The lavatory lens: Tracking the global movement of pathogens via aircraft wastewater

References

• Agan, M. L., Taylor, W. R., Willis, W. A., Lair, H., Murphy, A., Marinelli, A., Young, I., New, G. D., Juel, M. A. I., Dornburg, A., Munir, M., Schlueter, J., & Gibas, C. (2022). Wastewater as a back door to serology? medRxiv, 2022.11.11.22282224. https://doi.org/10.1101/2022.11.11.22282224
   Google Scholar
• Ahmed, W., Bertsch, P. M., Angel, N., Bibby, K., Bivins, A., Dierens, L., Edson, J., Ehret, J., Gyawali, P., & Hamilton, K. A. (2020a). Detection of SARS-CoV-2 RNA in commercial passenger aircraft and cruise ship wastewater: A surveillance tool for assessing the presence of COVID-19 infected travellers. Journal of Travel Medicine, 27(5), taaa116. https://doi.org/10.1093/jtm/taaa116
   PubMed Web of Science ®Google Scholar
• Ahmed, W., Bivins, A., Bertsch, P. M., Bibby, K., Choi, P. M., Farkas, K., Gyawali, P., Hamilton, K. A., Haramoto, E., Kitajima, M., Simpson, S. L., Tandukar, S., Thomas, K. V., & Mueller, J. F. (2020b). Surveillance of SARS-CoV-2 RNA in wastewater: Methods optimization and quality control are crucial for generating reliable public health information. Current Opinion in Environmental Science & Health, 17, 82–93. https://doi.org/10.1016/j.coesh.2020.09.003
   Google Scholar
• Ahmed, W., Bivins, A., Metcalfe, S., Smith, W. J. M., Ziels, R., Korajkic, A., McMinn, B., Graber, T. E., & Simpson, S. L. (2022c). RT-qPCR and ATOPlex sequencing for the sensitive detection of SARS-CoV-2 RNA for wastewater surveillance. Water Research, 220, 118621. https://doi.org/10.1016/j.watres.2022.118621
   PubMed Web of Science ®Google Scholar
• Ahmed, W., Bivins, A., Simpson, S. L., Bertsch, P. M., Ehret, J., Hosegood, I., Metcalfe, S. S., Smith, W. J. M., Thomas, K. V., Tynan, J., & Mueller, J. F. (2022a). Wastewater surveillance demonstrates high predictive value for COVID-19 infection on board repatriation flights to Australia. Environment International, 158, 106938. https://doi.org/10.1016/j.envint.2021.106938
   PubMed Web of Science ®Google Scholar
• Ahmed, W., Bivins, A., Smith, W. J. M., Metcalfe, S., Stephens, M., Jennison, A. V., Moore, F. A. J., Bourke, J., Schlebusch, S., McMahon, J., Hewitson, G., Nguyen, S., Barcelon, J., Jackson, G., Mueller, J. F., Ehret, J., Hosegood, I., Tian, W., Wang, H., … Simpson, S. L. (2022b). Detection of the Omicron (B. 1.1. 529) variant of SARS-CoV-2 in aircraft wastewater. The Science of the Total Environment, 820, 153171. https://doi.org/10.1016/j.scitotenv.2022.153171
   PubMed Web of Science ®Google Scholar
• Ahmed, W., Bivins, A., Stephens, M., Metcalfe, S., Smith, W. J. M., Sirikanchana, K., Kitajima, M., & Simpson, S. L. (2023a). Occurrence of multiple respiratory viruses in wastewater in Queensland, Australia: Potential for community disease surveillance. The Science of the Total Environment, 864, 161023. https://doi.org/10.1016/j.scitotenv.2022.161023
   PubMed Web of Science ®Google Scholar
• Ahmed, W., Smith, W., Tiwari, A., Bivins, A., & Simpson, S. (2023b). Application of adsorption-extraction and Nanotrap® microbiome a particles workflows for detection and quantification of indicator, enteric, and respiratory viruses in aircraft lavatory wastewater. The Science of the Total Environment, 896, 165007. https://doi.org/10.1016/j.scitotenv.2023.165007
   PubMed Web of Science ®Google Scholar
• Albastaki, A., Naji, M., Lootah, R., Almeheiri, R., Almulla, H., Almarri, I., Alreyami, A., Aden, A., & Alghafri, R. (2021). First confirmed detection of SARS-COV-2 in untreated municipal and aircraft wastewater in Dubai, UAE: The use of wastewater based epidemiology as an early warning tool to monitor the prevalence of COVID-19. The Science of the Total Environment, 760, 143350. https://doi.org/10.1016/j.scitotenv.2020.143350
   PubMed Web of Science ®Google Scholar
• Amoruso, I., & Baldovin, T. (2021). On-board toilets of long-haul flights: Is sewage epidemiology effective for COVID-19 global surveillance? Travel Medicine and Infectious Disease, 40, 102006. https://doi.org/10.1016/j.tmaid.2021.102006
   PubMed Web of Science ®Google Scholar
• Bajardi, P., Poletto, C., Ramasco, J. J., Tizzoni, M., Colizza, V., & Vespignani, A. (2011). Human mobility networks, travel restrictions, and the global spread of 2009 H1N1 pandemic. PloS One, 6(1), e16591. https://doi.org/10.1371/journal.pone.0016591
   PubMed Web of Science ®Google Scholar
• Balcan, D., Gonçalves, B., Hu, H., Ramasco, J. J., Colizza, V., & Vespignani, A. (2010). Modeling the spatial spread of infectious diseases: The GLobal Epidemic and Mobility computational model. Journal of Computational Science, 1(3), 132–145. https://doi.org/10.1016/j.jocs.2010.07.002
