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Research Article

Association of methylenetetrahydrofolate reductase C677T and reduced-f carrier-1 G80A gene polymorphism with preeclampsia in Sudanese women

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Pages 77-81 | Received 13 Jun 2019, Accepted 29 Jan 2020, Published online: 03 Feb 2020

References

  • American College of Obstetricians and Gynecologists. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American college of obstetricians and gynecologists. Int J Gynaecol Obstet. 2002;77(1):67–75.
  • Lo JO, Mission JF, Caughey AB. Hypertensive disease of pregnancy and maternal mortality. Curr Opin Obstet Gynecol. 2013;25:124–132.
  • Abalos E, Cuesta C, Grosso AL, et al. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2013;170:1–7.
  • Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science. 2005;308:1592–1594.
  • Redman CW. Current topic: pre-eclampsia and the placenta. Placenta. n.d.;12:301–308.
  • Lisowska M, Pietrucha T, Sakowicz A. Preeclampsia and related cardiovascular risk: common genetic background. Curr Hypertens Rep. 2018;20:71.
  • Rajkovic A, Mahomed K, Rozen R, et al. Methylenetetrahydrofolate reductase 677 C –> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. Mol Genet Metab. 2000;69:33–39.
  • Nazki FH, Sameer AS, Ganaie BA. Folate: metabolism, genes, polymorphisms and the associated diseases. Gene. 2014;533:11–20.
  • Bhargava S, Tyagi SC. Nutriepigenetic regulation by folate-homocysteine-methionine axis: a review. Mol Cell Biochem. 2014;387:55–61.
  • Hebbring SJ, Chai Y, Ji Y, et al. Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization. J Neurochem. 2012;120:881–890.
  • Yang Y, Chen J, Wang B, et al. Association between MTHFR C677T polymorphism and neural tube defect risks: A comprehensive evaluation in three groups of NTD patients, mothers, and fathers. Birth Defects Res A Clin Mol Teratol. 2015;103:488–500.
  • Turgal M, Gumruk F, Karaagaoglu E, et al. Methylenetetrahydrofolate reductase polymorphisms and pregnancy outcome. Geburtshilfe Frauenheilkd. 2018;78:871–878.
  • Lauszus FF, Grøn PL, Klebe JG. Association of polymorphism of methylene-tetrahydro-folate-reductase with urinary albumin excretion rate in type 1 diabetes mellitus but not with preeclampsia, retinopathy, and preterm delivery. Acta Obstet Gynecol Scand. 2001;80:803–806.
  • Wu X, Yang K, Tang X, et al. Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis. J Assist Reprod Genet. 2015;32:797–805.
  • Szabó G, Lazar L, Nagy B, et al. PP004. Study of the methylenetetrahydrofolate reductase and the reduced-folate carrier-1 gene polymorphism in healthy and severe pre-eclamptic patients. Pregnancy Hypertens. 2012;2:242.
  • Williams M, Sanchez S, Zhang C, et al. Methylenetetrahydrofolate reductase 677 C→T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. J Matern Neonatal Med. 2004;15:337–344.
  • Chedraui P, Salazar-Pousada D, Villao A, et al. Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in nulliparous women complicated with preeclampsia. Gynecol Endocrinol. 2014;30:392–396.
  • Pegoraro RJ, Chikosi A, Rom L, et al. Methylenetetrahydrofolate reductase gene polymorphisms in black South Africans and the association with preeclampsia. Acta Obstet Gynecol Scand. 2004;83:449–454.
  • Vieira AR, Murray JC, Trembath D, et al. Studies of reduced folate carrier 1 (RFC1) A80G and 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms with neural tube and orofacial cleft defects. Am J Med Genet A. 2005;135:220–223.
  • Ali AA, Okud A, Khojali A, et al. High incidence of obstetric complications in Kassala Hospital, Eastern Sudan. J Obstet Gynaecol. 2012;32:148–149.
  • Ali AAA, Rayis DA, Abdallah TM, et al. Hypertensive disorders in pregnancy in Kassala Hospital, Eastern Sudan. Khartoum Medical Journal. 2011;04:656–659.
