Increased epicardial adipose tissue thickness is associated with microalbuminuria in hypertensive patients with left ventricular hypertrophy

References

• Tsioufis C, Stefanadis C, Toutouza M, Kallikazaros I, Toutouzas K, Tousoulis D, Pitsavos C, Papademetriou V, Toutouzas P. Microalbuminuria is associated with unfavourable cardiac geometric adaptations in essential hypertensive subjects. J Hum Hypertens. 2002;16(4):249–254.
   PubMed Web of Science ®Google Scholar
• Wachtell K, Palmieri V, Olsen MH, Bella JN, Aalto T, Dahlöf B, Gerdts E, Wright JT, Papademetriou V, Mogensen CE, et al. Urine albumin/creatinine ratio and echocardiographic left ventricular structure and function in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study. Losartan Intervention for Endpoint Reduction. Am Heart J. 2002;143(2):319–326.
   Google Scholar
• Lieb W, Mayer B, Stritzke J, Doering A, Hense HW, Loewel H, Erdmann J, Schunkert H. Association of low-grade urinary albumin excretion with left ventricular hypertrophy in the general population: the MONICA/KORA Augsburg Echocardiographic Substudy. Nephrol Dial Transplant. 2006;21(10):2780–2787.
   PubMed Web of Science ®Google Scholar
• Smilde TD, Asselbergs FW, Hillege HL, Voors AA, Kors JA, Gansevoort RT, Van Gilst WH, De Jong PE, Van Veldhuisen DJ. Mild renal dysfunction is associated with electrocardiographic left ventricular hypertrophy. Am J Hypertens. 2005;18(3):342–347.
   PubMed Web of Science ®Google Scholar
• Hebert LA, Spetie DN, Keane WF. The urgent call of albuminuria/proteinuria. Heeding its significance in early detection of kidney disease. Postgrad Med. 2001;110(4):79-82, 87-88, 93-96.
   Google Scholar
• Klausen K, Borch-Johnsen K, Feldt-Rasmussen B, Jensen G, Clausen P, Scharling H, Appleyard M, Jensen JS. Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes. Circulation. 2004;110(1):32–35.
   PubMed Web of Science ®Google Scholar
• Mimran A, Ribstein J, DuCailar G. Is microalbuminuria a marker of early intrarenal vascular dysfunction in essential hypertension? Hypertension. 1994; 23 (6 Pt 2): 1018–1021.
   PubMed Web of Science ®Google Scholar
• Parving HH, Mogensen CE, Jensen HA, Evrin PE. Increased urinary albumin-excretion rate in benign essential hypertension. Lancet. 1974;1(7868):1190–1192.
   PubMed Web of Science ®Google Scholar
• Cerasola G, Cottone S, D’Ignoto G, Grasso L, Mangano MT, Carapelle E, Nardi E, Andronico G, Fulantelli MA, Marcellino T, et al. Micro-albuminuria as a predictor of cardiovascular damage in essential hypertension. J Hypertens Suppl. 1989;7(6):S332–333.
   PubMedGoogle Scholar
• Yudkin JS, Forrest RD, Jackson CA. Microalbuminuria as predictor of vascular disease in non-diabetic subjects. Islington Diabetes Survey. Lancet. 1988;2(8610):530–533.
   Google Scholar
• Wachtell K, Olsen MH, Dahlöf B, Devereux RB, Kjeldsen SE, Nieminen MS, Okin PM, Papademetriou V, Mogensen CE, Borch-Johnsen K, Ibsen H. Microalbuminuria in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study. J Hypertens. 2002;20(3):405–412.
   PubMed Web of Science ®Google Scholar
• Falqui V, Viazzi F, Leoncini G, Ratto E, Parodi A, Conti N, Tomolillo C, Deferrari G, Pontremoli R. Blood pressure load, vascular permeability and target organ damage in primary hypertension. J Nephrol. 2007;20 Suppl 12:S63–67.
   PubMed Web of Science ®Google Scholar
• Salmasi AM, Jepson E, Grenfell A, Kirollos C, Dancy M. The degree of albuminuria is related to left ventricular hypertrophy in hypertensive diabetics and is associated with abnormal left ventricular filling: a pilot study. Angiology. 2003;54(6):671–678.
   PubMed Web of Science ®Google Scholar
• Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F. Relation between epicardial adipose tissue and left ventricular mass. Am J Cardiol. 2004;94(8):1084–1087.
   PubMed Web of Science ®Google Scholar
• Corradi D, Maestri R, Callegari S, Pastori P, Goldoni M, Luong TV, Bordi C. The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts. Cardiovasc Pathol. 2004;13(6):313–316.
