An intron variant in the FLT1 gene increases the risk of preeclampsia in Iranian women

References

• Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol. 2011;25(4):391–403. doi:10.1016/j.bpobgyn.2011.01.006.
   PubMed Web of Science ®Google Scholar
• Musa SM, Adam I, Lutfi MF. Heart rate variability and autonomic modulations in preeclampsia. PLoS One. 2016;11(4):e0152704. doi:10.1371/journal.pone.0152704.
   PubMed Web of Science ®Google Scholar
• Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 2011;123(24):2856–69. doi:10.1161/CIRCULATIONAHA.109.853127.
   PubMed Web of Science ®Google Scholar
• Say L, Chou D, Gemmill A, Tuncalp O, Moller AB, Daniels J, Gülmezoglu AM, Temmerman M, Alkema L. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014;2(6):e323–33. doi:10.1016/S2214-109X(14)70227-X.
   PubMed Web of Science ®Google Scholar
• Turner JA. Diagnosis and management of pre-eclampsia: an update. Int J Womens Health. 2010;2:327–37. doi:10.2147/IJWH.S8550.
   PubMedGoogle Scholar
• Abedin Do A, Esmaeilzadeh E, Amin-Beidokhti M, Pirjani R, Gholami M, Mirfakhraie R. ACE gene rs4343 polymorphism elevates the risk of preeclampsia in pregnant women. J Hum Hypertens. 2018. Epub ahead of print. doi:10.1038/s41371-018-0096-4.
   PubMed Web of Science ®Google Scholar
• Furuya M, Kurasawa K, Nagahama K, Kawachi K, Nozawa A, Takahashi T, Aoki I. Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia. J Pregnancy. 2011;2011:123717. doi:10.1155/2011/123717.
   PubMedGoogle Scholar
• Gholami M, Mirfakhraie R, Pirjani R, Taheripanah R, Bayat S, Daryabari SA, Noori M, Ghaderian SMH. Association study of FOXP3 gene and the risk of 0020 pre-eclampsia. Clin Exp Hypertens. 2018;40(7):613–16. doi:10.1080/10641963.2017.1411500.
   PubMed Web of Science ®Google Scholar
• Pennington KA, Schlitt JM, Jackson DL, Schulz LC, Schust DJ. Preeclampsia: multiple approaches for a multifactorial disease. Dis Mod Mech. 2012;5(1):9–18. doi:10.1242/dmm.008516.
   PubMed Web of Science ®Google Scholar
• Silasi M, Cohen B, Karumanchi SA, Rana S. Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. Obstet Gynecol Clin North Am. 2010;37(2):239–53. doi:10.1016/j.ogc.2010.02.013.
   PubMed Web of Science ®Google Scholar
• Weel IC, Baergen RN, Romao-Veiga M, Borges VT, Ribeiro VR, Witkin SS, Bannwart-Castro C, Peraçoli JC, De Oliveira L, Peraçoli MT. . Association between placental lesions, cytokines and angiogenic factors in pregnant women with preeclampsia. Plos One. 2016;11:6. doi:10.1371/journal.pone.0157584.
   Web of Science ®Google Scholar
• Litwin S, Cortina ME, Barrientos GL, Prados MB, Roux ME, Miranda SE. Multiparity increases trophoblast invasion and vascular endothelial growth factor expression at the maternal-fetal interface in mice. J Reprod Immunol. 2010;85(2):161–67. doi:10.1016/j.jri.2010.03.004.
   PubMed Web of Science ®Google Scholar
• Arcondeguy T, Lacazette E, Millevoi S, Prats H, Touriol C. VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level. Nucleic Acids Res. 2013;41(17):7997–8010. doi:10.1093/nar/gkt539.
   PubMed Web of Science ®Google Scholar
• Chen DB, Zheng J. Regulation of placental angiogenesis. Microcirculation. 2014;21(1):15–25. doi:10.1111/micc.12093.
   PubMed Web of Science ®Google Scholar
• Azliana AF, Zainul-Rashid MR, Chandramaya SF, Farouk WI, Nurwardah A, Wong YP, Tan GC. Vascular endothelial growth factor expression in placenta of hypertensive disorder in pregnancy. Indian J Pathol Microb. 2017;60(4):515–20. doi:10.4103/IJPM.IJPM_376_16.
   PubMed Web of Science ®Google Scholar
• Gavalas NG, Tsiatas M, Tsitsilonis O, Politi E, Ioannou K, Ziogas AC, Rodolakis A, Vlahos G, Thomakos N, Haidopoulos D, et al.. VEGF directly suppresses activation of T cells from ascites secondary to ovarian cancer via VEGF receptor type 2. Brit J Cancer. 2012;107(11):1869–75. doi:10.1038/bjc.2012.468.
   PubMed Web of Science ®Google Scholar
• Yan D, He Y, Dai J, Yang L, Wang X, Ruan Q. Vascular endothelial growth factor modified macrophages transdifferentiate into endothelial-like cells and decrease foam cell formation. Bioscience Rep. 2017;37:3. doi:10.1042/BSR20170002.
