Association of serum VLDL level with hyperhomocysteinemia in hypertensive patients: A cross-sectional study

References

• WHO Cardiovascular diseases (CVDs)[EB/OL]. [2018Mar20].
   Google Scholar
• Cardiovascular disease - Wikipedia[EB/OL]. [2018/3/20].
   Google Scholar
• Towfighi A, Markovic D, Ovbiagele B. Pronounced association of elevated serum homocysteine with stroke in subgroups of individuals: a nationwide study. J Neurol Sci. 2010;298(1–2):153–57. doi:10.1016/j.jns.2010.07.013.
   PubMed Web of Science ®Google Scholar
• Deedi MK. Role of anthropometric measurements in development of CVD and stroke among T2DM in East Godavari District, Andhra Pradesh, India. J Clin Diagn Res. 2017;11(7):C1–C5.
   Web of Science ®Google Scholar
• Homocysteine TE. MTHFR gene polymorphisms, and cardio-cerebrovascular risk. J Appl Genet. 2008;49(3):267–82. doi:10.1007/BF03195624.
   PubMed Web of Science ®Google Scholar
• Qin X, Li J, Cui Y, Liu Z, Zhao Z, Ge J, Guan D, Hu J, Wang Y, Zhang F, et al. Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses? Pharmacogenet Genomics. 2012;22(6):421–28. doi:10.1097/FPC.0b013e32834ac5e8.
   PubMed Web of Science ®Google Scholar
• Liu J, Xu Y, Zhang H, Gao X, Fan H, Wang G, et al. Coronary flow velocity reserve is impaired in hypertensive patients with hyperhomocysteinemia. J Hum Hypertens. 2014;28(12):743–47. doi:10.1038/jhh.2014.22.
   PubMed Web of Science ®Google Scholar
• Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015;14(1):6. doi:10.1186/1475-2891-14-6.
   PubMed Web of Science ®Google Scholar
• Huo Y, Li J, Qin X, Huang Y, Wang X, Gottesman RF, Tang G, Wang B, Chen D, He M, et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA. 2015;313(13):1325–35. doi:10.1001/jama.2015.2274.
   PubMed Web of Science ®Google Scholar
• Punekar RS, Fox KM, Richhariya A, Fisher MD, Cziraky M, Gandra SR, Toth PP. Burden of First and recurrent cardiovascular events among patients with hyperlipidemia. Clin Cardiol. 2015;38(8):483–91. doi:10.1002/clc.22428.
   PubMed Web of Science ®Google Scholar
• Adiels M, Olofsson S-O, Taskinen M-R, Boren J. Overproduction of very low–density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2008;28(7):1225–36. doi:10.1161/ATVBAHA.107.160192.
   PubMed Web of Science ®Google Scholar
• Namekata K, Enokido Y, Ishii I, Nagai Y, Harada T, Kimura H, et al. Abnormal lipid metabolism in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia. J Biol Chem. 2004;279(51):52961–69. doi:10.1074/jbc.M406820200.
   PubMed Web of Science ®Google Scholar
• Qin X, Huo Y. H-Type hypertension, stroke and diabetes in China: opportunities for primary prevention. J Diabetes. 2016;8(1):38–40. doi:10.1111/1753-0407.12333.
   PubMed Web of Science ®Google Scholar
• Lopez AD, Mathers CD, Ezzati M, et al. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 2006;367(9524):1747–57. doi:10.1016/S0140-6736(06)68770-9.
   PubMed Web of Science ®Google Scholar
• Chen QR, Jiang SQ, Xu XP. [Polymorphism of genes encoding homocysteine metabolism-related enzymes and risk for cardio-cerebrovascular disease]. Zhonghua Xin Xue Guan Bing Za Zhi. 2012;40(9):801–03.
   PubMedGoogle Scholar
• Liu LS. [2010 Chinese guidelines for the management of hypertension]. Zhonghua Xin Xue Guan Bing Za Zhi. 2011;39(7):579–615.
   PubMedGoogle Scholar
• Esteghamati A, Hafezi-Nejad N, Zandieh A, Sheikhbahaei S, Ebadi M, Nakhjavani M, et al. Homocysteine and metabolic syndrome: from clustering to additional utility in prediction of coronary heart disease. J Cardiol. 2014;64(4):290–96. doi:10.1016/j.jjcc.2014.02.001.
   PubMed Web of Science ®Google Scholar
• Zhou S, Zhang Z, Xu G. Notable epigenetic role of hyperhomocysteinemia in atherogenesis. Lipids Health Dis. 2014;13(1):134. doi:10.1186/1476-511X-13-134.
