Rethinking neck-related arm pain: hypothetical clinical scenarios to differentiate the underlying IASP-defined pain mechanisms

References

• Tea V, Abajobir AA, Abate KH. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1211–1259. Epub 2017/09/19 Epub 2017/09/19. doi: 10.1016/S0140-6736(17)32154-2
   PubMed Web of Science ®Google Scholar
• Blanpied PR, Gross AR, Elliott JM, et al. Neck pain: revision 2017. J Orthop Sports Phys Ther. 2017;47(7):A1–a83. Epub 2017/07/02 PubMed PMID: 28666405. doi: 10.2519/jospt.2017.0302
   PubMed Web of Science ®Google Scholar
• Fejer R, Kyvik KO, Hartvigsen J. The prevalence of neck pain in the world population: a systematic critical review of the literature. Epub 2005/07/07 PubMed PMID: 15999284; PubMed Central PMCID: PMCPMC3489448 Eur Spine J. 2006;15(6):834–848. doi: 10.1007/s00586-004-0864-4
   PubMed Web of Science ®Google Scholar
• Hoy DG, Protani M, De R, et al. The epidemiology of neck pain. Best Pract Res Clin Rheumatol. Epub 2011/06/15 PubMed PMID: 21665126. 2010;24(6):783–92. DOI:10.1016/j.berh.2011.01.019
   Google Scholar
• Kazeminasab S, Nejadghaderi SA, Amiri P, et al. Neck pain: global epidemiology, trends and risk factors. BMC Musculoskelet Disord. 2022;23(1):26. Epub 2022/01/05 PubMed PMID: 34980079. doi: 10.1186/s12891-021-04957-4
   PubMed Web of Science ®Google Scholar
• Bogduk N. The anatomy and pathophysiology of neck pain. Physical medicine and rehabilitation clinics of North America. vii. Epub 2011/08/10 PubMed PMID: 21824580. 2011;22(3):367–82. DOI:10.1016/j.pmr.2011.03.008
   Google Scholar
• Bier JD, Scholten-Peeters GGM, Staal JB, et al. Royal Dutch Society For Physical Therapy, KNGF Guideline: Neck Pain. 2016. www.Fysionet.nl.
   Google Scholar
• Swanson BT, Creighton D. Cervical disc degeneration: important considerations for the manual therapist. J Man Manip Ther. 2021:1–15. doi: 10.1080/10669817.2021.2000089. Epub 2021/11/26 PubMed PMID: 34821212.
   Google Scholar
• Cloward RB. Cervical diskography. A contribution to the etiology and mechanism of neck, shoulder and arm pain. Ann Surg. 1959;150(6):1052–1064. Epub 1959/12/01 PubMed PMID: 13810738; PubMed Central PMCID: PMCPMC1629000. doi: 10.1097/00000658-195912000-00013
   PubMed Web of Science ®Google Scholar
• Slipman CW, Plastaras C, Patel R, et al. Provocative cervical discography symptom mapping. Spine J. 2005;5(4):381–388. Epub 2005/07/06 PubMed PMID: 15996607. doi: 10.1016/j.spinee.2004.11.012
   PubMedGoogle Scholar
• Leffler AS, Hansson P, Kosek E. Somatosensory perception in patients suffering from long-term trapezius myalgia at the site overlying the most painful part of the muscle and in an area of pain referral. Epub 2003/05/03 PubMed PMID: 12725850 Eur J Pain. 2003;7(3):267–276. doi: 10.1016/s1090-3801(02)00138-6
   PubMed Web of Science ®Google Scholar
• Carette S, Fehlings MG. Clinical practice. Cervical radiculopathy. Epub 2005/07/29 PubMed PMID: 16049211 N Engl J Med. 2005;353(4):392–399. doi: 10.1056/NEJMcp043887
   PubMedGoogle Scholar
• Gifford L. Acute low cervical nerve root conditions: symptom presentations and pathobiological reasoning. Man Ther. 2001;6(2):106–115. Epub 2001/06/21 PubMed PMID: 11414780. doi: 10.1054/math.2000.0386
   PubMed Web of Science ®Google Scholar
• Cohen SP, Mao J. Neuropathic pain: mechanisms and their clinical implications. BMJ. 2014;348:f7656. Epub 2014/02/07 PubMed PMID: 24500412. doi: 10.1136/bmj.f7656.
