Structure-Toxicity Relationships for Aminoalkanols: A Comparison with Alkanols and Alkanamines

References

• Schultz , T. W. , Sinks , G. D. and Hunter , R. S. 1995a . Structure-toxicity relationships for alkanones and alkenones. . SAR QSAR Environ. Res. , 3 : 27 – 36 .
   PubMedGoogle Scholar
• Cronin , M. T. D. and Dearden , J. C. 1995 . Review: QSAR in toxicology. 1. Prediction of aquatic toxicity. . Quant. Struct.-Act. Relat. , 14 : 1 – 7 .
   Web of Science ®Google Scholar
• Bradbury , S. P. 1994 . Predicting modes of toxic action from chemical structure: An overview. . SAR QSAR Environ. Res. , 2 : 89 – 104 .
   PubMedGoogle Scholar
• Nendza , M. and Russom , C. L. 1991 . QSAR modeling of the ERL-D fathead minnow acute toxicity database. . Xenobiotica , 21 : 147 – 170 .
   PubMed Web of Science ®Google Scholar
• Schultz , T. W. , Lin , D. T. and Wesley , S. K. 1992 . QSARs for monosubstituted phenols and the polar narcosis mechanism of toxicity. . Quai. Assur. Good Pract., Regul. Law , 2 : 132 – 143 .
   Google Scholar
• Veith , G. D. , Call , D. J. and Brooke , L. T. 1983 . Structure-toxicity relationships for the fathead minnow Pimephelas promelas: Narcotic industrial chemicals. . Can. J. Fish Aquat. Sci. , 40 : 743 – 748 .
   Web of Science ®Google Scholar
• Veith , G. D. and Broderius , S. J. 1990 . Rules for distinguishing toxicants that cause type I and type II narcosis syndromes. . Environ. Health Perspect. , 87 : 207 – 211 .
   PubMed Web of Science ®Google Scholar
• Hansch , C. , Kim , D. , Leo , A. J. , Novellino , E. , Silipo , C. and Vittoria , A. 1989 . Toward a quantitative comparative toxicology of organic compounds. . Crit. Rev. Toxicol. , 19 : 185 – 226 .
   PubMed Web of Science ®Google Scholar
• Jaworska , J. S. and Schultz , T. W. 1993 . Quantitative relationships of structure-activity and volume fraction for selected nonpolar and polar narcotics chemicals. . SAR QSAR Environ. Res. , 1 : 3 – 19 .
   PubMedGoogle Scholar
• van Wezel , A. P. and Opperhuizen , A. 1995 . Narcosis due to environmental pollutants in aquatic organisms: Residue-based toxicity, mechanisms, and membrane burdens. . Crit. Rev. Toxicol. , 25 : 255 – 279 .
   PubMed Web of Science ®Google Scholar
• Newsome , L. D. , Johnson , D. E. , Lipnick , R. L. , Broderius , S. J. and Russom , C. L. 1991 . A QSAR study of the toxicity of amines to the fathead minnow. . Sci. Total Environ. , 109/110 : 537 – 551 .
   Web of Science ®Google Scholar
• Newsome , L. D. , Johnson , D. E. and Nabholtz , J. V. 1993a . “ Validation and upgrade of a QSAR study of the toxicity of amines to freshwater fish. ” . In Environmental Toxicology and Risk Assessment, ASTM STP 1179 , Edited by: Lamdis , W. G. , Hughes , J. S. and Lewis , M. A. 413 – 426 . Philadelphia, Pennsylvania : Amer. Soc. Test. Mat. .
   Google Scholar
• Newsome , L. D. , Johnson , D. E. and Nabholtz , J. V. 1993b . “ Quantitative structure activity predictions for amine toxicity to algae and daphnids. ” . In Environmental Toxicology and Risk Assessment, 2nd Vol. , Edited by: Gorsuch , J. W. 591 – 609 . Philadelphia, Pennsylvania : Amer. Soc. Test. Mat. . ASTM STP 1216
   Google Scholar
• Schultz , T. W. , Wilke , T. S. , Bryant , S. E. and Hosein , L. M. 1991 . QSARs for selected aliphatic and aromatic amines. . Sci. Total Environ. , 109/110 : 581 – 587 .
   Google Scholar
• Schultz , T. W. and Tichy , M. 1993 . Structure-toxicity relationships for unsaturated alcohols to Tetrahymena pyriformis: C5 and C6 analogs and primary propargylic alcohols. . Bull. Environ. Contam. Toxicol. , 51 : 681 – 688 .
   PubMed Web of Science ®Google Scholar
• Schultz , T. W. 1996 . “ Proceedings of the International Workshop on a Protozoan Test Protocol with Tetrahymena in Aquatic Toxicity Testing ” . In Tetrahymena, in aquatic toxicology: QSARs and ecological hazard assessment. , Edited by: Pauli , W. and Berger , S. 31 – 66 . Mauerstr 45–52, 14191 Berlin : German Federal Environmental Agency .