   PubMed Web of Science ®Google Scholar
• Balcan, D., Hu, H., Goncalves, B., Bajardi, P., Poletto, C., Ramasco, J. J., Paolotti, D., Perra, N., Tizzoni, M., Van den Broeck, W., Colizza, V., & Vespignani, A. (2009). Seasonal transmission potential and activity peaks of the new influenza A(H1N1): A Monte Carlo likelihood analysis based on human mobility. BMC Medicine, 7(1), 45. https://doi.org/10.1186/1741-7015-7-45
   PubMedGoogle Scholar
• Bart, S. M., Smith, T. C., Guagliardo, S. A. J., Walker, A. T., Rome, B. H., Li, S. L., Aichele, T. W. S., Stein, R., Ernst, E. T., Morfino, R. C., Cetron, M. S., & Friedman, C. R. (2023). Effect of predeparture testing on postarrival SARS-CoV-2–positive test results among international travelers—CDC traveler-based genomic surveillance program, four U.S. airports, March–September 2022. MMWR. Morbidity and Mortality Weekly Report, 72(8), 206–209. https://doi.org/10.15585/mmwr.mm7208a2
   PubMed Web of Science ®Google Scholar
• Bibby, K., & Peccia, J. (2013). Identification of viral pathogen diversity in sewage sludge by metagenome analysis. Environmental Science & Technology, 47(4), 1945–1951. https://doi.org/10.1021/es305181x
   PubMed Web of Science ®Google Scholar
• Bibby, K., Viau, E., & Peccia, J. (2011). Viral metagenome analysis to guide human pathogen monitoring in environmental samples. Letters in Applied Microbiology, 52(4), 386–392. https://doi.org/10.1111/j.1472-765X.2011.03014.x
   PubMed Web of Science ®Google Scholar
• Bisseux, M., Colombet, J., Mirand, A., Roque-Afonso, A.-M., Abravanel, F., Izopet, J., Archimbaud, C., Peigue-Lafeuille, H., Debroas, D., Bailly, J.-L., & Henquell, C. (2018). Monitoring human enteric viruses in wastewater and relevance to infections encountered in the clinical setting: A one-year experiment in central France, 2014 to 2015. Eurosurveillance, 23(7), 17–00237. https://doi.org/10.2807/1560-7917.ES.2018.23.7.17-00237
   Web of Science ®Google Scholar
• Bivins, A., Lott, M., Shaffer, M., Wu, Z., North, D. K., Lipp, E., & Bibby, K. (2022). Building-level wastewater surveillance using tampon swabs and RT-LAMP for rapid SARS-CoV-2 RNA detection. Environmental Science: Water Research & Technology, 8(1), 173–183. https://doi.org/10.1039/D1EW00496D
   Google Scholar
• Bogoch, I. I., Creatore, M. I., Cetron, M. S., Brownstein, J. S., Pesik, N., Miniota, J., Tam, T., Hu, W., Nicolucci, A., Ahmed, S., Yoon, J. W., Berry, I., Hay, S. I., Anema, A., Tatem, A. J., MacFadden, D., German, M., & Khan, K. (2015). Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak. Lancet (London, England), 385(9962), 29–35. https://doi.org/10.1016/S0140-6736(14)61828-6
   PubMed Web of Science ®Google Scholar
• Bogoch, I. I., Maxim, T., Acosta, H., Bhatia, D., Chen, S., Huber, C., Janes, A., Yong, J. H. E., Thomas, A., Kraemer, M. U. G., Watts, A., & Khan, K. (2018). Potential plague exportation from Madagascar via international air travel. The Lancet. Infectious Diseases, 18(3), 247–248. https://doi.org/10.1016/S1473-3099(18)30077-X
   PubMed Web of Science ®Google Scholar
• Bouwer, J., Krishan, V., Saxon, S., & Tufft, C. (2022). Taking stock on the pandemic’s impact on global aviation. https://www.mckinsey.com/industries/travel-logistics-and-infrastructure/our-insights/taking-stock-of-the-pandemics-impact-on-global-aviation
   Google Scholar
• Brockmann, D., & Helbing, D. (2013). The hidden geometry of complex, network-driven contagion phenomena. Science (New York, N.Y.), 342(6164), 1337–1342. https://doi.org/10.1126/science.1245200
   PubMed Web of Science ®Google Scholar
• Broeck, W. V., den, Gioannini, C., Gonçalves, B., Quaggiotto, M., Colizza, V., & Vespignani, A. (2011). The GLEaMviz computational tool, a publicly available software to explore realistic epidemic spreading scenarios at the global scale. BMC Infectious Diseases, 11(1), 37. https://doi.org/10.1186/1471-2334-11-37
   PubMedGoogle Scholar
• Broughton, J. P., Deng, X., Yu, G., Fasching, C. L., Servellita, V., Singh, J., Miao, X., Streithorst, J. A., Granados, A., Sotomayor-Gonzalez, A., Zorn, K., Gopez, A., Hsu, E., Gu, W., Miller, S., Pan, C.-Y., Guevara, H., Wadford, D. A., Chen, J. S., & Chiu, C. Y. (2020). CRISPR–Cas12-based detection of SARS-CoV-2. Nature Biotechnology, 38(7), 870–874. https://doi.org/10.1038/s41587-020-0513-4
   PubMed Web of Science ®Google Scholar
• Brownstein, J. S., Wolfe, C. J., & Mandl, K. D. (2006). Empirical evidence for the effect of airline travel on inter-regional influenza spread in the United States. PLoS Medicine, 3(10), e401. https://doi.org/10.1371/journal.pmed.0030401
