The NAD(P)H Oxidase Inhibitor Apocynin Improves Endothelial NO/Superoxide Balance and Lowers Effectively Blood Pressure in Spontaneously Hypertensive Rats: Comparison to Calcium Channel Blockade

References

• Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jr, Jones DW, Materson BJ, Oparil S, Wright JT, Jr, Roccella EJ. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42: 1206–1252
   PubMed Web of Science ®Google Scholar
• Didion SP, Ryan MJ, Baumbach GL, Sigmund CD, Faraci FM. Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. Am J Physiol Heart Circ Physiol 2002; 283: H1569–H1576
   PubMed Web of Science ®Google Scholar
• Laursen JB, Rajagopalan S, Galis Z, Tarpey M, Freeman BA, Harrison DG. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation 1997; 95: 588–593
   PubMed Web of Science ®Google Scholar
• McIntyre M, Bohr DF, Dominiczak AF. Endothelial function in hypertension: the role of superoxide anion. Hypertension 1999; 34: 539–545
   PubMed Web of Science ®Google Scholar
• Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T, Inoue M. Does superoxide underlie the pathogenesis of hypertension?. Proc Natl Acad Sci USA 1991; 88: 10045–10048
   PubMed Web of Science ®Google Scholar
• Suzuki H, Swei A, Zweifach BW, Schmid-Schonbein GW. In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats. Hydroethidine microfluorography. Hypertension 1995; 25: 1083–1089
   PubMed Web of Science ®Google Scholar
• Swei A, Lacy F, De Lano FA, Schmid-Schonbein GW. Oxidative stress in the Dahl hypertensive rat. Hypertension 1997; 30: 1628–1633
   PubMed Web of Science ®Google Scholar
• Holland JA, Ziegler LM, Meyer JW. Atherogenic levels of low-density lipoprotein increase hydrogen peroxide generation in cultured human endothelial cells: possible mechanism of heightened endocytosis. J Cell Physiol 1996; 166: 144–151
   PubMed Web of Science ®Google Scholar
• Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000; 86: 494–501
   PubMed Web of Science ®Google Scholar
• Rey FE, Pagano PJ. The reactive adventitia: fibroblast oxidase in vascular function. Arterioscler Thromb Vasc Biol 2002; 22: 1962–1971
   PubMed Web of Science ®Google Scholar
• Zhang Y, Jang R, Mori TA, Croft KD, Schyvens CG, McKenzie KU, Whitworth JA. The anti-oxidant tempol reverses and partially prevents adrenocorticotrophic hormone-induced hypertension in the rat. J Hypertens 2003; 21: 1513–1518
   PubMed Web of Science ®Google Scholar
• Garcia CE, Kilcoyne CM, Cardillo C, Cannon RO, Quyyumi AA, Panza JA. Effect of copper-zinc superoxide dismutase on endothelium-dependent vasodilation in patients with essential hypertension. Hypertension 1995; 26: 863–868
   PubMed Web of Science ®Google Scholar
• Chu Y, Iida S, Lund DD, Weiss RM, DiBona GF, Watanabe Y, Faraci FM, Heistad DD. Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain. Circ Res 2003; 92: 461–468
   PubMed Web of Science ®Google Scholar
• Stolk J, Hiltermann TJ, Dijkman JH, Verhoeven AJ. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am J Respir Cell Mol Biol 1994; 11: 95–102
   PubMed Web of Science ®Google Scholar
• Li L, Watts SW, Banes AK, Galligan JJ, Fink GD, Chen AF. NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension. Hypertension 2003; 42: 316–321
   PubMed Web of Science ®Google Scholar
• Paliege A, Parsumathy A, Mizel D, Yang T, Schnermann J, Bachmann S. Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 2006; 290: R694–R700
   Web of Science ®Google Scholar
• Ghosh M, Wang HD, McNeill JR. Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats. Br J Pharmacol 2004; 141: 562–573
   PubMed Web of Science ®Google Scholar
• Hu L, Zhang Y, Lim PS, Miao Y, Tan C, McKenzie KU, Schyvens CG, Whitworth JA. Apocynin but not L-arginine prevents and reverses dexamethasone-induced hypertension in the rat. Am J Hypertens 2006; 19: 413–418
   PubMed Web of Science ®Google Scholar
• Park YM, Park MY, Suh YL, Park JB. NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats. Biochem Biophys Res Commun 2004; 313: 812–817
   PubMed Web of Science ®Google Scholar
