317
Views
12
CrossRef citations to date
0
Altmetric
Articles

Type 2 diabetes with hypertensive patients results in changes to features of adipocytokines: Leptin, Irisin, LGR4, and Sfrp5

, , , , , , , , & show all
Pages 645-650 | Received 20 Jul 2018, Accepted 17 Sep 2018, Published online: 11 Oct 2018

References

  • Horr S, Nissen S. Managing hypertension in type 2 diabetes mellitus.Best. Pract Res Clin Endocrinol Metab. 2016;30(3):445–54.
  • Cryer MJ, Horani T, Dipette DJ. Diabetes and Hypertension: A Comparative Review of Current Guidelines. J Clin Hypertens (Greenwich). 2016;18(2):95–100.
  • Vong L, Ye C, Yang Z, Choi B, Chua S Jr, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron. 2011;71(1):142–54.
  • López-Jaramillo P, Gómez-Arbeláez D, López-López J, Lopez-Lopez C, Martinez-Ortega J, Gomez-Rodriguez A, Triana-Cubillos S. The role of Leptin/adiponectin ratio in metabolic syndrome and diabetes. Horm Mol Biol Clin Investig. 2014;18(1):37–45.
  • Lee Y, Berglund ED, Wang MY, Fu X, Yu X, Charron MJ, Burgess SC, Unger RH. Metabolic manifestations of insulin deficiency do not occur without glucagon action. Proc Natl Acad Sci USA. 2012;109(37):14972–76.
  • Mele M, Iachetta G, Alò R,Avolio E, Fazzari G, Carelli A, Laforgia V, Canonaco M. Catestatin and GABA(A)R related feeding habits rely on dopamine, ghrelin plus Leptin neuroreceptor expression variations. Physiol Behav. 2016;157(1):225–30.
  • Uslu S, Kebapçi N, Kara M, Bal C. Relationship between adipoc ytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus. Exp Ther Med. 2012;4(1):113–20.
  • Xin C, Liu J, Zhang J, Zhu D, Wang H, Xiong L, Lee Y, Ye J, Lian K, Xu C, et al. Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway. Int J Obes (Lond). 2016;40(3):443–51.
  • Palacios-González B, Vadillo-Ortega F, Polo-Oteyza E, Snchez T, Ancira-Moreno M, Romero-Hidalgo S, Merz N, Antuna-Puente B. Irisin levels before and after physical activity among school-age children with different BMI: a direct relation with Leptin. Obesity (Silver Spring). 2015;23(4):729–32.
  • Quiñones M, Folgueira C, Sánchez-Rebordelo E, Al-Massadi O. Circulating irisin levels are not regulated by nutritional status, obesity, or Leptin levels in rodents. Mediators Inflamm. 2015;34(2):642–49.
  • Zhu C, Zheng XF, Yang YH, Li B, Wang YR, Jiang SD, Jiang LS. LGR4 acts as a key receptor for R-spondin 2 to promote osteogenesis through Wnt signaling pathway. Cell Signal. 2016;28(8):989–1000.
  • Li JY, Chai BX, Zhang WZ, Fritze DM, Zhang C, Mulholland MW. LGR4 and its ligands, R-Spondin 1 and R-Spondin 3, regulate food intake in the hypothalamus of male rats. Endocrinology. 2014;155(2):429–40.
  • Deng D, Diao Z, Han X, Liu W. Secreted frizzled-related protein 5 attenuates high phosphate-induced calcification in vascular smooth muscle cells by inhibiting the Wnt/ß-catenin pathway. Calcif Tissue Int. 2016;99(1):66–75.
  • Carstensen-Kirberg M, Kannenberg JM, Huth C, Koenig W, Heier M, Peter A, Rathmann W, Roden M, Herder C, Thorand B. Inverse associations between serum levels of secreted frizzled-related protein-5 (Sfrp5) and multiple cardiometabolic risk factors: KORA F4 study. Cardiovasc Diabetol. 2017;16(1):1–10.
  • Carstensen-Kirberg M, Hatziagelaki E, Tsiavou A, Chounta A, Nowotny P, Pacini G, Dimitriadis G, Roden M, Herder C. Sfrp5 associates with beta-cell function in humans. Eur J Clin Invest. 2016;46(6):535–43.
  • Shen T, Wang J, Yu Y, Yu J. Comparison of real-world effectiveness between valsartan and non-RAS inhibitor monotherapy on the incidence of new diabetes in Chinese hypertensive patients: an electronic health recording system based study. Clin Exp Hypertens. 2018(2);1–11.
  • Nagalingam S, Uppuluri MV, Gunda P,Ravishanker U, Tirunilai P. Evaluation of Leptin and Leptin receptor gene 3ʹ UTR polymorphisms in essential hypertension. Clin Exp Hypertens. 2014;36(6):419–25.
  • Fujikawa T, Chuang JC, Sakata I, Ramadori G, Coppari R. Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc Natl Acad Sci USA. 2010;107(40):17391–96.
  • Nishiguchi T, Yoshikawa Y, Yasui H. Anti-diabetic effect of organo-chalcogen (Sulfur and Selenium) zinc complexes with hydroxy-pyrone derivatives on Leptin-deficient type 2 diabetes model ob/ob mice. Int J Mol Sci. 2017;18(12):201–12.
  • Gu X, Chen Z, El Bayoumy I. Serum Leptin levels in obese women with and without type 2 diabetes mellitus. Minerva Endocrinol. 2014;39(3):223–29.
  • Kelly CB, Hookham MB, Yu JY, Lockhart SM, Du M, Jenkins AJ, Nankervis A, Hanssen KF, Henriksen T, Garg SK, et al. Circulating adipokines are associated with pre-eclampsia in women with type 1 diabetes. Diabetologia. 2017;60(12):2514–24.
  • Xie C, Zhang Y, Tran TD, Wang H, Li S, George EV, Zhuang H, Zhang P, Kandel A, Lai Y, et al. Irisin controls growth, intracellular Ca2+ signals, and mitochondrial thermogenesis in cardiomyoblasts. PLoS One. 2015;10(8):e0136816.
  • Fu J, Han Y, Wang J, Liu Y, Zheng S, Zhou L, Joes PA, Zeng C. Irisin lowers blood pressure by improvement of endothelial dysfunction via AMPK-Akt-eNOS-NO pathway in the spontaneously hypertensive rat. J Am Heart Assoc. 2016;5(11):e003433.
  • Hu Z, Deng H, Qu H. Plasma Sfrp5 levels are decreased in Chinese subjects with obesity and type 2 diabetes and negatively correlated with parameters of insulin resistance. Diabetes Res Clin Pract. 2013;99(3):391–95.
  • Hu W, Li L, Yang M, Luo X, Ran W, Liu D, Xiong Z, Liu H, Yang G. Circulating Sfrp5 is a signature of obesity-related metabolic disorders and is regulated by glucose and liraglutide in humans. J Clin Endocrinol Metab. 2013;98(1):290–98.
  • Wang J, Liu R, Wang F, Hong J, Li X, Chen M, Ke Y, Zhang X, Ma Q, Wang R, et al. Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Nat Cell Biol. 2013;15(12):1455–63.
  • Yi J, Xiong W, Gong X, Bellister S, Ellis LM, Liu Q. Analysis of LGR4 receptor distribution in human and mouse tissues. PLoS One. 2013;8(10):e78144.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.