   PubMed Web of Science ®Google Scholar
• Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, Di Mario U, Leonetti F. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab. 2003;88(11):5163–5168.
   PubMed Web of Science ®Google Scholar
• Ertas F, Kaya H, Acet H, Cil H, Akyüz A, Islamoğlu Y, Tekbaş E, Aritürk Z, Aydin M, Soydinç S. Increased echocardiographic epicardial fat thickness is related to impaired diurnal blood pressure profiles. Blood Press. 2012;21(3):202–208.
   PubMed Web of Science ®Google Scholar
• Ozturk MT, Ebinç FA, Okyay GU, Kutlugün AA. Epicardial Adiposity is Associated with Microalbuminuria in Patients with Essential Hypertension. Acta Cardiol Sin. 2017;33(1):74–80.
   PubMed Web of Science ®Google Scholar
• Akbas EM, Demirtas L, Ozcicek A, Timuroglu A, Bakirci EM, Hamur H, Ozcicek F, Turkmen K. Association of epicardial adipose tissue, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with diabetic nephropathy. Int J Clin Exp Med. 2014;7(7):1794–1801.
   PubMed Web of Science ®Google Scholar
• Darabian S, Backlund JY, Cleary PA, Sheidaee N, Bebu I, Lachin JM, Budoff MJ; DCCT/EDIC Research Group. Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study. PLoS One. 2016;11(7):e0159958.
   Google Scholar
• Natale F, Tedesco MA, Mocerino R, de Simone V, Di Marco GM, Aronne L, Credendino M, Siniscalchi C, Calabrò P, Cotrufo M, et al. Visceral adiposity and arterial stiffness: echocardiographic epicardial fat thickness reflects, better than waist circumference, carotid arterial stiffness in a large population of hypertensives. Eur J Echocardiogr. 2009;10(4):549–555.
   PubMed Web of Science ®Google Scholar
• Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella EJ; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003; 42(6):1206–1252.
   Google Scholar
• Pontremoli R, Sofia A, Ravera M, Nicolella C, Viazzi F, Tirotta A, Ruello N, Tomolillo C, Castello C, Grillo G, Sacchi G, Deferrari G. Prevalence and clinical correlates of microalbuminuria in essential hypertension: the MAGIC Study. Microalbuminuria: A Genoa Investigation on Complications. Hypertension. 1997;30(5):1135–1143.
   PubMed Web of Science ®Google Scholar
• Mattix HJ, Hsu CY, Shaykevich S, Curhan G. Use of the albumin/creatinine ratio to detect microalbuminuria: implications of sex and race. J Am Soc Nephrol. 2002;13(4):1034–1039.
   PubMed Web of Science ®Google Scholar
• Viazzi F, Leoncini G, Pontremoli R. Global cardiovascular risk assessment in the management of primary hypertension: the role of the kidney. Int J Hypertens. 2013;2013:542646.
   PubMedGoogle Scholar
• Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57(6):450–458.
   PubMed Web of Science ®Google Scholar
• Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2015;16(3):233–270.
   PubMed Web of Science ®Google Scholar
• Iacobellis G, Assael F, Ribaudo MC, Zappaterreno A, Alessi G, Di Mario U, Leonetti F. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res. 2003;11(2):304–310.
   PubMedGoogle Scholar
• Ljungman S, Wikstrand J, Hartford M, Berglund G. Urinary albumin excretion--a predictor of risk of cardiovascular disease. A prospective 10-year follow-up of middle-aged nondiabetic normal and hypertensive men. Am J Hypertens. 1996;9(8):770–778.
   PubMed Web of Science ®Google Scholar
• Bigazzi R, Bianchi S, Baldari D, Campese VM. Microalbuminuria predicts cardiovascular events and renal insufficiency in patients with essential hypertension. J Hypertens. 1998;16(9):1325–1333.
   PubMed Web of Science ®Google Scholar
• Pontremoli R, Viazzi F, Sofia A, Tomolillo C, Ruello N, Bezante GP, Del Sette M, Martinoli C, Lotti R, Sacchi G, et al. Microalbuminuria: a marker of cardiovascular risk and organ damage in essential hypertension. Kidney Int Suppl. 1997;63:S163–165.
   PubMed Web of Science ®Google Scholar
• Tsioufis C, Dimitriadis K, Selima M, Miliou A, Toutouzas K, Roussos D, Stefanadi E, Tousoulis D, Kallikazaros I, Stefanadis C. Association of resistin with urinary albumin excretion in nondiabetic patients with essential hypertension. Am J Hypertens. 2010;23(6):681–686.
