Multivariate Analysis of the First 10 MEIC Chemicals

References

• Ekwall , B. , Gomez-Lechon , M. J. , Hellberg , S. , Bondesson , I. , Castell , J. V. , Jover , R. , Högberg , J. , Ponsoda , X. , Romert , L. , Stenberg , K. and Walum , E. 1990 . Preliminary results from the Scandinavian multicentre evaluation of in vitro cytotoxicity (MEIC) . Toxic. in Vitro , 4 : 688 – 691 .
   PubMedGoogle Scholar
• Hughes , I. E. 1992 . The use of computers to reduce animal experimentation in pharmacology . ATLA , 19 : 271 – 276 .
   Google Scholar
• Jacobsen , T. 1992 . Estimation of toxicity of chemicals from the MEIC list by colony radial growth rate measurements in the fungus . Geotrichum candidum. ATLA , 20 : 280 – 284 .
   Google Scholar
• Jover , R. , Ponsoda , X. , Castell , J. V. and Gomez-Lechon , M. J. 1992 . Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: Predictability of human toxicity and comparison with rodent cell culture sytems . Toxic, in Vitro , 6 : 47 – 52 .
   PubMed Web of Science ®Google Scholar
• Weitzner , M. I. 1993 . Developments and Ethical Considerations in Toxicology , 201 Cambridge : Royal Society of Chemistry .
   Google Scholar
• Clothier , R. H. and Balls , M. 1990 . Validation of alternative toxicity tests: Principles, practices and cases . Toxic. in Vitro , 4 : 692 – 693 .
   Google Scholar
• Purchase , I. F.H. 1990 . Strategic considerations in industry's use of in vitro toxicology . Toxic. in Vitro , 4 : 667 – 67 .
   PubMedGoogle Scholar
• Balls , M. 1987 . The US congress office of technology assessment report on alternatives to animal use in research, testing and education . ATLA , 14 : 289 – 306 .
   Google Scholar
• Ekwall , B. , Bondesson , I. , Castell , J. V. , Gomez-Lechon , M. J. , Hellberg , S. , Högberg , J. , Jover , R. , Ponsoda , X. , Romert , L. , Stenberg , K. and Walum , E. 1989 . Cytotoxicity evaluation of the first ten MEIC chemicals: Acute lethal toxicity in man predicted by cytotoxicity in five cellular assays and by oral LD50 tests in rodents . ATLA , 17 : 283 – 100 .
   Google Scholar
• Mayer , F. L. , Whalen , E. A. and Rheins , L. A. 1994 . A regulatory overview of alternatives to animal testing: United States, Europe, and Japan . J. Toxicol. Cut. Ocular Toxicol , 13 : 3 – 22 .
   PubMed Web of Science ®Google Scholar
• Ponsoda , X. , Jover , R. , Castell , J. V. and Gomez-Lechon , M. J. 1990 . In vitro toxicity to two cellular systems of the first ten chemicals on the MEIC list . ATLA , 17 : 218 – 223 .
   Google Scholar
• Gülden , M. and Finger , J. 1992 . Effects of the first twenty MEIC reference chemicals on viability, glucose consumption and spontaneous contractility of primary cultured rat skeletal muscle cells . ATLA , 20 : 222 – 225 .
   Google Scholar
• Rasmussen , E. S. 1993 . Evaluation of the cytotoxicity of the first ten MEIC chemicals in 3T3 mouse fibroblasts with and without microsomal activation, using the neutral red assay . ATLA , 21 : 157 – 163 .
   Google Scholar
• Isomaa , B. , Lilius , H. and West , A. 1992 . Evaluation of cytotoxicity of the first twenty MEIC chemicals by using haemolysis of human erythrocytes as an endpoint . ATLA , 20 : 226 – 229 .
   Google Scholar
• Skaanild , M. T. and Clausen , J. 1991 . The use of human lymphocytes for the in vitro estimation of acute toxicity of ten chemicals from the MEIC list . ATLA , 19 : 187 – 190 .
   Google Scholar
• Sammon , J. W. 1969 . A nonlinear mapping for data structure analysis . IEEE Trans. Comput. , C-18 : 401 – 409 .
   Web of Science ®Google Scholar
• Domine , D. , Devillers , J. , Chastrette , M. and Karcher , W. 1993 . Non-linear mapping for structure-activity and structure-property modelling . J. Chemometrics , 7 : 227 – 242 .
   Google Scholar
• Domine , D. , Devillers , J. and Chastrette , M. 1994 . A nonlinear map of substituent constants for selecting test series and deriving structure-activity relationships. 1. Aromatic series . J. Med. Chem. , 37 : 973 – 980 .
   PubMedGoogle Scholar
• Domine , D. , Devillers , J. and Chastrette , M. 1994 . A nonlinear map of substituent constants for selecting test series and deriving structure-activity relationships. 2. Aliphatic series . J. Med. Chem. , 37 : 981 – 987 .
   PubMedGoogle Scholar
• Domine , D. , Devillers , J. , Garrigues , P. , Budzinski , H. , Chastrette , M. and Karcher , W. 1994 . Chemometrical Evaluation of the PAH contamination in the sediments of the Gulf of Lion (France) . Sci. Total Environ , (in press)
   Google Scholar
• Devillers , J. 1994 . “ Display of multivariate data using nonlinear mapping ” . In QSAR: Chemometric Methods in Molecular Design , Edited by: van de Waterbeemd , H. Weinheim : VCH . (in press)
   Google Scholar
• Domine , D. , Devillers , J. , Chastrette , M. and Doré , J. C. 1994 . “ Combined use of linear and nonlinear multivariate analyses in SAR studies: Application to chemoreception ” . In Application of Computer Aided Molecular Design: Agrochemicals, Materials, and Pharmaceuicals , ACS Symposium Series Edited by: Reynolds , C. H. , Holloway , M. K. and Cox , H. Washington, DC : ACS Books . (in press)
   Google Scholar
• Devillers , J. , Thioulouse , J. , Domine , D. , Chastrette , M. and Karcher , W. 1991 . “ Multivariate analysis of the input and output data in the fugacity model level I ” . In Applied Multivariate Analysis in SAR and Environmental Studies , Edited by: Devillers , J. and Karcher , W. 281 – 345 . Dordrecht : Kluwer Academic Publishers .
   Google Scholar
• Thioulouse , J. , Devillers , J. , Chessel , D. and Auda , Y. 1991 . “ Graphical techniques for multidimensional data analysis ” . In Applied Multivariate Analysis in SAR and Environmental Studies , Edited by: Devillers , J. and Karcher , W. 153 – 205 . Dordrecht : Kluwer Academic Publishers .
   Google Scholar
• Domine , D. , Devillers , J. , Chastrette , M. and Karcher , W. 1992 . Multivariate structure-property relationships (MSPR) of pesticides . Pestic. Sci. , 35 : 73 – 82 .
   Google Scholar
• Devillers , J. , Thioulouse , J. and Karcher , W. 1993 . Chemometrical evaluation of multispeciesmultichemical data by means of graphical techniques combined to multivariate analysis . Ecotoxicol. Environ. Safety , 26 : 333 – 345 .
   PubMedGoogle Scholar
• STATQSAR . 1993 . Lyon, , France CTIS, 21 rue de la Bannière, 69003
   Google Scholar
• Thioulouse , J. 1990 . MacMul and GraphMu: Two Macintosh programs for the display and analysis of multivariate data . Comput. Geosci. , 16 : 1235 – 1240 .
   Google Scholar