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Original Articles

Induction of cytochrome P450 as a biomarker for environmental contamination in aquatic ecosystems

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Pages 201-268 | Published online: 09 Jan 2009

References

  • Achazi , R. K. and Leydecker , A. 1992 . Health status of thirteen fish species of low and high polluted fresh water habitats of Berlin west . Zool. Beitr. , 34 : 447
  • Adams , S. M. 1990 . Status and use of biological indicators for evaluating the effects of stress on fish . Am. Fish. Soc. Symp. , 8 : 1
  • Adams , S. M. , Shepard , K. L. , Greeley , M. S. Jr. , Jimenez , B. D. , Ryon , M. G. , Shugart , L. R. and McCarthy , J. F. 1989 . The use of bioindicators for assessing the effects of pollutant stress on fish . Mar. Environ. Res. , 28 : 459
  • Adams , S. M. , Crumby , W. D. , Greeley , M. S. , Shugart , L. R. and Saylor , C. F. 1992 . Responses of fish populations and communities to pulp mill effluents: a holistic assessment . Ecotoxicol. Environ. Saf. , 24 : 347
  • Addison , R. F. and Edwards , A. J. 1988 . Hepatic microsomal mono‐oxygenase activity in flounder Platichthys flesus from polluted sites in Langesundfjord and from mesocosms experimentally dosed with diesel oil and copper . Mar. Ecol. Prog. Ser. , 46 : 51
  • Ahner , B. A. , Price , N. M. and Morel , F. M. M. 1994 . Phytochelation production by marine phytoplankton at low free metal ion concentration: laboratory studies and field data from Massachusetts bay . Proc. Natl. Acad. Sci. U. S. A. , 91 : 8433
  • Ahokas , J. T. , Holdway , D. A. , Brennan , S. E. , Goudey , R. W. and Bibrowska , H. B. 1994 . MFO activity in carp (Cyprinus carpio) exposed to treated pulp and paper mill effluent in Lake Coleman, Victoria, Australia, in relation to AOX, EOX, and muscle PCDD/PCDF . Environ. Toxicol. Chem. , 13 : 41
  • Albores , A. , Cerbian , M. E. , Connelly , J. C. , Bach , P. H. and Bridges , J. W. 1992 . Effects of arsenite on hepatic mixed‐function oxidase activity in rats . Xenobiotica , 22 : 591
  • Ames , B. N. and Gold , L. S. 1991 . Carcinogenesis mechanisms . Science , 252 : 902
  • Andersson , T. 1990 . Sex differences in cytochrome P‐450‐dependent xenobiotic and steroid metabolism in the mature rainbow trout kidney . J. Endocrinol. , 126 : 9
  • Andersson , T. and Koivussari , U. 1985 . Influence of environmental temperature on the induction of xenobiotic metabolism by β‐naphthoflavone in rainbow trout, Salmo gairdneri . Toxicol. Appl. Pharmacol. , 80 : 43
  • Andersson , T. and Förlin , L. 1992 . Regulation of the cytochrome P450 enzyme system in fish . Aquat. Toxicol. , 24 : 1
  • Andersson , T. , Pesonen , M. and Johansson , C. 1985 . Differential induction of cytochrome P‐450‐depen‐dent monooxygenase, glutathione S‐transferase, and UDP‐glucuronosyltransferase activities in the liver of the rainbow trout by P‐naphthoflavone or Clophen A50 . Biochem. Pharmacol. , 34 : 3309
  • Andersson , T. , Bengtsson , B.‐E. , Förlin , L. , Hardig , J. and Larsson , A. 1987 . Long‐term effects of bleached kraft mill effluent on carbohydrate metabolism and hepatic biotransformation enzymes in fish . Ecotoxicol. Environ. Saf. , 13 : 53
  • Andersson , T. , Förlin , L. , Härdig , J. and Larsson , A. 1988 . Physiological disturbances in fish living in coastal water polluted with bleached kraft pulp mill effluents . Can. J. Fish. Aquat. Sci. , 45 : 1525
  • Ankley , G. T. , Reinert , R. E. , Wade , A. E. and White , W. A. 1985 . Temperature compensation in the hepatic mixed‐function oxidase system in bluegill . Comp. Biochem. Physiol. C , 81 : 125
  • Ankley , G. T. , Tillitt , D. E. , Giesy , J. P. , Jones , P. D. and Verbrugge , D. A. 1991 . Bioassay‐derived 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin equivalents in PCB‐containing extracts from the flesh and eggs of Lake Michigan chinook salmon (Oncorhynchus tshawytscha) and possible implications for reproduction . Can. J. Fish Aquat. Sci. , 48 : 1685
  • Arinç , E. and Sen , A. 1993 . Effects of in vivo benzene treatment on cytochrome P450 and mixed‐function oxidase activities of gilthead seabream (Spams aurata) liver microsomes . Comp. Biochem. Physiol., C , 104 : 61
  • Ashburner , M. and Bonner , J. J. 1979 . The induction of gene activity in Drosophila by heat shock . Cell , 17 : 241
  • Bhatia , A. , Tobil , F. , Lepschy , G. , Werk , X. and Mazzucco , K. 1994 . Biomonitoring of pollution: the hepatic cytochrome P‐450 enzyme system in the feral mouse Apodemus flavicollis as indicator . Chemosphere , 28 : 1525
  • Berndtson , A. K. and Chen , T. T. 1994 . Two unique CYP1 genes are expressed in response to 3‐methyl‐cholanthrene treatment in rainbow trout . Arch. Biochem. Biophys. , 310 : 187
  • Beyer , J. , Sleiderink , H. M. and Goks⊘yr , A. 1993 . “ P450 1A1 ELISA measurements in dab (Limanda limanda). INP‐MICON cruises 1991–92 (Abstr.) ” . In Seventh International Symposium on Responses of Marine Organisms to Pollutants (PRIMO 7) , Goteborg, , Sweden : University of Goteborg .
  • Blanck , J. , Lindström‐Seppä , P. , Agren , J. J. , Hänninen , O. , Rein , H. and Ruckpaul , K. 1989 . Temperature compensation of hepatic microsomal cytochrome P‐450 activity in rainbow trout. I. Thermody‐namic regulation during water cooling in autumn . Comp. Biochem. Physiol. C , 93 : 55
  • Blom , A. , Harder , W. and Matin , A. 1992 . Unique and overlapping pollutant stress proteins of Escherichia coli . Appl. Environ. Microbiol. , 58 : 331
  • Bolognesi , C. , Parrini , M. , Valerio , F. , Piccardo , M. T. and Pellegrino , C. 1990 . Genotoxic effects and tissue concentrations of polycyclic aromatic hydrocarbons in mussel: a comparison study . Paper presented at 4th Int. Conf. Environ. Contain. . October 1 to 4 1990 , Barcelona, Spain.
  • Boon , J. P. , Everhaarts , J. M. , Hillebrand , M. T. J. , Eggens , M. L. , Pijnenburg , J. and Goks⊘yr , A. 1992 . Changes in levels of hepatic biotransformation enzymes and haemoglobin levels in female plaice (Pleuronectes platessa) after oral administration of a technical polychlorinated biphenyl mixture (Clophen A40) . Sci. Total Environ. , 114 : 113
  • Boon , J. P. , Everhaarts , J. M. , Ten Hallers , C. C. , Seiderink , H. M. , Beyer , J. , Goks⊘yr , A. , Klungs⊘yr , J. , Wilhelmsen , S. , Halbrook , R. S. , Shugart , L. R. , Ariese , F. , Nieuwenhuize , J. , Van Liere , J. M. , Vethaak , A. D. and Eggens , M. L. . The integrated North Sea programme 1991–92; theme microcontaminants (Abstr.) . Seventh International Symposium on Responses of Marine Organisms to Pollutants (PRIMO 7) . Göteborg, , Sweden : University of Göteborg .
  • Bosveld , A. T. C. , Gradener , J. , Van Kampen , M. , Evers , E. H. G. and Van den Berg , M. 1992 . A comparative laboratory breeding study with eggs from common tern collected at eight different colonies in The Netherlands and Belgium . Paper presented at 13th Annu. Meet. Soc. Environ. Toxicol. Chem. . November 8 to 12 1992 , Cincinnati, Ohio. Abstr. 584
  • Braunbeck , T. and Völkl , A. 1993 . “ Toxicant‐induced cytological alterations in fish liver as biomarkers of environmental pollution? A case study on hepatocellular effects of dinitro‐o‐cresol in golden ide (Leuciscus idus melanotus) ” . In Fish Toxicology and Ecophysiology , Edited by: Braunbeck , T. , Hanke , W. and Segner , H. 55 Weinheim, , West Germany : VCH Publishers .
  • Brunetti , R. , Majone , F. , Gola , I. and Beltrame , C. 1988 . The micronucleus test: examples of application to marine ecology . Mar. Ecol. Prog. Ser. , 44 : 65
  • Brunetti , R. , Majone , F. , Zordan , M. and Levis , A. G. 1989 . “ Cytogenetic alterations in Mytilus galloprovincialis as indicators of genotoxic pollutants in the environment: methodological aspects ” . In Carcinogenic, Mutagenic, and Teratogenic Marine Pollutants: Impact on Human Health and the Environment , Adv. Appl. Biotechnol. Ser. 101 The Woodlands, TX : World Health Organization Regional Office for Europe and United Nations Environmental Programme .
  • Bucher , F. , Hofer , R. and Salvenmoser , W. 1992 . Effects of treated paper mill effluents on hepatic morphology in male bullhead (Cottus gobio L.) . Arch. Contam. Toxicol. , 23 : 410
  • Buhler , D. R. and Williams , D. E. 1989 . “ Enzymes involved in metabolism of PAH by fishes and other aquatic animals: oxidative enzymes (or phase I enzymes) ” . In Metabolism of Polycyclic Aromatic Hydrocarbons in the Aquatic Environment , Edited by: Varanasi , U. 151 Boca Raton, FL : CRC Press .