   PubMed Web of Science ®Google Scholar
• Albuquerque FN, Somers VK, Blume G, Miranda W, Korenfeld Y, Calvin AD, Qin R, Lopez-Jimenez F. Usefulness of epicardial adipose tissue as predictor of cardiovascular events in patients with coronary artery disease. Am J Cardiol. 2012;110(8):1100–1105.
   PubMed Web of Science ®Google Scholar
• Shim IK, Cho KI, Kim HS, Heo JH, Cha TJ. Impact of Gender on the Association of Epicardial Fat Thickness, Obesity, and Circadian Blood Pressure Pattern in Hypertensive Patients. J Diabetes Res. 2015;2015:924539.
   PubMed Web of Science ®Google Scholar
• Yasuno S, Ueshima K, Oba K, Fujimoto A, Ogihara T, Saruta T, Nakao K. Clinical significance of left ventricular hypertrophy and changes in left ventricular mass in high-risk hypertensive patients: a subanalysis of the Candesartan Antihypertensive Survival Evaluation in Japan trial. J Hypertens. 2009;27(8):1705–1712.
   PubMed Web of Science ®Google Scholar
• Tsioufis C, Dimitriadis K, Andrikou E, Thomopoulos C, Tsiachris D, Stefanadi E, Mihas C, Miliou A, Papademetriou V, Stefanadis C. ADMA, C-reactive protein, and albuminuria in untreated essential hypertension: a cross-sectional study. Am J Kidney Dis. 2010;55(6):1050–1059.
   PubMed Web of Science ®Google Scholar
• Stehouwer CD, Smulders YM. Microalbuminuria and risk for cardiovascular disease: Analysis of potential mechanisms. J Am Soc Nephrol. 2006;17(8):2106–2111.
   PubMed Web of Science ®Google Scholar
• Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med. 2005;2(10):536–543.
   PubMedGoogle Scholar
• Ahn SG, Lim HS, Joe DY, Kang SJ, Choi BJ, Choi SY, Yoon MH, Hwang GS, Tahk SJ, Shin JH. Relationship of epicardial adipose tissue by echocardiography to coronary artery disease. Heart. 2008;94(3):e7.
   PubMed Web of Science ®Google Scholar
• Iacobellis G, Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab. 2005;90(11):6300–6302.
   PubMed Web of Science ®Google Scholar
• Eroğlu S, Sade LE, Yıldırır A, Demir O, Müderrisoğlu H. Association of epicardial adipose tissue thickness by echocardiography and hypertension. Turk Kardiyol Dern Ars. 2013;41(2):115–122.
   PubMedGoogle Scholar
• Dicker D, Atar E, Kornowski R, Bachar GN. Increased epicardial adipose tissue thickness as a predictor for hypertension: a cross-sectional observational study. J Clin Hypertens (Greenwich). 2013;15(12):893–898.
   PubMed Web of Science ®Google Scholar
• Womack HC. The relationship between human body weight, subcutaneous fat, heart weight, and epicardial fat. Hum Biol. 1983;55(3):667–676.
   PubMed Web of Science ®Google Scholar
• Teijeira-Fernandez E, Eiras S, Grigorian-Shamagian L, Fernandez A, Adrio B, Gonzalez-Juanatey JR. Epicardial adipose tissue expression of adiponectin is lower in patients with hypertension. J Hum Hypertens. 2008;22(12):856–863.
   PubMed Web of Science ®Google Scholar
• Iacobellis G, Barbaro G. The double role of epicardial adipose tissue as pro- and anti-inflammatory organ. Horm Metab Res. 2008;40(7):442–445.
   PubMed Web of Science ®Google Scholar
• Sacks HS, Fain JN. Human epicardial fat: what is new and what is missing?. Clin Exp Pharmacol Physiol. 2011;38(12):879–887.
   PubMed Web of Science ®Google Scholar
• Sons HU, Hoffmann V. Epicardial fat cell size, fat distribution and fat infiltration of the right and left ventricle of the heart. Anat Anz. 1986;161(5):355–373.
   PubMedGoogle Scholar
• Iozzo P. Myocardial, perivascular, and epicardial fat. Diabetes Care. 2011;34 Suppl 2 (Suppl 2):S371–S379.
   PubMed Web of Science ®Google Scholar
• Sharma K, Ramachandrarao S, Qiu G, Usui HK, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, et al. Adiponectin regulates albuminuria and podocyte function in mice. Version 2. J Clin Invest. 2008;118(5):1645–1656.
   PubMed Web of Science ®Google Scholar