• Zhang Y, Chan MM, Andrews MC, Mori TA, Croft KD, McKenzie KU, Schyvens CG, Whitworth JA. Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat. Am J Hypertens 2005; 18: 910–916
   PubMed Web of Science ®Google Scholar
• Pech V, Sikka SC, Sindhu RK, Vaziri ND, Majid DS. Oxidant stress and blood pressure responses to angiotensin ii administration in rats fed varying salt diets. Am J Hypertens 2006; 19: 534–540
   PubMed Web of Science ®Google Scholar
• Virdis A, Neves MF, Amiri F, Touyz RM, Schiffrin EL. Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice. J Hypertens 2004; 22: 535–542
   PubMed Web of Science ®Google Scholar
• Turek Z, Kubat K, Kazda S, Hoofd L, Rakusan K. Improved myocardial capillarisation in spontaneously hypertensive rats treated with nifedipine. Cardiovasc Res 1987; 21: 725–729
   PubMed Web of Science ®Google Scholar
• Wassmann S, Laufs U, Baumer AT, Muller K, Ahlbory K, Linz W, Itter G, Rosen R, Bohm M, Nickenig G. HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species. Hypertension 2001; 37: 1450–1457
   PubMed Web of Science ®Google Scholar
• Fukui T, Ishizaka N, Rajagopalan S, Laursen JB, Capers Q, Taylor WR, Harrison DG, De Leon H, Wilcox JN, Griendling KK. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res 1997; 80: 45–51
   PubMed Web of Science ®Google Scholar
• Cosentino F, Patton S, d'Uscio LV, Werner ER, Werner-Felmayer G, Moreau P, Malinski T, Luscher TF. Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. J Clin Invest 1998; 101: 1530–1537
   PubMed Web of Science ®Google Scholar
• Ungvari Z, Csiszar A, Kaminski PM, Wolin MS, Koller A. Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system. Am J Pathol 2004; 165: 219–226
   PubMed Web of Science ®Google Scholar
• Beswick RA, Dorrance AM, Leite R, Webb RC. NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat. Hypertension 2001; 38: 1107–1111
   PubMed Web of Science ®Google Scholar
• Chou TC, Yen MH, Li CY, Ding YA. Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension 1998; 31: 643–648
   PubMed Web of Science ®Google Scholar
• Gil-Longo J, Fernandez-Grandal D, Alvarez M, Sieira M, Orallo F. Study of in vivo and in vitro resting vasodilator nitric oxide tone in normotensive and genetically hypertensive rats. Eur J Pharmacol 1996; 310: 175–183
   PubMed Web of Science ®Google Scholar
• Radaelli A, Mircoli L, Mori I, Mancia G, Ferrari AU. Nitric oxide dependent vasodilation in young spontaneously hypertensive rats. Hypertension 1998; 32: 735–739
   PubMed Web of Science ®Google Scholar
• Hamilton CA, Brosnan MJ, Al Benna S, Berg G, Dominiczak AF. NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension 2002; 40: 755–762
   PubMed Web of Science ®Google Scholar
• Jackson SH, Gallin JI, Holland SM. The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med 1995; 182: 751–758
   PubMed Web of Science ®Google Scholar
• Holland JA. Prevention of atherosclerosis using NADPH oxidase inhibitors. United States patent 5902831. November 5. 1999
   Google Scholar
• Irita K, Fujita I, Takeshige K, Minakami S, Yoshitake J. Calcium channel antagonist induced inhibition of superoxide production in human neutrophils. Mechanisms independent of antagonizing calcium influx. Biochem Pharmacol 1986; 35: 3465–3471
   PubMed Web of Science ®Google Scholar
• Yamagishi S, Inagaki Y, Kikuchi S. Nifedipine inhibits tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 overexpression by blocking NADPH oxidase-mediated reactive oxygen species generation. Drugs Exp Clin Res 2003; 29: 147–152
   PubMedGoogle Scholar
• Naruse M, Tanabe A, Seki T, Adachi C, Yoshimoto T, Mishina N, Imaki T, Naruse K, Demura R, Demura H. Effects of two calcium channel blockers on messenger RNA expression of endothelin-1 and nitric oxide synthase in cardiovascular tissue of hypertensive rats. J Hypertens 1999; 17: 53–60
   PubMed Web of Science ®Google Scholar
• Clarke R, Armitage J. Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials. Cardiovasc Drugs Ther 2002; 16: 411–415
   PubMed Web of Science ®Google Scholar
• Marchioli R, Schweiger C, Levantesi G, Tavazzi L, Valagussa F. Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trial data. Lipids 2001; 36: S53–S63
   PubMed Web of Science ®Google Scholar