  • Burdon , R. H. 1986 . Heat shock and heat shock proteins . Biochem. J. , 240 : 313
  • Castren , M. and Oikari , A. 1987 . Changes of the liver UDP‐glucuronosyltransferase activity in trout (Salmo gairdneri Rich.) acutely exposed to selected aquatic toxicants . Comp. Biochem. Physiol. C , 86 : 357
  • Celander , M. and Förlin , L. 1991 . Catalytic activity and immunochemical quantification of hepatic cytochrome P‐450 in beta‐naphthoflavone and isosafrol treated rainbow trout (Oncorhynchus mykiss) . Fish Physiol. Biochem. , 9 : 189
  • Celander , M. , Leaver , M. J. , George , S. G. and Förlin , L. 1993 . Induction of cytochrome P450 1A1 and conjugating enzymes in rainbow trout (Oncorhynchus mykiss) liver: a time course study . Comp. Biochem. Physiol. C , 106 : 343
  • Cochrane , B. J. , Irby , R. B. and Snell , T. W. 1991 . Effects of copper and tributyltin on stress protein abundance in the rotifer Brachionus picatilis . Comp. Biochem. Physiol. C , 98 : 385
  • Collier , T. K. and Varanasi , U. 1991 . Hepatic activities of xenobiotic metabolizing enzymes and biliary levels of xenobiotics in English sole (Parophrys vetulus) exposed to environmental contaminants . Arch. Environ. Contam. Toxicol. , 20 : 462
  • Collier , T. K. , Denise Connor , S. D. , Eberhart , B.‐T. L. , Anulacion , B. F. , Goks⊘yr , A. and Varanasi , U. 1992 . Using cytochrome P450 to monitor the aquatic environment: initial results from regional and national surveys . Mar. Environ. Res. , 34 : 193
  • Courtenay , S. , Grunwald , C. , Kreamer , G.‐L. , Alexander , R. and Wirgin , I. 1993 . Induction and clearance of cytochrome P4501A mRNA in Atlantic tomcod caged in bleached kraft mill effluent in the Miramichi River . Aquat. Toxicol. , 27 : 225
  • Cousins , R. J. 1985 . Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin . Physiol. Rev. , 65 : 238
  • Craig , E. A. , Gambill , B. D. and Nelson , R. J. 1993 . Heat shock proteins: molecular chaperons of protein biogenesis . Microbiol. Rev. , 57 : 402
  • Curtis , L. R. , Carpenter , H. M. , Donohoe , R. M. , Williams , D. E. , Hedstrom , O. R. , Deinzer , M. L. , Beilstein , M. A. , Foster , E. and Gates , R. 1993 . Sensitivity of cytochrome P450–1A1 induction in fish as a biomarker for distribution of TCDD and TCDF in the Willamette River, Oregon . Environ. Sci. Technol. , 27 : 2149
  • Dasmahapatra , A. K. and Lee , P. C. 1993 . Down regulation of CYP 1A1 by glucocorticoids in trout hepatocytes in vitro, In Vitro . Cell. Dev. Biol. , 29A : 643
  • Davies , J. M. , Bell , J. S. and Houghton , C. 1984 . A comparison of the levels of hepatic aryl hydrocarbon hydroxylase in fish caught close or distant from North Sea oil fields . Mar. Environ. Res. , 14 : 23
  • De Flora , S. , Bagnasco , M. and Zanacchi , P. 1991a . Genotoxic, carcinogenetic, and teratogenic hazards in the marine environment, with special reference to the Mediterranean Sea . Mutat. Res. , 258 : 285
  • De Flora , S. , Zanacchi , P. , Bagnasco , M. , Brunetti , R. , Majone , F. and Levis , A. G. 1991b . “ Metabolic and genetic effects of marine pollution on aquatic organisms ” . In New Horizons in Biological Dosimetry , Edited by: Gledhill , B. L. and Mauro , F. 69 New York : Wiley‐Liss .
  • De Flora , S. , Vigano , L. , D'Agostini , F. , Camoirano , A. , Bagnasco , M. , Bennicelli , C. , Melodia , F. and Arillo , A. 1993 . Multiple genotoxicity biomarkers in fish exposed in situ to polluted river water . Mutat. Res. , 319 : 167
  • Den Besten , P. J. , Herwig , H. J. , Van Donselaar , E. G. and Livingstone , D. R. 1990 . Cytochrome P‐450 monooxygenase system and benzo(a)pyrene metabolism in echinoderms . Mar. Biol. , 107 : 171
  • Den Besten , P. J. , Lemaire , P. , Livingstone , D. R. , Woodin , B. , Stegeman , J. J. , Herwig , H. J. and Seinen , W. 1993 . Time‐course and dose‐response of the apparent induction of the cytochrome P450 monooxygenase system of pyloric caeca microsomes of the female sea star Asterias rubens L. by benzo[a]pyrene and polychlorinated biphenyls . Aquat. Toxicol. , 26 : 23
  • Devaux , A. , Pesonen , M. , Monod , G. and Andersson , T. 1992 . Glucocorticoid‐mediated potentiation of P450 induction in primary culture of rainbow trout hepatocytes . Biochem. Pharmacol. , 43 : 898
  • Dewaide , J. H. and Henderson , P. T. H. 1970 . Seasonal variation of hepatic drug metabolism in the roach (Leuciscus rutilus L.) . Comp. Biochem. Physiol. , 32 : 489
  • Di Guilio , R. T. , Habig , C. and Gallagher , E. P. 1993 . Effects of Black Rock Harbor sediments on indices of biotransformation, oxidative stress, and DNA integrity in channel catfish . Aquat. Toxicol. , 26 : 1
  • Dixon , D. R. and Presser , H. 1986 . An investigation of the genotoxic effects of an organotin antifouling compound (bis(tributyltin)oxide) on the chromosomes of the edible mussel, Mytilus edulis . Aquat. Toxicol. , 8 : 185
  • Donato , M. T. , Castell , J. V. and Gomez‐Lechon , M. J. 1992 . A rapid and sensitive method for measuring monooxygenase activities in hepatocytes cultured in 96‐well plates . J. Tiss. Cult. Methods , 14 : 153
  • Dunn , B. P. , Black , J. J. and Maccubbin , A. 1987 . 32P‐postlabeling analysis of aromatic DNA adducts in fish from polluted areas . Cancer Res. , 47 : 6543
  • Dyer , S. D. , Brooks , G. L. , Dickson , K. L. , Sandes , B. M. and Zimmerman , E. G. 1993a . Synthesis and accumulation of stress proteins in tissues of arsenite‐exposed fathead minnows (Pimephales promelas) . Environ. Toxicol. Chem. , 12 : 913
  • Dyer , S. D. , Brooks , G. L. and Zimmerman , E. G. 1993b . “ A laboratory evaluation of the use of stress proteins in fish to detect changes in water quality ” . In Environmental Toxicology and Risk Assessment , Edited by: Landis , W. G. , Huges , J. J. and Lewis , M. A. 273 Philadelphia : American Society for Testing and Materials .
  • Eggens , M. L. and Galgani , F. 1992 . Ethoxyresorufin‐O‐deethylase (EROD) activity in flatfish: fast determination with a fluorescense plate‐reader . Mar. Environ. Res. , 33 : 213
  • Elcombe , C. R. and Lech , J. J. 1979 . Induction and characterization of hemoprotein(s) P450 and monooxygenation in rainbow trout (Salmo gairdneri) . Toxicol. Appl. Pharmacol. , 49 : 437
  • Elliot , J. E. , Whitehead , P. E. , Norstrom , R. J. , Sandersson , J. T. , Hart , L. E. , Cheng , K. and Bellward , G. D. 1992 . Monitoring biological effects of dioxin exposure in great blue heron embryos . Paper presented at 13th Annu. Meet. Soc. Environ. Toxicol. Chem. . November 8 to 12 1992 , Cincinnati, Ohio. Abstr. 581
  • Elskus , A. A. and Stegeman , J. J. 1989 . Induced cytochrome P‐450 in Fundulus heteroclitus associated with environmental contamination by polychlorinated biphenyls and polynuclear aromatic hydrocarbons . Mar. Environ. Res. , 27 : 31
  • Elskus , A. A. , Stegeman , J. J. , Susani , L. C. , Black , D. , Pruell , R. J. and Fluck , S. J. 1989 . Polychlorinated biphenyls concentration and cytochrome P‐450E expression in winter flounder from contaminated environments . Mar. Environ. Res. , 28 : 25
  • Elskus , A. A. , Pruell , R. and Stegeman , J. J. 1992 . Endogenously‐mediated, pretranslational suppression of cytochrome P4501A in PCB‐contaminated flounder . Mar. Environ. Res. , 34 : 97
  • Fabacher , D. L. and Baumann , P. C. 1985 . Enlarged livers and hepatic microsomal mixed‐function oxidase components in tumor‐bearing brown bullheads from a chemically contaminated river . Environ. Toxicol. Chem. , 4 : 703
  • Fent , K. and Stegeman , J. J. 1991 . Effects of tributyltin chloride in vitro on the hepatic microsomal monooxygenase system in the fish Stenotomus chrysops . Aquat. Toxicol. , 20 : 159
  • Fent , K. and Stegeman , J. J. 1993 . Effects of tributyltin in vivo on hepatic cytochrome P450 forms in marine fish . Aquat. Toxicol. , 24 : 219
  • Fent , K. and Bucheli , T. D. 1994 . Inhibition of hepatic microsomal monooxygenase system by organotins in vitro in freshwater fish . Aquat. Toxicol. , 28 : 107
  • Focardi , S. , Fossi , C. , Leonzio , C. and Di Simplicio , P. 1989 . Mixed‐function oxygenase activity and conjugating enzymes in two species of antarctic fish . Mar. Environ. Res. , 28 : 31
  • Förlin , L. and Celander , M. 1993 . Induction of cytochrome P450 1A in teleosts: environmental monitoring in Swedish fresh, brackish and marine waters . Aquat. Toxicol. , 26 : 41
  • Förlin , L. , Andersson , T. , Koivussari , U. and Hannson , T. 1984 . Influence of biological and environmental factors on hepatic steroid and xenobiotic metabolism in fish: interaction with PCB and ß‐naphthoflavone . Mar. Environ. Res. , 14 : 47
  • Förlin , L. , Andersson , T. , Bengtsson , B.‐E. , Härdig , J. and Larsson , A. 1985 . Effects of pulp bleach plant effluents on hepatic xenobiotic biotransformation enzymes in fish: laboratory and field studies . Mar. Environ. Res. , 17 : 109
  • Förlin , L. , Haux , C. , Karlsson‐Norrgren , L. , Runn , P. and Larsson , A. 1986 . Biotransformation enzyme activities and histopathology in rainbow trout, Salmo gairdneri, treated with cadmium . Aquat. Toxicol. , 8 : 51
  • Förlin , L. , Balk , L. , Celander , M. , Bergek , S. , Hjelt , M. , Rappe , C. , de Wit , C. and Jansson , B. 1992 . Biotransformation enzyme activities and PCDD/PCDF levels in pike caught in a Swedish lake . Mar. Environ. Res. , 34 : 169
  • Foureman , G. L. 1989 . “ Enzymes involved in metabolism of PAH by fishes and other aquatic animals: hydrolysis and conjugation enzymes (or phase II enzymes) ” . In Metabolism of Polycyclic Aromatic Hydrocarbons in the Aquatic Environment , Edited by: Varanasi , U. 185 Boca Raton, FL : CRC Press .
