Are Sewage Treatment Plants Promoting Antibiotic Resistance?

REFERENCES

• Aarestrup , F. M. 2000 . Characterization of glycopeptide-resistant Enterococcus faecium (GRE) from broilers and pigs in Denmark: Genetic evidence that persistence of GRE in pig herds is associated with coselection by resistance to macrolides . Journal of Clinical Microbiology , 38 : 2774 – 2777 .
   PubMed Web of Science ®Google Scholar
• Aires , J. R. , Kohler , T. , Nikaido , H. and Plesiat , P. 1999 . Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides . Antimicrob Agents Chemother , 43 : 2624 – 2628 .
   PubMed Web of Science ®Google Scholar
• Al-Ahmad , A. , Daschner , F. D. and Kümmerer , K. 1999 . Biodegradability of cefotiam, ciprofloxacin, meropenem, penicillin G, and sulfamethoxazole and inhibition of waste water bacteria . Arch Environ Contam Toxicol , 37 : 158 – 163 .
   PubMed Web of Science ®Google Scholar
• Andersen , S. R. 1993 . Effects of waste-water treatment on the species composition and antibiotic resistance of coliform bacteria . Curr Microbiol , 26 : 97 – 103 .
   Web of Science ®Google Scholar
• Beaber , J. W. , Hochhut , B. and Waldor , M. K. 2004 . SOS response promotes horizontal dissemination of antibiotic resistance genes . Nature , 427 ( 6969 ) : 72 – 74 .
   PubMed Web of Science ®Google Scholar
• Bell , J. B. , Elliott , G. E. and Smith , D. W. 1983 . Influence of sewage treatment and urbanization on selection of multiple resistance in fecal coliform populations . Appl Environ Microbiol , 46 : 227 – 232 .
   PubMed Web of Science ®Google Scholar
• Bischoff , K. M. , White , D. G. , Hume , M. E. , Poole , T. L. and Nisbet , D. J. 2005 . The chloramphenicol resistance gene cmlA is disseminated on transferable plasmids that confer multiple-drug resistance in swine Escherichia coli . Fems Microbiol Lett , 243 : 285 – 291 .
   PubMed Web of Science ®Google Scholar
• Boerlin , P. , Wissing , A. , Aarestrup , F. M. , Frey , J. and Nicolet , J. 2001 . Antimicrobial growth promoter ban and resistance to macrolides and vancomycin in enterococci from pigs . Journal of Clinical Microbiology , 39 : 4193 – 4195 .
   PubMed Web of Science ®Google Scholar
• Bolhuis , H. , van Veen , H. W. , Poolman , B. , Driessen , A. J. and Konings , W. N. 1997 . Mechanisms of multidrug transporters . FEMS Microbiol Rev , 21 : 55 – 84 .
   PubMed Web of Science ®Google Scholar
• Bonemann , G. , Stiens , M. , Puhler , A. and Schluter , A. 2006 . Mobilizable IncQ-related plasmid carrying a new quinolone resistance gene, qnrS2, isolated from the bacterial community of a wastewater treatment plant . Antimicrob Agents Chemother , 50 : 3075 – 3080 .
   PubMed Web of Science ®Google Scholar
• Boon , P. I. and Cattanach , M. 1999 . Antibiotic resistance of native and faecal bacteria isolated from rivers, reservoirs and sewage treatment facilities in Victoria, southeastern Australia . Lett Appl Microbiol , 28 : 164 – 168 .
   PubMed Web of Science ®Google Scholar
• Bramucci , M. and Nagarajan , V. 2006 . Bacterial communities in industrial wastewater bioreactors . Curr Opin Microbiol , 9 : 275 – 278 .
   PubMed Web of Science ®Google Scholar
• Brown , T. A. 1990 . Gene cloning. An introduction , 2nd ed , London : Chapman and Hall .
   Google Scholar
• Carlier , J. P. , Sellier , N. , Rager , M. N. and Reysset , G. 1997 . Metabolism of a 5-nitroimidazole in susceptible and resistant isogenic strains of Bacteroides fragilis . Antimicrob Agents Chemother , 41 : 1495 – 1499 .
   PubMed Web of Science ®Google Scholar
• Cetinkaya , Y. , Falk , P. and Mayhall , C. G. 2000 . Vancomycin-resistant enterococci . Clin Microbiol Rev , 13 : 686 – 707 .
   PubMed Web of Science ®Google Scholar
• Cha , J. M. , Yang , S. and Carlson , K. H. 2006 . Trace determination of β-lactam antibiotics in surface water and urban wastewater using liquid chromatography combined with electrospray tandem mass spectrometry . J Chromatogr A , 1115 ( 1-2 ) : 46 – 57 .
   PubMed Web of Science ®Google Scholar
• Chambers , H. F. 1997 . Methicillin resistance in staphylococci: Molecular and biochemical basis and clinical implications . Clin Microbiol Rev , 10 : 781 – 791 .
