Antiapoptotic Activities of Bcl-2 Correlate with Vascular Maturation and Transcriptional Modulation of Human Endothelial Cells

REFERENCES

• Affara M., Dunmore B. J., Savoie S., Imoto S., Tamada Y., Araki H., Charnock-Jones D. S., Miyano S., Print C. G. Understanding endothelial cell apoptosis: What can the transcriptome, glycome and proteome reveal?. Philosophical Transactions of the Royal Society B 2007; 362: 1469–1487
   PubMed Web of Science ®Google Scholar
• Baldi P., Long A. D. A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes. Bioinformatics 2001; 17: 509–519
   PubMed Web of Science ®Google Scholar
• Beissbarth T., Speed T. P. GOstat: Find statistically overrepresented gene ontologies within a group of genes. Bioinformatics 2004; 20: 1464–1465
   PubMed Web of Science ®Google Scholar
• Bellas R. E., Lee J. S., Sonenshein G. E. Expression of a constitutive NF-kappa B-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells. Journal of Clinical Investigation 1995; 96: 2521–2527
   PubMed Web of Science ®Google Scholar
• Bostrom K., Tsao D., Shen S., Wang Y., Demer L. L. Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells. Journal of Biological Chemistry 2001; 276: 14044–14052
   PubMed Web of Science ®Google Scholar
• Cheng E. H.-Y., Kirsch D. G., Clem R. J., Ravi R., Kastan M. B., Bedi A., Ueno K., Hardwick J. M. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 1997; 278: 1966–1968
   PubMed Web of Science ®Google Scholar
• Choi J., Choi K., Benveniste E. N., Hong Y.-S., Lee J.-H., Kim J., Park K. Bcl-2 promotes invasion and lung metastasis by inducing matrix metalloproteinase-2. Cancer Res 2005; 65: 5554–5560
   PubMed Web of Science ®Google Scholar
• Cory S., Adams J. M. Killing cancer cells by flipping the Bcl-2/Bax switch. Cancer Cell 2005; 8: 5–6
   PubMed Web of Science ®Google Scholar
• de Moissac D., Mustapha S., Greenberg A. H., Kirshenbaum L. A. Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha. Journal of Biological Chemistry 1998; 273: 23946–23951
   PubMed Web of Science ®Google Scholar
• Duval H., Harris M., Li J., Johnson N., Print C. New insights into the function and regulation of endothelial cell apoptosis. Angiogenesis 2003; 6: 171–183
   PubMedGoogle Scholar
• Duval H., Johnson N., Li J., Evans A., Chen S., Licence D., Skepper J., Charnock-Jones D. S., Smith S., Print C. Vascular development is disrupted by endothelial cell-specific expression of the anti-apoptotic protein Bcl-2. Angiogenesis 2007; 10: 55–68
   PubMedGoogle Scholar
• Enis D. R., Shepherd B. R., Wang Y., Qasim A., Shanahan C. M., Weissberg P. L., Kashgarian M., Pober J. S., Schechner J. S. Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells. Proceedings of the National Academy of Sciences of the United States of America 2005; 102: 425–430
   PubMed Web of Science ®Google Scholar
• Filippov S., Koenig G. C., Chun T. H., Hotary K. B., Ota I., Bugge T. H., Roberts J. D., Fay W. P., Birkedal-Hansen H., Holmbeck K., et al. MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. Journal of Experimental Medicine 2005; 202: 663–671
   PubMed Web of Science ®Google Scholar
• Gimbrone M. A., Jr. Culture of vascular endothelium. Progress in Hemostasis and Thrombosis 1976; 3: 1–28
   PubMedGoogle Scholar
• Gross A., McDonnell J. M., Korsmeyer S. J. BCL-2 family members and the mitochondria in apoptosis. Genes and Development 1999; 13: 1899–1911
   PubMed Web of Science ®Google Scholar
• Hsieh T., Gordon R. E., Clemmons D. R., Busby W. H., Jr., Duan C. Regulation of vascular smooth muscle cell responses to insulin-like growth factor (IGF)-I by local IGF-binding proteins. Journal of Biological Chemistry 2003; 278: 42886–42892
   PubMed Web of Science ®Google Scholar
