The Harvard Twin Study of Substance Abuse: What We Have Learned

REFERENCES

• Eisen S, True W, Goldberg J, Henderson W, Robinette CD. The Vietnam Era Twin (VET) Registry: method of construction. Acta Genet Med Gemellol (Roma) 1987;36:61–6.
   PubMedGoogle Scholar
• Henderson WG, Eisen S, Goldberg J, True WR, Barnes JE, Vitek ME. The Vietnam Era Twin Registry: a resource for medical research. Public Health Rep 1990;105:368–73.
   PubMedGoogle Scholar
• Eisen S, Neuman R, Goldberg J, Rice J, True W. Determining zygosity in the Vietnam Era Twin Registry: an approach using questionnaires. Clin Genet 1989;35:423–32.
   PubMed Web of Science ®Google Scholar
• Goldberg J, True W, Eisen S, Henderson W, Robinette CD. The Vietnam Era Twin (VET) Registry: ascertainment bias. Acta Genet Med Gemellol (Roma) 1987;36:67–78.
   Google Scholar
• Robins L, Helzer J, Cottler L, Goldring E. NIMH Diagnostic Interview Schedule Version III Revised (DIS-III-R). St. Louis, Missouri: Department of Psychiatry, Washington University Medical School, 1989.
   Google Scholar
• Gfroerer JC, Hughes AL. The feasibility of collecting drug abuse data by telephone. Public Health Rep 1991;106:384–93.
   PubMed Web of Science ®Google Scholar
• Rohde P, Lewinsohn PM, Seeley JR. Comparability of tele- phone and face-to-face interviews in assessing Axis I and II disorders. Am J Psychiatry 1997;154:1593–8.
   PubMed Web of Science ®Google Scholar
• Sobin C, Weissman MM, Goldstein RB, Adams P, Wickrama- ratne P, Warner V, et al. Diagnostic interviewing for family studies: comparing telephone and face-to-face methods for the diagnosis of lifetime psychiatric disorders. Psychiatr Genet 1993;3:227–33.
   Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd ed, revised. Washington, DC: American Psychiatric Association, 1987.
   Google Scholar
• Warner LA, Kessler RC, Hughes M, Anthony JC, Nelson CB. Prevalence and correlates of drug use and dependence in the United States: results from the National Comorbidity Survey. Arch Gen Psychiatry 1995;52:219–29.
   PubMed Web of Science ®Google Scholar
• Tsuang MT, Lyons MJ, Eisen SA, Goldberg J, True W, Lin N, et al. Genetic influences on DSM-III-R drug abuse and depen- dence: a study of 3,372 twin pairs. Am J Med Genet 1996; 67:473–7.
   PubMed Web of Science ®Google Scholar
• Grove WM, Eckert ED, Heston L, Bouchard TJ Jr, Segal N, Lykken DT. Heritability of substance abuse and antisocial be- havior: a study of monozygotic twins reared apart. Biol Psychi- atry 1990;27:1293–304.
   PubMed Web of Science ®Google Scholar
• Pickens RW, Svikis DS, McGue M, Lykken DT, Heston LL, Clayton PJ. Heterogeneity in the inheritance of alcoholism: a study of male and female twins. Arch Gen Psychiatry 1991; 48:19–28.
   PubMed Web of Science ®Google Scholar
• Tsuang MT, Lyons MJ, Meyer JM, Doyle T, Eisen SA, Gold- berg J, et al. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry 1998;55:967–72.
   Google Scholar
• Golub A, Johnson BD. The shifting importance of alcohol and marijuana as gateway substances among serious drug abus- ers. J Stud Alcohol 1994;55:607–14.
   PubMed Web of Science ®Google Scholar
• Kandel DB, Yamaguchi K, Chen K. Stages of progression in drug involvement from adolescence to adulthood: further evidence for the gateway theory. J Stud Alcohol 1992;53:447–57.
   PubMed Web of Science ®Google Scholar
• Yamaguchi K, Kandel DB. Patterns of drug use from adoles- cence to young adulthood, III: Predictors of progression. Am J Public Health 1984;74:673–81.
   PubMed Web of Science ®Google Scholar
• DeWit H, Johanson CD. A drug preference procedure for use with human volunteers. In: Bozarth MA, ed. Methods of as- sessing the reinforcing properties of abused drugs. New York: Springer, 1987:559–72.
   Google Scholar
• Lyons MJ, Toomey R, Meyer JM, Green AI, Eisen SA, Gold- berg J, et al. How do genes influence marijuana use? The role of subjective effects. Addiction 1997;92:409–17.
   Google Scholar
• Ball DM, Murray RM. Genetics of alcohol misuse. Br Med Bull 1994;50:18–35.
   Google Scholar
• McClearn GE, Anderson SM. Genetics and ethanol tolerance. Drug Alcohol Depend 1979;4:61–76.