   PubMed Web of Science ®Google Scholar
• Fitzcharles MA, Cohen SP, Clauw DJ, et al. Nociplastic pain: towards an understanding of prevalent pain conditions. Lancet. 2021;397(10289):2098–2110. Epub 2021/06/02 PubMed PMID: 34062144. doi: 10.1016/s0140-6736(21)00392-5
   PubMed Web of Science ®Google Scholar
• Roselt D. Somatic referred pain. In: Gebhart G Schmidt R, editors Encyclopedia of pain. Berlin, Heidelberg: Springer; 2013. pp. 3527–31.
   Google Scholar
• World Health Organization. International classification of functioning, disability and health: ICF. Classif Int Fonct handicap santé CIF [Internet]. Geneva: World Health Organization; 2001. https://apps.who.int/iris/handle/10665/42407.
   Google Scholar
• Jones M, Rivett D, Clinical Reasoning in Musculoskeletal Practice, 2nd ed. Edinburgh: Elsevier; 2019.
   Google Scholar
• IASP. Terminology of pain; International Association for the study of pain. Available from: https://www.iasp-pain.org/publications/pain/.
   Google Scholar
• Fenton BW, Shih E, Zolton J. The neurobiology of pain perception in normal and persistent pain. Pain Manag. 2015;5(4):297–317. Epub 2015/06/20 PubMed PMID: 26088531. doi: 10.2217/pmt.15.27
   PubMedGoogle Scholar
• Murray GM. Guest editorial: referred pain. J Appl Oral Sci. 2009;17(6). Epub 2009/12/23 PubMed PMID: 20027423; PubMed Central PMCID: PMCPMC4327510. doi: 10.1590/s1678-77572009000600001
   PubMedGoogle Scholar
• Shraim MA, Sluka KA, Sterling M, et al. Features and methods to discriminate between mechanism-based categories of pain experienced in the musculoskeletal system: a Delphi expert consensus study. Pain. 2022;163(9):1812–1828. Epub 2022/03/24 PubMed PMID: 35319501; PubMed Central PMCID: PMCPMC9294075. doi: 10.1097/j.pain.0000000000002577
   PubMed Web of Science ®Google Scholar
• Haanpaa M, Attal N, Backonja M, et al. NeuPSIG guidelines on neuropathic pain assessment. Pain. 2011;152(1):14–27. Epub 2010/09/21 PubMed PMID: 20851519. doi: 10.1016/j.pain.2010.07.031
   PubMed Web of Science ®Google Scholar
• Shraim MA, Massé-Alarie H, Hodges PW. Methods to discriminate between mechanism-based categories of pain experienced in the musculoskeletal system: a systematic review. Epub 2020/11/03 PubMed PMID: 33136983 Pain. 2021;162(4):1007–1037. doi: 10.1097/j.pain.0000000000002113
   PubMed Web of Science ®Google Scholar
• Abbed KM, Coumans JV. Cervical radiculopathy: pathophysiology, presentation, and clinical evaluation. Neurosurgery. 2007;60(1 Supp1 1):S28–34. Epub 2007/01/06 PubMed PMID: 17204882. doi: 10.1227/01.Neu.0000249223.51871.C2
   PubMed Web of Science ®Google Scholar
• Murphy DR, Hurwitz EL, Gerrard JK, et al. Pain patterns and descriptions in patients with radicular pain: does the pain necessarily follow a specific dermatome? Chiropr Osteopat. 2009;17(1):9. Epub 2009/09/24 PubMed PMID: 19772560; PubMed Central PMCID: PMCPMC2753622. doi: 10.1186/1746-1340-17-9
   PubMedGoogle Scholar
• Tampin B, Slater H, Hall T, et al. Quantitative sensory testing somatosensory profiles in patients with cervical radiculopathy are distinct from those in patients with nonspecific neck-arm pain. Pain. 2012;153(12):2403–14. Epub 2012/09/18 PubMed PMID: 22980746. doi: 10.1016/j.pain.2012.08.007
   PubMed Web of Science ®Google Scholar
• Lam KN, Heneghan NR, Mistry J, et al. Classification criteria for cervical radiculopathy: An international e-Delphi study. Musculoskelet Sci Pract. Epub 2022/06/08 PubMed PMID: 35671539 2022;61:102596. doi: 10.1016/j.msksp.2022.102596
   PubMed Web of Science ®Google Scholar
• Sleijser-Koehorst MLS, Coppieters MW, Epping R, et al. Diagnostic accuracy of patient interview items and clinical tests for cervical radiculopathy. Physiotherapy. 2021;111:74–82. doi: 10.1016/j.physio.2020.07.007. Epub 2020/12/15 PubMed PMID: 33309074.
