Critical review of ARGs reduction behavior in various sludge and sewage treatment processes in wastewater treatment plants

References

• Ahmed, M. B., Zhou, J. L., Ngo, H. H., Guo, W., Thomaidis, N. S., & Xu, J. (2017). Progress in the biological and chemical treatment technologies for emerging contaminant removal from wastewater: A critical review. Journal of Hazardous Materials, 323(Pt A), 274–298. doi: 10.1016/j.jhazmat.2016.04.045
   PubMedGoogle Scholar
• Alexander, J., Knopp, G., Dötsch, A., Wieland, A., & Schwartz, T. (2016). Ozone treatment of conditioned wastewater selects antibiotic resistance genes, opportunistic bacteria, and induce strong population shifts. Science of the Total Environment, 559, 103–112. doi: 10.1016/j.scitotenv.2016.03.154
   PubMed Web of Science ®Google Scholar
• Allen, H. K., Donato, J., Wang, H. H., Cloud-Hansen, K. A., Davies, J., & Handelsman, J. (2010). Call of the wild: Antibiotic resistance genes in natural environments. Nature Reviews Microbiology, 8(4), 251–259. doi: 10.1038/nrmicro2312
   PubMed Web of Science ®Google Scholar
• Alrousan, D. M., Dunlop, P. S., Mcmurray, T. A., & Byrne, J. A. (2009). Photocatalytic inactivation of E. coli in surface water using immobilised nanoparticle TiO2 films. Water Research, 43(1), 47–54. doi: 10.1016/j.watres.2008.10.015
   PubMed Web of Science ®Google Scholar
• Auerbach, E. A., Seyfried, E. E., & Mcmahon, K. D. (2007). Tetracycline resistance genes in activated sludge wastewater treatment plants. Water Research, 41(5), 1143–1151. doi: 10.1016/j.watres.2006.11.045
   PubMed Web of Science ®Google Scholar
• Aydin, S., Ince, B., & Ince, O. (2016). Assessment of anaerobic bacterial diversity and its effects on anaerobic system stability and the occurrence of antibiotic resistance genes. Bioresource Technology, 207, 332–338. doi: 10.1016/j.biortech.2016.01.080
   PubMed Web of Science ®Google Scholar
• Baquero, F., Martínez, J. L., & Cantón, R. (2008). Antibiotics and antibiotic resistance in water environments. Current Opinion in Biotechnology, 19(3), 260–265. doi: 10.1016/j.copbio.2008.05.006
   PubMed Web of Science ®Google Scholar
• Baran, W., Adamek, E., Ziemiańska, J., & Sobczak, A. (2011). Effects of the presence of sulfonamides in the environment and their influence on human health. Journal of Hazardous Materials, 196, 1–15. doi: 10.1016/j.jhazmat.2011.08.082
   PubMed Web of Science ®Google Scholar
• Barancheshme, F., & Munir, M. (2017). Strategies to combat antibiotic resistance in the wastewater treatment plants. Front Microbiology, 8, 2603.
   PubMed Web of Science ®Google Scholar
• Batt, A. L., Kim, S., & Aga, D. S. (2007). Comparison of the occurrence of antibiotics in four full-scale wastewater treatment plants with varying designs and operations. Chemosphere, 68(3), 428–435. doi: 10.1016/j.chemosphere.2007.01.008
   PubMed Web of Science ®Google Scholar
• Beaber, J. W., Hochhut, B., & Waldor, M. K. (2004). SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature, 427(6969), 72–74. doi: 10.1038/nature02241
   PubMed Web of Science ®Google Scholar
• Ben, W., Qiang, Z., Adams, C., Zhang, H., & Chen, L. (2008). Simultaneous determination of sulfonamides, tetracyclines and tiamulin in swine wastewater by solid-phase extraction and liquid chromatography-mass spectrometry. Journal of Chromatography A, 1202(2), 173–180. doi: 10.1016/j.chroma.2008.07.014
   PubMed Web of Science ®Google Scholar
• Bosshard, F., Bucheli, M., Meur, Y., & Egli, T. (2010). The respiratory chain is the cell's Achilles' heel during UVA inactivation in Escherichia coli. Microbiology (Reading, England)), 156(Pt 7), 2006–2015. doi: 10.1099/mic.0.038471-0
   PubMedGoogle Scholar
• Bouki, C., Venieri, D., & Diamadopoulos, E. (2013). Detection and fate of antibiotic resistant bacteria in wastewater treatment plants: A review. Ecotoxicology and Environmental Safety, 91(4), 1–9. doi: 10.1016/j.ecoenv.2013.01.016
   PubMedGoogle Scholar
• Breazeal, M. V., Novak, J. T., Vikesland, P. J., & Pruden, A. (2013). Effect of wastewater colloids on membrane removal of antibiotic resistance genes. Water Research, 47(1), 130–140. doi: 10.1016/j.watres.2012.09.044
   PubMed Web of Science ®Google Scholar
• Burch, T. R., Sadowsky, M. J., & LaPara, T. M. (2013a). Aerobic digestion reduces the quantity of antibiotic resistance genes in residual municipal wastewater solids. Front Microbiology, 4(4), 17.
   PubMedGoogle Scholar
• Burch, T. R., Sadowsky, M. J., & LaPara, T. M. (2013b). Air-drying beds reduce the quantities of antibiotic resistance genes and class 1 integrons in residual municipal wastewater solids. Environmental Science & Technology, 47(17), 9965–9971. doi: 10.1021/es4024749
   PubMed Web of Science ®Google Scholar
• Burch, T. R., Sadowsky, M. J., & LaPara, T. M. (2017). Effect of different treatment technologies on the fate of antibiotic resistance genes and class 1 Integrons when residual municipal wastewater solids are applied to Soil. Environmental Science & Technology, 51(24), 14225–14232. doi: 10.1021/acs.est.7b04760
   PubMed Web of Science ®Google Scholar
• Burch, T. R., Sadowsky, M. J., & LaPara, T. M. (2014). Fate of antibiotic resistance genes and class 1 integrons in soil microcosms following the application of treated residual municipal wastewater solids. Environmental Science & Technology, 48(10), 5620–5627. doi: 10.1021/es501098g
   PubMed Web of Science ®Google Scholar
• Burch, T. R., Sadowsky, M. J., & LaPara, T. M. (2016). Modeling the fate of antibiotic resistance genes and class 1 integrons during thermophilic anaerobic digestion of municipal wastewater solids. Applied Microbiology and Biotechnology, 100(3), 1437–1444. doi: 10.1007/s00253-015-7043-x
   PubMed Web of Science ®Google Scholar
• Calero-Cáceres, W., Melgarejo, A., Colomer-Lluch, M., Stoll, C., Lucena, F., Jofre, J., & Muniesa, M. (2014). Sludge as a potential important source of antibiotic resistance genes in both the bacterial and bacteriophage fractions. Environmental Science & Technology, 48(13), 7602–7611. doi: 10.1021/es501851s
   PubMed Web of Science ®Google Scholar
• Calerocáceres, W., & Muniesa, M. (2016). Persistence of naturally occurring antibiotic resistance genes in the bacteria and bacteriophage fractions of wastewater. Water Research, 95, 11–18. doi: 10.1016/j.watres.2016.03.006
   PubMed Web of Science ®Google Scholar
• Cano, R., Nielfa, A., & Fdz-Polanco, M. (2014). Thermal hydrolysis integration in the anaerobic digestion process of different solid wastes: Energy and economic feasibility study. Bioresource Technology, 168(3), 14–22. doi: 10.1016/j.biortech.2014.02.007
   PubMedGoogle Scholar
• Carattoli, A. (2013). Plasmids and the spread of resistance. International Journal of Medical Microbiology: Ijmm, 303(6-7), 298–304. doi: 10.1016/j.ijmm.2013.02.001
   PubMed Web of Science ®Google Scholar
• Carey, D. E., Zitomer, D. H., Kappell, A. D., Choi, M. J., Hristova, K. R., & Mcnamara, P. J. (2016). Chronic exposure to triclosan sustains microbial community shifts and alters antibiotic resistance gene levels in anaerobic digesters. Environmental Science: Processes & Impacts, 18(8), 1060–1067. doi: 10.1039/C6EM00282J
   PubMed Web of Science ®Google Scholar
• Chen, H., & Zhang, M. (2013). Effects of advanced treatment systems on the removal of antibiotic resistance genes in wastewater treatment plants from Hangzhou, China. Environmental Science & Technology, 47(15), 8157–8163.