   PubMed Web of Science ®Google Scholar
• J G L, Pratico D. High levels of homocysteine results in cerebral amyloid angiopathy in mice. J Alzheimers Dis. 2015;43(1):29–35. doi:10.3233/JAD-141101.
   PubMed Web of Science ®Google Scholar
• Zhou F, Chen B, Chen C, Huang J, Chen S, Guo F, Hu Z, et al. Elevated homocysteine levels contribute to larger hematoma volume in patients with intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2015;24(4):784–88. doi:10.1016/j.jstrokecerebrovasdis.2014.11.005.
   PubMed Web of Science ®Google Scholar
• Gariglio L, Riviere S, Morales A, Porcile R, Potenzoni M, Fridman O, et al. Comparison of homocysteinemia and MTHFR 677CT polymorphism with Framingham coronary heart risk score. Arch Cardiol Mex. 2014;84(2):71–78. doi:10.1016/j.acmx.2013.12.006.
   PubMedGoogle Scholar
• Varga EA, Sturm AC, Misita CP, Moll S, et al. Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease. Circulation. 2005;111(19):e289–e293. doi:10.1161/01.CIR.0000165142.37711.E7.
   PubMed Web of Science ®Google Scholar
• Moll S, Varga EA. Homocysteine and MTHFR mutations. Circulation. 2015;132(1):e6–e9. doi:10.1161/CIRCULATIONAHA.114.013311.
   PubMed Web of Science ®Google Scholar
• Wang G, Dai J, Mao J, Zeng X, Yang X, Wang X, et al. Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia. Atherosclerosis. 2005;179(2):395–402. doi:10.1016/j.atherosclerosis.2004.10.033.
   PubMed Web of Science ®Google Scholar
• Yan -T-T, Li Q, Zhang X-H, Wu W-K, Sun J, Li L, Zhang Q, Tan H-M, et al. Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling. Clin Exp Pharmacol Physiol. 2010;37(11):1071–77. doi:10.1111/j.1440-1681.2010.05438.x.
   PubMed Web of Science ®Google Scholar
• Dhillon B, Badiwala MV, Maitland A, et al. Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction. Mol Cell Biochem. 2003;247(1–2):223–27. doi:10.1023/A:1024146501743.
   PubMed Web of Science ®Google Scholar
• Suematsu N, Ojaimi C, Kinugawa S, Wang Z, Xu X, Koller MD A, Recchia FA, Hintze TH, et al. Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress. Circulation. 2007;115(2):255–62. doi:10.1161/CIRCULATIONAHA.106.652693.
   PubMed Web of Science ®Google Scholar
• Lai WKC, Kan MY. Homocysteine-induced endothelial dysfunction. Ann Nutr Metab. 2015;67(1):1–12. doi:10.1159/000437098.
   PubMed Web of Science ®Google Scholar
• Miller A, Mujumdar V, Shek E, Guillot J, Angelo M, Palmer L, Tyagi SC, et al. Hyperhomocyst(e)inemia induces multiorgan damage. Heart and Vessels. 2000;15(3):135–43. doi:10.1007/s003800070030.
   PubMed Web of Science ®Google Scholar
• Malloy MJ, Kane JP. Hyperlipidemia and cardiovascular disease. Curr Opin Lipidol. 2012;23(6):591–92. doi:10.1097/MOL.0b013e328359f162.
   PubMed Web of Science ®Google Scholar
• Sumner AE, Harman JL, Buxbaum SG, Miller BV, Tambay AV, Wyatt SB, Taylor HA, Rotimi CN, Sarpong DF, et al. The triglyceride/high-density lipoprotein cholesterol ratio fails to predict insulin resistance in African-American women: an analysis of Jackson heart study. Metab Syndr Relat Disord. 2010;8(6):511–14. doi:10.1089/met.2010.0028.
   PubMed Web of Science ®Google Scholar
• Barzi F, Patel A, Woodward M, lawes CMM, Ohkubo T, Gu D, lam TH, Ueshima H, Asia Pacific Cohort Studies Collaboration. A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific region. Ann Epidemiol. 2005;15:405–13.
   PubMed Web of Science ®Google Scholar
• Fernandez ML, Webb D. The LDL to HDL cholesterol ratio as a valuable tool to evaluate coronary heart disease risk. J Am Coll Nutr. 2008;27(1):1–5. doi:10.1080/07315724.2008.10719668.
   PubMed Web of Science ®Google Scholar
• Liao D, Yang X, Wang H. Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular disease. Clin Chem Lab Med. 2007;45(12):1652–59. doi:10.1515/CCLM.2007.358.
   PubMed Web of Science ®Google Scholar