   PubMed Web of Science ®Google Scholar
• Bates D, Schultheis BC, Hanes MC, et al. A comprehensive algorithm for management of neuropathic pain. Pain Med. 2019;20(Suppl 1):S2–s12. Epub 2019/06/04 PubMed PMID: 31152178; PubMed Central PMCID: PMCPMC6544553. doi: 10.1093/pm/pnz075
   PubMed Web of Science ®Google Scholar
• McCarberg B, D’Arcy Y, Parsons B, et al. Neuropathic pain: a narrative review of etiology, assessment, diagnosis, and treatment for primary care providers. Curr Med Res Opin. 2017;33(8):1361–1369. Epub 2017/04/20 PubMed PMID: 28422517. doi: 10.1080/03007995.2017.1321532
   PubMed Web of Science ®Google Scholar
• Bussa M, Mascaro A, Sbacchi E, et al. Understanding peripheral neuropathic pain in primary care: diagnosis and management. Eur Rev Med Pharmacol Sci. 2021;25(4):1990–1996. Epub 2021/03/05 PubMed PMID: 33660810. doi: 10.26355/eurrev_202102_25100
   PubMed Web of Science ®Google Scholar
• Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021;397(10289):2082–2097. Epub 2021/06/02 PubMed PMID: 34062143. doi: 10.1016/s0140-6736(21)00393-7
   PubMed Web of Science ®Google Scholar
• Nijs J, Lahousse A, Kapreli E, et al. Nociplastic pain criteria or Recognition of Central Sensitization? Pain phenotyping in the past, present and future. J Clin Med. 2021;10(15): Epub 2021/08/08 PubMed PMID: 34361986; PubMed Central PMCID: PMCPMC8347369. doi: 10.3390/jcm10153203
   Web of Science ®Google Scholar
• Kosek E, Clauw D, Nijs J, et al. Chronic nociplastic pain affecting the musculoskeletal system: clinical criteria and grading system. Pain. 2021;162(11):2629–2634. Epub 2021/05/12 PubMed PMID: 33974577. doi: 10.1097/j.pain.0000000000002324
   PubMed Web of Science ®Google Scholar
• van Griensven H, Schmid A, Trendafilova T, et al. Central Sensitization in Musculoskeletal Pain: Lost in Translation? J Orthop Sports Phys Ther. 2020;50(11):592–596. Epub 2020/11/03 PubMed PMID: 33131390. doi: 10.2519/jospt.2020.0610
   PubMed Web of Science ®Google Scholar
• Nee RJ, Butler D. Management of peripheral neuropathic pain: integrating neurobiology, neurodynamics, and clinical evidence. Phys Ther Sport. 2006;7(1):36–49. doi: 10.1016/j.ptsp.2005.10.002
   Web of Science ®Google Scholar
• Gangavelli R, Nair NS, Bhat AK, et al. Cervicobrachial pain - how often is it neurogenic? J Clin Diagn Res. 2016;10(3):Yc14–6. Epub 2016/05/03 PubMed PMID: 27134988; PubMed Central PMCID: PMCPMC4843373. doi: 10.7860/jcdr/2016/16456.7492
   PubMedGoogle Scholar
• Smart KM, Blake C, Staines A, et al. Clinical indicators of ‘nociceptive’, ‘peripheral neuropathic’ and ‘central’ mechanisms of musculoskeletal pain. A Delphi survey of expert clinicians. Man Ther. 2010;15(1):80–87. Epub 2009/08/15 PubMed PMID: 19679504. doi: 10.1016/j.math.2009.07.005
   PubMed Web of Science ®Google Scholar
• Smart KM, Blake C, Staines A, et al. The Discriminative validity of “nociceptive,” “peripheral neuropathic,” and “central sensitization” as mechanisms-based classifications of musculoskeletal pain. Clin J Pain. 2011;27(8):655–663. PubMed PMID: 21471812. doi: 10.1097/AJP.0b013e318215f16a
   PubMed Web of Science ®Google Scholar
• Lam KN, Rushton A, Thoomes E, et al. Neck pain with radiculopathy: a systematic review of classification systems. Musculoskelet Sci Pract. 2021;54:102389. Epub 2021/05/17 PubMed PMID: 33992884. doi: 10.1016/j.msksp.2021.102389.