   PubMed Web of Science ®Google Scholar
• Chen, J., Ying, G. G., Wei, X. D., Liu, Y. S., Liu, S. S., Hu, L. X., … Yang, Y. Q. (2016). Removal of antibiotics and antibiotic resistance genes from domestic sewage by constructed wetlands: Effect of flow configuration and plant species. Science of the Total Environment, 571, 974–982. doi: 10.1016/j.scitotenv.2016.07.085
   PubMed Web of Science ®Google Scholar
• Chen, J., Yu, Z., Michel, F. C., Wittum, T., & Morrison, M. (2007). Development and application of real-time PCR assays for quantification of erm genes conferring resistance to macrolides-lincosamides-streptogramin B in livestock manure and manure management systems. Applied and Environmental Microbiology, 73(14), 4407–4416. doi: 10.1128/AEM.02799-06
   PubMed Web of Science ®Google Scholar
• Chi, Y., Li, Y., Fei, X., Wang, S., & Yuan, H. (2011). Enhancement of thermophilic anaerobic digestion of thickened waste activated sludge by combined microwave and alkaline pretreatment. Journal of Environmental Science, 23(8), 1257–1265. doi: 10.1016/S1001-0742(10)60561-X
   Google Scholar
• Cho, M., Kim, J., Kim, J. Y., Yoon, J., & Kim, J. H. (2010). Mechanisms of Escherichia coli inactivation by several disinfectants. Water Research, 44(11), 3410–3418. doi: 10.1016/j.watres.2010.03.017
   PubMed Web of Science ®Google Scholar
• Christgen, B., Yang, Y., Ahammad, S. Z., Li, B., Rodriquez, D. C., Zhang, T., & Graham, D. W. (2015). Metagenomics shows that low-energy anaerobic-aerobic treatment reactors reduce antibiotic resistance gene levels from domestic wastewater. Environmental Science & Technology, 49(4), 2577–2584. doi: 10.1021/es505521w
   PubMed Web of Science ®Google Scholar
• Daghrir, R., & Drogui, P. (2013). Tetracycline antibiotics in the environment: A review. Environmental Chemistry Letters, 11(3), 209–227. doi: 10.1007/s10311-013-0404-8
   Web of Science ®Google Scholar
• Dang, B., Mao, D., Xu, Y., & Luo, Y. (2017). Conjugative multi-resistant plasmids in Haihe River and their impacts on the abundance and spatial distribution of antibiotic resistance genes. Water Research, 111, 81–91. doi: 10.1016/j.watres.2016.12.046
   PubMed Web of Science ®Google Scholar
• Diao, H. F., Li, X. Y., Gu, J. D., Shi, H. C., & Xie, Z. M. (2004). Electron microscopic investigation of the bactericidal action of electrochemical disinfection in comparison with chlorination, ozonation and Fenton reaction. Process Biochemistry, 39(11), 1421–1426. doi: 10.1016/S0032-9592(03)00274-7
   Web of Science ®Google Scholar
• Diehl, D. L., & LaPara, T. M. (2010). Effect of temperature on the fate of genes encoding tetracycline resistance and the integrase of class 1 integrons within anaerobic and aerobic digesters treating municipal wastewater solids. Environmental Science & Technology, 44(23), 9128–9133. doi: 10.1021/es102765a
   PubMed Web of Science ®Google Scholar
• Dodd, M. C. (2012). Potential impacts of disinfection processes on elimination and deactivation of antibiotic resistance genes during water and wastewater treatment. Journal of Environmental Monitoring, 14(7), 1754. doi: 10.1039/c2em00006g
   PubMedGoogle Scholar
• Du, J., Geng, J., Ren, H., Ding, L., Xu, K., & Zhang, Y. (2015). Variation of antibiotic resistance genes in municipal wastewater treatment plant with A(2)O-MBR system. Environmental Science and Pollution Research, 22(5), 3715–3726. doi: 10.1007/s11356-014-3552-x
   PubMed Web of Science ®Google Scholar
• Dunford, R., Salinaro, A., Cai, L., Serpone, N., Horikoshi, S., Hidaka, H., & Knowland, J. (1997). Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients. FEBS Letters, 418(1–2), 87–90. doi: 10.1016/S0014-5793(97)01356-2
   PubMed Web of Science ®Google Scholar
• Eischeid, A. C., Meyer, J. N., & Linden, K. G. (2009). UV disinfection of adenoviruses: molecular indications of DNA damage efficiency. Applied and Environmental Microbiology, 75(1), 23–28. doi: 10.1128/AEM.02199-08
   PubMed Web of Science ®Google Scholar
• Fang, H., Zhang, Q., Nie, X., Chen, B., Xiao, Y., Zhou, Q., … Liang, X. (2017). Occurrence and elimination of antibiotic resistance genes in a long-term operation integrated surface flow constructed wetland. Chemosphere, 173, 99–106. doi: 10.1016/j.chemosphere.2017.01.027
   PubMed Web of Science ®Google Scholar
• Feng, L., Luo, J., & Chen, Y. (2015). Dilemma of sewage sludge treatment and disposal in China. Environmental Science &Amp; Technology, 49(8), 4781–4782. doi: 10.1021/acs.est.5b01455
   PubMed Web of Science ®Google Scholar
• Ferro, G., Fiorentino, A., Alferez, M. C., Polo-López, M. I., Rizzo, L., & Fernández-Ibáñez, P. (2015). Urban wastewater disinfection for agricultural reuse: Effect of solar driven AOPs in the inactivation of a multidrug resistant E. coli strain. Applied Catalysis B, 178(Pt 3), 65–73. doi: 10.1016/j.apcatb.2014.10.043
   Google Scholar
• Ferro, G., Guarino, F., Castiglione, S., & Rizzo, L. (2016). Antibiotic resistance spread potential in urban wastewater effluents disinfected by UV/H2O2 process. Science of the Total Environment, 560–561, 29–35. doi: 10.1016/j.scitotenv.2016.04.047
   PubMed Web of Science ®Google Scholar
• Ferro, G., Guarino, F., Cicatelli, A., & Rizzo, L. (2017). β-lactams resistance gene quantification in an antibiotic resistant Escherichia coli water suspension treated by advanced oxidation with UV/H2O2. Journal of Hazardous Materials, 323, 426–433. doi: 10.1016/j.jhazmat.2016.03.014
   PubMed Web of Science ®Google Scholar
• Fiorentino, A., Ferro, G., Alferez, M. C., Polo-López, M. I., Fernández-Ibañez, P., & Rizzo, L. (2015). Inactivation and regrowth of multidrug resistant bacteria in urban wastewater after disinfection by solar-driven and chlorination processes. Journal of Photochemistry and Photobiology B, 148, 43–50. doi: 10.1016/j.jphotobiol.2015.03.029
   PubMed Web of Science ®Google Scholar
• Gallert, C., Fund, K., & Winter, J. (2005). Antibiotic resistance of bacteria in raw and biologically treated sewage and in groundwater below leaking sewers. Applied Microbiology and Biotechnology, 69(1), 106–112. doi: 10.1007/s00253-005-0033-7
   PubMed Web of Science ®Google Scholar
• Gao, L., Shi, Y., Li, W., Niu, H., Liu, J., & Cai, Y. (2012). Occurrence of antibiotics in eight sewage treatment plants in Beijing, China. Chemosphere, 86(6), 665–671. doi: 10.1016/j.chemosphere.2011.11.019
   PubMed Web of Science ®Google Scholar
• Gao, P., Gu, C., Wei, X., Li, X., Chen, H., Jia, H., … Ma, C. (2017). The role of zero valent iron on the fate of tetracycline resistance genes and class 1 integrons during thermophilic anaerobic co-digestion of waste sludge and kitchen waste. Water Research, 111, 92–99. doi: 10.1016/j.watres.2016.12.047
   PubMed Web of Science ®Google Scholar
• Gao, P., Munir, M., & Xagoraraki, I. (2012). Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant. Science of the Total Environment, 421–422(3), 173–183. doi: 10.1016/j.scitotenv.2012.01.061
   PubMedGoogle Scholar
• Ghosh, S., Ramsden, S. J., & LaPara, T. M. (2009). The role of anaerobic digestion in controlling the release of tetracycline resistance genes and class 1 integrons from municipal wastewater treatment plants. Applied Microbiology and Biotechnology, 84(4), 791–796. doi: 10.1007/s00253-009-2125-2
   PubMed Web of Science ®Google Scholar
• Gu, C., & Karthikeyan, K. G. (2005). Interaction of tetracycline with aluminum and iron hydrous oxides. Environmental Science &Amp; Technology, 39(8), 2660–2667.
