journal of Biological Chemistry 2002; 277: 32552–32557
   PubMed Web of Science ®Google Scholar