   PubMed Web of Science ®Google Scholar
• Rasmussen PV, Sindrup SH, Jensen TS, et al. Symptoms and signs in patients with suspected neuropathic pain. Pain. 2004;110(1–2):461–9. Epub 2004/07/28 PubMed PMID: 15275799. doi: 10.1016/j.pain.2004.04.034
   PubMed Web of Science ®Google Scholar
• Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 2010;9(8):807–819. Epub 2010/07/24 PubMed PMID: 20650402. doi: 10.1016/s1474-4422(10)70143-5
   PubMed Web of Science ®Google Scholar
• Jones M, Edwards I, Jensen G. Clinical reasoning in physiotherapy. In: Higgs J, Jensen G, Loftus S Christensen N, editors Clinical reasoning in the health professions. 4 ed. Edinburgh: Elsevier; 2019. pp. 247–60.
   Google Scholar
• Bennett M. The LANSS pain scale: the Leeds assessment of neuropathic symptoms and signs. Pain. 2001;92(1–2):147–57. Epub 2001/04/27 PubMed PMID: 11323136. doi: 10.1016/s0304-3959(00)00482-6
   PubMed Web of Science ®Google Scholar
• Nikaido T, Sumitani M, Sekiguchi M, et al. The Spine painDETECT questionnaire: development and validation of a screening tool for neuropathic pain caused by spinal disorders. Epub 2018/03/22 Epub 2018/03/22 Epub 2018/03/22 PLoS One. 2018;13(3):e0193987. doi: 10.1371/journal.pone.0193987
   PubMed Web of Science ®Google Scholar
• Bouhassira D, Attal N, Alchaar H, et al. Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain. 2005;114(1–2):29–36. Epub 2005/03/01 PubMed PMID: 15733628. doi: 10.1016/j.pain.2004.12.010
   PubMed Web of Science ®Google Scholar
• Cruccu G, Sommer C, Anand P, et al. EFNS guidelines on neuropathic pain assessment: revised 2009. Eur J Neurol. 2010;17(8):1010–1018. Epub 2010/03/20 PubMed PMID: 20298428. doi: 10.1111/j.1468-1331.2010.02969.x
   PubMed Web of Science ®Google Scholar
• Mayer TG, Neblett R, Cohen H, et al. The development and psychometric validation of the central sensitization inventory. Pain Pract. 2012;12(4):276–285. Epub 2011/09/29 PubMed PMID: 21951710; PubMed Central PMCID: PMCPMC3248986. doi: 10.1111/j.1533-2500.2011.00493.x
   PubMed Web of Science ®Google Scholar
• Mistry J, Falla D, Noblet T, et al. Clinical indicators to identify neuropathic pain in low back related leg pain: a modified Delphi study. BMC Musculoskelet Disord. 2020;21(1):601. Epub 2020/09/10 PubMed PMID: 32900367; PubMed Central PMCID: PMCPMC7487834. doi: 10.1186/s12891-020-03600-y
   PubMed Web of Science ®Google Scholar
• Backonja MM, Attal N, Baron R, et al. Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain. 2013;154(9):1807–19. Epub 2013/06/08 PubMed PMID: 23742795. doi: 10.1016/j.pain.2013.05.047