• Iervolino A., Trisciuoglio D., Ribatti D., Candiloro A., Biroccio A., Zupi G., Del Bufalo D. Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity. FASEB Journal 2002; 16: 1453–1455
   PubMed Web of Science ®Google Scholar
• Ilan N., Mahooti S., Madri J. A. Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis. Journal of Cell Science 1998; 111: 3621–3631
   PubMed Web of Science ®Google Scholar
• Johnson N. A., Sengupta S., Saidi S. A., Lessan K., Charnock-Jones S. D., Scott L., Stephens R., Freeman T. C., Tom B. D., Harris M., et al. Endothelial cells preparing to die by apoptosis initiate a program of transcriptome and glycome regulation. FASEB Journal 2004; 18: 188–190
   PubMed Web of Science ®Google Scholar
• Kahn J., Mehraban F., Ingle G., Xin X., Bryant J. E., Vehar G., Schoenfeld J., Grimaldi C. J., Peale F., Draksharapu A., et al. Gene expression profiling in an in vitro model of angiogenesis. American Journal of Pathology 2000; 156: 1887–1900
   PubMed Web of Science ®Google Scholar
• Karl E., Warner K., Zeitlin B., Kaneko T., Wurtzel L., Jin T., Chang J., Wang S., Wang C. Y., Strieter R. M., et al. Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines. Cancer Research 2005; 65: 5063–5069
   PubMed Web of Science ®Google Scholar
• Kuwana T., Mackey M. R., Perkins G., Ellisman M. H., Latterich M., Schneiter R., Green D. R., Newmeyer D. D. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 2002; 111: 331–342
   PubMed Web of Science ®Google Scholar
• Li C., Wong W. H. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proceedings of the National Academy of Sciences of the United States of America 2001; 98: 31–36
   PubMed Web of Science ®Google Scholar
• Linette G. P., Li Y., Roth K., Korsmeyer S. J. Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. Proceedings of the National Academy of Sciences of the United States of America 1996; 93: 9545–9552
   PubMed Web of Science ®Google Scholar
• Lum J. J., DeBerardinis R. J., Thompson C. B. Autophagy in metazoans: Cell survival in the land of plenty. Nature Reviews in Molecular and Cellular Biology 2005; 6: 439–448
   PubMed Web of Science ®Google Scholar
• Madge L. A., Sierra-Honigmann M. R., Pober J. S. Apoptosis-inducing agents cause rapid shedding of tumor necrosis factor receptor 1 (TNFR1). A nonpharmacological explanation for inhibition of TNF-mediated activation. Journal of Biological Chemistry 1999; 274: 13643–13549
   PubMed Web of Science ®Google Scholar
• Massaad C. A., Portier B. P., Taglialatela G. Inhibition of transcription factor activity by nuclear compartment-associated Bcl-2. Journal of Biological Chemistry 1999; 279: 54470–54478
   Google Scholar
• Nor J. E., Christensen J., Mooney D. J., Polverini P. J. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. American Journal of Pathology 1999; 154: 375–384
   PubMed Web of Science ®Google Scholar
• Ohtsu H., Dempsey P. J., Frank G. D., Brailoiu E., Higuchi S., Suzuki H., Nakashima H., Eguchi K., Eguchi S. ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. Arteriosclerosis, Thrombosis, and Vascular Biology 2006; 26: e133–e137
   PubMed Web of Science ®Google Scholar
• Proudfoot D., Shanahan C. M. Molecular mechanisms mediating vascular calcification: Role of matrix Gla protein. Nephrology (Carlton) 2006; 11: 455–461
   PubMed Web of Science ®Google Scholar
• Rivard A., Principle N., Andres V. Age-dependent increase in c-fos activity and cyclin A expression in vascular smooth muscle cells. A potential link between aging, smooth muscle cell proliferation and atherosclerosis. Cardiovascular Research 2000; 54: 1026–1034
   Google Scholar
• Rosenkilde M. M., Schwartz T. W. The chemokine system—a major regulator of angiogenesis in health and disease. APMIS 2004; 112: 481–495
   PubMed Web of Science ®Google Scholar