   PubMed Web of Science ®Google Scholar
• Chambers , H. F. 2001 . The changing epidemiology of Staphylococcus aureus? . Emerg Infect Dis , 7 : 178 – 182 .
   PubMed Web of Science ®Google Scholar
• Chiew , Y. F. , Yeo , S. F. , Hall , L. M. and Livermore , D. M. 1998 . Can susceptibility to an antimicrobial be restored by halting its use? The case of streptomycin versus Enterobacteriaceae . J Antimicrob Chemother , 41 : 247 – 251 .
   PubMed Web of Science ®Google Scholar
• Chopra , I. and Roberts , M. 2001 . Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance . Microbiology and Molecular Biology Reviews , 65 : 232 – 260 .
   PubMed Web of Science ®Google Scholar
• Cirz , R. T. , Jones , M. B. , Gingles , N. A. , Minogue , T. D. , Jarrahi , B. Peterson , S. N. 2007 . Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin . J Bacteriol , 189 : 531 – 539 .
   PubMed Web of Science ®Google Scholar
• Cirz , R. T. , O’Neill , B M , Hammond , J. A. , Head , S. R. and Romesberg , F. E. 2006 . Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin . J Bacteriol , 188 : 7101 – 7110 .
   PubMed Web of Science ®Google Scholar
• Costanzo , S. D. , Murby , J. and Bates , J. 2005 . Ecosystem response to antibiotics entering the aquatic environment . Mar Pollut Bull , 51 : 218 – 223 .
   PubMed Web of Science ®Google Scholar
• Cui , L. , Murakami , H. , Kuwahara-Arai , K. , Hanaki , H. and Hiramatsu , K. 2000 . Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by Staphylococcus aureus Mu50 . Antimicrob Agents Chemother , 44 : 2276 – 2285 .
   PubMed Web of Science ®Google Scholar
• Da Silva , M. F. , Tiago , I. , Verissimo , A. , Boaventura , R. A. R. , Nunes , O. C. and Manaia , C. M. 2006 . Antibiotic resistance of enterococci and related bacteria in an urban wastewater treatment plant . FEMS Microbiol Ecol , 55 : 322 – 329 .
   PubMed Web of Science ®Google Scholar
• De Gelder , L. , Vandecasteele , F. P. , Brown , C. J. , Forney , L. J. and Top , E. M. 2005 . Plasmid donor affects host range of promiscuous IncP-1beta plasmid pB10 in an activated-sludge microbial community . Appl Environ Microb , 71 : 5309 – 5317 .
   PubMed Web of Science ®Google Scholar
• Deshpande , A. D. , Baheti , K. G. and Chatterjee , N. R. 2004 . Degradation of beta-lactam antibiotics . Current Science , 87 : 1684 – 1695 .
   Web of Science ®Google Scholar
• Diaz-Torres , M. L. , McNab , R. , Spratt , D. A. , Villedieu , A. , Hunt , N. Wilson , M. 2003 . Novel tetracycline resistance determinant from the oral metagenome . Antimicrob Agents Ch , 47 : 1430 – 1432 .
   PubMed Web of Science ®Google Scholar
• Dillon , P. , Pavelic , P. , Toze , S. , Ragusa , S. , Wright , M. Peter , P. 1999 . Storing recycled water in an aquifer: Benefits and risks . Water , 26 : 21 – 29 .
   Google Scholar
• Dröge , M. , Pühler , A. and Selbitschka , W. 2000 . Phenotypic and molecular characterization of conjugative antibiotic resistance plasmids isolated from bacterial communities of activated sludge . Molecular and General Genetics , 263 : 471 – 482 .
   PubMedGoogle Scholar
• Enne , V. I. , King , A. , Livermore , D. M. , H and L. M. 2002 . Sulfonamide resistance in Haemophilus influenzae mediated by acquisition of sul2 or a short insertion in chromosomal folP . Antimicrob Agents Chemother , 46 : 1934 – 1939 .
   PubMed Web of Science ®Google Scholar
• Enne , V. I. , Livermore , D. M. , Stephens , P. and Hall , L. M. 2001 . Persistence of sulphonamide resistance in Escherichia coli in the UK despite national prescribing restriction . Lancet , 357 : 1325 – 1328 .
   PubMed Web of Science ®Google Scholar
• Errampalli , D. , Leung , K. , Cassidy , M. B. , Kostrzynska , M. , Blears , M. Lee , H. 1999 . Applications of the green fluorescent protein as a molecular marker in environmental microorganisms . J Microbiol Methods , 35 : 187 – 199 .
   PubMed Web of Science ®Google Scholar
• Espigares , E. , Bueno , A. , Espigares , M. and Galvez , R. 2006 . Isolation of Salmonella serotypes in wastewater and effluent: Effect of treatment and potential risk . Int J Hyg Envir Heal , 209 : 103 – 107 .
