References
- Spande , T. F. , Garraffo , H. M. , Edwars , M. W. , Yeh , H. J. C. , Pannell , L. and Daly , J. W. 1992 . Epibatidine: A novel (chloropyryl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog . J. Amer. Chem. Soc. , 114 : 3475 – 3478 .
- Emsley , J. 1992 . Potent painkiller from poisonous frog . New Scientist , 134 : 14
- Feinberg , A. P. , Creese , I. and Snyder , S. H. 1976 . The opiate receptor: A model explaining structure-activity relationships of opiate agonists and antagonists . Proc. Natl. Acad. Sci. USA , 73 : 4215 – 4219 .
- Goldblum , A. and Loew , G. H. 1991 . A molecular model for an anionic opiate μ-receptor: affinity and activation of morphin conformers . Eur. J. Pharm. Mol. Pharm. Sect , 206 : 119 – 131 .
- Cometta-Morini , C. and Loew , G. H. 1991 . Development of a conformational search strategy for flexible ligands: A study of the potent μ-selective opioid analgesic fentanyl . J. Comput. Aided Mol. Design , 5 : 335 – 356 .
- Brandt , W. and Barth , A. 1993 . A new consistent model explaining structure (conformation)-activity relationships of opiates with μ-selectivity . Drug Design and Discovery , 10 ( 4 ) in press.
- Tripos Associates, Inc. 1699 . 63144 St. Louis, MO : S. Hanley Road . Suite 303
- Clark , M. , Cramer , R. D. III and Van Opdenbosch , N. 1989 . Validation of the general purpose Tripos 5.2. Force Field . J. Comp. Chem. , 10 : 982 – 1012 .
- Gasteiger , J. and Marsili , M. 1980 . Iterative partial equalization of orbital electronegativity: a rapid access to atomic charges . Tetrahedron , 36 : 3219 – 3228 .