   PubMed Web of Science ®Google Scholar
• Guardabassi, L., Wong, D. M. A. L. F., & Dalsgaard, A. (2002). The effects of tertiary wastewater treatment on the prevalence of antimicrobial resistant bacteria. Water Research, 36(8), 1955–1964. doi: 10.1016/S0043-1354(01)00429-8
   PubMed Web of Science ®Google Scholar
• Guo, C., Wang, K., Hou, S., Wan, L., Lv, J., Zhang, Y., … Xu, J. (2017). H2O2 and/or TiO2 photocatalysis under UV irradiation for the removal of antibiotic resistant bacteria and their antibiotic resistance genes. Journal of Hazardous Materials, 323(Pt B), 710–718. doi: 10.1016/j.jhazmat.2016.10.041
   PubMedGoogle Scholar
• Guo, J., Li, J., Chen, H., Bond, P. L., & Yuan, Z. (2017). Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements. Water Research, 123, 468. doi: 10.1016/j.watres.2017.07.002
   PubMed Web of Science ®Google Scholar
• Gupta, S. K., Shin, H., Han, D., Hur, H. G., & Unno, T. (2018). Metagenomic analysis reveals the prevalence and persistence of antibiotic- and heavy metal-resistance genes in wastewater treatment plant. Journal of Microbiology, 56(6), 408–415. doi: 10.1007/s12275-018-8195-z
   PubMed Web of Science ®Google Scholar
• Hao, R., Zhao, R., Qiu, S., Wang, L., & Song, H. (2015). Antibiotics crisis in China. Science (New York, N.Y.), 348(6239), 1100–1101. doi: 10.1126/science.348.6239.1100-d
   PubMed Web of Science ®Google Scholar
• Hirsch, R., Ternes, T., Haberer, K., & Kratz, K. L. (1999). Occurrence of antibiotics in the aquatic environment. The Science of the Total Environment, 225(1–2), 109–118.
   PubMed Web of Science ®Google Scholar
• Hogg, M., Wallace, S. S., & Doublié, S. (2005). Bumps in the road: How replicative DNA polymerases see DNA damage. Current Opinion in Structural Biology, 15(1), 86–93. doi: 10.1016/j.sbi.2005.01.014
   PubMed Web of Science ®Google Scholar
• Hong, S. M., Park, J. K., & Lee, Y. O. (2004). Mechanisms of microwave irradiation involved in the destruction of fecal coliforms from biosolids. Water Research, 38(6), 1615–1625. doi: 10.1016/j.watres.2003.12.011
   PubMed Web of Science ®Google Scholar
• Huang, H., Chen, Y., Zheng, X., Su, Y., Wan, R., & Yang, S. (2016). Distribution of tetracycline resistance genes in anaerobic treatment of waste sludge: The role of pH in regulating tetracycline resistant bacteria and horizontal gene transfer. Bioresource Technology, 218, 1284–1289. doi: 10.1016/j.biortech.2016.07.097
   PubMed Web of Science ®Google Scholar
• Huang, H., Zheng, X., Chen, Y., Liu, H., Wan, R., & Su, Y. (2017). Alkaline fermentation of waste sludge causes a significant reduction of antibiotic resistance genes in anaerobic reactors. Science of the Total Environment, 580, 380–387. doi: 10.1016/j.scitotenv.2016.11.186
   PubMed Web of Science ®Google Scholar
• Huang, J. J., Hu, H. Y., Lu, S. Q., Li, Y., Tang, F., Lu, Y., & Wei, B. (2012). Monitoring and evaluation of antibiotic-resistant bacteria at a municipal wastewater treatment plant in China. Environment International, 42(1), 31–36. doi: 10.1016/j.envint.2011.03.001
   PubMedGoogle Scholar
• Huang, M. H., Zhang, W., Liu, C., & Hu, H. Y. (2015). Fate of trace tetracycline with resistant bacteria and resistance genes in an improved AAO wastewater treatment plant. Process Safety and Environmental Protection, 93, 68–74. doi: 10.1016/j.psep.2014.04.004
   Web of Science ®Google Scholar
• Ikehata, K., Naghashkar, N. J., & El-Din, M. G. (2006). Degradation of aqueous pharmaceuticals by ozonation and advanced oxidation processes: A review. Ozone: Science & Engineering, 28(6), 353–414. doi: 10.1080/01919510600985937
   Web of Science ®Google Scholar
• Imlay, J. A. (2003). Pathways of oxidative damage. Annual Review of Microbiology, 57(1), 395–418. doi: 10.1146/annurev.micro.57.030502.090938
   PubMedGoogle Scholar
• Ishizaki, K., Sawadaishi, K., Miura, K., & Shinriki, N. (1987). Effect of ozone on plasmid DNA of Escherichia coli in situ. Water Research, 21(7), 823–827. doi: 10.1016/0043-1354(87)90158-8
   Web of Science ®Google Scholar
• Iwane, T., Urase, T., & Yamamoto, K. (2001). Possible impact of treated wastewater discharge on incidence of antibiotic resistant bacteria in river water. Water Science and Technology, 43(2), 91–99. doi: 10.2166/wst.2001.0077
   PubMed Web of Science ®Google Scholar
• Jang, H. M., Shin, J., Choi, S., Shin, S. G., Park, K. Y., Cho, J., & Kim, Y. M. (2017). Fate of antibiotic resistance genes in mesophilic and thermophilic anaerobic digestion of chemically enhanced primary treatment (CEPT) sludge. Bioresource Technology, 244(Pt 1), 433–444. doi: 10.1016/j.biortech.2017.07.153
   PubMedGoogle Scholar
• Ju, F., Li, B., Ma, L., Wang, Y., Huang, D., & Zhang, T. (2016). Antibiotic resistance genes and human bacterial pathogens: Co-occurrence, removal, and enrichment in municipal sewage sludge digesters. Water Research, 91, 1–10. doi: 10.1016/j.watres.2015.11.071
   PubMed Web of Science ®Google Scholar
• Karaolia, P., Michael, I., García-Fernández, I., Agüera, A., Malato, S., Fernández-Ibáñez, P., & Fatta-Kassinos, D. (2014). Reduction of clarithromycin and sulfamethoxazole-resistant Enterococcus by pilot-scale solar-driven Fenton oxidation. Science of the Total Environment, 468-469, 19–27. doi: 10.1016/j.scitotenv.2013.08.027
   PubMed Web of Science ®Google Scholar
• Karkman, A., Johnson, T. A., Lyra, C., Stedtfeld, R. D., Tamminen, M., Tiedje, J. M., & Virta, M. (2016). High-throughput quantification of antibiotic resistance genes from an urban wastewater treatment plant. FEMS Microbiology Ecology, 92(3), fiw014. doi: 10.1093/femsec/fiw014
   PubMed Web of Science ®Google Scholar
• Kemper, N. (2008). Veterinary antibiotics in the aquatic and terrestrial environment. Ecological Indicators, 8(1), 1–13. doi: 10.1016/j.ecolind.2007.06.002
   Web of Science ®Google Scholar
• LaPara, T. M., Burch, T. R., Mcnamara, P. J., Tan, D. T., Yan, M., & Eichmiller, J. J. (2011). Tertiary-treated municipal wastewater is a significant point source of antibiotic resistance genes into Duluth-superior harbor. Environmental Science & Technology, 45(22), 9543–9549. doi: 10.1021/es202775r
   PubMed Web of Science ®Google Scholar
• Lee, J., Jeon, J. H., Shin, J., Jang, H. M., Kim, S., Song, M. S., & Kim, Y. M. (2017). Quantitative and qualitative changes in antibiotic resistance genes after passing through treatment processes in municipal wastewater treatment plants. Science of the Total Environment, 605–606, 906–914. doi: 10.1016/j.scitotenv.2017.06.250
   PubMed Web of Science ®Google Scholar
• Lee, J., Shin, S. G., Jang, H. M., Kim, Y. B., Lee, J., & Kim, Y. M. (2017). Characterization of antibiotic resistance genes in representative organic solid wastes: Food waste-recycling wastewater, manure, and sewage sludge. Science of the Total Environment, 579, 1692–1698. doi: 10.1016/j.scitotenv.2016.11.187
   PubMed Web of Science ®Google Scholar
• Li, A. D., Li, L. G., & Zhang, T. (2015). Exploring antibiotic resistance gene and metal resistance genes in plasmid metagenomes from wastewater treatment plants. Front Microbiology, 6, 1025.