  • Ahmed NA, Adam I, Elzaki SEG, et al. Factor-V Leiden G1691A and prothrombin G20210A polymorphisms in Sudanese women with preeclampsia, a case -control study. BMC Med Genet. 2019;20:2.
  • Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16:1215.
  • Frosst P, Blom H, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. NatureCom. Nat Genet. 1995 May; 10(1): 111-3.
  • Elhassan HOM, Abdalla, M. Methylenetetrahydrofolate reductase (MTHFR C677T) polymorphism in Sudanese patients with deep vein thrombosis. Int J Biomed Res. 2015;6:323–326.
  • Das S, Mitra K, Mandal M. Sample size calculation: basic principles. Indian J Anaesth. 2016;60:652.
  • Michael C. A simple calculator to determine whether observed genotype frequencies are consistent with Hardy-Weinberg equilibrium; 2008. Http//WwwTuftsEdu/~mcourt01/Documents/Courtlab- HW Calc 2008.
  • LYKKE JA, BARE LA, OLSEN J, et al. Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort. J Thromb Haemost. 2012;10:1320–1325.
  • Mello G, Parretti E, Marozio L, et al. Thrombophilia is significantly associated with severe preeclampsia. Hypertension. 2005;46:1270–1274.
  • Xia X, Chang W, Cao Y. Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia. Hypertens Res. 2012;35:1129–1134.
  • Wang X, Wu H, Qiu X. Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T polymorphism and risk of preeclampsia: an updated meta-analysis based on 51 studies. Arch Med Res. 2013;44:159–168.
  • Salimi S, Saravani M, Yaghmaei M, et al. The early-onset preeclampsia is associated with MTHFR and FVL polymorphisms. Arch Gynecol Obstet. 2015;291:1303–1312.
  • Zhang Y, He X, Xiong X, et al. The association between maternal methylenetetrahydrofolate reductase C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes. Prenat Diagn. 2019;39:3–9.
  • Canto P, Canto-Cetina T, Juárez-Velázquez R, et al. Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women. Hypertens Res. 2008;31:1015–1019.
  • Esfahani ST, Cogger EA, Caudill MA. Heterogeneity in the prevalence of methylenetetrahydrofolate reductase gene polymorphisms in women of different ethnic groups. J Am Diet Assoc. 2003;103:200–207.
  • Gorlick R, Goker E, Trippett T, et al. Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. Blood. 1997;89:1013–1018.
  • Stanisławska-Sachadyn A, Mitchell LE, Woodside JV, et al. The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women. Ann Hum Genet. 2009;73:484–491.
  • DS R. Inherited disorders of folate transport and metabolism. In: Scriver CR, Beaudet AL, Sly WSVD, editors. Metab. Mol. Bases Inherit. Dis. New York: McGraw-Hill; 1995. p. 3111–3128.
  • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111–113.
  • Voutilainen S, Morrow JD, Roberts LJ, et al. Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels. Arterioscler Thromb Vasc Biol. 1999;19:1263–1266.
  • Zhang X, Li H, Jin H, et al. Effects of homocysteine on endothelial nitric oxide production. Am J Physiol Renal Physiol. 2000;279:F671–8.
  • VAN GULDENER C, STEHOUWER CDA. Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction. Semin Thromb Hemost. 2000;26:281–290.
  • Stover PJ. One-carbon metabolism-genome interactions in folate-associated pathologies. J Nutr. 2009;139:2402–2405.
  • Tsitsiou E, Sibley CP, D’Souza SW, et al. Homocysteine transport by systems L, A and y+L across the microvillous plasma membrane of human placenta. J Physiol. 2009;587:4001–4013.
  • Hoffer LJ. Homocysteine remethylation and trans-sulfuration. Metabolism. 2004;53:1480–1483.
  • Solanky N, Requena Jimenez A, D’Souza SW, et al. Expression of folate transporters in human placenta and implications for homocysteine metabolism. Placenta. 2010;31:134–143.
  • Kamudhamas A, Pang L, Smith SD, et al. Homocysteine thiolactone induces apoptosis in cultured human trophoblasts: a mechanism for homocysteine-mediated placental dysfunction? Am J Obstet Gynecol. 2004;191:563–571.

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