  • Foureman , G. L. , White , N. B. Jr. and Bend , J. R. 1983 . Biochemical evidence that winter flounder (Pseudopleuronectes americanus) have induced hepatic cytochrome P‐450‐dependent monooxygenase activities . Can. J. Fish. Aquat. Sci. , 40 : 854
  • Fries , C. R. and Lee , R. F. 1984 . Pollutant effects on the mixed function oxygenase (MFO) and reproductive systems of the marine polychaete . Nereis virens, Mar. Biol. , 79 : 187
  • Gagnon , M. M. , Dodson , J. J. , Hodson , P. V. , Van der Kraak , G. and Carey , J. H. 1994 . Seasonal effects of bleached kraft mill effluent on reproductive parameters of white sucker (Catostomus commersoni) populations of the St. Maurice River, Quebec, Canada . Can. J. Fish. Aquat. Sci. , 51 : 337
  • Galgani , F. , Bocquene , G. , Lucon , M. , Grzebyk , D. , Letrouit , F. and Claisse , D. 1991 . EROD measurements in fish from the northwest part of France . Mar. Pollut. Bull , 22 : 494
  • Gallagher , E. P. and Di Giulio , R. T. 1989 . Effects of complex waste mixtures on hepatic monooxygenase activities in brown bullheads (Ictalurus nebulosus) . Environ. Pollut. , 62 : 113
  • Gatenby , A. A. , Donaldson , G. K. , Goloubinoff , P. , LaRossa , R. A. , Lorimer , G. H. , Lubben , T. H. , Van Dyk , T. K. and Viitanen , P. V. 1990 . “ The cellular functions of chaperonins ” . In Stress Proteins: Induction and Function , Edited by: Schlesinger , M. J. , Santoro , M. G. and Garaci , E. 57 New York : Springer‐Verlag .
  • George , S. G. 1989 . Cadmium effects on plaice liver xenobiotic and metal detoxication systems: dose‐response . Aquat. Toxicol. , 15 : 303
  • George , S. and Henderson , J. 1992 . Influence of dietary PUFA content on cytochrome P450 and transferase activities in Atlantic salmon (Salmo salar) . Mar Environ. Res. , 34 : 127
  • George , S. , Leaver , M. , Frerichs , N. and Burgess , D. 1989 . Fish metallothioneins: molecular cloning studies and induction in cultured cells . Mar. Environ. Res. , 28 : 173
  • George , S. G. , Groman , D. , Brown , S. and Holmes , K. 1992 . Studies of a fatal pollutant‐induced hyperbilirubinaemia in spawning Atlantic salmon . Mar. Environ. Res. , 34 : 81
  • Gerhart , E. H. and Carlson , R. M. 1978 . Hepatic mixed‐function oxidase activity in rainbow trout exposed to several polycyclic aromatic hydrocarbons . Environ. Res. , 17 : 284
  • Gilewicz , M. , Guillaume , J. R. , Carles , D. , Leveau , M. and Bertrand , J. C. 1984 . Effects of petroleum hydrocarbons on the cytochrome P‐450 content of the mollusc bivalve Mytilus galloprovincialis . Mar. Biol. , 80 : 155
  • Goddard , K. A. , Schultz , R. J. and Stegeman , J. J. 1987 . Uptake, toxicity, and distribution of benzo[o]pyrene and monooxygenase induction in the topminnows Poeciliopsis monacha and Poeciliopsis lucida . Drug Metab. Dispos. , 15 : 449
  • Goering , P. L. , Fisher , B. R. and Kish , C. L. 1993 . Stress protein synthesis induced in rat liver by cadmium precedes hepatotoxicity . Toxicol. Appl. Pharmacol. , 122 : 139
  • Goks⊘yr , A. 1991 . Semi‐quantitative cytochrome P450 IA1 ELISA: a simple method for studying the monooxygenase induction response in environmental monitoring and ecotoxicological testing offish . Sci. Total Environ. , 101 : 255
  • Goks⊘yr , A. and Förlin , L. 1992 . The cytochrome P‐450 system in fish, aquatic toxicology and environmental monitoring . Aquat. Toxicol. , 22 : 287
  • Goks⊘yr , A. and Hus⊘y , A. M. 1992 . The cytochrome P450 1A1 response in fish: application of immunodetection in environmental monitoring and toxicological testing . Mar. Environ. Res. , 34 : 147
  • Goks⊘yr , A. , Andersson , T. , Hansson , T. , Klungs⊘yr , J. , Zhang , Y. and Förlin , L. 1987 . Species characteristics of the hepatic xenobiotic and steroid biotransformation systems of two teleost fish, Atlantic cod (Gadus morhua) and rainbow trout (Salmo gairdneri) . Toxicol. Appl. Pharmacol. , 89 : 347
  • Goks⊘yr , A. , Hus⊘y , A.‐M. , Larsen , H. E. , Klungs⊘yr , J. , Wilhelmsen , S. , Maage , A. , Brevik , E. M. , Andersson , T. , Celander , M. , Pesonen , M. and Förlin , L. 1991 . Environmental contaminants and biochemical responses in flatfish from the Hvaler Archipelago in Norway . Arch. Environ. Contant. Toxicol. , 21 : 486
  • Goks⊘yr , A. , Beyer , J. and Larsen , H. E. 1992 . Cytochrome P450 in seals: monooxygenase activities, immunochemical cross‐reactions and response to phénobarbital treatment . Mar. Environ. Res. , 34 : 113
  • Goks⊘yr , A. , Bj⊘rnevik , M. and Maage , A. 1994 . Effects of dietary iron concentrations on the cytochrome P450 system of Atlantic salmon (Salmo salar) . Can. J. Fish. Aquat. Sci , 51 : 315
  • Gooch , J. W. , Elskus , A. A. , Kloepper‐Sams , P. J. , Hahn , M. E. and Stegeman , J. J. 1989 . Effects of ortho non‐ortho substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops) . Toxicol. Appl. Pharmacol. , 98 : 422
  • Guengerich , F. P. 1993 . Cytochrome P450 enzymes . Am. Sci. , 81 : 440
  • Haasch , M. L. , Quardokus , E. M. , Sutherland , L. A. , Goodrich , M. S. and Lech , J. J. 1993a . Hepatic CYP1A1 induction in rainbow trout by continuous flowthrough exposure to ß‐naphthoflavone . Fundam. Appl. Toxicol. , 20 : 72
  • Haasch , M. L. , Prince , R. , Wejksnora , P. J. , Cooper , K. R. and Lech , J. J. 1993b . Caged and wild fish induction of hepatic cytochrome P‐450 CYP1A1 as an environmental biomonitor . Environ. Toxicol. Chem. , 12 : 885
  • Hahn , M. E. and Stegeman , J. J. 1990 . Sustained induction of cytochrome P450IA1 mRNA, protein, and catalytic activity by 2,3,7,8‐tetrachlorodibenzofuran (2,3,7,8‐TCDF) in the marine teleost Stenotomus chrysops . Toxicologist , 10 : 28
  • Hahn , M. E. , Woodin , B. R. and Stegeman , J. J. 1989 . Induction of cytochrome P450E (P450IA1) by 2,3,7,8‐tetrachlorodibenzofuran (2,3,7,8‐TCDF) in the marine fish scup (Stenotomus chrysops) . Mar. Environ. Res. , 28 : 61
  • Hahn , M. E. , Poland , A. , Glover , E. and Stegeman , J. J. 1992 . The Ah receptor in marine animais: phylogenetic distribution and relationship to P450IA inducibility . Mar. Environ. Res. , 34 : 87
  • Hahn , M. E. , Lamb , T. M. , Schultz , M. E. , Smolowitz , R. M. and Stegeman , J. J. 1993 . Cytochrome P4501A induction and inhibition by 3,3’,4,4'‐tetrachlorobiphenyl in an Ah receptor‐containing fish hepatoma cell line (PLHC‐1) . Aquat. Toxicol. , 26 : 185
  • Hahn , M. E. , Poland , A. , Glover , E. and Stegeman , J. J. 1994 . Photoaffinity labeling of the Ah receptor: phylogenetic survey of diverse vertebrate and invertebrate species . Arch. Biochem. Biophys. , 310 : 218
  • Halbrook , R. S. , Kirkpatrick , R. L. , Bevan , D. R. and Dunn , B. P. 1992 . DNA adducts detected in muskrats by 32P‐postlabeling analysis . Environ. Toxicol. Chenu , 11 : 1605
  • Hamilton , S. J. and Mehrle , P. M. 1986 . Metallothionein in fish: review of its importance in assessing stress from metal contaminants . Trans. Am. Fish. Soc. , 115 : 596
  • Haux , C. and Förlin , L. 1988 . Biochemical methods for detecting effects of contaminants on fish . Ambio , 17 : 376
  • Heikkila , J. J. , Schultz , G. A. , Iartou , K. and Gedamu , L. 1982 . Expression of a set of fish genes following heat or metal exposure . J. Biol. Chem. , 257 : 12000
  • Heilmann , L. J. , Sheen , Y.‐Y. , Bigelow , S. W. and Nebert , D. W. 1988 . Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance . DNA , 7 : 379
  • Hightower , L. E. 1980 . Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides . J. Cell Physiol. , 102 : 407
  • Hightower , L. E. 1993 . A brief perspective on the heat‐shock response and stress proteins . Mar. Environ. Res. , 35 : 79
  • Hinton , D. E. and Laurén , D. J. 1990 . “ Liver structural alterations accompanying chronic toxicity in fishes: potential biomarkers of exposure ” . In Biomarkers of Environmental Contamination , Edited by: McCarty , J. F. and Shugart , L. R. 17 Boca Raton, FL : Lewis Publishers .