   PubMed Web of Science ®Google Scholar
• Burton, N. C., & McCleery, R. E. (2000). Case studies exposure potentials during cleaning, overhauling and repairing of aircraft lavatory tanks and hardware. Applied Occupational and Environmental Hygiene, 15(11), 803–808. https://doi.org/10.1080/10473220050175652
   PubMedGoogle Scholar
• Capone, D., Berendes, D., Cumming, O., Knee, J., Nalá, R., Risk, B. B., Stauber, C., Zhu, K., & Brown, J. (2020). Analysis of fecal sludges reveals common enteric pathogens in urban Maputo, Mozambique. Environmental Science & Technology Letters, 7(12), 889–895. https://doi.org/10.1021/acs.estlett.0c00610
   Web of Science ®Google Scholar
• Christaki, E. (2015). New technologies in predicting, preventing and controlling emerging infectious diseases. https://doi.org/10.1080/21505594.2015.1040975
   Google Scholar
• Colizza, V., Barrat, A., Barthélemy, M., & Vespignani, A. (2006a). The modeling of global epidemics: Stochastic dynamics and predictability. Bulletin of Mathematical Biology, 68(8), 1893–1921. https://doi.org/10.1007/s11538-006-9077-9
   PubMed Web of Science ®Google Scholar
• Colizza, V., Barrat, A., Barthélemy, M., & Vespignani, A. (2006b). The role of the airline transportation network in the prediction and predictability of global epidemics. Proceedings of the National Academy of Sciences of the United States of America, 103(7), 2015–2020. https://doi.org/10.1073/pnas.0510525103
   PubMed Web of Science ®Google Scholar
• Colizza, V., Barrat, A., Barthélemy, M., & Vespignani, A. (2007). Predictability and epidemic pathways in global outbreaks of infectious diseases: The SARS case study. BMC Medicine, 5(1), 34. https://doi.org/10.1186/1741-7015-5-34
   PubMedGoogle Scholar
• Costello, V., Sowash, M., Gaur, A., Cardis, M., Pasieka, H., Wortmann, G., & Ramdeen, S. (2022). Imported monkeypox from international traveler, Maryland, USA, 2021. Emerging Infectious Diseases, 28(5), 1002–1005. https://doi.org/10.3201/eid2805.220292
   PubMed Web of Science ®Google Scholar
• Cox, N. J., & Subbarao, K. (2000). Global epidemiology of influenza: Past and present. Annual Review of Medicine, 51, 407–421. https://doi.org/10.1146/annurev.med.51.1.407
   PubMed Web of Science ®Google Scholar
• Crank, K., Chen, W., Bivins, A., Lowry, S., & Bibby, K. (2022). Contribution of SARS-CoV-2 RNA shedding routes to RNA loads in wastewater. The Science of the Total Environment, 806(Pt 2), 150376. https://doi.org/10.1016/j.scitotenv.2021.150376
   PubMedGoogle Scholar
• Crits-Christoph, A., Kantor, R. S., Olm, M. R., Whitney, O. N., Al-Shayeb, B., Lou, Y. C., Flamholz, A., Kennedy, L. C., Greenwald, H., Hinkle, A., Hetzel, J., Spitzer, S., Koble, J., Tan, A., Hyde, F., Schroth, G., Kuersten, S., Banfield, J. F., & Nelson, K. L. (2021). Genome sequencing of sewage detects regionally prevalent SARS-CoV-2 variants. mBio, 12(1), e02703-20. https://doi.org/10.1128/mBio.02703-20
   PubMed Web of Science ®Google Scholar
• Ehret, J., Cook, J., King, T., & Limited, Q. A. (2022). Aircraft lavatory wastewater sampling utilising the Qantas sample trap (QST) MK III, https://doi.org/10.5281/zenodo.6565202
   Google Scholar
• European Commission. (2023). Ad-hoc guidance: Wastewater sampling of aircrafts for SARS-CoV-2 surveillance. https://wastewater-observatory.jrc.ec.europa.eu/static/pdf/Sampling%20Aircrafts_FINAL_Version%209%20Jan%202023.pdf
   Google Scholar
• Farkas, K., Williams, R., Alex-Sanders, N., Grimsley, J. M. S., Pântea, I., Wade, M. J., Woodhall, N., & Jones, D. L. (2023). Wastewater-based monitoring of SARS-CoV-2 at UK airports and its potential role in international public health surveillance. PLOS Global Public Health, 3(1), e0001346. https://doi.org/10.1371/journal.pgph.0001346
   PubMedGoogle Scholar
• Frost, I., Van Boeckel, T. P., Pires, J., Craig, J., & Laxminarayan, R. (2019). Global geographic trends in antimicrobial resistance: The role of international travel. Journal of Travel Medicine, 26(8), taz036. https://doi.org/10.1093/jtm/taz036
   PubMed Web of Science ®Google Scholar
• Gostic, K., Gomez, A. C., Mummah, R. O., Kucharski, A. J., & Lloyd-Smith, J. O. (2020). Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19. ELife, 9, e55570. https://doi.org/10.7554/eLife.55570
   PubMed Web of Science ®Google Scholar
• Grais, R. F., Ellis, J. H., & Glass, G. E. (2003). Assessing the impact of airline travel on the geographic spread of pandemic influenza. European Journal of Epidemiology, 18(11), 1065–1072. https://doi.org/10.1023/A:1026140019146
   PubMed Web of Science ®Google Scholar
• Haggett, P. (2000). The geographical structure of epidemics. Oxford University Press.