   PubMed Web of Science ®Google Scholar
• Falkow , S. 1975 . Infectious multiple drug resistance , London : Pion Ltd .
   Google Scholar
• Fars , S. , Oufdou , K. , Nejmeddine , A. , Hassani , L. , Melloul , A. A. Bousselhaj , K. 2005 . Antibiotic resistance and survival of faecal coliforms in activated sludge system in a semi-arid region (Beni Mellal, Morocco) . World J Microb Biot , 21 : 493 – 500 .
   Web of Science ®Google Scholar
• Fontaine , T. D. III and Hoadley , A. W. 1976 . Transferable drug resistance associated with coliforms isolated from hospital and domestic sewage . Health Lab Sci , 13 : 238 – 245 .
   PubMedGoogle Scholar
• Gallert , C. , Fund , K. and Winter , J. 2005 . Antibiotic resistance of bacteria in raw and biologically treated sewage and in groundwater below leaking sewers . Applied Microbiology and Biotechnology , 69 : 106 – 112 .
   PubMed Web of Science ®Google Scholar
• Garcia , S. , Wade , B. , Bauer , C. , Craig , C. , Nakaoka , K. and Lorowitz , W. 2007 . The effect of wastewater treatment on antibiotic resistance in Escherichia coli and Enterococcus sp . Water Environ Res , 79 : 2387 – 2395 .
   PubMed Web of Science ®Google Scholar
• Gobel , A. , McArdell , C. S. , Joss , A. , Siegrist , H. and Giger , W. 2007 . Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies . Sci Total Environ , 372 : 361 – 371 .
   PubMed Web of Science ®Google Scholar
• Goldstein , C. , Lee , M. D. , Sanchez , S. , Hudson , C. , Phillips , B. Register , B. 2001 . Incidence of class 1 and 2 integrases in clinical and commensal bacteria from livestock, companion animals, and exotics . Antimicrob Agents Chemother , 45 : 723 – 726 .
   PubMed Web of Science ®Google Scholar
• Grabow , W. O. K. and Prozesky , O. W. 1973 . Drug resistance of coliform bacteria in hospital and city sewage . Antimicrob Agents Chemother , 3 : 175 – 180 .
   PubMed Web of Science ®Google Scholar
• Grape , M. 2006 . Molecular basis for trimethoprim and sulphonamide resistance in Gram negative pathogens , Doctoral dissertation, Stockholm: Karolinska Institutet .
   Google Scholar
• Grape , M. , Sundstrom , L. and Kronvall , G. 2003 . Sulphonamide resistance gene sul3 found in Escherichia coli isolates from human sources . J Antimicrob Chemother , 52 : 1022 – 1024 .
   PubMed Web of Science ®Google Scholar
• Guardabassi , L. , Lo Fo Wong , D. M. A. and Dalsgaard , A. 2002 . The effects of tertiary wastewater treatment on the prevalence of antimicrobial resistant bacteria . Water Res , 36 : 1955 – 1964 .
   PubMed Web of Science ®Google Scholar
• Guardabassi , L. , Petersen , A. , Olsen , J. E. and Dalsgaard , A. 1998 . Antibiotic resistance in Acinetobacter spp. isolated from sewers receiving waste effluent from a hospital and a pharmaceutical plant . Appl Environ Microb , 64 : 3499 – 3502 .
   PubMed Web of Science ®Google Scholar
• Hakenbeck , R. , Grebe , T. , Zahner , D. and Stock , J. B. 1999 . Beta-lactam resistance in Streptococcus pneumoniae: Penicillin-binding proteins and nonpenicillin-binding proteins . Mol Microbiol , 33 : 673 – 678 .
   PubMed Web of Science ®Google Scholar
• Hall , R. M. and Collis , C. M. 1995 . Mobile gene cassettes and integrons: Capture and spread of genes by site-specific recombination . Molecular Microbiology , 15 : 593 – 600 .
   PubMed Web of Science ®Google Scholar
• Hassani , L. , Rafouk , L. and Alla , A. A. 1999 . Antibiotic resistance among fecal coliform bacteria isolated from wastewater before and after treatment by an experimental sand filter . World J Microbiol & Biotechnol , 15 : 277 – 279 .
   Web of Science ®Google Scholar
• Hata , M. , Suzuki , M. , Matsumoto , M. , Takahashi , M. , Sato , K. Ibe , S. 2005 . Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b . Antimicrob Agents Chemother , 49 : 801 – 803 .
   PubMed Web of Science ®Google Scholar
• Herman , D. J. and Gerding , D. N. 1991 . Screening and treatment of infections caused by resistant enterococci . Antimicrob Agents Chemother , 35 : 215 – 219 .
   PubMed Web of Science ®Google Scholar
• Hooper , D. C. 2000 . Mechanisms of action and resistance of older and newer fluoroquinolones . Clin Infect Dis , 31 ( Suppl 2 ) : S24 – S28 .