  • Hodson , P. V. , McWhirter , M. , Ralph , K. , Gray , B. , Thivierge , D. , Carey , J. H. , Van der Kraak , G. , Whittle , D. M. and Levesque , M.‐C. 1992 . Effects of bleached kraft mill effluent on fish in the St. Maurice River, Quebec . Environ. Toxicol. Chem. , 11 : 1635
  • Hoffman , D. J. , Smith , G. J. and Rattner , B. A. 1993 . Biomarkers of contaminant exposure in common terns and black‐crowned night herons in the Great Lakes . Environ. Toxicol. Chem. , 12 : 1095
  • Hogstrand , C. 1991 . Regulation of Metallothionein in Teleost Fish During Metal Exposure , Göteborg, , Sweden : Department of Zoophysiology, University of Göteborg . Ph. D. thesis
  • Holm , G. , Norrgren , L. , Andersson , T. and Thurén , A. 1993 . Effects of exposure to food contaminated with PBDE, PCN or PCB on reproduction, liver morphology and cytochrome P450 activity in the three‐spined stickleback, Gasterosteus aculeatus . Aquat. Toxicol. , 27 : 33
  • Howard , C. L. , Whitt , K. R. and Reeves , M. in press . Relationship between stress protein in grass shrimp and pollution tolerance in the ambient environment . Environ. Toxicol. Chem. ,
  • James , M. O. 1989 . Cytochrome P450 monooxygenases in crustaceans . Xenobiotica , 19 : 1063
  • James , M. O. and Bend , J. R. 1980 . Polycyclic aromatic hydrocarbon induction of cytochrome P‐450‐dependent mixed‐function oxidases in marine fish . Toxicol. Appl. Pharmacol. , 54 : 117
  • James , M. O. , Heard , C. S. and Hawkins , W. E. 1988 . Effects of 3‐methylcholanthrene on monooxygenase, epoxide hydrolase, and glutathione S‐transferase activities in small estuarine and freshwater fish . Aquat. Toxicol. , 12 : 1
  • Janz , D. M. and Metcalfe , C. D. 1991 . Relative induction of aryl hydrocarbon hydroxylase by 2,3,7,8‐TCDD and two coplanar PCBs in rainbow trout (Oncorhynchus mykiss) . Environ. Toxicol. Chem. , 10 : 917
  • Jedamski‐Grymlas , J. , Lange , U. , Siebers , D. and Karbe , L. 1994 . Induction of the hepatic biotransforma tion system of the golden ide [Leuciscus idus (L.)] after exposure in the river Elbe . Ecotoxicol Environ. Saf. , 28 : 35
  • Jimenez , B. D. and Stegeman , J. J. 1990 . “ Detoxication enzymes as indicators of environmental stress on fish ” . In Biological Indicators of Stress in Fish , American Fisheries Symposium 8 Edited by: Adams , S. M. 67 Bethesda, MD : American Fisheries Society .
  • Jimenez , B. D. , Burtis , L. S. , Ezell , G. H. , Egan , B.Z. , Lee , N. E. , Beauchamp , J. J. and McCarthy , J. F. 1988 . The mixed function oxidase system of bluegill sunfish, Lepomis macrochirus: correlation of activities in experimental and wild fish . Environ. Toxicol. Chem. , 7 : 623
  • Jimenez , B. D. , Oikari , A. , Adams , S. M. , Hinton , D. E. and McCarthy , J. F. 1990 . “ Hepatic enzymes as biomarkers: interpreting the effects of environmental, physiological and toxicological variables ” . In Biomarkers of Environmental Contamination , Edited by: McCarthy , J. F. and Shugart , L. E. 123 Boca Raton, FL : Lewis Publishers .
  • Johnson , L. L. , Casillas , E. , Collier , T. K. , McCain , B. B. and Varanasi , U. 1988 . Contaminant effects on ovarian development in English sole (Parophyrs vetulus) from Puget Sound, Washington . Can. J. Fish. Aquat. Sci. , 45 : 2133
  • Johnson , L. L. , Stehr , C. M. , Olson , O. P. , Myers , M. S. , Pierce , S. M. , Wigren , C. A. , McCain , B. B. and Varanasi , U. 1993 . Chemical contaminants and hepatic lesions in winter flounder (Pleuronectes americanus) from the northeast coast of the United States . Environ. Sci. Technol. , 27 : 2759
  • Jones , M. I. and Harrison , F. L. 1987 . Variability in the frequency of sister chromatid exchanges in larvae of Mytilus edulis: implications for field monitoring . J. Exp. Mar. Biol Ecol. , 113 : 283
  • Kägi , J. H. R. and Kojima , Y. 1987 . Chemistry and biochemistry of metallothionein . Experientia Suppl. , 52 : 35
  • Kennedy , S. W. , Lorenzen , A. , James , C. A. and Collins , B. T. 1993 . Ethoxyresorufin‐O‐deethylase and porphyrin analysis in chicken hepatocyte cultures with a fluorescence multiwell plate reader . Anal. Biochem. , 211 : 102
  • Keziç , N. , Britvic , S. , Protic , M. , Simmons , J. E. , Rijavec , M. , Zahn , R. K. and Kurelec , B. 1983 . Activity of benzo[a]pyrene monooxygenase in fish from the Sava River, Yugoslavia: correlation with pollution . Sci. Total Environ. , 27 : 59
  • Kille , P. , Kay , J. , Leaver , M. and George , S. 1992 . Induction of piscine metallothionein as a primary response to heavy metal pollutants: applicability of new sensitive molecular probes . Aquat. Toxicol. , 22 : 279
  • Kleinow , K. M. , Melancon , M. J. and Lech , J. J. 1987 . Biotransformation and induction: implications for toxicity, bioaccumulation and monitoring of environmental xenobiotics in fish . Environ. Health Perspect. , 71 : 105
  • Kloepper‐Sams , P. J. . Biomarkers in context: significance of P4501A induction in fish exposed to bleached kraft mill effluents (Abstr.) . Seventh International Symposium on Responses of Marine Organisms to Pollutants (PRIMO 7) . Göteborg, , Sweden : University of Göteborg .
  • Kloepper‐Sams , P. J. and Stegeman , J. J. 1989 . The temporal relationships between cytochrome P‐450E protein content, catalytic activity and mRNA levels in the teleost Fundulus heteroclitus follow ing treatment with β‐naphthoflavone . Arch. Biochem. Biophys. , 268 : 525
  • Kloepper‐Sams , P. J. and Stegeman , J. J. 1992 . Effects of temperature acclimation on the expression of hepatic cytochrome P4501A mRNA and protein in the fish Fundulus heteroclitus . Arch. Biochem. Biophys. , 299 : 38
  • Kloepper‐Sams , P. J. and Swanson , S. 1992 . Bioindicator field monitoring: use of fish biochemical parameters at a modern bleached kraft pulp mill site . Mar. Environ. Res. , 34 : 163
  • Kloepper‐Sams , P. J. and Owens , J. W. 1993 . Environmental biomarkers as indicators of chemical exposure . J. Hazard Mater. , 35 : 283
  • Kloepper‐Sams , P. J. and Benton , E. 1994 . Exposure of fish to biologically treated bleached‐kraft effluent. II. Induction of hepatic cytochrome P4501A in mountain whitefish (Prosopium williamsoni) and other species . Environ. Toxicol. Chem. , 13 : 1483
  • Kloepper‐Sams , P. J. , Park , S. S. , Gelboin , H. V. and Stegeman , J. J. 1987 . Specificity and cross‐reactivity of monoclonal and polyclonal antibodies against cytochrome P450E of the marine fish scup . Arch. Biochem. Biophys. , 253 : 268
  • Kloepper‐Sams , P. J. , Marchant , T. , Bernstein , J. and Swanson , S. 1991 . Use of Fish Biomarkers and Exposure Measures to Assess Fish Health at a Canadian Bleached Kraft Mill Site , Rep. 4031 283 Swedish Environmental Protection Agency .
  • Kloepper‐Sams , P. L. , Swanson , S. M. , Marchant , T. , Schryer , R. and Owens , J. W. 1994 . Exposure of fish to biologically treated bleached‐kraft effluent. I. Biochemical, physiological and pathological assessment of Rocky Mountain whitefish (Prosopium williamsoni) and longnose sucker (Catostomus catostomus) . Environ. Toxicol. Chem. , 13 : 1469
  • Klotz , A. V. , Stegeman , J. J. and Walsh , C. 1984 . An alternative 7‐ethoxyresorufin O‐deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P‐450 monooxygenase activity . Anal. Biochem. , 140 : 138
  • Koeman , J.H. , Köhler‐Günther , A. , Kurelec , B. , Riviere , J.L. , Versteeg , D. and Walker , C.H. 1991 . Biomarkers; research and application in the assessment of environmental health . Proceedings of the NATO Advanced Research Workshop on Biological Markers . May 12 to 17 1991 , Texel. pp. 1
  • Köhler , A. and Pluta , H. J. . Central detoxification and biotransformation systems in the liver of flounder (Platichthys flesus L.) during tumorigenesis (Abstr.) . Seventh International Symposium on Responses of Marine Organisms to Pollutants (PRIMO 7) . Göteborg, , Sweden : University of Göteborg .
  • Kopponen , P. , Törrönen , R. , Mäki‐Paakkanen , J. , von Wright , A. and Kärenlampi , S. 1994 . Comparison of CYP1A1 induction and genotoxicity in vitro as indicators of potentially harmful effects of environmental samples . Arch. Toxicol. , 68 : 167
  • Kothary , R. K. and Candido , E. P. M. 1982 . Induction of a novel set of polypeptides by heat shock or sodium arsenite in cultured cells of rainbow trout, Salmo gairdneri . Can. J. Biochem. , 60 : 347
  • Kurelec , B. , Britvic , S. , Rijavec , M. , Müller , W. E. B. and Zahn , R. K. 1977 . Benzo(a)pyrene monooxygenase induction in marine fish — molecular response to oil pollution . Mar. Biol. , 44 : 211
  • Kurelec , B. , Garg , A. , Krea , S. , Chacko , M. and Gupta , R. C. 1989 . Natural environment surpasses polluted environment in inducing DNA damage in fish . Carcinogenesis , 10 : 1337
  • Lange , U. , Danischewski , D. and Siebers , D. 1993 . “ Regional variability and sexual differences in ethoxyresorufin‐O‐deethylase activities and cytochrome P450 concentrations in the liver of mature dab (Limanda limanda L.) in the German bight ” . In Fish: Toxicology and Ecophysiology , Edited by: Braunbeck , T. , Hanke , W. and Segner , H. 37 Weinheim, , West Germany : VCH Publishers .