   Web of Science ®Google Scholar
• Powers RW, Jeyabalan A, Clifton RG, Van Dorsten P, Hauth JC, Klebanoff MA, Lindheimer MD, Sibai B, Landon M, Miodovnik M, et al. Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies. PLoS One. 2010;5(10):e13263. doi:10.1371/journal.pone.0013263.
   PubMed Web of Science ®Google Scholar
• Palmer KR, Kaitu’u-Lino TJ, Hastie R, Hannan NJ, Ye L, Binder N, Cannon P, Tuohey L, Johns TG, Shub A, et al. Placental-specific sFLT-1 e15a protein is increased in preeclampsia, antagonizes vascular endothelial growth factor signaling, and has antiangiogenic activity. Hypertension. 2015;66(6):1251–59. doi:10.1161/HYPERTENSIONAHA.115.05883.
   PubMed Web of Science ®Google Scholar
• Boyd HA, Tahir H, Wohlfahrt J, Melbye M. Associations of personal and family preeclampsia history with the risk of early-, intermediate- and late-onset preeclampsia. Am J Epidemiol. 2013;178(11):1611–19. doi:10.1093/aje/kwt189.
   PubMed Web of Science ®Google Scholar
• English FA, Kenny LC, McCarthy FP. Risk factors and effective management of preeclampsia. Integr Blood Press Control. 2015;8:7–12. doi:10.2147/IBPC.S50641.
   PubMed Web of Science ®Google Scholar
• Srinivas SK, Morrison AC, Andrela CM, Elovitz MA. Allelic variations in angiogenic pathway genes are associated with preeclampsia. Am J Obstet Gynecol. 2010;202(5):445e1–11. doi:10.1016/j.ajog.2010.01.040.
   Web of Science ®Google Scholar
• Andraweera PH, Dekker GA, Dissanayake VH, Bianco-Miotto T, Jayasekara RW, Roberts CT. Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka. J Matern Fetal Neonatal Med. 2013;26(5):532–36. doi:10.3109/14767058.2012.743520.
   PubMed Web of Science ®Google Scholar
• Shim JY, Jun JK, Jung BK, Kim SH, Won HS, Lee PR, Kim A. Vascular endothelial growth factor gene+936 C/T polymorphism is associated with preeclampsia in Korean women. Am J Obstet Gynecol. 2007;197:3. doi:10.1016/j.ajog.2007.06.045.
   PubMed Web of Science ®Google Scholar
• Papazoglou D, Galazios G, Koukourakis MI, Panagopoulos I, Kontomanolis EN, Papatheodorou K, Maltezos E. Vascular endothelial growth factor gene polymorphisms and pre-eclampsia. Mol Hum Reprod. 2004;10(5):321–24. doi:10.1093/molehr/gah048.
   PubMed Web of Science ®Google Scholar
• Amosco MD, Villar VA, Naniong JM, David-Bustamante LM, Jose PA, Palmes-Saloma CP. VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population. Clin Exp Hypertens. 2016;38(7):578–85. doi:10.3109/10641963.2016.1174252.
   PubMed Web of Science ®Google Scholar
• Sole X, Guino E, Valls J, Iniesta R, Moreno V. SNPStats: a web tool for the analysis of association studies. Bioinformatics. 2006;22(15):1928–29. doi:10.1093/bioinformatics/btl268.
   PubMed Web of Science ®Google Scholar
• Shibuya M. Vascular Endothelial Growth Factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies. Genes Cancer. 2011;2(12):1097–105. doi:10.1177/1947601911423031.
   PubMedGoogle Scholar
• Hayden MS, Ghosh S. NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev. 2012;26(3):203–34. doi:10.1101/gad.183434.111.
   PubMed Web of Science ®Google Scholar
• Vaughan JE, Walsh SW. Activation of NF-kappaB in placentas of women with preeclampsia. Hypertens Pregnancy. 2012;31(2):243–51. doi:10.3109/10641955.2011.642436.
   PubMed Web of Science ®Google Scholar
• Vaiman D, Calicchio R, Miralles F. Landscape of transcriptional deregulations in the preeclamptic placenta. PLoS One. 2013;8(6):e65498. doi:10.1371/journal.pone.0065498.
   PubMed Web of Science ®Google Scholar
• Jung JJ, Tiwari A, Inamdar SM, Thomas CP, Goel A, Choudhury A. Secretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1/sFlt1) requires Arf1, Arf6, and Rab11 GTPases. PLoS One. 2012;7(9):e44572. doi:10.1371/journal.pone.0044572.
   PubMed Web of Science ®Google Scholar
• Bergmann A, Ahmad S, Cudmore M, Gruber AD, Wittschen P, Lindenmaier W, Christofori G, Gross V, Gonzalves ACDC, Gröne H-J, et al. Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model. J Cell Mol Med. 2010;14(6B):1857–67. doi:10.1111/j.1582-4934.2009.00820.x.
   PubMed Web of Science ®Google Scholar
• Fan X, Rai A, Kambham N, Sung JF, Singh N, Petitt M, Dhal S, Agrawal R, Sutton RE, Druzin ML, et al. Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications. J Clin Invest. 2014;124(11):4941–52. doi:10.1172/JCI76864.
   PubMed Web of Science ®Google Scholar