   PubMed Web of Science ®Google Scholar
• Hughes , V. M. and Datta , N. 1983 . Conjugative plasmids in bacteria of the pre-antibiotic era . Nature , 302 ( 5910 ) : 725 – 726 .
   PubMed Web of Science ®Google Scholar
• Huovinen , P. 1987 . Trimethoprim resistance . Antimicrob Agents Chemother , 31 : 1451 – 1456 .
   PubMed Web of Science ®Google Scholar
• Ings , R. M. , McFadzean , J. A. and Ormerod , W. E. 1974 . The mode of action of metronidazole in Trichomonas vaginalis and other micro-organisms . Biochem Pharmacol , 23 : 1421 – 1429 .
   PubMed Web of Science ®Google Scholar
• Iversen , A. , Kuhn , I. , Franklin , A. and Mollby , R. 2002 . High prevalence of vancomycin-resistant enterococci in Swedish sewage . Appl Environ Microb , 68 : 2838 – 2842 .
   PubMed Web of Science ®Google Scholar
• Jones , C. S. , Osborne , D. J. and Stanley , J. 1992 . Enterobacterial tetracycline resistance in relation to plasmid incompatibility . Mol Cell Probes , 6 : 313 – 317 .
   PubMed Web of Science ®Google Scholar
• Joss , A. , Keller , E. , Alder , A. C. , Gobel , A. , McArdell , C. S. Ternes , T. 2005 . Removal of pharmaceuticals and fragrances in biological wastewater treatment . Water Res , 39 : 3139 – 3152 .
   PubMed Web of Science ®Google Scholar
• Karthikeyan , K. G. and Meyer , M. T. 2006 . Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA . Sci Total Environ , 361 ( 1–3 ) : 196 – 207 .
   PubMed Web of Science ®Google Scholar
• Kim , S. and Aga , D. S. 2007 . Potential ecological and human health impacts of antibiotic and antibiotic-resistant bacteria from wastewater treatment plants . J Toxicol Environ Health, Part B , 10 : 559 – 573 .
   PubMed Web of Science ®Google Scholar
• Klare , I. , Konstabel , C. , Badstubner , D. , Werner , G. and Witte , W. 2003 . Occurrence and spread of antibiotic resistances in Enterococcus faecium . Int J Food Microbiol , 88 : 269 – 290 .
   PubMed Web of Science ®Google Scholar
• Knapp , C. W. , Engemann , C. A. , Hanson , M. L. , Keen , P. L. , Hall , K. J. and Graham , D. W. 2008 . Indirect evidence of transposon-mediated selection of antibiotic resistance genes in aquatic systems at low-level oxytetracycline exposures . Environ Sci Technol , 42 : 5348 – 5353 .
   PubMed Web of Science ®Google Scholar
• Kümmerer , K. , Helmers , E. , Hubner , P. , Mascart , G. , Milandri , M. Reinthaler , F. 1999 . European hospitals as a source for platinum in the environment in comparison with other sources . Sci Total Environ , 225 : 155 – 165 .
   PubMed Web of Science ®Google Scholar
• Launay , F. M. , Young , P. B. , Sterk , S. S. , Blokland , M. H. and Kennedy , D. G. 2004 . Confirmatory assay for zeranol, taleranol and the Fusarium spp. toxins in bovine urine using liquid chromatography-tandem mass spectrometry . Food Addit Contam , 21 : 52 – 62 .
   PubMed Web of Science ®Google Scholar
• Lawrence , J. G. and Ochman , H. 1998 . Molecular archaeology of the Escherichia coli genome . PNAS , 95 : 9413 – 9417 .
   PubMed Web of Science ®Google Scholar
• Leclercq , R. and Courvalin , P. 1991a . Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification . Antimicrob Agents Chemother , 35 : 1267 – 1272 .
   PubMed Web of Science ®Google Scholar
• Leclercq , R. and Courvalin , P. 1991b . Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria . Antimicrob Agents Chemother , 35 : 1273 – 1276 .
   PubMed Web of Science ®Google Scholar
• Leclercq , R. and Courvalin , P. 1997 . Resistance to glycopeptides in enterococci . Clin Infect Dis , 24 : 545 – 554 .
   PubMed Web of Science ®Google Scholar
• Leff , L. G. , Vaun McArthur , J. and Shimkets , L. J. 1993 . Spatial and temporal variability of antibiotic resistance in freshwater bacterial assemblages . FEMS Microbiol Ecol , 13 : 135 – 143 .
   Web of Science ®Google Scholar
• Levy , S. and Miller , R. 1989 . Gene transfer in the environment , New York : McGraw-Hill .
   Google Scholar
• Levy , S. B. , Marshall , B. , Schluederberg , S. , Rowse , D. and Davis , J. 1988 . High frequency of antimicrobial resistance in human fecal flora . Antimicrob Agents Chemother , 32 : 1801 – 1806 .