  • Leaver , M. J. , Clarke , D. J. and George , S. G. 1992 . Molecular studies of the phase II conjugative enzymes of marine pleuronectid flatfish . Aquat. Toxicol. , 22 : 265
  • Lee , P. C. , Yoon , H. I. , Haasch , M. L. and Lech , J. J. 1993 . Negative control of cytochrome P450 1A1 (CYP1A1) by glucocorticoids in rainbow trout liver . Comp. Biochem. Physiol. C , 104 : 457
  • Lee , R. F. 1981 . Mixed function oxygenase (MFO) in marine invertebrates . Mar. Biol. Lett. , 2 : 87
  • Lee , R. F. , Singer , S. C. and Page , D. S. 1981 . Responses of cytochrome P‐450 systems in marine crab and polychaetes to organic pollutants . Aquat. Toxicol. , 1 : 355
  • Lemaire‐Gony , S. and Lemaire , P. 1992 . Interactive effects of cadmium and benzo(a)pyrene on cellular structure and biotransformation enzymes of the liver of the European eel Anguilla anguilla . Aquat. Toxicol. , 22 : 145
  • Lindquist , S. 1986 . The heat shock response . Annu. Rev. Biochem. , 55 : 1151
  • Lindström‐Seppä , P. and Hänninen , O. 1981 . Extrahepatic xenobiotic metabolism in North European freshwater fish . Comp. Biochem. Physiol. C , 69 : 259
  • Lindström‐Seppä , P. and Oikari , A. 1989a . Biotransformation and other physiological responses in white‐fish caged in a lake receiving pulp and paper mill effluents . Ecotoxicol Environ. Saf. , 18 : 191
  • Lindström‐Seppä , P. and Oikari , A. 1989b . Bleached kraft pulpmill effluents and TCDD: effects on biotransformation and testosterone status of mature male rainbow trout (Salmo gairdneri) . Mar. Environ. Res. , 28 : 99
  • Lindström‐Seppä , P. and Oikari , A. 1990a . Biotransformation and other toxicological and physiological responses in rainbow trout (Salmo gairdneri Richardson) caged in a lake receiving effluents of pulp and paper industry . Aquat. Toxicol. , 16 : 187
  • Lindström‐Seppä , P. and Oikari , A. 1990b . Biotransformation activities of feral fish in waters receiving bleached pulp mill effluents . Environ. Toxicol. Chem. , 9 : 1415
  • Lindström‐Seppä , P. , Hänninen , O. and Hudd , R. 1985 . “ Biomonitoring of the petroleum spill in Vassa Archipelago, Finland by biotransformation activities in fish ” . In Cytochrome P450: Biochemistry, Biophysics and Induction , Edited by: Vereczkey , L. and Magyar , K. 357 Kiado, , Budapest : Akademiai .
  • Lindström‐Seppä , P. , Huuskonen , S. , Pesonen , M. , Muona , P. and Hänninen , O. 1992 . Unbleached pulp mill effluents affect cytochrome P450 monooxygenase enzyme activities . Mar. Environ. Res. , 34 : 157
  • Livingstone , D. R. 1985 . Responses of the detoxication/toxication enzyme systems of molluscs to organic pollutants and xenobiotics . Mar. Pollut. Bull. , 16 : 158
  • Livingstone , D. R. 1988 . Responses of microsomal NADPH‐cytochrome c reductase activity and cytochrome P‐450 in digestive glands of Mytilus edulis Littorina littorea to environmental and experimental exposure to pollutants . Mar. Ecol. Prog. Ser. , 46 : 37
  • Livingstone , D. R. 1993 . Biotechnology and pollution monitoring: use of molecular biomarkers in the aquatic environment . J. Chem. Tech. Biotechnol. , 57 : 195
  • Livingstone , D. R. , Kirchin , M. A. and Wiseman , A. 1989 . Cytochrome P‐450 and oxidative metabolism in molluscs . Xenobiotica , 19 : 1041
  • Lockhart , W. L. and Metner , D. A. 1992 . Applications of hepatic mixed function oxidase enzyme activities to northern freshwater fish. I. Burdot, Lota lota . Mar. Environ. Res. , 34 : 175
  • Longwell , A. C. and Hughes , J. B. 1980 . Cytologie, cytogenetic, and development state of Atlantic mackerel eggs from sea surface waters of the New York Bight, and prospects for biological effects monitoring with ichthyoplankton . Rapp. Reun. Cons. Int. Explor. Mer. , 179 : 275
  • Lorenzana , R. M. , Hedstrom , O. R. and Buhler , D. R. 1988 . Localization of cytochrome P‐450 in the head and trunk kidney of rainbow trout (Salmo gairdneri) . Toxicol. Appl. Pharmacol. , 96 : 159
  • Lubet , R. A. , Nims , R. W. , Beebe , L. E. , Fox , S. D. , Issaq , H. J. and McBee , K. 1992 . Induction of hepatic CYP1A activity as a biomarker for environmental exposure to Aroclor 1254 in feral rodents . Arch. Environ. Contam. Toxicol. , 22 : 339
  • Malins , D. C. , McCain , B. B. , Brown , D. W. , Chan , S.‐L. , Myers , M. S. , Landahl , J. T. , Prohaska , P. G. , Friedmann , A. J. , Rhodes , L. E. , Burrows , D. G. , Gronlund , W. D. and Hodgins , H. O. 1984 . Chemical pollutants in sediments and diseases of bottom‐dwelling fish in Puget Sound, Washington . Environ. Sci. Technol. , 18 : 705
  • Malins , D. C. , McCain , B. B. , Brown , D. W. , Myers , M. S. , Krahn , M. M. and Chan , S.‐L. 1987 . Toxic chemicals, including aromatic and chlorinated hydrocarbons and their derivatives, and liver lesions in white croaker (Genyonemus lineatus) from the vicinity of Los Angeles . Environ. Sci. Technol. , 21 : 765
  • Malins , D. C. , McCain , B. B. , Landahl , J. T. , Myers , M. S. , Krahn , M. M. , Brown , D. W. , Chan , S.‐L. and Roubal , W. T. 1988 . Neoplastic and other diseases in fish in relation to toxic chemicals: an overview . Aquat. Toxicol. , 11 : 43
  • Martel , P. H. , Kovacs , T. G. , O'Conner , B.I. and Voss , R. H. 1994 . A survey of pulp and paper mill effluents for their potential to induce mixed function oxidase enzyme activity in fish . Water Res. , 28 : 1835
  • Marty , J. , Riviere , J. L. , Guinaudy , M. J. , Kremers , P. and Lesca , P. 1992 . Induction and characterization of cytochrome P4501A and‐IIB in the newt, Pleurodeles waltl . Ecotoxicol. Environ. Saf. , 24 : 144
  • Masfaraud , J. F. , Monod , G. and Devaux , A. 1990 . Use of the fish cytochrome P‐450‐dependent 7‐ethylresorufin O‐deethylase activity as a biochemical indicator of water pollution. Study of the liver and the kidney of male and female nase (Chondrostoma nasus) from the River Rhone . Sci. Total Environ. , 97–98 : 729
  • Masfaraud , J.‐F. , Pfohl‐Leszkowic , A. , Malaveille , C. , Keith , G. and Monod , G. 1992 . 7‐Ethylresorufin O‐deethylase activity and level of DNA‐adducts in trout treated with benzo(a)pyrene . Mar. Environ. Res. , 34 : 351
  • McCain , B. B. , Chan , S.‐L. , Krahn , M. M. , Brown , D. W. , Myers , M. S. , Landahl , J. T. , Pierce , S. , Clark , R. C. and Varanasi , U. 1992 . Chemical contamination and associated fish diseases in the San Diego Bay . Environ. Sci. Technol. , 26 : 725
  • McCarthy , J. F. and Shugart , L. R. 1990 . “ Biological markers of environmental contamination ” . In Biomarkers of Environmental Contamination , Edited by: McCarthy , J. F. and Shugart , L. R. 3 Lewis Publishers .
  • McKee , M. J. , Hendricks , A. C. and Ebel , R. E. 1983 . Effects of naphthalene on benzo[a]pyrene hydroxy‐lase and cytochrome P‐450 in Fundulus heteroclitus . Aquat. Toxicol. , 3 : 103
  • McMahon , G. , Huber , L. J. , Moore , M. J. , Stegeman , J. J. and Wogan , G. N. 1990 . Mutations in c‐Ki‐ras oncogenes in diseased livers of winter flounder from Boston Harbor . Proc. Natl. Acad. Sci. U. S. A. , 87 : 841
  • Melancon , M. J. and Lech , J. J. 1983 . Dose‐effect relationship for induction of hepatic monooxygenase activity in rainbow trout and carp by Aroclor 1254 . Aquat. Toxicol. , 4 : 51
  • Melancon , M. J. , Yeo , S. E. and Lech , J. J. 1987 . Induction of hepatic microsomal monooxygenase activity in fish by exposure to river water . Environ. Toxicoi. Chem. , 6 : 127
  • Michel , X. R. , Suteau , P. , Robertson , L. W. and Narbonne , J. F. 1993 . Effects of benzo(a)pyrene, 3,3’,4,4'‐tetrachlorobiphenyl and 2,2’,4,4’,5,5'‐hexachlorobiphenyl on the xenobiotic‐metabolizing enzymes in the mussel (Mytilus galloprovincialis) . Aquat. Toxicol. , 27 : 335
  • Miranda , C. , Wang , J.‐L. , Chang , H.‐S. and Buhler , D. 1990 . Multiple effects of 3,4,5,3’,4’,5'‐hexachlorobiphenyl administration on hepatic cytochrome P450 isozymes and associated mixed‐function oxidase activities in rainbow trout . Biochem. Pharmacol. , 40 : 387
  • Mobbs , C. V. , Romano , G. J. , Schwartz‐Giblin , S. and Pfaff , D. W. 1989 . “ Biochemistry of a steroid‐regulated mammalian mating behavior; heat shock proteins and secretion, enkephalin and GABA ” . In Neutral Control of Reproductive Function , Edited by: Lakowski , J. M. , Perez‐Polo , J. R. and Rassin , D. K. 95 New York : Alan R. Liss .