   Google Scholar
• Heß, S., Kneis, D., Österlund, T., Li, B., Kristiansson, E., & Berendonk, T. U. (2019). Sewage from airplanes exhibits high abundance and diversity of antibiotic resistance genes. Environmental Science & Technology, 53(23), 13898–13905. https://doi.org/10.1021/acs.est.9b03236
   PubMed Web of Science ®Google Scholar
• Hill, M., & Pollard, A. J. (2022). Detection of poliovirus in London highlights the value of sewage surveillance. Lancet (London, England), 400(10362), 1491–1492. https://doi.org/10.1016/S0140-6736(22)01885-2
   PubMed Web of Science ®Google Scholar
• Hjelmsø, M. H., Mollerup, S., Jensen, R. H., Pietroni, C., Lukjancenko, O., Schultz, A. C., Aarestrup, F. M., & Hansen, A. J. (2019). Metagenomic analysis of viruses in toilet waste from long distance flights—A new procedure for global infectious disease surveillance. PloS One, 14(1), e0210368. https://doi.org/10.1371/journal.pone.0210368
   PubMed Web of Science ®Google Scholar
• Hobson, G., Adamson, J., Adler, H., Firth, R., Gould, S., Houlihan, C., Johnson, C., Porter, D., Rampling, T., Ratcliffe, L., Russell, K., Shankar, A. G., & Wingfield, T. (2021). Family cluster of three cases of monkeypox imported from Nigeria to the United Kingdom, May 2021. Eurosurveillance, 26(32), 2100745. https://doi.org/10.2807/1560-7917.ES.2021.26.32.2100745
   Web of Science ®Google Scholar
• Hsu, C.-I., & Shih, H.-H. (2010). Transmission and control of an emerging influenza pandemic in a small-world airline network. Accident; Analysis and Prevention, 42(1), 93–100. https://doi.org/10.1016/j.aap.2009.07.004
   PubMed Web of Science ®Google Scholar
• Hughes, B., Duong, D., White, B. J., Wigginton, K. R., Chan, E. M. G., Wolfe, M. K., & Boehm, A. B. (2022). Respiratory syncytial virus (RSV) RNA in wastewater settled solids reflects RSV clinical positivity rates. Environmental Science & Technology Letters, 9(2), 173–178. https://doi.org/10.1021/acs.estlett.1c00963
   Web of Science ®Google Scholar
• Huizer, Y. L., Swaan, C. M., Leitmeyer, K. C., & Timen, A. (2015). Usefulness and applicability of infectious disease control measures in air travel: A review. Travel Medicine and Infectious Disease, 13(1), 19–30. https://doi.org/10.1016/j.tmaid.2014.11.008
   PubMed Web of Science ®Google Scholar
• IATA. (2018). Future of the airline industry 2035. https://www.iata.org/contentassets/086e8361b2f4423e88166845afdd2f03/iata-future-airline-industry.pdf
   Google Scholar
• IATA. (2020). Passenger confidence is fundamental to the recovery in air travel [Data set]. https://www.iata.org/en/iata-repository/publications/economic-reports/Passenger-confidence-is-fundamental-to-the-recovery-in-air-travel/
   Google Scholar
• IATA. (2022). Number of scheduled passengers boarded by the global airline industry from 2004 to 2022 (in millions). Statista. https://www.statista.com/statistics/564717/airline-industry-passenger-traffic-globally/
   Google Scholar
• IATA. (2023, February 6). Passenger demand recovery continued in December 2022 & for the full year. IATA.Org. https://www.iata.org/en/pressroom/2023-releases/2023-02-06-02/
   Google Scholar
• International Energy Agency. (2022). World air passenger traffic evolution, 1980-2020 – Charts – Data & Statistics. IEA. https://www.iea.org/data-and-statistics/charts/world-air-passenger-traffic-evolution-1980-2020
   Google Scholar
• International Trade Administration. (2023). APIS/I-92 monitor. Retrieved May 4, 2023, from https://www.trade.gov/data-visualization/apisi-92-monitor
   Google Scholar
• Izquierdo-Lara, R., Elsinga, G., Heijnen, L., Munnink, B. B. O., Schapendonk, C. M. E., Nieuwenhuijse, D., Kon, M., Lu, L., Aarestrup, F. M., Lycett, S., Medema, G., Koopmans, M. P. G., & de Graaf, M. (2021). Monitoring SARS-CoV-2 circulation and diversity through community wastewater sequencing, the Netherlands and Belgium. Emerging Infectious Diseases, 27r(5), 1405–1415. https://doi.org/10.3201/eid2705.204410
   PubMed Web of Science ®Google Scholar
• Johansson, M. A., Wolford, H., Paul, P., Diaz, P. S., Chen, T.-H., Brown, C. M., Cetron, M. S., & Alvarado-Ramy, F. (2021). Reducing travel-related SARS-CoV-2 transmission with layered mitigation measures: Symptom monitoring, quarantine, and testing. BMC Medicine, 19(1), 94. https://doi.org/10.1186/s12916-021-01975-w