   PubMed Web of Science ®Google Scholar
• Liebl , W. , Kloos , W. E. and Ludwig , W. 2002 . Plasmid-borne macrolide resistance in Micrococcus luteus . Microbiology , 148 : 2479 – 2487 .
   PubMed Web of Science ®Google Scholar
• Lindberg , R. H. , Wennberg , P. , Johansson , M. I. , Tysklind , M. and Andersson , B. A. V. 2005 . Screening of human antibiotic substances and determination of weekly mass flows in five sewage treatment plants in Sweden . Environ Sci Technol , 39 : 3421 – 3429 .
   PubMed Web of Science ®Google Scholar
• Linton , K. B. , Richmond , M. H. , Bevan , R. and Gillespie , W. A. 1974 . Antibiotic resistance and R factors in coliform bacilli isolated from hospital and domestic sewage . J Med Microbiol , 7 : 91 – 103 .
   PubMed Web of Science ®Google Scholar
• Livermore , D. M. 1995 . Beta-lactamases in laboratory and clinical resistance . Clin Microbiol Rev , 8 : 557 – 584 .
   PubMed Web of Science ®Google Scholar
• Lopez , P. , Espinosa , M. , Greenberg , B. and Lacks , S. A. 1987 . Sulfonamide resistance in Streptococcus pneumoniae: DNA sequence of the gene encoding dihydropteroate synthase and characterization of the enzyme . J Bacteriol , 169 : 4320 – 4326 .
   PubMed Web of Science ®Google Scholar
• Luna , V. A. , Coates , P. , Eady , E. A. , Cove , J. H. , Nguyen , T. T. and Roberts , M. C. 1999 . A variety of gram-positive bacteria carry mobile mef genes . J Antimicrob Chemother , 44 : 19 – 25 .
   PubMed Web of Science ®Google Scholar
• Ma , D. , Cook , D. N. , Alberti , M. , Pon , N. G. , Nikaido , H. and Hearst , J. E. 1995 . Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli . Molecular Microbiology , 16 : 45 – 55 .
   PubMed Web of Science ®Google Scholar
• Mach , P. A. and Grimes , D. J. 1982 . R-plasmid transfer in a wastewater treatment plant . Appl Environ Microb , 44 : 1395 – 1403 .
   PubMed Web of Science ®Google Scholar
• Maiques , E. , Ubeda , C. , Campoy , S. , Salvador , N. , Lasa , I. Novick , R. P. 2006 . beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus . J Bacteriol , 188 : 2726 – 2729 .
   PubMed Web of Science ®Google Scholar
• Marcinek , H. , Wirth , R. , Muscholl-Silberhorn , A. and Gauer , M. 1998 . Enterococcus faecalis gene transfer under natural conditions in municipal sewage water treatment plants . Appl Environ Microbiol , 64 : 626 – 632 .
   PubMed Web of Science ®Google Scholar
• Martinez-Martinez , L. , Pascual , A. , Garcia , I. , Tran , J. and Jacoby , G. A. 2003 . Interaction of plasmid and host quinolone resistance . J Antimicrob Chemother , 51 : 1037 – 1039 .
   PubMed Web of Science ®Google Scholar
• Martinez-Martinez , L. , Pascual , A. and Jacoby , G. A. 1998 . Quinolone resistance from a transferable plasmid . Lancet , 351 : 797 – 799 .
   PubMed Web of Science ®Google Scholar
• Martins da Costa , P. , Vaz-Pires , P. and Bernardo , F. 2006 . Antimicrobial resistance in Enterococcus spp. isolated in inflow, effluent and sludge from municipal sewage water treatment plants . Water Res , 40 : 1735 – 1740 .
   PubMed Web of Science ®Google Scholar
• Masters , P. A. , O’Bryan , T. A. , Zurlo , J. , Miller , D. Q. and Joshi , N. 2003 . Trimethoprim-sulfamethoxazole revisited . Arch Intern Med , 163 : 402 – 410 .
   PubMed Web of Science ®Google Scholar
• Mazel , D. 2006 . Integrons: Agents of bacterial evolution . Nature Reviews Microbiology , 4 : 608 – 620 .
   PubMed Web of Science ®Google Scholar
• Mazel , D. and Davies , J. 1999 . Antibiotic resistance in microbes . Cell Mol Life Sci , 56 : 742 – 754 .
   PubMed Web of Science ®Google Scholar
• McMurry , L. M. , McDermott , P. F. and Levy , S. B. 1999 . Genetic evidence that InhA of mycobacterium smegmatis is a target for triclosan . Antimicrob Agents Chemother , 43 : 711 – 713 .
   PubMed Web of Science ®Google Scholar
• Mills , W. R. , Bradford , S. M. , Rigby , M. and Wehner , M. P. 1998 . “ Groundwater recharge at the Orange County water district ” . In Wastewater reclamation and reuse , Edited by: Asano , T. 1105 – 1142 . Lancaster, PA : Technomic .