  • Monod , G. and Vindimian , E. 1991 . Effect of storage conditions and subcellular fractionation of fish liver on cytochrome P‐450‐dependent enzymatic activities used for the monitoring of water pollution . Water Res. , 25 : 173
  • Monod , G. , Devaux , A. and Riviere , J. L. 1988 . Effects of chemical pollution on the activities of hepatic xenobiotic metabolizing enzymes in fish from the River Rhone . Sci. Total Environ. , 73 : 189
  • Monosson , E. and Stegeman , J. J. 1991 . Cytochrorae P450E (P450IA) induction and inhibition in winter flounder by 3,3’.4,4'‐tetrachlorobiphenyl: comparison of response in fish from Georges Bank and Narragansett Bay . Environ. Toxicol. Chem. , 10 : 765
  • Monosson , E. and Stegeman , J. J. 1994 . Induced cytochrome P4501A in winter flounder, Pleuronectes americanus, from offshore and coastal sites . Can. J. Fish Aquat. Sci. , 51 : 933
  • Moore , M. N. 1992 . Pollutant‐induced cell injury in fish liver: use of fluorescent molecular probes in live hepatocytes . Mar. Environ. Res. , 34 : 25
  • Moore , M. N. , Livingstone , D. R. , Donkin , P. , Bayne , B. L. , Widdows , J. and Lowe , D. M. 1980 . Mixed function oxygenases and xenobiotic detoxication/toxication systems in bivalve molluscs . Helgol. Wiss. Meeresunters , 33 : 278
  • Muir , D. C. G. , Yarechewski , A. L. , Metner , D. A. , Lockhart , W. L. , Webster , G. R. B. and Friesen , K. J. 1990 . Dietary accumulation and sustained hepatic mixed function oxidase induction by 2,3,4,7,8‐pentachlorodibenzofuran in rainbow trout . Environ. Toxicol. Chem. , 9 : 1463
  • Munkittrick , K. R. , Portt , C. B. , Van der Kraak , G. J. , Smith , I. R. and Rokosh , D. A. 1991 . Impact of bleached kraft mill effluent on population characteristics, liver MFO activity, and serum steroid levels of a Lake Superior white sucker (Catostomus commersoni) population . Can. J. Fish Aquat. Sci. , 48 : 1371
  • Munkittrick , K. R. , Van der Kraak , G. J. , McMaster , M. E. and Portt , C. B. 1992a . Response of hepatic MFO activity and plasma sex steroids to secondary treatment of bleached kraft pulp mill effluent and mill shutdown . Environ. Toxicol. Chem. , 11 : 1427
  • Munkittrick , K. R. , McMaster , M. E. , Portt , C. B. , Van der Kraak , G. J. , Smith , I. R. and Dixon , D. G. 1992b . Changes in maturity, plasma sex steroid levels, hepatic mixed‐function oxygenase activity, and the presence of external lesions in lake whitefish (Coregonus clupeaformis) exposed to bleached kraft mill effluents . Can. J. Fish Aquat. Sci. , 49 : 1560
  • Munkittrick , K. R. , Van den Heuvel , M. R. , Metner , D. A. , Lockhart , W. L. and Stegeman , J. J. 1993 . Interlaboratory comparison and optimization of hepatic microsomal ethoxyresorufin O‐deethylase activity in white sucker (Catostomus commersoni) exposed to bleached kraft pulp mill effluent . Environ. Toxicol. Chem. , 12 : 1273
  • Murchelano , R. A. and Wolke , R. E. 1985 . Epizootic carcinoma in the winter flounder Pseudopleuronectes americanus . Science , 228 : 587
  • Myers , M. S. , Willis , M. L. , Hus⊘y , A.‐M. , Goks⊘yr , A. and Collier , T. K. . Immunohistochemical localization of cytochrome P4501A in contaminant‐associated hepatic lesions of English sole (Pleuronectes vetulus) (Abstr.) . Seventh International Symposium on Responses of Marine Organisms to Pollutants (PRIMO 7) . Göteborg, , Sweden : University of Göteborg .
  • Narbonne , J. F. , Garrigues , P. , Ribera , D. , Raoux , C. , Mathieu , A. , Lemaire , P. , Salaun , J. P. and Lafaurie , M. 1991 . Mixed‐function oxygenase enzymes as tools for pollution monitoring: field studies on the French coast of the Mediterranean Sea . Comp. Biochem. Physiol. C , 100 : 37
  • National Academy of Science/National Research Council . 1989 . Biological Markers in Reproductive Toxicology , 395 Washington, D. C. : National Academy Press .
  • Nielson , K. B. , Atkin , C. L. and Winge , D. R. 1985 . Distinct metal‐binding configurations in metallothionein . J. Biol. Chem. , 260 : 5342
  • Nikunen , E. 1985 . Toxic impact from petrochemical industry . Ecotoxicol. Environ. Saf. , 9 : 84
  • Norstrom , R. J. , Muir , D. C. G. , Ford , C. A. , Simon , M. , Macdonald , C. R. and Beland , P. 1992 . Indications of P450 monooxygenase activities in beluga (Delphinapterus leucas) and narwhal (Monodon monoceros) from patterns of PCB, PCDD and PCDF accumulation . Mar. Environ. Res. , 34 : 267
  • Olsson , P. E. and Haux , C. 1986 . Increased hepatic metallothionein content correlates to cadmium accumulation in environmentally exposed perch (Perca fluviatilis) . Aquat. Toxicol. , 9 : 231
  • Olsson , P. E. , Hyllner , S. J. , Zafarullah , M. , Andersson , T. and Gedamu , L. 1990 . Differences in metallothionein gene expression in primary cultures of rainbow trout hepatocytes and the RTH‐149 cell line . Biochim. Biophys. Acta , 1049 : 78
  • Ortiz de Montellano , P. R. 1986 . “ Oxygen activation and transfer ” . In Cytochrome P‐450: Structure, Mechanism and Biochemistry , Edited by: Ortiz de Montellano , P. R. 217 New York : Plenum Press .
  • Pangrekar , J. and Sikka , H. C. 1992 . Xenobiotic metabolizing enzyme activity in the liver and kidney of the brown bullhead (Jctalurus nebulosus) . Mar. Environ. Res. , 34 : 287
  • Payne , J. F. 1976 . Field evaluation of benzopyrene hydroxylase induction as a monitor for marine pollution . Science , 191 : 945
  • Payne , J. F. and Penrose , W. R. 1975 . Induction of aryl hydrocarbon (benzo[a]pyrene) hydroxylase in fish by petroleum . Bull. Environ. Contamin. Toxicol. , 14 : 112
  • Payne , J. F. , Bauld , C. , Dey , A. C. , Kiceniuk , J. W. and Williams , U. 1984 . Selectivity of mixed‐function oxygenase enzyme induction in flounder (Pseudopleuronectes americanus) collected at the site of the Baie Verte, Newfoundland oil spill . Comp. Biochem. Physiol. C , 79 : 15
  • Payne , J. F. , Fancey , L. , Rahimtula , A. and Porter , E. 1987 . Review and perspective on the use of mixed‐function oxygenase enzymes in biological monitoring . Comp. Biochem. Physiol. C , 86 : 233
  • Pedersen , M. G. , Harshberger , W. K. , Zachariah , P. K. and Juchau , M. R. 1976 . Hepatic biotransformation of environmental xenobiotics in six strains of rainbow trout (Salmo gairdneri) . J. Fish. Res. Bd. Can. , 33 : 666
  • Pesonen , M. , Goks⊘yr , A. and Andersson , T. 1992 . Expression of P4501A1 in a primary culture of rainbow trout hepatocytes exposed to β‐naphthoflavone or 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin . Arch. Biochem. Biophys. , : 292
  • Peters , L. D. , Porte , C. , Albaigés , J. and Livingstone , D. R. 1994 . 7‐Ethoxyresorufin O‐deethylase and antioxidant enzyme activities in larvae of sardine (Sardina pilchardus) from the north coast of Spain . Mar. Pollut. Bull. , 28 : 299
  • Petersen , D. W. and Lech , J. J. 1987 . Hepatic effects of acrylamide in rainbow trout . Toxicol. Appl. Pharmacol. , 89 : 249
  • Pluta , H.‐J. 1993 . “ Investigations on biotransformation (mixed function oxygenase activities) in fish liver ” . In Fish: Toxicology and Ecophysiology , Edited by: Braunbeck , T. , Hanke , W. and Segner , H. 13 Weinheim, , West Germany : Publishers .
  • Poland , A. and Glover , E. 1987 . Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats . Biochem. Biophys. Res. Commun. , 146 : 1439
  • Porte , C. , Solé , M. , Albaigés , J. and Livingstone , D. R. 1991 . Responses of mixed‐function oxygenase and antioxidase enzyme system of Mytilus sp. to organic pollution . Comp. Biochem. Physiol., C , 100 : 183
  • Powell , M. A. , Griswold , C. and Cooper , R. A. 1992 . Stress protein levels as an indicator of exposure to toxic materials in amphipods collected from submarine canyons off the New England coast . 13th Annu. Meet. Soc. Environ. Toxicol. Chem. . November 8 to 12 1992 , Cincinnati, OH. Abstr. 99
  • Ramachandran , C. , Catelli , M. G. , Schneider , W. and Shyamala , G. 1988 . Estrogenic regulation of uterine 90‐kilodalton heat shock protein . Endocrinology , 123 : 956
  • Rattner , B. A. , Hoffman , D. J. and Marn , C. M. 1989 . Use of mixed function oxygenases to monitor contaminant exposure in wildlife . Environ. Toxicol. Chem. , 8 : 1093
  • Rattner , B. A. , Melancon , M. J. , Custer , T. W. , Hothem , R. L. , King , K. A. , LeCaptain , L. J. , Spann , J. W. , Woodin , B. R. and Stegeman , J. J. 1993 . Biomonitoring environmental contamination with pipping black‐crowned night heron embryos: induction of cytochrome P450 . Environ. Toxicol. Chem. , 12 : 1719
  • Ray , S. , Dunn , B. P. , Payne , J. F. , Fancey , L. , Helbig , R. and Béland , P. 1991 . Aromatic DNA‐adducts in Beluga whales from the Canadian Arctic and Gulf of St. Lawrence . Mar. Pollut. Bull. , 22 : 392
  • Reily , L. A. and Means , J. C. 1992 . Induction of ethoxyresorufin O‐deethylase (EROD) in the sandworm (Nereis virens) exposed to petroleum‐contaminated sediment . 13th Annu. Meet. Soc. Environ. Toxicol Chem. . November 8 to 12 1992 , Cincinnati, Ohio. Abstr. TA6F11
  • Renton , K. W. and Addison , R. F. 1992 . The utilization of cytochrome P4501A mRNA in Limanda limanda (dab) as a monitor of chemical exposure in the North Sea . Mar. Environ. Res. , 34 : 151
  • Rice , D. W. , Seltenrich , C. P. , Keller , M. L. , Spies , R. and Feiton , J. S. 1994 . Mixed‐function oxidase‐specific activity in wild and caged speckled sanddabs Citharichthys stigmaeus in Elkhorn Slough, Moss Landing Harbor and nearshore Monterey Bay, California . Environ. Pollut. , 84 : 179
  • Rijavec , M. , Protic , M. and Kurelec , B. 1981 . A study of some biological (sublethal and mutagenic) effects of the wastewaters of the INA Petrol Refinery, Rijeka . Thalassia Jugosl. , 17 : 237
  • Ritossa , F. 1962 . A new puffing pattern induced by heat shock and DNP in Drosophila . Experientia , 18 : 571
  • Rodriguez‐Ariza , A. , Peinado , J. , Pueyo , C. and Lopez‐Barea , J. 1993 . Biochemical indicators of oxidative stress in fish from polluted littoral areas . Can. J. Fish. Aquat. Sci. , 50 : 2568
  • Roesijadi , G. 1981 . The significance of low molecular weight, metallothionein‐like proteins in marine invertebrates: current status . Mar. Environ. Res. , 4 : 167
  • Ronis , M. J. J. , Celander , M. , Förlin , L. and Badger , T. M. 1992 . The use of polyclonal antibodies raised against rat and trout cytochrome P450 CYP1 Al orthologues to monitor environmental induction in the channel catfish (Ictalurus punctatus) . Mar. Environ. Res. , 34 : 181
  • Rutten , A. A. J. J. L. , Falke , H. E. , Catsburg , J. F. , Wortelboer , H. M. , Blaauboer , B. J. , Doom , L. , Van Leeuwen , F. X. R. , Theelen , R. and Rietjens , I. M. C. M. 1992 . Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O‐dealkylation determinations: standardization of assay conditions . Arch. Toxicol. , 66 : 237
  • Ryan , J. A. and Hightower , L. E. 1994 . Evaluation of heavy‐metal ion toxicity in fish cells using a combined stress protein and cytotoxicity assay . Environ. Toxicol. Chem. , 13 : 1231
  • Safe , S. 1987 . Determination of 2,3,7,8‐TCDD toxic equivalent factors (TEFs): support for the use of the in vitro AHH induction assay . Chemosphere , 16 : 791
  • Sanders , B. M. 1990 . “ Stress proteins: potential as multitiered biomarkers ” . In Biomarkers of Environmental Contamination , Edited by: McCarthy , J. F. and Shugart , L. R. 165 Boca Raton, FL : Lewis Publishers .