   PubMed Web of Science ®Google Scholar
• Jones, D. L., Rhymes, J. M., Wade, M. J., Kevill, J. L., Malham, S. K., Grimsley, J. M. S., Rimmer, C., Weightman, A. J., & Farkas, K. (2023). Suitability of aircraft wastewater for pathogen detection and public health surveillance. The Science of the Total Environment, 856(Pt 2), 159162. https://doi.org/10.1016/j.scitotenv.2022.159162
   PubMedGoogle Scholar
• Kaminski, M. M., Abudayyeh, O. O., Gootenberg, J. S., Zhang, F., & Collins, J. J. (2021). CRISPR-based diagnostics. Nature Biomedical Engineering, 5(7), 643–656. https://doi.org/10.1038/s41551-021-00760-7
   PubMed Web of Science ®Google Scholar
• Karthikeyan, S., Levy, J. I., De Hoff, P., Humphrey, G., Birmingham, A., Jepsen, K., Farmer, S., Tubb, H. M., Valles, T., Tribelhorn, C. E., Tsai, R., Aigner, S., Sathe, S., Moshiri, N., Henson, B., Mark, A. M., Hakim, A., Baer, N. A., Barber, T., … Knight, R. (2022). Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Nature, 609(7925), 101–108. https://doi.org/10.1038/s41586-022-05049-6
   PubMed Web of Science ®Google Scholar
• Karthikeyan, S., Ronquillo, N., Belda-Ferre, P., Alvarado, D., Javidi, T., Longhurst, C. A., & Knight, R. (2021). High-throughput wastewater SARS-CoV-2 detection enables forecasting of community infection dynamics in San Diego County. mSystems, 6(2), e00045–21. https://doi.org/10.1128/mSystems.00045-21
   PubMed Web of Science ®Google Scholar
• Khanh, N. C., Thai, P. Q., Quach, H.-L., Thi, N.-A H., Dinh, P. C., Duong, T. N., Mai, L. T. Q., Nghia, N. D., Tu, T. A., Quang, L. N., Quang, T. D., Nguyen, T.-T., Vogt, F., & Anh, D. D. (2020). Transmission of SARS-CoV 2 during long-haul flight. Emerging Infectious Diseases, 26(11), 2617–2624. https://doi.org/10.3201/eid2611.203299
   PubMed Web of Science ®Google Scholar
• Kilaru, P., Hill, D., Anderson, K., Collins, M. B., Green, H., Kmush, B. L., & Larsen, D. A. (2023). Wastewater surveillance for infectious disease: A systematic review. American Journal of Epidemiology, 192(2), 305–322. https://doi.org/10.1093/aje/kwac175
   PubMed Web of Science ®Google Scholar
• Kolm, C., Martzy, R., Führer, M., Mach, R. L., Krska, R., Baumgartner, S., Farnleitner, A. H., & Reischer, G. H. (2019). Detection of a microbial source tracking marker by isothermal helicase-dependent amplification and a nucleic acid lateral-flow strip test. Scientific Reports, 9(1), Article 1. https://doi.org/10.1038/s41598-018-36749-7
   PubMedGoogle Scholar
• Kuenzli, E. (2016). Antibiotic resistance and international travel: Causes and consequences. Travel Medicine and Infectious Disease, 14(6), 595–598. https://doi.org/10.1016/j.tmaid.2016.11.010
   PubMed Web of Science ®Google Scholar
• La Rosa, G., Mancini, P., Veneri, C., Ferraro, G. B., Lucentini, L., Iaconelli, M., & Suffredini, E. (2023). Detection of monkeypox virus DNA in airport wastewater, Rome, Italy. Emerging Infectious Diseases, 29(1), 193–196. https://doi.org/10.3201/eid2901.221311
   PubMed Web of Science ®Google Scholar
• Lacey, S. E., Abelmann, A., & Dorevitch, S. (2010). Exposure to human waste from spills while servicing aircraft lavatories: Hazards and methods of prevention. Industrial Health, 48(1), 123–128. https://doi.org/10.2486/indhealth.48.123
   PubMed Web of Science ®Google Scholar
• Lara-Jacobo, L. R., Islam, G., Desaulniers, J.-P., Kirkwood, A. E., & Simmons, D. B. D. (2022). Detection of SARS-CoV-2 proteins in wastewater samples by mass spectrometry. Environmental Science & Technology, 56(8), 5062–5070. https://doi.org/10.1021/acs.est.1c04705
   PubMed Web of Science ®Google Scholar
• Le Targa, L., Wurtz, N., Lacoste, A., Penant, G., Jardot, P., Annessi, A., Colson, P., La Scola, B., & Aherfi, S. (2022). SARS-CoV-2 testing of aircraft wastewater shows that mandatory tests and vaccination pass before boarding did not prevent massive importation of omicron variant into Europe. Viruses, 14(7) Article 7. https://doi.org/10.3390/v14071511
   Web of Science ®Google Scholar
• Levy, J. I., Andersen, K. G., Knight, R., & Karthikeyan, S. (2023). Wastewater surveillance for public health. Science (New York, N.Y.), 379(6627), 26–27. https://www.science.org/doi/10 .1126/science.ade2503