   PubMed Web of Science ®Google Scholar
• Li, H., Zhu, X., & Ni, J. (2011). Comparison of electrochemical method with ozonation, chlorination and monochloramination in drinking water disinfection. Electrochimica Acta, 56(27), 9789–9796. doi: 10.1016/j.electacta.2011.08.053
   Web of Science ®Google Scholar
• Li, J., Cheng, W., Xu, L., Jiao, Y., Baig, S. A., & Chen, H. (2016). Occurrence and removal of antibiotics and the corresponding resistance genes in wastewater treatment plants: Effluents' influence to downstream water environment. Environmental Science and Pollution Research, 23(7), 6826–6835. doi: 10.1007/s11356-015-5916-2
   PubMed Web of Science ®Google Scholar
• Li, N., Sheng, G. P., Lu, Y. Z., Zeng, R. J., & Yu, H. Q. (2017). Removal of antibiotic resistance genes from wastewater treatment plant effluent by coagulation. Water Research, 111, 204–212. doi: 10.1016/j.watres.2017.01.010
   PubMed Web of Science ®Google Scholar
• Li, X. W., Shi, H. C., Li, K. X., Zhang, L., & Gan, Y. (2014). Occurrence and fate of antibiotics in advanced wastewater treatment facilities and receiving rivers in Beijing, China. Frontiers of Environmental Science & Engineering, 8(6), 888–894. doi: 10.1007/s11783-014-0735-0
   Web of Science ®Google Scholar
• Liao, H., Lu, X., Rensing, C., Friman, V. P., Geisen, S., Chen, Z., … Zhu, Y. (2018). Hyperthermophilic composting accelerates the removal of antibiotic resistance genes and mobile genetic elements in sewage sludge. Environmental Science & Technology, 52(1), 266–276. doi: 10.1021/acs.est.7b04483
   PubMed Web of Science ®Google Scholar
• Lin, W., Li, S., Zhang, S., & Yu, X. (2016). Reduction in horizontal transfer of conjugative plasmid by UV irradiation and low-level chlorination. Water Research, 91, 331–338. doi: 10.1016/j.watres.2016.01.020
   PubMed Web of Science ®Google Scholar
• Lin, W., Zhang, M., Zhang, S., & Yu, X. (2016). Can chlorination co-select antibiotic-resistance genes? Chemosphere, 156, 412–419.
   PubMed Web of Science ®Google Scholar
• Liu, J., Hu, G., Li, F., & Li, L. (2011). Advances in the microbial flora of anaerobic digestive systems. Industrial Water Treatment, 31(10), 10–14.
   Google Scholar
• Liu, M., Ding, R., Zhang, Y., Gao, Y., Tian, Z., Zhang, T., & Yang, M. (2014). Abundance and distribution of macrolide-lincosamide-streptogramin resistance genes in an anaerobic-aerobic system treating spiramycin production wastewater. Water Research, 63(1), 33–41. doi: 10.1016/j.watres.2014.05.045
   PubMedGoogle Scholar
• Luo, Y., Mao, D., Rysz, M., Zhou, Q., Zhang, H., Xu, L., & P, J. J. A. (2010). Trends in antibiotic resistance genes occurrence in the Haihe River, China. Environmental Science & Technology, 44(19), 7220–7225. doi: 10.1021/es100233w
   PubMed Web of Science ®Google Scholar
• Lupo, A., Coyne, S., & Berendonk, T. U. (2012). Origin and evolution of antibiotic resistance: The common mechanisms of emergence and spread in water bodies. Front Microbiology, 3(3), 18.
   PubMedGoogle Scholar
• Ma, Y., Wilson, C. A., Novak, J. T., Riffat, R., Aynur, S., Murthy, S., & Pruden, A. (2011). Effect of various sludge digestion conditions on sulfonamide, macrolide, and tetracycline resistance genes and class I Integrons. Environmental Science & Technology, 45(18), 7855–7861. doi: 10.1021/es200827t
   PubMed Web of Science ®Google Scholar
• Macauley, J. J., Qiang, Z., Adams, C. D., Surampalli, R., & Mormile, M. R. (2006). Disinfection of swine wastewater using chlorine, ultraviolet light and ozone. Water Research, 40(10), 2017–2026. doi: 10.1016/j.watres.2006.03.021
   PubMed Web of Science ®Google Scholar
• Macwan, D. P., Dave, P. N., & Chaturvedi, S. (2011). A review on nano-TiO2 sol–gel type syntheses and its applications. Journal of Materials Science, 46(11), 3669–3686. doi: 10.1007/s10853-011-5378-y
   Web of Science ®Google Scholar
• Makowska, N., Koczura, R., & Mokracka, J. (2016). Class 1 integrase, sulfonamide and tetracycline resistance genes in wastewater treatment plant and surface water. Chemosphere, 144, 1665–1673. doi: 10.1016/j.chemosphere.2015.10.044
   PubMed Web of Science ®Google Scholar
• Malato, S., Fernández-Ibáñez, P., Maldonado, M. I., Blanco, J., & Gernjak, W. (2009). Decontamination and disinfection of water by solar photocatalysis: Recent overview and trends. Catalysis Today, 147(1), 1–59. doi: 10.1016/j.cattod.2009.06.018
   Web of Science ®Google Scholar
• Mateo-Sagasta, J., Raschid-Sally, L., & Thebo, A. (2015). Global wastewater and sludge production, treatment and use. Netherlands: Springer.
