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Original Articles

Physiologically based pharmacokinetic (PBPK) tool kit for environmental pollutants – metals

, , , &
Pages 603-618 | Received 16 Jun 2010, Accepted 25 Sep 2010, Published online: 29 Nov 2010

References

  • Clewell , HJ , Gentry , PR and Kester , JE . 2005 . Evaluation of physiologically based pharmacokinetic models in risk assessment: An example with perchloroethylene . Crit. Rev. Toxicol. , 35 : 413 – 433 .
  • Fisher , JW , Mahle , D and Abbas , R . 1998 . A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichoroacetic acid and free trichloroethanol . Toxicol. Appl. Pharmacol. , 152 : 339 – 359 .
  • Andersen , ME , Gargas , ML and Jones , RA . 1979 . The use of inhalation techniques to assess the kinetic constants of 1,1-dichloroethylene metabolism . Toxicol. Appl. Pharmacol. , 47 : 395 – 409 .
  • Clewell , HJ , Gentry , PR and Gearhart , JM . 2001 . Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone . Toxicol. Sci. , 63 : 160 – 172 .
  • Andersen , ME . 1994 . Physiologically based pharmacokinetics and cancer risk assessment . Environ. Health Perspect. , 102 ( suppl 1 ) : 103 – 104 .
  • Bailer , AJ . 1997 . An introduction to the use of physiologically based pharmacokinetic models in risk assessment . Stat. Meth. Med. Res. , 6 : 341 – 358 .
  • Ruiz , P , Mumtaz , M , Osterloh , J , Fisher , J and Fowler. , BA . 2010 . Interpreting NHANES biomonitoring data, cadmium . Toxicol. Lett. , 198 : 44 – 48 .
  • Jarup , L . 2003 . Hazards of heavy metal contamination . Br. Med. Bull. , 68 : 167 – 182 .
  • Agency for Toxic Substances and Disease Registry . 2007a . Toxicological profile for arsenic , Atlanta, GA, , USA : U.S. Department of Health and Human Services, Public Health Service .
  • Agency for Toxic Substances and Disease Registry, Toxicological profile for cadmium, U.S. Department of Health and Human Services, Atlanta, GA, USA, 2008-draft. Available at http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=48&tid=15
  • Agency for Toxic Substances and Disease Registry . 2007b . Toxicological Profile for Lead , Atlanta, GA, , USA : U.S. Department of Health and Human Services, Public Health Service .
  • Agency for Toxic Substances and Disease Registry . 2004 . Interaction profile for arsenic, cadmium, chromium and lead , Atlanta, GA, , USA : U.S. Department of Health and Human Services, Public Health Service .
  • Agency for Toxic Substances and Disease Registry, Toxicological Profile for Mercury [Update], U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA, USA, 1999
  • Steinmaus , C , Carrigan , K and Kalman , D . 2005 . Dietary intake and arsenic methylation in a U.S. population . Environ. Health Perspect. , 113 : 1153 – 1159 .
  • Tao , SS and Bolger , PM . 1999 . Dietary intakes of arsenic in the United States . Food Addit. Contam. , 16 : 465 – 472 .
  • Hightower , JM and Moore , D . 2003 . Mercury levels in high-end consumers of fish . Environ. Health Perspect. , 111 : 604 – 608 .
  • Passos , CJ , Mergler , D and Lemire , M . 2007 . Fish consumption and bioindicators of inorganic mercury exposure . Sci. Total Environ. , 373 : 68 – 76 .
  • Jarup , L , Berglund , M and Elinder , CG . 1998 . Health effects of cadmium exposure—a review of the literature and a risk estimate . Scand. J. Work Environ. Health , 24 ( Suppl 1 ) : 1 – 51 .
  • Flanagan , PR , McLellan , JS and Haist , J . 1978 . Increased dietary cadmium absorption in mice and human subjects with iron deficiency . Gastroenterology , 74 : 841 – 846 .
  • G.F. Nordberg, B.A. Fowler, and M. Nordberg (eds.), Handbook on the Toxicology of Metals. Academic Press, Burlington, MA, 2007, pp. 446–486
  • El-Masri , HA and Kenyon , EM . 2008 . Development of a human physiologically based pharmacokinetic (PBPK) model for inorganic arsenic and its mono- and di-methylated metabolites . J. Pharmacokinet. Pharmacodyn. , 35 : 31 – 68 .
  • Carrier , G , Brunet , RC and Caza , M . 2001 . A toxicokinetic model for predicting the tissue distribution and elimination of organic and inorganic mercury following exposure to methyl mercury in animals and humans. I. Development and validation of the model using experimental data in rats . Toxicol. Appl. Pharmacol. , 171 : 38 – 49 .
  • Carrier , G , Bouchard , M and Brunet , RC . 2001 . A toxicokinetic model for predicting the tissue distribution and elimination of organic and inorganic mercury following exposure to methyl mercury in animals and humans. II. Application and validation of the model in humans . Toxicol. Appl. Pharmacol. , 171 : 50 – 60 .
  • Choudhury , H , Harvey , T and Thayer , WC . 2001 . Urinary cadmium elimination as a biomarker of exposure for evaluating a cadmium dietary exposure-biokinetics model . J. Toxicol. Environ. Health , 63 : 321 – 350 .
  • Diamond , GL , Thayer , WC and Choudhury , H . 2003 . Pharmacokinetics/pharmacodynamics (PK/PD) modeling of risks of kidney toxicity from exposure to cadmium: Estimates of dietary risks in the U.S. population . J. Toxicol. Environ. Health , 66 : 2141 – 2164 .
  • Kjellström , T and Nordberg , GF . 1978 . A kinetic model of cadmium metabolism in the human being . Environ. Res. , 16 : 248 – 269 .
  • R.I. Macey and G.F. Oster, Berkeley Madonna. Version 8.3.9, Berkeley Madonna Inc. 1996–2006
  • Morgan , MG and Henrion , M . 1990 . “ The propagation and analysis of uncertainty ” . In Uncertainty. A Guide to Dealing with Uncertainty and Quantitative Risk and Policy Analysis , 172 – 219 . Cambridge, MA : Cambridge University Press .
  • Centers for Disease Control and Prevention, Fourth national report on human exposure to environmental chemicals, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, Georgia, 2009. Available at http//www.cdc.gov/exposurereport/
  • Miettinen , JK , Rahola , T and Hattula , T . 1971 . Elimination of 203Hg-methylmercury in man . Ann. Clin. Res. , 3 : 116 – 122 .
  • Aberg , B , Ekman , L and Falk , R . 1969 . Metabolism of methyl mercury (203 Hg) compounds in man. Excretion and distribution . Arch. Environ. Occup. Health , 19 : 478 – 484 .
  • Falk , R , Snihs , JO and Ekman , L . 1970 . Whole body measurements on the distribution of mercury-203 in humans after oral intake of methylradiomercury nitrate . Acta Radiol. Ther. Phys. Biol. , 9 : 55 – 72 .

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