   PubMedGoogle Scholar
• George FR. Genetic models in the study of alcoholism and sub- stance abuse mechanisms. Prog Neuropsychopharmacol Biol Psychiatry 1993;17:345–61.
   Google Scholar
• Tsuang MT, Lyons MJ, Harley RM, Xian H, Eisen S, Goldberg J, et al. Genetic and environmental influences on transitions in drug use. Behav Genet 1999;29:473–9.
   PubMed Web of Science ®Google Scholar
• Heath AC, Bucholz KK, Madden PAF, Dinwiddie SH, Slutske WS, et al. Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med 1997;27:1381–96.
   PubMed Web of Science ®Google Scholar
• McGue M. Genes, environment and the etiology of alcohol- ism. In: Zucker R, Boyd G, Howard J, eds. The development of alcohol problems: exploring the biopsychosocial matrix of risk. Rockville, Maryland: National Institutes of Health, 1994: 1–40.
   Google Scholar
• McGue M. Phenotyping alcoholism [Letter]. Alcohol Clin Exp Res 1999;23:757–8.
   Google Scholar
• True WR, Heath AC, Bucholz K, Slutske W, Romeis JC, Scher- rer JF, et al. Models of treatment seeking for alcoholism: the role of genes and environment. Alcohol Clin Exp Res 1996; 20:1577–81.
   PubMed Web of Science ®Google Scholar
• Johnson EO, Van den Bree MBM, Pickens RW. Indicators of genetic and environmental influence in alcohol-dependent in- dividuals. Alcohol Clin Exp Res 1996;20:67–74.
   PubMed Web of Science ®Google Scholar
• Slutske WS, True WR, Scherrer JF, Heath AC, Bucholz KK, Eisen SA, et al. The heritability of alcoholism symptoms: “in- dicators of genetic and environmental influence in alcohol- dependent individuals” revisited. Alcohol Clin Exp Res 1999; 23:759–69.
   PubMedGoogle Scholar
• Leevy CB, Leevy CM. Alcoholic liver disease. Compr Ther 1994;20:6–9.
   Google Scholar
• Moos RH, Moos BS. The process of recovery from alcoholism, III: Comparing functioning in families of alcoholics and matched control families. J Stud Alcohol 1984;45:111–8.
   PubMed Web of Science ®Google Scholar
• Romeis JC, Waterman B, Scherrer JF, Goldberg J, Eisen SA, Heath AC, et al. The impact of sociodemographics, comorbidity and symptom recency on health-related quality of life in alco- holics. J Stud Alcohol 1999;60:653–62.
   PubMedGoogle Scholar
• True WR, Heath AC, Scherrer JF, Waterman B, Goldberg J, Lin N, et al. Genetic and environmental contributions to smoking. Addiction 1997;92:1277–87.
   PubMed Web of Science ®Google Scholar
• Boomsma DI, Koopmans JR, Van Doornen LJP, Orlebeke JF. Genetic and social influences on starting to smoke: a study of Dutch adolescent twins and their parents. Addiction 1994; 89:219–26.
   PubMed Web of Science ®Google Scholar
• Heath AC, Madden PAF. Genetic influences on smoking be- havior. In: Turner JR, Cardon LR, Hewitt JK, eds. Behavior genetic approaches in behavioral medicine: perspectives on in- dividual differences. New York: Plenum, 1995:45–66.
   Google Scholar
• Heath AC. Persist or quit? Testing for a genetic contribution to smoking persistence. Acta Genet Med Gemellol (Roma) 1990;39:447–58.
   Google Scholar
• Heath AC, Madden PAF, Slutske WS, Martin NG. Personality and the inheritance of smoking behavior: a genetic perspec- tive. Behav Genet 1995;25:103–17.
   Google Scholar
• Heath AC, Martin NG. Genetic models for the natural history of smoking: evidence for a genetic influence on smoking persis- tence. Addict Behav 1993;18:19–34.
   PubMed Web of Science ®Google Scholar
• Peto R, Lopez AD, Boreham J, Thun M, Heath C, Doll R. Mor- tality from smoking worldwide. Br Med Bull 1996;52:12–21.
   PubMed Web of Science ®Google Scholar
• Raaschou-Nielsen E. Smoking habits in twins. Dan Med Bull 1960;7:82–8.
   PubMedGoogle Scholar
• Marks MJ, Campbell SM, Romm E, Collins AC. Genotype in- fluences the development of tolerance to nicotine in the mouse. J Pharmacol Exp Ther 1991;259:392–402.
   Google Scholar
• Pomerleau OF. Individual differences in sensitivity to nico- tine: implications for genetic research on nicotine dependence. Behav Genet 1995;25:161–77.
   PubMed Web of Science ®Google Scholar
• Pomerleau OF, Collins AC, Shiffman S, Pomerleau CS. Why some people smoke and others do not: new perspectives. J Consult Clin Psychol 1993;61:723–31.