   Google Scholar
• Mazel, D. (2006). Integrons: Agents of bacterial evolution. Nature Reviews Microbiology, 4(8), 608–620. doi: 10.1038/nrmicro1462
   PubMed Web of Science ®Google Scholar
• Mckinney, C. W., & Pruden, A. (2012). Ultraviolet disinfection of antibiotic resistant bacteria and their antibiotic resistance genes in water and wastewater. Environmental Science & Technology, 46(24), 13393–13400. doi: 10.1021/es303652q
   PubMed Web of Science ®Google Scholar
• Michael, I., Rizzo, L., Mcardell, C. S., Manaia, C. M., Merlin, C., Schwartz, T., … Fatta-Kassinos, D. (2013). Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: A review. Water Research, 47(3), 957–995. doi: 10.1016/j.watres.2012.11.027
   PubMed Web of Science ®Google Scholar
• Michaelkordatou, I., Karaolia, P., & Fattakassinos, D. (2017). The role of operating parameters and oxidative damage mechanisms of advanced chemical oxidation processes in the combat against antibiotic-resistant bacteria and resistance genes present in urban wastewater. Water Research, 129, 208–230. doi: 10.1016/j.watres.2017.10.007
   PubMed Web of Science ®Google Scholar
• Michalova, E., Novotna, P., & Schlegelova, J. (2004). Tetracyclines in veterinary medicine and bacterial resistance to them. A review. Veterinary Medicine, 49(3), 79–100.
   Web of Science ®Google Scholar
• Michod, R. E., Bernstein, H., & Nedelcu, A. M. (2008). Adaptive value of sex in microbial pathogens. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 8(3), 267–285. doi: 10.1016/j.meegid.2008.01.002
   PubMed Web of Science ®Google Scholar
• Miller, J., Novak, J. T., Pruden, A., Knocke, W. R., Young, K., Young, Y., … Hull, M. (2012). Effect of nanosilver and antibiotic loading on Fate of antibiotic resistance genes in thermophilic and mesophilic anaerobic digesters. Proceedings of the Water Environment Federation, 2012(2), 1221–1234. doi: 10.2175/193864712811693579
   Google Scholar
• Miller, J. H., Novak, J. T., Knocke, W. R., & Amy, P. (2016). Survival of antibiotic resistant bacteria and horizontal gene transfer control antibiotic resistance gene content in anaerobic digesters. Frontiers in Microbiology, 7(18), 263.
   PubMedGoogle Scholar
• Miller, J. H., Novak, J. T., Knocke, W. R., Young, K., Hong, Y., Vikesland, P. J., … Pruden, A. (2013). Effect of silver nanoparticles and antibiotics on antibiotic resistance genes in anaerobic digestion. Water Environment Research, 85(5), 411–421. doi: 10.2175/106143012X13373575831394
   PubMed Web of Science ®Google Scholar
• Mishra, S., & Imlay, J. (2012). Why do bacteria use so many enzymes to scavenge hydrogen peroxide? Archives of Biochemistry and Biophysics, 525(2), 145–160. doi: 10.1016/j.abb.2012.04.014
   PubMed Web of Science ®Google Scholar
• Mitchell, S. M., Ullman, J. L., Bary, A., Cogger, C. G., Teel, A. L., & Watts, R. J. (2015). Antibiotic degradation during thermophilic composting. Water, Air, & Soil Pollution, 226(2), 13.
   Web of Science ®Google Scholar
• Moreira, N. F., Sousa, J. M., Macedo, G., Ribeiro, A. R., Barreiros, L., Pedrosa, M., … Segundo, M. A. (2016). Photocatalytic ozonation of urban wastewater and surface water using immobilized TiO2 with LEDs: Micropollutants, antibiotic resistance genes and estrogenic activity. Water Research, 94, 10–22. doi: 10.1016/j.watres.2016.02.003
   PubMed Web of Science ®Google Scholar
• Munir, M., Wong, K., & Xagoraraki, I. (2011). Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan. Water Research, 45(2), 681–693. doi: 10.1016/j.watres.2010.08.033
   PubMed Web of Science ®Google Scholar
• Nelson, M. L., & Levy, S. B. (2011). The history of the tetracyclines. Annals of the New York Academy of Sciences, 1241, 17–32. doi: 10.1111/j.1749-6632.2011.06354.x
   PubMed Web of Science ®Google Scholar
• Nnadozie, C. F., Kumari, S., & Bux, F. (2017). Status of pathogens, antibiotic resistance genes and antibiotic residues in wastewater treatment systems. Reviews in Environmental Science and Bio/Technology, 16(2), 1–25.
   Google Scholar
• Oh, J., Salcedo, D. E., Medriano, C. A., & Kim, S. (2014). Comparison of different disinfection processes in the effective removal of antibiotic-resistant bacteria and genes. Journal of Environmental Sciences, 26(6), 1238–1242. doi: 10.1016/S1001-0742(13)60594-X
   Web of Science ®Google Scholar
• Ohtani, B. (2010). Photocatalysis A to Z—What we know and what we do not know in a scientific sense. Journal of Photochemistry and Photobiology C, 11(4), 157–178. doi: 10.1016/j.jphotochemrev.2011.02.001
   Google Scholar
• Öncü, N. B., Menceloğlu, Y. Z., & Balcıoğlu, I. A. (2016). Comparison of the effectiveness of chlorine, ozone, and photocatalytic disinfection in reducing the risk of antibiotic resistance pollution. Journal of Advanced Oxidation Technologies, 14(14), 196–203.
   Google Scholar
• Oppenländer, T. (2007). Photochemical purification of water and air. Advanced oxidation processes (AOPs): Principles, reaction mechanisms, reactor concepts. Chemistry International – Newsmagazine for IUPAC, 25(4), 31–31.
   Google Scholar
• Pak, G., Espineli, S. D., Lee, H., Oh, J., Maeng, S. K., Song, K. G., … Kim, S. (2016). Comparison of antibiotic resistance removal efficiencies using ozone disinfection under different pH and suspended solids and humic substance concentrations. Environmental Science & Technology, 50(14), 7590. doi: 10.1021/acs.est.6b01340
   PubMed Web of Science ®Google Scholar
• Park, S., You, X., & Imlay, J. A. (2005). Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 102(26), 9317–9322. doi: 10.1073/pnas.0502051102
   PubMed Web of Science ®Google Scholar
• Pei, J., Yao, H., Wang, H., Ren, J., & Yu, X. (2016). Comparison of ozone and thermal hydrolysis combined with anaerobic digestion for municipal and pharmaceutical waste sludge with tetracycline resistance genes. Water Research, 99, 122–128. doi: 10.1016/j.watres.2016.04.058
   PubMed Web of Science ®Google Scholar
• Pei, J., Yao, H., Wang, H., Shan, D., Jiang, Y., Ma, L., & Yu, X. (2015). Effect of ultrasonic and ozone pre-treatments on pharmaceutical waste activated sludge's solubilisation, reduction, anaerobic biodegradability and acute biological toxicity. Bioresource Technology, 192, 418–423. doi: 10.1016/j.biortech.2015.05.079
   PubMed Web of Science ®Google Scholar
• Pilli, S., Bhunia, P., Yan, S., Leblanc, R. J., Tyagi, R. D., & Surampalli, R. Y. (2011). Ultrasonic pretreatment of sludge: A review. Ultrasonics Sonochemistry, 18(1), 1–18. doi: 10.1016/j.ultsonch.2010.02.014
   PubMed Web of Science ®Google Scholar
• Pruden, A., Pei, R., Storteboom, H., & Carlson, K. H. (2006). Antibiotic resistance genes as emerging contaminants: studies in Northern Colorado. Environmental Science & Technology, 40(23), 7445–7450. doi: 10.1021/es060413l
   PubMed Web of Science ®Google Scholar
• Pryor, W. A., Das, B., & Church, D. F. (1991). The ozonation of unsaturated fatty acids: Aldehydes and hydrogen peroxide as products and possible mediators of ozone toxicity. Chemical Research in Toxicology, 4(3), 341–348. doi: 10.1021/tx00021a014
   PubMed Web of Science ®Google Scholar
• Qian, Y., Xu, K., Su, C., Zheng, J., & Chen, H. (2015). Effect of initial pH on the behavior characteristics of antibiotic resistance genes in sludge under anaerobic environment. Journal of Ecotoxicology, 10(5), 47–55.