   PubMed Web of Science ®Google Scholar
• Li, J., Hosegood, I., Powell, D., Tscharke, B., Lawler, J., Thomas, K. V., & Mueller, J. F. (2023). A global aircraft-based wastewater genomic surveillance network for early warning of future pandemics. The Lancet Global Health, 11(5), e791–e795. https://doi.org/10.1016/S2214-109X(23)00129-8
   PubMed Web of Science ®Google Scholar
• Li, P., Zhang, T., Y ()., & T., Zhang. (2022). Measuring the flushing-generated flow and aerosols in lavatory of commercial aircraft. Building and Environment, 214, 108948. https://doi.org/10.1016/j.buildenv.2022.108948
   Web of Science ®Google Scholar
• Lodder, W., Husman, A. M., & de, R. (2020). SARS-CoV-2 in wastewater: Potential health risk, but also data source. The Lancet. Gastroenterology & Hepatology, 5(6), 533–534. https://doi.org/10.1016/S2468-1253(20)30087-X
   PubMed Web of Science ®Google Scholar
• Madden, D. (2021). The Covid-19 pandemic has cost the global tourism industry $935 billion. Forbes. https://www.forbes.com/sites/duncanmadden/2021/01/14/the-covid-19-pandemic-has-cost-the-global-tourism-industry-935-billion/
   Google Scholar
• Mangili, A., & Gendreau, M. A. (2005). Transmission of infectious diseases during commercial air travel. Lancet (London, England), 365(9463), 989–996. https://doi.org/10.1016/S0140-6736(05)71089-8
   PubMed Web of Science ®Google Scholar
• Mangili, A., Vindenes, T., & Gendreau, M. (2015). Infectious risks of air travel. Microbiology Spectrum, 3(5), 3.5.12. https://doi.org/10.1128/microbiolspec.IOL5-0009-2015
   Google Scholar
• Massey, A. (1933). Epidemiology in relation to air travel. H.K. Lewis and Co. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5163508/
   Google Scholar
• Morfino, R. C., Bart, S. M., Franklin, A., Rome, B. H., Rothstein, A. P., Aichele, T. W. S., Li, S. L., Bivins, A., Ernst, E. T., & Friedman, C. R. (2023). Notes from the field: Aircraft wastewater surveillance for early detection of SARS-CoV-2 variants—John F. Kennedy International Airport, New York City. MMWR. Morbidity and Mortality Weekly Report, 72(8), 210–211. https://doi.org/10.15585/mmwr.mm7208a3
   PubMed Web of Science ®Google Scholar
• Myers, J. F., Snyder, R. E., Porse, C. C., Tecle, S., Lowenthal, P., Danforth, M. E., Powers, E., Kamali, A., Jain, S., Fritz, C. L., & Chai, S. J. (2020). Identification and monitoring of international travelers during the initial phase of an outbreak of COVID-19—California, February 3–March 17, 2020. MMWR. Morbidity and Mortality Weekly Report, 69(19), 599–602. https://doi.org/10.15585/mmwr.mm6919e4
   PubMed Web of Science ®Google Scholar
• Ng, T. F. F., Marine, R., Wang, C., Simmonds, P., Kapusinszky, B., Bodhidatta, L., Oderinde, B. S., Wommack, K. E., & Delwart, E. (2012). High variety of known and new RNA and DNA viruses of diverse origins in untreated sewage. Journal of Virology, 86(22), 12161–12175. https://doi.org/10.1128/JVI.00869-12
   PubMed Web of Science ®Google Scholar
• Nikolaou, P., & Dimitriou, L. (2020). Identification of critical airports for controlling global infectious disease outbreaks: Stress-tests focusing in Europe. Journal of Air Transport Management, 85, 101819. https://doi.org/10.1016/j.jairtraman.2020.101819
   PubMed Web of Science ®Google Scholar
• Nkambule, S., Johnson, R., Mathee, A., Mahlangeni, N., Webster, C., Horn, S., Mangwana, N., Dias, S., Sharma, J. R., Ramharack, P., Louw, J., Reddy, T., Surujlal-Naicker, S., Mdhluli, M., Gray, G., Muller, C., & Street, R. (2023). Wastewater-based SARS-CoV-2 airport surveillance: Key trends at the Cape Town International Airport. Journal of Water and Health, 21(3), 402–408. https://doi.org/10.2166/wh.2023.281
   PubMed Web of Science ®Google Scholar
• Nordahl Petersen, T., Rasmussen, S., Hasman, H., Carøe, C., Bælum, J., C., Schultz, A., Bergmark, L., Svendsen, C. A., Lund, O., Sicheritz-Pontén, T., & Aarestrup, F. M. (2015). Meta-genomic analysis of toilet waste from long distance flights; a step towards global surveillance of infectious diseases and antimicrobial resistance. Scientific Reports, 5(1), 11444. https://doi.org/10.1038/srep11444
   PubMedGoogle Scholar