   Google Scholar
• Moore , R. A. , DeShazer , D. , Reckseidler , S. , Weissman , A. and Woods , D. E. 1999 . Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei . Antimicrob Agents Chemother , 43 : 465 – 470 .
   PubMed Web of Science ®Google Scholar
• Narikawa , S. 1986 . Distribution of metronidazole susceptibility factors in obligate anaerobes . J Antimicrob Chemother , 18 : 565 – 574 .
   PubMed Web of Science ®Google Scholar
• Nielsen , P. H. 2002 . The activated sludge floc , Chichester, , England : Wiley .
   Google Scholar
• Niemi , M. , Sibakov , M. and Niemela , S. 1983 . Antibiotic resistance among different species of fecal coliforms isolated from water samples . Appl Environ Microbiol , 45 : 79 – 83 .
   PubMed Web of Science ®Google Scholar
• Nikaido , H. 1994 . Prevention of drug access to bacterial targets: Permeability barriers and active efflux . Science , 264 ( 5157 ) : 382 – 388 .
   PubMed Web of Science ®Google Scholar
• Nonaka , L. and Suzuki , S. 2002 . New Mg2+-dependent oxytetracycline resistance determinant Tet 34 in Vibrio isolates from marine fish intestinal contents . Antimicrob Agents Ch , 46 : 1550 – 1552 .
   PubMed Web of Science ®Google Scholar
• Nordmann , P. and Poirel , L. 2005 . Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae . J Antimicrob Chemother , 56 : 463 – 469 .
   PubMed Web of Science ®Google Scholar
• Novais , C. , Coque , T. M. , Ferreira , H. , Sousa , J. C. and Peixe , L. 2005 . Environmental contamination with vancomycin-resistant enterococci from hospital sewage in Portugal . Appl Environ Microbiol , 71 : 3364 – 3368 .
   PubMed Web of Science ®Google Scholar
• Ochman , H. , Lawrence , J. G. and Groisman , E. A. 2000 . Lateral gene transfer and the nature of bacterial innovation . Nature , 405 ( 6784 ) : 299 – 304 .
   PubMed Web of Science ®Google Scholar
• Patel , S. J. , Larson , E. L. , Kubin , C. J. and Saiman , L. 2007 . A review of antimicrobial control strategies in hospitalized and ambulatory pediatric populations . Pediatr Infect Dis J , 26 : 531 – 537 .
   PubMed Web of Science ®Google Scholar
• Phillips , I. 2007 . Withdrawal of growth-promoting antibiotics in Europe and its effects in relation to human health . Int J Antimicrob Agents , 30 : 101 – 107 .
   PubMed Web of Science ®Google Scholar
• Phillips , I. , Casewell , M. , Cox , T. , De Groot , B. , Friis , C. Jones , R. 2004 . Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data . J Antimicrob Chemoth , 53 : 28 – 52 .
   PubMed Web of Science ®Google Scholar
• Poole , K. 2000 . Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria . Antimicrob Agents Chemother , 44 : 2233 – 2241 .
   PubMed Web of Science ®Google Scholar
• Poole , K. 2002 . Mechanisms of bacterial biocide and antibiotic resistance . J Appl Microbiol , 92 ( S1 ) : 55S – 64S .
   PubMed Web of Science ®Google Scholar
• Powell , S. J. , Macleod , I. , Wilmot , A. J. and Elsdon-Dew , R. 1966 . Metronidazole in amoebic dysentery and amoebic liver abscess . Lancet , 288 ( 7477 ) : 1329 – 1331 .
   Web of Science ®Google Scholar
• Quon , D. V. K. , d’Oliveira , C. E. and Johnson , P. J. 1992 . Reduced transcription of the Ferredoxin gene in metronidazole-resistant Trichomonas vaginalis . PNAS , 89 : 4402 – 4406 .
   PubMed Web of Science ®Google Scholar
• Radström , P. and Swedberg , G. 1988 . RSF1010 and a conjugative plasmid contain sulII, one of two known genes for plasmid-borne sulfonamide resistance dihydropteroate synthase . Antimicrob Agents Chemother , 32 : 1684 – 1692 .
   PubMed Web of Science ®Google Scholar
• Recchia , G. D. and Hall , R. M. 1995 . Gene cassettes: A new class of mobile element . Microbiology , 141 : 3015 – 3027 .
   PubMed Web of Science ®Google Scholar
• Ridenhour , M. B. , Fletcher , H. M. , Mortensen , J. E. and Daneo-Moore , L. 1996 . A novel tetracycline-resistant determinant, tet(U), is encoded on the plasmid pKq10 in Enterococcus faecium . Plasmid , 35 : 71 – 80 .
   PubMed Web of Science ®Google Scholar
• Roberts , M. C. 2005 . Update on acquired tetracycline resistance genes . Fems Microbiol Lett , 245 : 195 – 203 .