   Google Scholar
• Qiao, M., Ying, G. G., Singer, A. C., & Zhu, Y. G. (2018). Review of antibiotic resistance in China and its environment. Environment International, 110, 160–172. doi: 10.1016/j.envint.2017.10.016
   PubMed Web of Science ®Google Scholar
• Quach-Cu, J., Herrera-Lynch, B., Marciniak, C., Adams, S., Simmerman, A., & Reinke, R. (2018). The effect of primary, secondary, and tertiary wastewater treatment processes on antibiotic resistance gene (ARG) concentrations in solid and dissolved wastewater fractions. Water, 10(1), 37. doi: 10.3390/w10010037
   Web of Science ®Google Scholar
• Rahube, T. O., Marti, R., Scott, A., Tien, Y. C., Murray, R., Sabourin, L., … Topp, E. (2014). Impact of fertilizing with raw or anaerobically digested sewage sludge on the abundance of antibiotic-resistant coliforms, antibiotic resistance genes, and pathogenic bacteria in soil and on vegetables at harvest. Applied and Environmental Microbiology, 80(22), 6898–6907. doi: 10.1128/AEM.02389-14
   PubMed Web of Science ®Google Scholar
• Riber, L., Poulsen, P. H. B., Al-Soud, W. A., Skov Hansen, L. B., Bergmark, L., Brejnrod, A., … Sørensen, S. J. (2014). Exploring the immediate and long-term impact on bacterial communities in soil amended with animal and urban organic waste fertilizers using pyrosequencing and screening for horizontal transfer of antibiotic resistance. FEMS Microbiology Ecology, 90(1), 206–224. doi: 10.1111/1574-6941.12403
   PubMed Web of Science ®Google Scholar
• Rizzo, L., Manaia, C., Merlin, C., Schwartz, T., Dagot, C., Ploy, M. C., … Fattakassinos, D. (2013). Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: A review. Science of the Total Environment, 447(9), 345–360. doi: 10.1016/j.scitotenv.2013.01.032
   PubMedGoogle Scholar
• Roberts, M. C. (2010). Update on acquired tetracycline resistance genes. FEMS Microbiology Letters, 245(2), 195–203. doi: 10.1016/j.femsle.2005.02.034
   Google Scholar
• Sørensen, S. J., Bailey, M., Hansen, L. H., Kroer, N., & Wuertz, S. (2005). Studying plasmid horizontal transfer in situ: A critical review. Nature Reviews. Microbiology, 3(9), 700–710. doi: 10.1038/nrmicro1232
   PubMed Web of Science ®Google Scholar
• Sarmah, A. K., Meyer, M. T., & Boxall, A. (2006). A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere, 65(5), 725–759. doi: 10.1016/j.chemosphere.2006.03.026
   PubMed Web of Science ®Google Scholar
• Selvam, A., Xu, D., Zhao, Z., & Wong, J. W. (2012). Fate of tetracycline, sulfonamide and fluoroquinolone resistance genes and the changes in bacterial diversity during composting of swine manure. Bioresource Technology, 126(4), 383–390. doi: 10.1016/j.biortech.2012.03.045
   PubMedGoogle Scholar
• Selvam, A., Zhao, Z., & Wong, J. W. C. (2012). Composting of swine manure spiked with sulfadiazine, chlortetracycline and ciprofloxacin. Bioresource Technology, 126(12), 412–417. doi: 10.1016/j.biortech.2011.12.073
   PubMedGoogle Scholar
• Sharma, V. K., Johnson, N., Cizmas, L., Mcdonald, T. J., & Kim, H. (2016). A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes. Chemosphere, 150(3), 702–714. doi: 10.1016/j.chemosphere.2015.12.084
   PubMedGoogle Scholar
• Singh, R., Schroeder, C. M., Meng, J., White, D. G., Mcdermott, P. F., Wagner, D. D., … Walker, R. D. (2005). Identification of antimicrobial resistance and class 1 integrons in Shiga toxin-producing Escherichia coli recovered from humans and food animals. Journal of Antimicrobial Chemotherapy, 56(1), 216–219. doi: 10.1093/jac/dki161
   PubMed Web of Science ®Google Scholar
• Sousa, J. M., Macedo, G., Pedrosa, M., Becerra-Castro, C., Castro-Silva, S., Pereira, M. F. R., … Manaia, C. M. (2017). Ozonation and UV 254 nm radiation for the removal of microorganisms and antibiotic resistance genes from urban wastewater. J Hazard Mater, 323(Pt A), 434–441. doi: 10.1016/j.jhazmat.2016.03.096
   PubMedGoogle Scholar
• Su, J. Q., Wei, B., Ou-Yang, W. Y., Huang, F. Y., Zhao, Y., Xu, H. J., & Zhu, Y. G. (2015). Antibiotic resistome and its association with bacterial communities during sewage sludge composting. Environmental Science & Technology, 49(12), 7356–7363. doi: 10.1021/acs.est.5b01012
   PubMed Web of Science ®Google Scholar
• Su, J. Q., An, X. L., Li, B., Gillings, M. R., Chen, H., Zhang, T., & Zhu, Y. G. (2017). Metagenomics of urban sewage identifies an extensively shared antibiotic resistome in China. Microbiome, 5(1), 84.
   PubMedGoogle Scholar
• Sukul, P., & Spiteller, M. (2006). Sulfonamides in the environment as veterinary drugs. Reviews of Environmental Contamination and Toxicology, 187, 66–101.
   Web of Science ®Google Scholar
• Sun, W., Qian, X., Gu, J., Wang, X. J., & Duan, M. L. (2016). Mechanism and effect of temperature on variations in antibiotic resistance genes during anaerobic digestion of dairy manure. Scientific Reports, 6, 30237.
   PubMed Web of Science ®Google Scholar
• Sunada, K., Watanabe, T., & Hashimoto, K. (2003). Studies on photokilling of bacteria on TiO2 thin film. Journal of Photochemistry and Photobiology A, 156(1–3), 227–233. doi: 10.1016/S1010-6030(02)00434-3
   Web of Science ®Google Scholar
• Suquet, C., Warren, J. J., Seth, N., & Hurst, J. K. (2010). Comparative study of HOCl-inflicted damage to bacterial DNA ex vivo and within cells. Archives of Biochemistry and Biophysics, 493(2), 135–142. doi: 10.1016/j.abb.2009.10.006
   PubMed Web of Science ®Google Scholar
• Szczepanowski, R., Linke, B., Krahn, I., Gartemann, K. H., Gützkow, T., Eichler, W., … Schlüter, A. (2009). Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics. Microbiology, 155(7), 2306–2319. doi: 10.1099/mic.0.028233-0
   PubMedGoogle Scholar
• Metcalf & Eddy, Tchobanoglous, G., Burton, F. L., & Stensel, H. D. (2003). Wastewater engineering: Treatment and reuse (4th ed.). Boston: McGraw-Hill.