   PubMed Web of Science ®Google Scholar
• Suzuki H, Tahara S, Mitsuda M, et al. Current concept of Quantitative sensory testing and pressure pain threshold in neck/shoulder and low back pain. Healthcare. 2022;10(8): Epub 2022/08/27 PubMed PMID: 36011141; PubMed Central PMCID: PMCPMC9408781. doi: 10.3390/healthcare10081485
   Web of Science ®Google Scholar
• Georgopoulos V, Akin-Akinyosoye K, Zhang W, et al. Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis. Pain. 2019;160(9):1920–1932. Epub 2019/05/03 PubMed PMID: 31045746; PubMed Central PMCID: PMCPMC6701980. doi: 10.1097/j.pain.0000000000001590
   PubMed Web of Science ®Google Scholar
• Thoomes EJ, van Geest S, van der Windt DA, et al. Value of physical tests in diagnosing cervical radiculopathy: a systematic review. Spine J. 2018;18(1):179–189. Epub 2017/08/26 PubMed PMID: 28838857. doi: 10.1016/j.spinee.2017.08.241
   PubMed Web of Science ®Google Scholar
• Nee RJ, Vicenzino B, Jull GA, et al. Baseline characteristics of patients with nerve-related neck and arm pain predict the likely response to neural tissue management. J Orthop Sports Phys Ther. 2013;43(6):379–391. Epub 2013/05/02 PubMed PMID: 23633626. doi: 10.2519/jospt.2013.4490
   PubMed Web of Science ®Google Scholar
• Nee RJ, Vicenzino B, Jull GA, et al. Neural tissue management provides immediate clinically relevant benefits without harmful effects for patients with nerve-related neck and arm pain: a randomised trial. J Physiother. 2012;58(1):23–31. doi: 10.1016/s1836-9553(12)70069-3
   PubMed Web of Science ®Google Scholar
• Apelby-Albrecht M, Andersson L, Kleiva IW, et al. Concordance of upper limb neurodynamic tests with medical examination and magnetic resonance imaging in patients with cervical radiculopathy: a diagnostic cohort study. J Manipulative Physiol Ther. 2013;36(9):626–632. Epub 2013/10/29 PubMed PMID: 24161389. doi: 10.1016/j.jmpt.2013.07.007
   PubMed Web of Science ®Google Scholar
• Wainner RS, Fritz JM, Irrgang JJ, et al. Reliability and diagnostic accuracy of the clinical examination and patient self-report measures for cervical radiculopathy. Spine (phila Pa 1976). Spine. 2003;28(1):52–62. Epub 2003/01/25 PubMed PMID: 12544957. doi: 10.1097/00007632-200301010-00014
   PubMed Web of Science ®Google Scholar
• Koulidis K, Veremis Y, Anderson C, et al. Diagnostic accuracy of upper limb neurodynamic tests for the assessment of peripheral neuropathic pain: a systematic review. Musculoskelet Sci Pract. 2019;40:21–33. Epub 2019/01/22 PubMed PMID: 30665045. doi: 10.1016/j.msksp.2019.01.001.
