352
Views
35
CrossRef citations to date
0
Altmetric
Articles

Increased circulating trimethylamine N-oxide plays a contributory role in the development of endothelial dysfunction and hypertension in the RUPP rat model of preeclampsia

, , , &
Pages 96-104 | Received 29 Dec 2018, Accepted 14 Feb 2019, Published online: 01 Mar 2019

References

  • George EM, Granger JP. Recent insights into the pathophysiology of preeclampsia. Expert Rev Obstet Gynecol. 2010 Sep 1;5(5):557–566. PubMed PMID: 21170149; PubMed Central PMCID: PMC3001629.
  • McLaughlin K, Audette MC, Parker JD, et al. Mechanisms and clinical significance of endothelial dysfunction in high-risk pregnancies. Can J Cardiol. 2018 Apr;34(4):371–380. PubMed PMID: 29571421.
  • Oliveira OP, Araujo Junior E, Lima JW, et al. Flow-mediated dilation of brachial artery and endothelial dysfunction in pregnant women with preeclampsia: a case control study. Minerva Ginecol. 2015 Aug;67(4):307–313. PubMed PMID: 25476264.
  • Weissgerber TL. Flow-mediated dilation: can new approaches provide greater mechanistic insight into vascular dysfunction in preeclampsia and other diseases? Curr Hypertens Rep. 2014 Nov;16(11):487. PubMed PMID: 25182159; PubMed Central PMCID: PMC4324696.
  • Savvidou MD, Hingorani AD, Tsikas D, et al. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet. 2003 May 3;361(9368):1511–1517. PubMed PMID: 12737861.
  • McLaughlin K, Baczyk D, Potts A, et al. Low molecular weight heparin improves endothelial function in pregnant women at high risk of preeclampsia. Hypertension. 2017 Jan;69(1):180–188. PubMed PMID: 27840330.
  • Tinsley JH, South S, Chiasson VL, et al. Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R713–R719. PubMed PMID: 20053959.
  • Zhu M, Ren Z, Possomato-Vieira JS, et al. Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R505–R521. PubMed PMID: 27280428; PubMed Central PMCID: PMC5142222.
  • Crews JK, Herrington JN, Granger JP, et al. Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat. Hypertension. 2000 Jan;35(1 Pt 2):367–372. PubMed PMID: 10642326.
  • Li T, Chen Y, Gua C, et al. Elevated circulating trimethylamine N-oxide levels contribute to endothelial dysfunction in aged rats through vascular inflammation and oxidative stress. Front Physiol. 2017;8:350. PubMed PMID: 28611682; PubMed Central PMCID: PMCPMC5447752.
  • Li T, Gua C, Wu B, et al. Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease. Biochem Biophys Res Commun. 2018 Jan 8;495(2):2071–2077. PubMed PMID: 29247650.
  • Ufnal M, Jazwiec R, Dadlez M, et al. Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats. Can J Cardiol. 2014 Dec;30(12):1700–1705. PubMed PMID: 25475471.
  • Sun G, Yin Z, Liu N, et al. Gut microbial metabolite TMAO contributes to renal dysfunction in a mouse model of diet-induced obesity. Biochem Biophys Res Commun. 2017 Nov 18;493(2):964–970. PubMed PMID: 28942145.
  • Wang Z, Klipfell E, Bennett BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011 Apr 07;472(7341):57–63. PubMed PMID: 21475195; PubMed Central PMCID: PMC3086762.
  • Kitai T, Kirsop J, Tang WH. Exploring the microbiome in heart failure. Curr Heart Fail Rep. 2016 Apr;13(2):103–109. PubMed PMID: 26886380; PubMed Central PMCID: PMC4791185.
  • Johnson C, Prokopienko AJ, West RE 3rd, et al. Decreased kidney function is associated with enhanced hepatic flavin monooxygenase activity and increased circulating trimethylamine N-oxide concentrations in mice. Drug Metab Dispos. 2018 Sep;46(9):1304–1309. PubMed PMID: 29915157.
  • Liu J, Yang H, Yin Z, et al. Remodeling of the gut microbiota and structural shifts in preeclampsia patients in South China. Eur J Clin Microbiol Infect Dis. 2017 Apr;36(4):713–719. PubMed PMID: 27988814.
  • Harmon A, Cornelius D, Amaral L, et al. IL-10 supplementation increases tregs and decreases hypertension in the RUPP rat model of preeclampsia. Hypertens Pregnancy. 2015;34(3):291–306. PubMed PMID: 25996051; PubMed Central PMCID: PMC4904776.
  • Kao CK, Morton JS, Quon AL, et al. Mechanism of vascular dysfunction due to circulating factors in women with pre-eclampsia. Clin Sci (Lond). 2016 Apr 1;130(7):539–549. PubMed PMID: 26733722.
  • Choi JW, Im MW, Pai SH. Nitric oxide production increases during normal pregnancy and decreases in preeclampsia. Ann Clin Lab Sci. 2002 Summer;32(3):257–263. PubMed PMID: 12175088.
  • Schiessl B, Strasburger C, Bidlingmaier M, et al. Plasma- and urine concentrations of nitrite/nitrate and cyclic guanosinemonophosphate in intrauterine growth restricted and preeclamptic pregnancies. Arch Gynecol Obstet. 2006 Jun;274(3):150–154. PubMed PMID: 16532320.
  • Begum S, Yamasaki M, Mochizuki M. Urinary levels of nitric oxide metabolites in normal pregnancy and preeclampsia. J Obstet Gynaecol Res. 1996 Dec;22(6):551–559. PubMed PMID: 9037944.
  • Cubro H, Kashyap S, Nath MC, et al. The role of interleukin-10 in the pathophysiology of preeclampsia. Curr Hypertens Rep. 2018 Apr 30;20(4):36. PubMed PMID: 29713810.
  • Velasquez MT, Ramezani A, Manal A, et al. Trimethylamine N-oxide: the good, the bad and the unknown. Toxins (Basel). 2016 Nov 8;8(11):326. PubMed PMID: 27834801; PubMed Central PMCID: PMCPMC5127123.
  • Cornelis T, Odutayo A, Keunen J, et al. The kidney in normal pregnancy and preeclampsia. Semin Nephrol. 2011 Jan;31(1):4–14. PubMed PMID: 21266261.
  • Paauw ND, Joles JA, Spradley FT, et al. Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats. Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R664–R670. PubMed PMID: 28202440; PubMed Central PMCID: PMC5451567.
  • Chatterjee P, Chiasson VL, Kopriva SE, et al. Interleukin 10 deficiency exacerbates toll-like receptor 3-induced preeclampsia-like symptoms in mice. Hypertension. 2011 Sep;58(3):489–496. PubMed PMID: 21768525.
  • Zhang H, Meng J, Yu H. Trimethylamine N-oxide supplementation abolishes the cardioprotective effects of voluntary exercise in mice fed a western diet. Front Physiol. 2017;8:944. PubMed PMID: 29218015; PubMed Central PMCID: PMC5703864.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.