   Google Scholar
• Schultz , T. W. and Cajina-Quezada , M. 1982 . Structure toxicity relationships of selected nitrogenous heterocyclic compounds II. Dinitrogen molecules. . Arch. Environ. Contam. Toxicol. , 11 : 353 – 361 .
   PubMed Web of Science ®Google Scholar
• 1989 . SAS/STAT User's Guide, version 6 , fourth edition Vol. 2 , 846 Cary, , North Carolina : SAS Institute Inc. .
   Google Scholar
• Schultz , T. W. , Lin , D. T. , Wilke , T. S. and Arnold , L. M. 1990 . “ Quantitative structure-activity relationships for the Tetrahymena pyriformis, population growth endpoint: A mechanism of toxic action approach. Practical Applications of Quantitative Structure-Activity Relationships, (QSAR) ” . In In Environmental Chemistry and Toxicology , Edited by: Karcher , W. and Devillers , J. 241 – 262 . Dordrecht : Kluwer Academic Publishers .
   Google Scholar
• Broderius , S. J. and Kahl , M. 1985 . Acute toxicity of organic chemical mixtures to the fathead minnow. . Aquat. Toxicol. , 6 : 307 – 322 .
   Web of Science ®Google Scholar
• McKim , J. M. , Bradbury , S. P. and Niemi , G. J. 1987 . Fish acute toxicity syndromes and their use in the QSAR approach to hazard assessment. . Environ. Health Perspect. , 71 : 171 – 186 .
   PubMed Web of Science ®Google Scholar
• Lipnick , R. L. 1991 . Outliers: their origin and use in the classification of molecular mechanisms of toxicity. . Sci. Total Environ. , 109/110 : 131 – 153 .
   Web of Science ®Google Scholar
• Jackel , H. and Nendza , M. 1994 . Reactive substructures in the prediction of aquatic toxicity data. . Aquatic Toxicol , 29 : 305 – 314 .
   Web of Science ®Google Scholar
• Schultz , T. W. 1989 . “ Nonpolar Narcosis: A review of the mechanism of action for baseline toxicity. ” . In Aquatic Toxicology and Environmental Fate: Twelfth Volume , Edited by: Cowgill , U. M. and Williams , L. R. 104 – 109 . Philadelphia, Pennsylvania : Amer. Soc. Test. Mater. . ASTM STP 1027
   Google Scholar
• Bradbury , S. P. and Lipnick , R. L. 1990 . Introduction: Structural properties for determining mechanisms of toxic action. . Environ. Health Perspect. , 87 : 181 – 182 .
   Web of Science ®Google Scholar
• Schultz , T. W. , Jaworska , J. S. and Hunter , R. S. 1995b . “ Volume fraction analyses for selected mechanisms of toxic action. ” . In Environmental Toxicology and Risk Assessment: Third Volume , Edited by: Hughes , J. S. , Biddinger , G. R. and Mones , E. 172 – 184 . Philadelphia, Pennsylvania : Amer. Soc. Test. Mater. . ASTM STP 1218
   Google Scholar
• Barton , P. , Davis , A. M. , McCarthy , D. J. and Webborn , P. 1997 . Drug-phospholipid interaction. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients. . J. Pharm. Sci. , 86 : 1034 – 1039 .
   PubMedGoogle Scholar
• Austin , R. P. , Davis , A. M. and Manners , C. N. 1995 . Partitioning of ionizing molecules between aqueous buffers and phospholipid vesicles. . J. Pharm. Sci. , 84 : 1180 – 1183 .
   PubMed Web of Science ®Google Scholar
• Kovács , P. , Kõhidai , L. and Csada , G. 1997 . Effects of 3-amino-1-propanol on the phosphoatiylinositol (PI) and glycosyl phoshhatidylinositol (GPI) systems of . Tetrahymena. Comp. Biochem. Physiol. , 118C : 83 – 87 .
   Google Scholar
• Schultz , T. W. , Bryant , S. E. and Lin , D. T. 1994 . Structure-toxicity relationships for Tetrahymena: Aliphatic aldehydes. . Bull. Environ. Contam. Toxicol. , 52 : 279 – 285 .
   PubMed Web of Science ®Google Scholar
• Jaworska , J. S. , Hunter , R. S. , Gobble , J. R. and Schultz , T. W. 1997 . “ Structure-activity relationships for diesters: Aquatic toxicity to Tetrahymena ” . In Quantitative Structure-Activity Relationships in Environmental Sciences-VII , Edited by: Fredenslund , F. C. and Schüürmann , G. 277 – 283 . Pensacola, Florida : SETAC Press .
   Google Scholar
• Schultz , T. W. and Comeaux , J. L. 1996 . Structure-toxicity relationships for aliphatic isothiocyanates to . Tetrahymena pyriformis. Bull. Environ. Contam. Toxicol. , 56 : 638 – 642 .
   PubMedGoogle Scholar