   Google Scholar
• Tang, J. Y., Bu, Y. Q., Zhang, X. X., Huang, K. L., He, X. W., Ye, L., … Ren, H. Q. (2016). Metagenomic analysis of bacterial community composition and antibiotic resistance genes in a wastewater treatment plant and its receiving surface water. Ecotoxicology and Environmental Safety, 132, 260–269. doi: 10.1016/j.ecoenv.2016.06.016
   PubMed Web of Science ®Google Scholar
• Tian, Z., Zhang, Y., Yu, B., & Yang, M. (2016). Changes of resistome, mobilome and potential hosts of antibiotic resistance genes during the transformation of anaerobic digestion from mesophilic to thermophilic. Water Research, 98, 261. doi: 10.1016/j.watres.2016.04.031
   PubMed Web of Science ®Google Scholar
• Tong, J., Liu, J., Zheng, X., Zhang, J., Ni, X., Chen, M., & Wei, Y. (2016). Fate of antibiotic resistance bacteria and genes during enhanced anaerobic digestion of sewage sludge by microwave pretreatment. Bioresource Technology, 217, 37–43. doi: 10.1016/j.biortech.2016.02.130
   PubMed Web of Science ®Google Scholar
• Tong, J., Lu, X., Zhang, J., Sui, Q., Wang, R., Chen, M., & Wei, Y. (2017). Occurrence of antibiotic resistance genes and mobile genetic elements in enterococci and genomic DNA during anaerobic digestion of pharmaceutical waste sludge with different pretreatments. Bioresource Technology, 235, 316–324. doi: 10.1016/j.biortech.2017.03.104
   PubMed Web of Science ®Google Scholar
• Ungemach, F. R. (2000). Figures on quantities of antibacterials used for different purposes in the EU countries and interpretation. Acta Veterinaria Scandinavica. Supplementum, 93(4), 89–97.
   PubMedGoogle Scholar
• Van Boeckel, T. P., Gandra, S., Ashok, A., Caudron, Q., Grenfell, B. T., Levin, S. A., & Laxminarayan, R. (2014). Global antibiotic consumption 2000 to 2010: An analysis of national pharmaceutical sales data. The Lancet Infectious Diseases, 14(8), 742–750. doi: 10.1016/S1473-3099(14)70780-7
   PubMed Web of Science ®Google Scholar
• Venieri, D., Gounaki, I., Bikouvaraki, M., Binas, V., Zachopoulos, A., Kiriakidis, G., & Mantzavinos, D. (2017). Solar photocatalysis as disinfection technique: Inactivation of Klebsiella pneumoniae in sewage and investigation of changes in antibiotic resistance profile. Journal of Environmental Management, 195(Pt 2), 140–147. doi: 10.1016/j.jenvman.2016.06.009
   PubMedGoogle Scholar
• Wang, L., Oda, Y., Grewal, S., Morrison, M., Michel, F. C., & Yu, Z. (2012). Persistence of resistance to erythromycin and tetracycline in swine manure during simulated composting and lagoon treatments. Microbial Ecology, 63(1), 32–40. doi: 10.1007/s00248-011-9921-9
   PubMed Web of Science ®Google Scholar
• Wang, L. S., Hu, H. Y., & Wang, C. (2007). Effect of ammonia nitrogen and dissolved organic matter fractions on the genotoxicity of wastewater effluent during chlorine disinfection. Environmental Science & Technology, 41(1), 160–165. doi: 10.1021/es0616635
   PubMed Web of Science ®Google Scholar
• Wang, J., Ben, W. W., Yang, M., Zhang, Y., & Qiang, Z. M. (2016). Dissemination of veterinary antibiotics and corresponding resistance genes from a concentrated swine feedlot along the waste treatment paths. Environment International, 92–93, 317–323. doi: 10.1016/j.envint.2016.04.020
   PubMed Web of Science ®Google Scholar
• Wang, X., Ryu, D., Houtkooper, R. H., & Auwerx, J. (2015). Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment. Bioessays: News and Reviews in Molecular, Cellular and Developmental Biology, 37(10), 1045–1053. doi: 10.1002/bies.201500071
   PubMed Web of Science ®Google Scholar
• Wang, Z., Zhang, X. X., Huang, K. L., Miao, Y., Shi, P., Liu, B., … Li, A. M. (2013). Metagenomic profiling of antibiotic resistance genes and mobile genetic elements in a tannery wastewater treatment plant. PLoS ONE, 8, 76079.
   Web of Science ®Google Scholar
• Wéry, N., Lhoutellier, C., Ducray, F., Delgenès, G. P., & Godon, J. J. (2008). Behaviour of pathogenic and indicator bacteria during urban wastewater treatment and sludge composting, as revealed by quantitative PCR. Water Research, 42(1–2), 53–62. doi: 10.1016/j.watres.2007.06.048
   PubMed Web of Science ®Google Scholar
• WHO. (2001). WHO global strategy for containment of antimicrobial resistance. Geneva: World Health Organization. Retrieved from http://www.who.int/drugresistance/WHO_Global_Strategy_English.pdf
   Google Scholar
• Wu, D., Dolfing, J., & Xie, B. (2018). Bacterial perspectives on the dissemination of antibiotic resistance genes in domestic wastewater bio-treatment systems: Beneficiary to victim. Applied Microbiology and Biotechnology, 102(2), 597–604. doi: 10.1007/s00253-017-8665-y
   PubMed Web of Science ®Google Scholar
• Wu, Y., Cui, E., Zuo, Y., Cheng, W., & Chen, H. (2018). Fate of antibiotic and metal resistance genes during two-phase anaerobic digestion of residue sludge revealed by metagenomic approach. Environmental Science and Pollution Research, 25(14), 13956–13963. doi: 10.1007/s11356-018-1598-x
   PubMed Web of Science ®Google Scholar
• Wu, Y., Cui, E., Zuo, Y., Cheng, W., Rensing, C., & Chen, H. (2016). Influence of two-phase anaerobic digestion on fate of selected antibiotic resistance genes and class I integrons in municipal wastewater sludge. Bioresource Technology, 211, 414–421. doi: 10.1016/j.biortech.2016.03.086
   PubMed Web of Science ®Google Scholar
• Xi, C., Zhang, Y., Marrs, C. F., Ye, W., Simon, C., Foxman, B., & Nriagu, J. (2009). Prevalence of antibiotic resistance in drinking water treatment and distribution systems. Applied and Environmental Microbiology, 75(17), 5714–5718. doi: 10.1128/AEM.00382-09
   PubMed Web of Science ®Google Scholar
• Xie, W. Y., Yang, X. P., Li, Q., Wu, L. H., Shen, Q. R., & Zhao, F. J. (2016). Changes in antibiotic concentrations and antibiotic resistome during commercial composting of animal manures. Environmental Pollution, 219, 182–190. doi: 10.1016/j.envpol.2016.10.044
   PubMed Web of Science ®Google Scholar
• Xie, X., Zhou, Q., He, Z., & Bao, Y. (2010). Physiological and potential genetic toxicity of chlortetracycline as an emerging pollutant in wheat (Triticum aestivum L.). Environmental Toxicology and Chemistry, 29(4), 922–928. doi: 10.1002/etc.79
   PubMed Web of Science ®Google Scholar
• Xu, J., Xu, Y., Wang, H., Guo, C., Qiu, H., He, Y., … Meng, W. (2015). Occurrence of antibiotics and antibiotic resistance genes in a sewage treatment plant and its effluent-receiving river. Chemosphere, 119, 1379–1385. doi: 10.1016/j.chemosphere.2014.02.040
   PubMed Web of Science ®Google Scholar
• Yang, Y., Li, B., Ju, F., & Zhang, T. (2013). Exploring variation of antibiotic resistance genes in activated sludge over a four-year period through a metagenomic approach. Environmental Science & Technology, 47(18), 10197–10205. doi: 10.1021/es4017365
   PubMed Web of Science ®Google Scholar
• Yang, G., Zhang, G., & Wang, H. (2015). Current state of sludge production, management, treatment and disposal in China. Water Research, 78, 60–73. doi: 10.1016/j.watres.2015.04.002
   PubMed Web of Science ®Google Scholar