   PubMed Web of Science ®Google Scholar
• Shabat S, Leitner Y, David R, et al. The correlation between Spurling test and imaging studies in detecting cervical radiculopathy. J Neuroimaging. 2012;22(4):375–378. Epub 2011/09/03 PubMed PMID: 21883627. doi: 10.1111/j.1552-6569.2011.00644.x
   PubMed Web of Science ®Google Scholar
• Shah KC, Rajshekhar V. Reliability of diagnosis of soft cervical disc prolapse using Spurling’s test. Br J Neurosurg. 2004;18(5):480–3. Epub 2005/04/01 PubMed PMID: 15799149. doi: 10.1080/02688690400012350
   PubMed Web of Science ®Google Scholar
• Tong HC, Haig AJ, Yamakawa K. The Spurling test and cervical radiculopathy. Spine (phila Pa 1976). Epub 2002/01/24 PubMed PMID: 11805661. 2002;27(2):156–9. DOI:10.1097/00007632-200201150-00007
   Google Scholar
• Coppieters MW, Butler DS. Do ‘sliders’ slide and ‘tensioners’ tension? An analysis of neurodynamic techniques and considerations regarding their application. Man Ther. 2008;13(3):213–221. Epub 2007/04/03 PubMed PMID: 17398140. doi: 10.1016/j.math.2006.12.008
   PubMed Web of Science ®Google Scholar
• Engel GL. The need for a new medical model: a challenge for biomedicine. Epub 1977/04/08 PubMed PMID: 847460 Science. 1977;196(4286):129–136. doi: 10.1126/science.847460
   PubMed Web of Science ®Google Scholar
• Toda K. Pure nociceptive pain is very rare. Curr Med Res Opin. 2019;35(11):1991. Epub 2019/07/02 PubMed PMID: 31259612. doi: 10.1080/03007995.2019.1638761
   PubMed Web of Science ®Google Scholar
• Schmid AB, Fundaun J, Tampin B. Entrapment neuropathies: a contemporary approach to pathophysiology, clinical assessment, and management. Pain Rep. 2020;5(4):e829. Epub 2020/08/09 PubMed PMID: 32766466; PubMed Central PMCID: PMCPMC7382548. doi: 10.1097/PR9.0000000000000829
   PubMedGoogle Scholar
• Dilley A, Lynn B, Pang SJ. Pressure and stretch mechanosensitivity of peripheral nerve fibres following local inflammation of the nerve trunk. Epub 2005/09/13 PubMed PMID: 16154692; PubMed Central PMCID: PMCPMC1402335 Pain. 2005;117(3):462–472. doi: 10.1016/j.pain.2005.08.018
   PubMed Web of Science ®Google Scholar
• Shraim MA, Massé-Alarie H, Hall LM, et al. Systematic review and synthesis of mechanism-based classification systems for pain experienced in the musculoskeletal system. Clin J Pain. 2020;36(10):793–812. Epub 2020/08/28 PubMed PMID: 32852923. doi: 10.1097/ajp.0000000000000860
   PubMed Web of Science ®Google Scholar
• Hage R, Fourre A, Ramonfosse L, et al. Description and rules of a new card game to learn clinical reasoning in musculoskeletal physiotherapy. J Man Manip Ther. 2022;1–10. Epub 2022/11/02 PubMed PMID: 36317932.doi: 10.1080/10669817.2022.2132346.
   PubMed Web of Science ®Google Scholar
• Kuligowski T, Skrzek A, Cieślik B. Manual Therapy in cervical and Lumbar Radiculopathy: a systematic review of the literature. Int J Environ Res Public Health. 2021;18(11). Epub 2021/07/03 PubMed PMID: 34200510; PubMed Central PMCID: PMCPMC8201115. doi: 10.3390/ijerph18116176
   Web of Science ®Google Scholar
• Leitzelar BN, Koltyn KF. Exercise and neuropathic pain: a general overview of preclinical and clinical research. Sports Med - Open. 2021;7(1):21. Epub 2021/03/23 PubMed PMID: 33751253; PubMed Central PMCID: PMCPMC7984211. doi: 10.1186/s40798-021-00307-9
   PubMedGoogle Scholar
• Akyuz G, Kenis O. Physical therapy modalities and rehabilitation techniques in the management of neuropathic pain. Am J Phys Med Rehabil. 2014;93(3):253–259. Epub 2013/12/11 PubMed PMID: 24322437. doi: 10.1097/PHM.0000000000000037
   PubMed Web of Science ®Google Scholar
• Cook CE, Rhon DI, Bialosky J, et al. Developing manual therapy frameworks for dedicated pain mechanisms. J Orthop Sports Phys Ther Open. 2023;1(1):48–62. doi:10.2519/josptopen.2023.0002
   Google Scholar