   PubMed Web of Science ®Google Scholar
• Ross , J. I. , Eady , E. A. , Cove , J. H. and Cunliffe , W. J. 1998 . 16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium . Antimicrob Agents Chemother , 42 : 1702 – 1705 .
   PubMed Web of Science ®Google Scholar
• Schafer , A. , Kalinowski , J. and Puhler , A. 1994 . Increased fertility of corynebacterium-glutamicum recipients in intergeneric matings with Escherichia-coli after stress exposure . App Environ Microbiol , 60 : 756 – 759 .
   PubMed Web of Science ®Google Scholar
• Schluter , A. , Heuer , H. , Szczepanowski , R. , Forney , L. J. , Thomas , C. M. Puhler , A. 2003 . The 64 508 bp IncP-1 beta antibiotic multiresistance plasmid pB10 isolated from a waste-water treatment plant provides evidence for recombination between members of different branches of the IncP-1 beta group . Microbiology-Sgm , 149 : 3139 – 3153 .
   PubMed Web of Science ®Google Scholar
• Schluter , A. , Krause , L. , Szczepanowski , R. , Goesmann , A. and Puhler , A. 2008 . Genetic diversity and composition of a plasmid metagenome from a wastewater treatment plant . J Biotechnol , 136 ( 1-2 ) : 65 – 76 .
   PubMed Web of Science ®Google Scholar
• Schluter , A. , Szczepanowski , R. , Puhler , A. and Top , E. M. 2007 . Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool . FEMS Microbiol Rev , 31 : 449 – 477 .
   PubMed Web of Science ®Google Scholar
• Schneider , J. 1961 . Treatment of giardiasis (lambliasis) by metronidazole . Bull Soc Pathol Exot Filiales , 54 : 84 – 95 .
   PubMedGoogle Scholar
• Schwarz , S. , Cardoso , M. and Wegener , H. C. 1992 . Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance determinant encoded by plasmid pSTE1 from Staphylococcus hyicus . Antimicrob Agents Chemother , 36 : 580 – 588 .
   PubMed Web of Science ®Google Scholar
• Singleton , P. and Anson , A. E. 1981 . Conjugal transfer of R-plasmid R1drd-19 in Escherichia coli below 22°C . Appl Environ Microbiol , 42 : 789 – 791 .
   PubMed Web of Science ®Google Scholar
• Soda , S. , Otsuki , H. , Inoue , D. , Tsutsui , H. , Sei , K. and Ike , M. 2008 . Transfer of antibiotic multiresistant plasmid RP4 from Escherichia coli to activated sludge bacteria . J Biosci Bioengin , 106 : 292 – 296 .
   PubMed Web of Science ®Google Scholar
• Speer , B. S. , Bedzyk , L. and Salyers , A. A. 1991 . Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductase . J Bacteriol , 173 : 176 – 183 .
   PubMed Web of Science ®Google Scholar
• Stelzer , W. and Ziegert , E. 1988 . The occurrence of antibiotic resistant coliforms in the waste water of a water treatment plant . Zentralbl Mikrobiol , 143 : 415 – 423 .
   PubMedGoogle Scholar
• Stokes , H. W. and Hall , R. M. 1989 . A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: Integrons . Molec Microbiol , 3 : 1669 – 1683 .
   PubMed Web of Science ®Google Scholar
• Summers , A. O. , Wireman , J. , Vimy , M. J. , Lorscheider , F. L. , Marshall , B. Levy , S. B. 1993 . Mercury released from dental “silver” fillings provokes an increase in mercury- and antibiotic-resistant bacteria in oral and intestinal floras of primates . Antimicrob Agents Chemother , 37 : 825 – 834 .
   PubMed Web of Science ®Google Scholar
• Swedberg , G. , Fermer , C. and Skold , O. 1993 . Point mutations in the dihydropteroate synthase gene causing sulfonamide resistance . Adv Exp Med Biol , 338 : 555 – 558 .
   PubMedGoogle Scholar
• Szczepanowski , R. , Bekel , T. , Goesmann , A. , Krause , L. , Kromeke , H. Kaiser , O. 2008 . Insight into the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to antimicrobial drugs analysed by the 454-pyrosequencing technology . J Biotechnol , 136 ( 1-2 ) : 54 – 64 .
   PubMed Web of Science ®Google Scholar
• Szczepanowski , R. , Braun , S. , Riedel , V. , Schneiker , S. , Krahn , I. Puhler , A. 2005 . The 120 592 bp lncF plasmid pRSB107 isolated from a sewage-treatment plant encodes nine different anti biotic-resistance determinants, two iron-acquisition systems and other putative virulence-associated functions . Microbiology-Sgm , 151 : 1095 – 1111 .