• Ozonoff, D., & Pepper, L. (2005). Ticket to ride: Spreading germs a mile high. Lancet (London, England), 365(9463), 917–919. https://doi.org/10.1016/S0140-6736(05)71058-8
   PubMed Web of Science ®Google Scholar
• Peiris, J. S. M., Yuen, K. Y., Osterhaus, A. D. M. E., & Stöhr, K. (2003). The severe acute respiratory syndrome. The New England Journal of Medicine, 349(25), 2431–2441. https://doi.org/10.1056/NEJMra032498
   PubMed Web of Science ®Google Scholar
• Phan, L. T., Nguyen, T. V., Luong, Q. C., Nguyen, T. V., Nguyen, H. T., Le, H. Q., Nguyen, T. T., Cao, T. M., & Pham, Q. D. (2020). Importation and human-to-human transmission of a novel coronavirus in Vietnam. The New England Journal of Medicine, 382(9), 872–874. https://doi.org/10.1056/NEJMc2001272
   PubMed Web of Science ®Google Scholar
• Quick, J., Loman, N. J., Duraffour, S., Simpson, J. T., Severi, E., Cowley, L., Bore, J. A., Koundouno, R., Dudas, G., Mikhail, A., Ouédraogo, N., Afrough, B., Bah, A., Baum, J. H., Becker-Ziaja, B., Boettcher, J.-P., Cabeza-Cabrerizo, M., Camino-Sanchez, A., Carter, L. L., … Carroll, M. W. (2016). Real-time, portable genome sequencing for Ebola surveillance. Nature, 530(7589), 228–232. https://doi.org/10.1038/nature16996
   PubMed Web of Science ®Google Scholar
• Rao, A. K., Schulte, J., Chen, T.-H., Hughes, C. M., Davidson, W., Neff, J. M., Markarian, M., Delea, K. C., Wada, S., Liddell, A., Alexander, S., Sunshine, B., Huang, P., Honza, H. T., Rey, A., Monroe, B., Doty, J., Christensen, B., Delaney, L., … McCollum, A. M. (2022). Monkeypox in a traveler returning from Nigeria—Dallas, Texas, July 2021. MMWR. Morbidity and Mortality Weekly Report, 71(14), 509–516. https://doi.org/10.15585/mmwr.mm7114a1
   PubMed Web of Science ®Google Scholar
• Rilstone, V. (2019). The potential breach vectors in biosecurity practices and the issues associated with airplane lavatory waste. Queen’s University.
   Google Scholar
• Rosca, E. C., Heneghan, C., Spencer, E. A., Brassey, J., Plüddemann, A., Onakpoya, I. J., Evans, D. H., Conly, J. M., & Jefferson, T. (2021). Transmission of SARS-CoV-2 associated with aircraft travel: A systematic review. Journal of Travel Medicine, 28(7), taab133. https://doi.org/10.1093/jtm/taab133
   PubMed Web of Science ®Google Scholar
• Selvey, L. A., Antão, C., & Hall, R. (2015). Evaluation of border entry screening for infectious diseases in humans. Emerging Infectious Diseases, 21(2), 197–201. https://doi.org/10.3201/eid2102.131610
   PubMed Web of Science ®Google Scholar
• Shieh, Y. S., Baric, R. S., & Sobsey, M. D. (1997). Detection of low levels of enteric viruses in metropolitan and airplane sewage. Applied and Environmental Microbiology, 63(11), 4401–4407. https://doi.org/10.1128/aem.63.11.4401-4407.1997
   PubMed Web of Science ®Google Scholar
• Shu, P.-Y., Chien, L.-J., Chang, S.-F., Su, C.-L., Kuo, Y.-C., Liao, T.-L., Ho, M.-S., Lin, T.-H., & Huang, J.-H. (2005). Fever screening at airports and imported dengue. Emerging Infectious Diseases, 11(3), 460–462. https://doi.org/10.3201/eid1103.040420
   PubMed Web of Science ®Google Scholar
• Sotomayor-Castillo, C., Radford, K., Li, C., Nahidi, S., & Shaban, R. Z. (2021). Air travel in a COVID-19 world: Commercial airline passengers’ health concerns and attitudes towards infection prevention and disease control measures. Infection, Disease & Health, 26(2), 110–117. https://doi.org/10.1016/j.idh.2020.11.002
   PubMed Web of Science ®Google Scholar
• Statista. (2023). U.S. airports—International passenger traffic 2021. https://www.statista.com/statistics/639826/leading-airports-united-states-for-international-air-passenger-traffic/
   Google Scholar
• Tatem, A. J., Huang, Z., Das, A., Qi, Q., Roth, J., & Qiu, Y. (2012). Air travel and vector-borne disease movement. Parasitology, 139(14), 1816–1830. https://doi.org/10.1017/S0031182012000352
   PubMed Web of Science ®Google Scholar
• Tatem, A. J., Jia, P., Ordanovich, D., Falkner, M., Huang, Z., Howes, R., Hay, S. I., Gething, P. W., & Smith, D. L. (2017). The geography of imported malaria to non-endemic countries: A meta-analysis of nationally reported statistics. The Lancet. Infectious Diseases, 17(1), 98–107. https://doi.org/10.1016/S1473-3099(16)30326-7
   PubMed Web of Science ®Google Scholar