  • Sanders , B. M. 1993 . Stress proteins in aquatic organisms: an environmental perspective . Crit. Rev. Toxicol. , 23 : 49
  • Sanders , B. M. and Martin , L. S. 1991 . Relationships between accumulation of a 60 kDa stress protein and scope‐for‐growth in Mytilus edulis exposed to a range of copper concentrations . Mar. Environ. Res. , 31 : 81
  • Sanders , B. M. and Martin , L. S. 1993 . Stress proteins as biomarkers of contaminant exposure in archived environmental samples . Sci. Total Environ. , 139/140 : 459
  • Sanders , B. M. and Dyer , S. C. 1994 . Cellular stress response . Environ. Toxicol. Chem. , 13 : 1209
  • Sanders , B. M. , Martin , L. S. , Howe , S. R. , Nelson , W. G. , Hegre , E. S. and Phelps , D. K. 1994 . Tissue‐specific differences in accumulation of stress proteins in Mytilus edulis exposed to a range of copper concentrations . Toxicoi. Appl. Pharmacol. , 125 : 206
  • Sato , K. , Kitahara , A. , Yin , Z. , Eline , T. , Satoh , K. , Hatayama , I. , Nishinura , K. , Yamazaki , T. , Tsuda , H. , Ito , N. and Dempo , K. 1983 . Molecular forms of glutathione 5‐transferase and UDP‐glucuronosyltransferase as hepatic preneoplastic marker enzymes . Ann. N.Y. Acad. Sci. , 417 : 213
  • Scarpato , R. , Migliore , L. , Alfinito‐Cognetti , G. and Barale , R. 1990 . Induction of micronuclei in gill tissue of Mytilus galloprovincialis exposed to polluted marine waters . Mar. Pollut. Bull. , 21 : 74
  • Schenkman , J. B. and Greim , H. , eds. 1993 . Cytochrome P450 , Berlin : Springer‐Verlag .
  • Schlesinger , M. J. , Ashburner , M. and Tissieres , A. 1982 . Heat Shock. From Bacteria to Man , Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press .
  • Schrenk , D. , Lipp , H. P. , Brunner , H. , Wiesmüller , T. , Hagenmeyer , H. and Bock , K. W. 1991 . Induction of hepatic P450‐dependent monooxygenase in feral mice from a PCDD/PCDF‐contaminated area . Chemosphere , 22 : 1011
  • Shelton , D. W. , Goeger , D. E. , Hendricks , J. D. and Bailey , G. S. 1986 . Mechanisms of anticarcinogenesis: the distribution and metabolism of aflatoxin B1 in rainbow trout fed with Aroclor 1254 . Carcinogenesis , 7 : 1065
  • Shugart , L. R. , McCarthy , J. F. and Halbrook , R. S. 1992 . Biological markers of environmental and ecological contamination: an overview . Risk. Anal. , 12 : 353
  • Simmons , G. J. and McKee , M. J. 1992 . Alkoxyresorufin metabolism in whitefooted mice at relevant environmental concentrations of Aroclor 1254 . Fundam. Appl. Toxicol. , 19 : 446
  • Sivarajah , K. , Franklin , C. S. and Williams , W. P. 1978 . The effects of polychlorinated biphenyls on plasma steroid levels and hepatic microsomal enzymes in fish . J. Fish Biol. , 13 : 401
  • Sleiderink , H. M. , Beyer , J. , Scholtens , E. , Everhaarts , J. M. and Boon , J. P. . Ethoxyresorufin O‐deethylase in dab (Limanda limanda) from the Southern North Sea: results from a field survey, (Abstr.) . Seventh International Symposium on Responses of Marine Organisms to Pollutants (PRIMO 7) . Göteborg, , Sweden : University of Göteborg .
  • Slooff , W. , Van Kreijl , C. F. and Baars , A. J. 1983 . Relative liver weights and xenobiotic‐metabolizing enzymes offish from polluted surface waters in The Netherlands . Aquat. Toxicol. , 4 : 1
  • Smolowitz , R. M. , Hahn , M. E. and Stegeman , J. J. 1991 . Immunohistochemical localization of cyto‐chrome P450IA1 induced by 3,3’,4,4'‐tetrachlorobiphenyl and by 2,3,7,8‐tetrachlorodibenzofuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup) . Drug Metab. Dispos. , 19 : 113
  • Snegaroff , J. and Bach , J. 1990 . The effects of temperature on the basal activity of cytochrome P‐450 in rainbow trout (Salmo gairdneri) . Comp. Biochem. Physiol. B , 95 : 515
  • Södergren , A. 1989 . Biological Effects of Bleached Pulp Mill Effluents , Final Rep. No. 3558 National Swedish Environmental Protection Board .
  • Spies , R. B. , Felton , J. S. and Dillard , L. 1982 . Hepatic mixed function oxidases in California flatfishes are increased in contaminated environments and by oil and PCB ingestion . Mar. Biol. , 70 : 117
  • Spies , R. B. and Rice , D. W. 1988 . Effects of organic contaminants on reproduction of the starry flounder Platichthys stellatus in San Francisco Bay. II. Reproductive success of fish captured in San Francisco Bay and spawned in the laboratory . Mar. Biol. , 98 : 191
  • Spies , R. B. , Rice , D. W. and Felton , J. 1988 . Effects of organic contaminants on reproduction of the starry flounder Platichthys stellatus in San Francisco Bay. I. Hepatic contamination and mixed‐function oxidase (MFO) activity during the reproductive season . Mar. Biol. , 98 : 181
  • Spies , R. B. , Stegeman , J. J. , Rice , D. W. Jr. , Woodin , B. , Thomas , P. , Hose , J. E. , Cross , J. N. and Prieto , M. 1990 . “ Sublethal responses of Platichthys stellatus to organic contamination in San Francisco Bay with emphasis on reproduction ” . In Biomarkers of Environmental Contamination , Edited by: McCarthy , J. F. and Shugart , L. R. 87 Boca Raton, FL : Lewis Publishers .
  • Spooner , N. , Gibbs , P. E. , Bryan , G. W. and Goad , L. J. 1991 . The effect of tributyltin upon steroid titres in the female dogwhelk, Nucella lapillus, and the development of imposex . Mar. Environ. Res. , 32 : 37
  • Stegeman , J. J. 1979 . Temperature influence on basal activity and induction of mixed function oxygenase activity in Fundulus heteroclitus . Can. Fish. Res. Bd. Can. , 36 : 1400
  • Stegeman , J. J. 1985 . Benzo[a]pyrene oxidation and microsomal enzyme activity in the mussel (Mytilus edulis) and other bivalve mollusc species from the western N. Atlantic . Mar. Biol. , 89 : 21
  • Stegeman , J. J. 1992 . Nomenclature for hydrocarbon‐inducible cytochrome P450 in fish . Mar. Environ. Res. , 34 : 133
  • Stegeman , J. J. and Kloepper‐Sams , P. J. 1987 . Cytochrome P‐450 isozymes and monooxygenase activity in aquatic animals . Environ. Health Perspect. , 71 : 87
  • Stegeman , J. J. and Lech , J. J. 1991 . Cytochrome P‐450 monooxygenase systems in aquatic species: carcinogen metabolism and biomarkers for carcinogen and pollutant exposure . Environ. Health Perspect. , 90 : 101
  • Stegeman , J. J. and Hahn , M. E. 1994 . “ Biochemistry and molecular biology of monooxygenases: current perspectives on forms, functions, and regulation of cytochrome P450 in aquatic species ” . In Aquatic Toxicology: Molecular, Biochemical and Cellular Perspectives , Edited by: Ostrander , G. K. and Malins , D. 87 Boca Raton, FL : Lewis Publishers .
  • Stegeman , J. J. , Binder , R. L. and Orren , A. 1979 . Hepatic and extrahepatic microsomal electron transport components and mixed‐function oxygenases in the marine fish Stenotomus versicolor . Biochem. Pharmacol. , 28 : 3431
  • Stegeman , J. J. , Klotz , A. V. , Woodin , B. R. and Pajor , A. M. 1981 . Induction of hepatic cytochrome P‐450 in fish and the indication of environmental induction in scup . Aquat. Toxicol. , 1 : 197
  • Stegeman , J. J. , Kloepper‐Sams , P. J. and Farrington , J. W. 1986 . Monooxygenase induction and chlorobiphenyls in the deep‐sea fish Coryphaenoides armatus . Science , 231 : 1287
  • Stegeman , J. J. , Teng , F.Y. and Snowberger , E. A. 1987 . Induced cytochrome P‐450 in winter flounder (Pseudopleuronectes americanus) from coastal Massachusetts evaluated by catalytic assay and monoclonal antibody probes . Can. J. Fish. Aquat. Sci. , 44 : 1270
  • Stegeman , J. J. , Woodin , B. R. and Goks⊘yr , A. 1988 . Apparent cytochrome P‐450 induction as an indication of exposure to environmental chemicals in the flounder Platichthys flesus . Mar. Ecol. Prog. Ser. , 46 : 55
  • Stegeman , J. J. , Renton , K. W. , Woodin , B. R. , Zhang , Y.‐S. and Addison , R. F. 1990 . Experimental and environmental induction of cytochrome P450E in fish from Bermuda waters . J. Exp. Mar. Biol. Ecol. , 138 : 49
  • Stegeman , J. J. , Brouwer , M. , Di Guilio , R. T. , Förlin , L. , Fowler , B. A. , Sanders , B. M. and Van Veld , P. A. 1992 . “ Molecular responses to environmental contamination: enzyme and protein systems as indicators of chemical exposure and effect ” . In Biomarkers: Biochemical, Physiological, and Histological Markers of Anthropogenic Stress , Edited by: Huggett , R. J. , Kimerle , R. A. , Mehrle , J. and Bergman , H. L. 235 Colorado : Lewis Publishers .