• Yang, Y., Li, B., Zou, S., Fang, H. H., & Zhang, T. (2014). Fate of antibiotic resistance genes in sewage treatment plant revealed by metagenomic approach. Water Research, 62, 97–106. doi: 10.1016/j.watres.2014.05.019
   PubMed Web of Science ®Google Scholar
• Yang, Y., Song, W., Lin, H., Wang, W., Du, L., & Xing, W. (2018). Antibiotics and antibiotic resistance genes in global lakes: A review and meta-analysis. Environment International, 116, 60–73. doi: 10.1016/j.envint.2018.04.011
   PubMed Web of Science ®Google Scholar
• Yi, X., Tran, N. H., Yin, T., He, Y., & Gin, K. Y. (2017). Removal of selected PPCPs, EDCs, and antibiotic resistance genes in landfill leachate by a full-scale constructed wetlands system. Water Research, 121, 46–60. doi: 10.1016/j.watres.2017.05.008
   PubMed Web of Science ®Google Scholar
• Yoon, Y., Chung, H. J., Wen, D. D., Dodd, M. C., Hur, H. G., & Lee, Y. (2017). Inactivation efficiency of plasmid-encoded antibiotic resistance genes during water treatment with chlorine, UV, and UV/H2O2. Water Research, 123, 783–793. doi: 10.1016/j.watres.2017.06.056
   PubMed Web of Science ®Google Scholar
• Youngquist, C. P., Mitchell, S. M., & Cogger, C. G. (2016). Fate of antibiotics and antibiotic resistance during digestion and composting: A review. Journal of Environmental Quality, 45(2), 537–545. doi: 10.2134/jeq2015.05.0256
   PubMed Web of Science ®Google Scholar
• Yu, Z., Michel, F. C., Hansen, G., Wittum, T., & Morrison, M. (2005). Development and application of real-time PCR assays for quantification of genes encoding tetracycline resistance. Applied and Environmental Microbiology, 71(11), 6926–6933. doi: 10.1128/AEM.71.11.6926-6933.2005
   PubMed Web of Science ®Google Scholar
• Yuan, Q. B., Guo, M. T., Wei, W. J., & Yang, J. (2016). Reductions of bacterial antibiotic resistance through five biological treatment processes treated municipal wastewater. Environmental Science and Pollution Research, 23(19), 19495–19503. doi: 10.1007/s11356-016-7048-8
   PubMed Web of Science ®Google Scholar
• Zábranská, J., Dohányos, M., Jeníček, P., Ružičková, H., & Vránová, A. (2003). Efficiency of autothermal thermophilic aerobic digestion and thermophilic anaerobic digestion of municipal wastewater sludge in removing Salmonella spp. and indicator bacteria. Water Science and Technology, 47(3), 151–156. doi: 10.2166/wst.2003.0187
   PubMed Web of Science ®Google Scholar
• Zhang, J., Cai, X., Qi, L., Shao, C., Lin, Y., Zhang, J., … Wei, Y. (2015). Effects of aeration strategy on the evolution of dissolved organic matter (DOM) and microbial community structure during sludge bio-drying. Applied Microbiology and Biotechnology, 99(17), 7321–7331. doi: 10.1007/s00253-015-6640-z
   PubMed Web of Science ®Google Scholar
• Zhang, J., Chen, M., Sui, Q., Tong, J., Jiang, C., Lu, X., … Wei, Y. (2016a). Impacts of addition of natural zeolite or a nitrification inhibitor on antibiotic resistance genes during sludge composting. Water Research, 91(9), 339–349. doi: 10.1016/j.watres.2016.01.010
   PubMedGoogle Scholar
• Zhang, J., Chen, M., Sui, Q., Wang, R., Tong, J., & Wei, Y. (2016b). Fate of antibiotic resistance genes and its drivers during anaerobic co-digestion of food waste and sewage sludge based on microwave pretreatment. Bioresource Technology, 217, 28–36. doi: 10.1016/j.biortech.2016.02.140
   PubMed Web of Science ®Google Scholar
• Zhang, J., Liu, J., Wang, Y., Yu, D., Sui, Q., Wang, R., … Wei, Y. (2017). Profiles and drivers of antibiotic resistance genes distribution in one-stage and two-stage sludge anaerobic digestion based on microwave-H2O2 pretreatment. Bioresource Technology, 241, 573–581. doi: 10.1016/j.biortech.2017.05.157
   PubMed Web of Science ®Google Scholar
• Zhang, J., Lv, C., Tong, J., Liu, J., Liu, J., Yu, D., … Wei, Y. (2016c). Optimization and microbial community analysis of anaerobic co-digestion of food waste and sewage sludge based on microwave pretreatment. Bioresource Technology, 200(2), 253. doi: 10.1016/j.biortech.2015.10.037
   PubMedGoogle Scholar
• Zhang, J., Sui, Q., Tong, J., Buhe, C., Wang, R., Chen, M., & Wei, Y. (2016). Sludge bio-drying: Effective to reduce both antibiotic resistance genes and mobile genetic elements. Water Research, 106, 62–70. doi: 10.1016/j.watres.2016.09.055
   PubMed Web of Science ®Google Scholar
• Zhang, Q. Q., Ying, G. G., Pan, C. G., Liu, Y. S., & Zhao, J. L. (2015). Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance. Environmental Science & Technology, 49(11), 6772–6782. doi: 10.1021/acs.est.5b00729
   PubMed Web of Science ®Google Scholar
• Zhang, T., Yang, Y., & Pruden, A. (2015). Effect of temperature on removal of antibiotic resistance genes by anaerobic digestion of activated sludge revealed by metagenomic approach. Applied Microbiology and Biotechnology, 99(18), 7771. doi: 10.1007/s00253-015-6688-9
   PubMed Web of Science ®Google Scholar
• Zhang, X. X., Zhang, T., & Fang, H. H. P. (2009). Antibiotic resistance genes in water environment. Applied Microbiology and Biotechnology, 82(3), 397–414. doi: 10.1007/s00253-008-1829-z
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Zhuang, Y., Geng, J., Ren, H., Xu, K., & Ding, L. (2016). Reduction of antibiotic resistance genes in municipal wastewater effluent by advanced oxidation processes. Science of the Total Environment, 550, 184–191. doi: 10.1016/j.scitotenv.2016.01.078
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Zhuang, Y., Geng, J., Ren, H., Zhang, Y., Ding, L., & Xu, K. (2015). Inactivation of antibiotic resistance genes in municipal wastewater effluent by chlorination and sequential UV/chlorination disinfection. Science of the Total Environment, 512–513, 125–132. doi: 10.1016/j.scitotenv.2015.01.028
   PubMed Web of Science ®Google Scholar
• Zhao, L., Gu, W. M., He, P. J., & Shao, L. M. (2011). Biodegradation potential of bulking agents used in sludge bio-drying and their contribution to bio-generated heat. Water Research, 45(6), 2322–2330. doi: 10.1016/j.watres.2011.01.014
   PubMed Web of Science ®Google Scholar
• Zhao, L., Gu, W. M., He, P. J., & Shao, L. M. (2010). Effect of air-flow rate and turning frequency on bio-drying of dewatered sludge. Water Research, 44(20), 6144–6152. doi: 10.1016/j.watres.2010.07.002
   PubMed Web of Science ®Google Scholar
• Zhu, Y., Wang, Y., Zhou, S., Jiang, X., Ma, X., & Liu, C. (2018). Robust performance of a membrane bioreactor for removing antibiotic resistance genes exposed to antibiotics: Role of membrane foulants. Water Research, 130, 139–150. doi: 10.1016/j.watres.2017.11.067
   PubMed Web of Science ®Google Scholar
• Zhu, Y. G., Gillings, M., Simonet, P., Stekel, D., Banwart, S., & Penuelas, J. (2017). Human dissemination of genes and microorganisms in Earth's Critical Zone. Global Change Biology, 24(4), 1488–1499.
   PubMed Web of Science ®Google Scholar
• Zhuang, Y., Ren, H., Geng, J., Zhang, Y., Zhang, Y., Ding, L., & Xu, K. (2015). Inactivation of antibiotic resistance genes in municipal wastewater by chlorination, ultraviolet, and ozonation disinfection. Environmental Science and Pollution Research, 22(9), 7037–7044. doi: 10.1007/s11356-014-3919-z
   PubMed Web of Science ®Google Scholar