• Saidi S. A., Holland C. M., Kreil D. P., MacKay D. J., Charnock-Jones D. S., Print C. G., Smith S. K. Independent component analysis of microarray data in the study of endometrial cancer. Oncogene 2004; 23: 6677–6683
   PubMed Web of Science ®Google Scholar
• Schechner J. S., Nath A. K., Zheng L., Kluger M. S., Hughes C. C., Sierra-Honigmann M. R., Lorber M. I., Tellides G., Kashgarian M., Bothwell A. L., et al. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proceedings of the National Academy of Sciences of the United States of America 2000; 97: 9191–9196
   PubMed Web of Science ®Google Scholar
• Strasser A. The role of BH3-only proteins in the immune system. Nature Reviews in Immunology 2005; 5: 189–200
   PubMed Web of Science ®Google Scholar
• Thornton S. C., Mueller S. N., Levine E. M. Human endothelial cells: use of heparin in cloning and long-term serial cultivation. Science 1983; 222: 623–625
   PubMed Web of Science ®Google Scholar
• Vadigepalli R., Chakravarthula P., Zak D. E., Schwaber J. S., Gonye G. E. PAINT: A promoter analysis and interaction network generation tool for gene regulatory network identification. OMICS 2003; 7: 235–252
   PubMedGoogle Scholar
• Vailhe B., Vittet D., Feige J. J. In vitro models of vasculogenesis and angiogenesis. Laboratory Investigation 2001; 81: 439–452
   PubMed Web of Science ®Google Scholar
• Vaux D. L., Cory S., Adams J. M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988; 335: 440–442
   PubMed Web of Science ®Google Scholar
• Yana I., Sagara H., Takaki S., Takatsu K., Nakamura K., Nakao K., Katsuki M., Taniguchi S., Aoki T., Sato H., et al. Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells. Journal of Cell Science 2007; 120: 1607–1614
   PubMed Web of Science ®Google Scholar
• Yin X. M., Oltvai Z. N., Korsmeyer S. J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 1994; 369: 321–323
   PubMed Web of Science ®Google Scholar
• Zuckerbraun B. S., McCloskey C. A., Mahidhara R. S., Kim P. K., Taylor B. S., Tzeng E. Overexpression of mutated IkappaBalpha inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation. Journal of Vascular Surgery 2003; 38: 812–819
   PubMed Web of Science ®Google Scholar
• Zhang F., Hackett N. R., Lam G., Cheng J., Pergolizzi R., Luo L., Shmelkov S. V., Edelberg J., Crystal R. G., Rafii S. Green fluorescent protein selectively induces HSP70-mediated up-regulation of COX-2 expression in endothelial cells. Blood 2003; 102: 2115–2121
   PubMed Web of Science ®Google Scholar
• Zheng L., Ben L. H., Pober J. S., Bothwell A. L. Porcine endothelial cells, unlike human endothelial cells, can be killed by human CTL via Fas ligand and cannot be protected by Bcl-2. Journal of Immunology 2002; 169: 6850–6855
   PubMed Web of Science ®Google Scholar
• Zheng L., Dengler T. J., Kluger M. S., Madge L. A., Schechner J. S., Maher S. E., Pober J. S., Bothwell A. L. Cytoprotection of human umbilical vein endothelial cells against apoptosis and CTL-mediated lysis provided by caspase-resistant Bcl-2 without alterations in growth or activation responses. Journal of Immunology 2000; 164: 4665–4671
   PubMed Web of Science ®Google Scholar
• Zheng L., Gibson T. F., Schechner J. S., Pober J. S., Bothwell A. L. Bcl-2 transduction protects human endothelial cell synthetic microvessel grafts from allogeneic T cells in vivo. Journal of Immunology 2004; 173: 3020–3026
   PubMed Web of Science ®Google Scholar
• Zhou J., Callapina M., Goodall G. J., Brune B. Functional integrity of nuclear factor κ B, phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor α -evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypoxia-inducible factor 1alpha. Cancer Research 2004; 64: 9041–9048
   PubMed Web of Science ®Google Scholar