  • Stein , J. E. , Collier , T. K. , Reichert , W. L. , Casillas , E. , Horn , T. and Varanasi , U. 1992 . Bioindicators of contaminant exposure and sublethal effects: studies with benthic fish in Puget Sound, Washington . Environ. Toxicol. Chem. , 11 : 701
  • Steinert , S. A. and Pickwell , G. V. 1993 . Induction of HSP70 proteins in mussels by ingestion of tributyltin . Mar. Environ. Res. , 35 : 89
  • Stringham , E. G. and Candido , E. P. M. 1994 . Transgenic hsp 16‐lacZ strains of the soil nematode Caenorhabditis elegans as biological monitors of environmental stress . Environ. Toxicol. Chem. , 13 : 1211
  • Sved , D. W. , Van Veld , P. A. and Roberts , M. H. Jr. 1992 . Hepatic EROD activity in spot, Leistomus xanthurus, exposed to creosote‐contaminated sediments . Mar. Environ. Res. , 34 : 189
  • Swanson , H. I. and Perdew , G. H. 1991 . Detection of the Ah receptor in rainbow trout: use of 2‐azido‐3‐[125I]iodo‐7,8‐dibromodibenzo‐p‐dioxin in cell culture . Toxicoi. Lett. , 58 : 85
  • Swanson , S. , Shelast , R. , Schryer , R. , Kloepper‐Sams , P. , Marchant , T. , Kroeker , K. , Bernstein , J. and Owens , J. W. 1992 . Fish populations and biomarker responses at a Canadian bleached kraft mill site . Tappi J. , December : 139
  • Theodorakis , C. W. , D'Surney , S. J. , Bickham , J. W. , Lyne , T. B. , Bradley , B. P. , Hawkins , W. E. , Farkas , W. L. , McCarthy , J. F. and Shugart , L. R. 1992 . Sequential expression of biomarkers in bluegill sunfish exposed to contaminated sediment . Ecotoxicology , 1 : 45
  • Thomas , P. 1988 . Reproductive endocrine function in female Atlantic croaker exposed to pollutants . Mar. Environ. Res. , 24 : 179
  • Tillitt , D. E. and Giesy , J. P. 1991 . Characterization of the H4IIE rat hepatoma cell bioassay as a tool for assessing toxic potency of planar halogenated hydrocarbons in environmental samples . Environ. Sci. Technol. , 25 : 87
  • Tillitt , D. E. , Ankley , G. T. , Verbrugge , D. A. , Giesy , J. P. , Ludwig , J. P. and Kubiak , T. J. 1991 . H4IIE rat hepatoma cell bioassay‐derived 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin equivalents in colonial fish‐eating waterbird eggs from the Great Lakes . Arch. Environ. Contam. Toxicol. , 21 : 91
  • Upshall , C. , Payne , J. F. and Hellou , J. 1993 . Induction of MFO enzymes and production of bile metabolites in rainbow trout (Oncorhynchus mykiss) exposed to waste crankcase oil . Environ. Toxicol. Chem. , 12 : 2105
  • Van den Berg , M. , Craane , B. L. H. J. , Sinnige , T. , Van Mourik , S. , Dirksen , S. , Boudewijn , T. , Van der Gaag , M. , Lutke‐Schipholt , I. J. , Spenkelink , B. and Brouwer , A. 1994 . Biochemical and toxic effects of polychlorinated biphenyls (PCBs), dibenzo‐p‐dioxins (PCDDs) and dibenzofurans (PCDFs) in the cormorant (Phalacrocorax carbo) after in ovo exposure . Environ. Toxicol. Chem. , 13 : 803
  • Van der Oost , R. , Heida , H. , Opperhuizen , A. and Vermeulen , N. P. E. 1991 . Interrelationships between bioaccumulation of organic trace pollutants (PCBs, organochlorine pesticides and PAHs) and MFO‐induction in fish . Comp. Biochem. Physiol. , 100 : 43
  • Van der Weiden , M. E. J. , Celander , M. , Seinen , W. , Van den Berg , M. , Goks⊘yr , A. and Förlin , L. 1992a . Effects of 2,3,7,8‐TCDD and contaminated sediment on the cytochrome P4501A orthologue in rainbow trout (Onchorhynchus mykiss) and carp (Cyprinus carpio), using catalytic and immunochemical technique . Mar. Environ. Res. , 34 : 215
  • Van der Weiden , M. E. J. , Van der Kolk , J. , Bleumink , R. , Seinen , W. and Van den Berg , M. 1992b . Concurrence of P450 1A1 induction and toxic effects after administration of a low dose of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in the rainbow trout (Onchorhynchus mykiss) . Aquat. Toxicol. , 24 : 123
  • Van der Weiden , M. E. J. , Celander , M. , Seinen , W. , Van den Berg , M. , Goks⊘yr , A. and Förlin , L. 1993a . Induction of cytochrome P450 1A in fish treated with 2,3,7,8‐tetrachIorodibenzo‐p‐dioxin or chemically contaminated sediments . Environ. Toxicol. Chem. , 12 : 989
  • Van der Weiden , M. E. J. , Tibosch , H. J. H. , Bleumink , R. , Sinnige , T. L. , Van de Guchte , C. , Seinen , W. and Van den Berg , M. 1993b . Cytochrome P450 1A induction in the common carp (Cyprinus carpio) following exposure to contaminated sediments with halogenated polyaromatics . Chemo‐sphere , 27 : 1297
  • Van Veld , P. A. , Westbrook , D. J. , Woodin , B. R. , Hale , R. C. , Smith , C. L. , Huggett , R. J. and Stegeman , J. J. 1990 . Induced cytochrome P‐450 in intestine and liver of spot (Leiostomus xanthurus) from a polycyclic aromatic hydrocarbon contaminated environment . Aquat. Toxicol. , 17 : 119
  • Van Veld , P. A. , Ko , U. , Vogelbein , W. K. and Westbrook , D. J. 1991 . Glutathione transferase in intestine, liver and hepatic lesions of mummichog . Fish Physiol. Biochem. , 9 : 369
  • Varanasi , U. , Collier , T. K. , Williams , D. E. and Buhler , D. R. 1986 . Hepatic cytochrome P‐450 isoenzymes and aryl hydrocarbon hydroxylase in English sole (Parophrys vetulus) . Biochem. Pharmacol. , 35 : 2967
  • Varanasi , U. , Reichert , W. L. and Stein , J. E. 1989 . 32P‐postlabeling analysis of DNA adducts in liver of wild English sole (Parophrys vetulus) and winter flounder (Pseudopleuronectes americanus) . Cancer Res. , 49 : 1171
  • Veldhuizen‐Tsoerkan , M. B. , Holwerda , D. A. , de Bont , A. M. T. , Smaal , A. C. and Zandee , D. I. 1991 . A field study on stress indices in the sea mussel, Mytilus edulis: application of the “stress approach” in biomonitoring . Arch. Environ. Contam. Toxicol. , 21 : 497
  • Vigano , L. , Arillo , A. , Bagnasco , M. , Bennicelli , C. and Melodia , F. 1993 . Xenobiotic metabolizing enzymes in uninduced and induced rainbow trout (Oncorhynchus mykiss): effects of diets and food deprivation . Comp. Biochem. Physioi C , 104 : 51
  • Vindimian , E. and Garric , J. 1989 . Freshwater fish cytochrome P450‐dependent enzymatic activities: a chemical pollution indicator . Ecotoxicol. Environ. Saf. , 18 : 277
  • Vindimian , E. , Namour , P. , Migeon , B. and Garric , J. 1991 . In situ pollution induced cytochrome P450 activity of freshwater fish: barbel (Barbus barbus), chub (Leuciscus cephalus) and nase (Chondrostoma nasus) . Aquat. Toxicol. , 21 : 255
  • Vindimian , E. , Namour , P. , Munoz , J.‐F. , Gril , J.‐J. , Migeon , B. and Garric , J. 1993 . Ethoxyresorufin‐O‐deethylase induction in fish from a watershed exposed to a non‐point source pollution of agricultural origin . Water Res. , 27 : 449
  • Vogelbein , W. K. , Fournie , J. W. , Van Veld , P. A. and Huggett , R. J. 1990 . Hepatic neoplasms in the mummichog Fundulus heteroclitus from a creosote‐contaminated site . Cancer Res. , 50 : 5978
  • Vrolijk , N. H. , Targett , N. M. , Woodin , B. R. and Stegeman , J. J. . Biotransformation enzymes in the marine teleost Chaetodon capistratus: implications for detoxification of dietary allelochemicals, (Abstr.) . Seventh International Symposium on Responses of Marine Organisms to Pollutants (PRIMO 7) . Göteborg, , Sweden : University of Göteborg .
  • Walker , C. H. and Ronis , M. J. J. 1989 . The monooxygenases of birds, reptiles and amphibians . Xenobiotica , 19 : 1111
  • Walker , M. K. , Spitsbergen , J. M. , Olson , J. R. and Peterson , R. E. 1991 . 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) toxicity during early life stage development of lake trout (Salvelinus namaycush) . Can. J. Fish. Aquat. Sci. , 48 : 875
  • Welch , W. J. 1990 . “ The mammalian stress response: cell physiology and biochemistry of stress proteins ” . In The Role of the Stress Response in Biology and Disease , Edited by: Morimoto , R. and Tissieres , A. 223 Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press .
  • Welch , W. J. 1993 . How cells respond to stress . Sci. Am. , May : 34
  • Welch , W. J. and Mizzen , L. A. 1988 . Characterization of the thermotolerant cell. II. Effects on the intracellular distribution of heat shock protein 70, intermediate filaments and small ribonucleo‐protein complexes . J. Cell. Biol. , 106 : 1117
  • Whitlock , J. P. 1993 . Mechanistic aspects of dioxin action . Chem. Res. Toxicol. , 6 : 754
  • Wirgin , I. I. , Grunwald , C. and Courtenay , S. . Time and dose response of CYP1A mRNA induction in Atlantic tomcod exposed to 2,3,7,8 TCDD, 3,3’,4,4’ TCB, and B‐NF, (Abstr.) . Seventh International Symposium on Responses of Marine Organisms to Pollutants (PRIMO 7) . Göteborg, , Sweden : University of Göteborg .
  • Yawetz , A. , Manelis , R. and Fishelson , L. 1992 . The effects of Aroclor 1254 and petrochemical pollutants on cytochrome P450 from the digestive gland microsomes of four species of Mediterranean molluscs . Comp. Biochem. Physiol. C , 103 : 607
  • Zafarullah , M. , Olsson , P.E. and Gedamu , L. 1989 . Endogenous and heavy‐metal‐ion‐induced metallothionein gene expression tissues and cell lines . Gene , 83 : 85

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