   PubMed Web of Science ®Google Scholar
• Szczepanowski , R. , Krahn , I. , Linke , B. , Goesmann , A. , Puhler , A. and Schluter , A. 2004a . Antibiotic multiresistance plasmid pRSB101 isolated from a wastewater treatment plant is related to plasmids residing in phytopathogenic bacteria and carries eight different resistance determinants including a multidrug transport system . Microbiology , 150 : 3613 – 3630 .
   PubMed Web of Science ®Google Scholar
• Szczepanowski , R. , Krahn , I. , Puhler , A. and Schluter , A. 2004b . Different molecular rearrangements in the integron of the IncP-1 beta resistance plasmid pB10 isolated from a wastewater treatment plant result in elevated beta-lactam resistance levels . Arch Microbiol , 182 : 429 – 435 .
   PubMed Web of Science ®Google Scholar
• Szpirer , C. , Top , E. , Couturier , M. and Mergeay , M. 1999 . Retrotransfer or gene capture: a feature of conjugative plasmids, with ecological and evolutionary significance . Microbiology , 145 : 3321 – 3329 .
   PubMed Web of Science ®Google Scholar
• Tauch , A. , Gotker , S. , Puhler , A. , Kalinowski , J. and Thierbach , G. 2002 . The 27.8-kb R-plasmid pTET3 from Corynebacterium glutamicum encodes the aminoglycoside adenyltransferase gene cassette aadA9 and the regulated tetracycline efflux system Tet 33 flanked by active copies of the widespread insertion sequence IS6100 . Plasmid , 48 : 117 – 129 .
   PubMed Web of Science ®Google Scholar
• Theron , M. M. , Janse van Rensburg , M. N. and Chalkley , L. J. 2004 . Nitroimidazole resistance genes (nimB) in anaerobic Gram-positive cocci (previously Peptostreptococcus spp.) . J Antimicrob Chemother , 54 : 240 – 242 .
   PubMed Web of Science ®Google Scholar
• Thomas , C. M. 2000 . The horizontal gene pool: Bacterial plasmids and gene spread , Amsterdam : Harwood academic Publishers .
   Google Scholar
• Todar , K. 2002 . “ Antimicrobial agents used in treatment of infectious disease ” . Edited by: Todar , K. Todars Online Textbook of Bacteriology .
   Google Scholar
• Top , E. , Desmet , I. , Verstraete , W. , Dijkmans , R. and Mergeay , M. 1994 . Exogenous isolation of mobilizing plasmids from polluted soils and sludges . Appl Environ Microb , 60 : 831 – 839 .
   PubMed Web of Science ®Google Scholar
• Tran , J. H. and Jacoby , G. A. 2002 . Mechanism of plasmid-mediated quinolone resistance . PNAS , 99 : 5638 – 5642 .
   PubMed Web of Science ®Google Scholar
• Tran , J. H. , Jacoby , G. A. and Hooper , D. C. 2005 . Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase . Antimicrob Agents Chemother , 49 : 118 – 125 .
   PubMed Web of Science ®Google Scholar
• Upcroft , J. A. , Campbell , R. W. , Benakli , K. , Upcroft , P. and Vanelle , P. 1999 . Efficacy of new 5-nitroimidazoles against metronidazole-susceptible and resistant Giardia, Trichomonas, and Entamoeba spp . Antimicrob Agents Chemother , 43 : 73 – 76 .
   PubMed Web of Science ®Google Scholar
• Van Essen-Zandbergen , A. , Smith , H. , Veldman , K. and Mevius , D. 2007 . Occurrence and characteristics of class 1, 2 and 3 integrons in Escherichia coli, Salmonella and Campylobacter spp. in the Netherlands . J Antimicrob Chemother , 59 : 746 – 750 .
   PubMed Web of Science ®Google Scholar
• Wagner , M. , Amann , R. , Lemmer , H. and Schleifer , K. H. 1993 . Probing activated-sludge with oligonucleotides specific for Proteobacteria—inadequacy of culture-dependent methods for describing microbial community structure . Appl Environ Microb , 59 : 1520 – 1525 .
   PubMed Web of Science ®Google Scholar
• Wang , M. G. , Sahm , D. F. , Jacoby , G. A. and Hooper , D. C. 2004 . Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States . Antimicrob Agents Ch , 48 : 1295 – 1299 .
   PubMed Web of Science ®Google Scholar
• Wright , M. S. , Baker-Austin , C. , Lindell , A. H. , Stepanauskas , R. , Stokes , H. W. and McArthur , J. V. 2008 . Influence of industrial contamination on mobile genetic elements: Class 1 integron abundance and gene cassette structure in aquatic bacterial communities . Isme J , 2 : 417 – 428 .
   PubMed Web of Science ®Google Scholar
• Ziglam , H. M. and Finch , R. G. 2001 . Limitations of presently available glycopeptides in the treatment of Gram-positive infection . Clin Microbiol Infec , 7 ( S4 ) : 53 – 65 .
   PubMedGoogle Scholar