• Tatem, A. J., Rogers, D. J., Hay, S. I., Hay, S. I., Graham, A., & Rogers, D. J. (2006). Global transport networks and infectious disease spread. In (Eds.), Advances in parasitology (Vol. 62, pp. 293–343). Academic Press. https://doi.org/10.1016/S0065-308X(05)62009-X
   Google Scholar
• Thomas, R. (1992). Geomedical systems: Intervention and control. Routledge. https://research.manchester.ac.uk/en/publications/geomedical-systems-intervention-and-control
   Google Scholar
• Tiwari, A., Kurittu, P., Al-Mustapha, A. I., Heljanko, V., Johansson, V., Thakali, O., Mishra, S. K., Lehto, K.-M., Lipponen, A., Oikarinen, S., Pitkänen, T., Heikinheimo, A., Länsivaara, A., Hyder, R., Janhonen, E., Hokajärvi, A.-M., Sarekoski, A., Kolehmainen, A., … Mishra, S. K. (2022). Wastewater surveillance of antibiotic-resistant bacterial pathogens: A systematic review. Frontiers in Microbiology, 13, 977106. https://www.frontiersin.org/articles/10 .3389/fmicb.2022.977106
   PubMed Web of Science ®Google Scholar
• Toovey, S., & Jamieson, A. (2003). Rolling back malaria: How well is Europe doing? Travel Medicine and Infectious Disease, 1(3), 167–175. https://doi.org/10.1016/j.tmaid.2003.09.004
   PubMedGoogle Scholar
• UK Health Security Agency. (2022, April 9). Crimean-Congo haemorrhagic fever case identified in England, following travel to Central Asia. https://www.gov.uk/government/news/crimean-congo-haemorrhagic-fever-case-identified-in-england-following-travel-to-central-asia
   Google Scholar
• Uluseker, C., Kaster, K. M., Thorsen, K., Basiry, D., Shobana, S., Jain, M., Kumar, G., Kommedal, R., & Pala-Ozkok, I. (2021). A review on occurrence and spread of antibiotic resistance in wastewaters and in wastewater treatment plants: Mechanisms and perspectives. Frontiers in Microbiology, 12, 717809. https://www.frontiersin.org/article/10 .3389/fmicb.2021.717809
   PubMed Web of Science ®Google Scholar
• Vries, L., de, Koopmans, M., Morton, A., Baal., & P., van. (2021). The economics of improving global infectious disease surveillance. BMJ Global Health, 6(9), e006597. https://doi.org/10.1136/bmjgh-2021-006597
   PubMed Web of Science ®Google Scholar
• Wang, D., Coscoy, L., Zylberberg, M., Avila, P. C., Boushey, H. A., Ganem, D., & DeRisi, J. L. (2002). Microarray-based detection and genotyping of viral pathogens. Proceedings of the National Academy of Sciences of the United States of America, 99(24), 15687–15692. https://doi.org/10.1073/pnas.242579699
   PubMed Web of Science ®Google Scholar
• Wellcome Trust. (2021, September 13). The cost of not preparing for infectious diseases. https://wellcome.org/news/cost-of-not-preparing-for-infectious-diseases
   Google Scholar
• Wilkerson, J. T., Jacobson, M. Z., Malwitz, A., Balasubramanian, S., Wayson, R., Fleming, G., Naiman, A. D., & Lele, S. K. (2010). Analysis of emission data from global commercial aviation: 2004 and 2006. Atmospheric Chemistry and Physics, 10(13), 6391–6408. https://doi.org/10.5194/acp-10-6391-2010
   Web of Science ®Google Scholar
• Wolfe, M. K., Duong, D., Bakker, K. M., Ammerman, M., Mortenson, L., Hughes, B., Arts, P., Lauring, A. S., Fitzsimmons, W. J., Bendall, E., Hwang, C. E., Martin, E. T., White, B. J., Boehm, A. B., & Wigginton, K. R. (2022). Wastewater-based detection of two influenza outbreaks. Environmental Science & Technology Letters, 9(8), 687–692. https://doi.org/10.1021/acs.estlett.2c00350
   Web of Science ®Google Scholar
• Yan, T., O’Brien, P., Shelton, J. M., Whelen, A. C., & Pagaling, E. (2018). Municipal wastewater as a microbial surveillance platform for enteric diseases: A case study for Salmonella and Salmonellosis. Environmental Science & Technology, 52(8), 4869–4877. https://doi.org/10.1021/acs.est.8b00163
   PubMed Web of Science ®Google Scholar
• Zasada, A. A., Mosiej, E., Prygiel, M., Polak, M., Wdowiak, K., Formińska, K., Ziółkowski, R., Żukowski, K., Marchlewicz, K., Nowiński, A., Nowińska, J., Rastawicki, W., & Malinowska, E. (2022). Detection of SARS-CoV-2 using reverse transcription helicase dependent amplification and reverse transcription loop-mediated amplification combined with lateral flow assay. Biomedicines, 10(9), Article 9. https://doi.org/10.3390/biomedicines10092329
   Web of Science ®Google Scholar