   PubMed Web of Science ®Google Scholar
• Maletzky BM, Klotter J. Smoking and alcoholism. Am J Psy- chiatry 1974;131:445–7.
   PubMed Web of Science ®Google Scholar
• Cyr MG, Wartman SA. The effectiveness of routine screening questions in the detection of alcoholism. JAMA 1998;259:51–4.
   Google Scholar
• Johnson KA, Jennison KM. The drinking-smoking syndrome and social context. Int J Addict 1992;27:749–92.
   PubMed Web of Science ®Google Scholar
• Olsen J, Sabreo S, Fasting U. Interaction of alcohol and to- bacco as risk factors in cancer of the laryngeal region. J Epide- miol Community Health 1985;39:165–8.
   PubMedGoogle Scholar
• True WR, Xian H, Scherrer JF, Madden PAF, Bucholz KK, Heath AC, et al. Common genetic vulnerability for nicotine and alcohol dependence in men. Arch Gen Psychiatry 1999; 56:655–61.
   PubMed Web of Science ®Google Scholar
• Prescott CA, Kendler KS. Genetic and environmental influ- ences on alcohol and tobacco dependence among women. In: Fertig JB, Allen JP, eds. Alcohol and tobacco: from basic sci- ence to clinical practice. Bethesda, Maryland: National Insti- tutes of Health, 1995:59–87.
   Google Scholar
• Swan, GE, Carmelli D, Cardon LR. The consumption of to- bacco, alcohol, and coffee in Caucasian male twins: a multivar- iate analysis. J Subst Abuse 1996;8:19–31.
   PubMedGoogle Scholar
• Lin N, Eisen SA, Scherrer JF, Goldberg J, True WR, Lyons MJ, et al. The influence of familial and non-familial factors on the association between major depression and substance abuse/dependence in 1874 monozygotic male twin pairs. Drug Alcohol Depend 1996;43:49–55.
   PubMed Web of Science ®Google Scholar
• Kendler KS, Heath AC, Neale MC, Kessler RC, Eaves LJ. Al- coholism and major depression in women: a twin study of the causes of comorbidity. Arch Gen Psychiatry 1993;50:690–8.
   PubMed Web of Science ®Google Scholar
• Maier W, Lichtermann D, Minges J. The relationship between alcoholism and unipolar depression—a controlled family study. J Psychiatr Res 1994;28:303–17.
   PubMed Web of Science ®Google Scholar
• Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, et al. Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiologic Catchment Area (ECA) study. JAMA 1990;264:2511–8.
   PubMed Web of Science ®Google Scholar
• Kleinman PH, Miller AB, Millman RB, Woody GE, Todd T, Kemp J, et al. Psychopathology among cocaine abusers enter- ing treatment. J Nerv Ment Dis 1990;178:442–7.
   PubMed Web of Science ®Google Scholar
• Buckner JC, Mandell W. Risk factors for depressive symptom- atology in a drug using population. Am J Public Health 1990; 80:580–5.
   PubMed Web of Science ®Google Scholar
• Rounsaville BJ, Kosten TR, Weissman MM, Prusoff B, Pauls D, Anton SF, et al. Psychiatric disorders in relatives of pro- bands with opiate addiction. Arch Gen Psychiatry 1991;48:33–42.
   PubMed Web of Science ®Google Scholar
• Young SE, Mikulich SK, Goodwin MB, Hardy J, Martin CL, Zoccolillo MS, et al. Treated delinquent boys’ substance use: onset, pattern, relationship to conduct and mood disorders. Drug Alcohol Depend 1995;37:149–62.
   PubMed Web of Science ®Google Scholar
• True WR, Heath AC, Scherrer JF, Xian H, Lin N, Eisen SA, et al. Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. Am J Med Genet 1999;88:391–7.
   PubMed Web of Science ®Google Scholar
• Neale MC, Cardon LR. Methodology for genetic studies of twins and families. Norwell, Massachusetts: Kluwer, 1992.
   Google Scholar
• Lyons MJ, True WR, Eisen SA, Goldberg J, Meyer JM, Far- aone SV, et al. Differential heritability of adult and juvenile antisocial traits. Arch Gen Psychiatry 1995;52:906–15.
   Google Scholar
• Slutske WS, Heath AC, Dinwiddie SH, Madden PA, Bucholz KK, Dunne MP, et al. Modeling genetic and environmental in- fluences in the etiology of conduct disorder: a study of 2,682 adult twin pairs. J Abnorm Psychol 1997;106:266–79.
   PubMed Web of Science ®Google Scholar
• Lytton H. Child and parent effects in boys’ conduct disorder: a reinterpretation. Dev Psychol 1990;26:683–97.
   Web of Science ®Google Scholar
• Rutter M. Family discord and conduct disorder: cause, conse- quence, or correlate? J Fam Psychol 1994;8:170–86.
   Google Scholar