Three Repeats of CCCCTCC on the Pyrimidine-rich Sequence in the Proximal 5′ Flanking Region are Required for Efficient Transcriptional Activity of the Human Endothelial Nitric Oxide Synthase Gene

References

• Furchgott, RE (1989) "Endothelium-derived relaxing and contracting factors", FASEB J. 3, 2007–2018.
   PubMed Web of Science ®Google Scholar
• Nathan, C. (1991) "Nitric oxide as a secretory product of mammalian cells", FASEB J. 6, 3051–3064.
   Google Scholar
• Schmit, H.H. and Walter, U. (1994) "NO at work", Cell 78, 919–925.
   PubMedGoogle Scholar
• Lu, J.-L., Schmiege, ifi, L.M., Kuo, L. and Liao, J.C. (1996) "Downregulation of endothelial constitutive nitric oxide synthase expression by lipopolysaccharide", Biochem. Bio-phys. Res. Commun. 225, 1–5.
   PubMedGoogle Scholar
• Alonso, J., Sanchez de Miguel, L., Monton, M., Casado, S. and Lopez-Farre, A. (1997) "Endothelial cytosolic protein bind to the 3' untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha", Mol. Cell. Biol. 17, 5719–5726.
   PubMedGoogle Scholar
• Phelan, M.W. and Faller, D.V. (1996) "Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells", J. Cell. Physiol. 167, 469–476.
   PubMed Web of Science ®Google Scholar
• Nishida, K., Harrison, D.G., Navas, J.P., Fisher, A.A., Dockery, SE, Uematsu, M., Nerem, R.M., Alexander, W. and Murphy, T.J. (1992) "Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase", J. Clin. Investig. 90, 2092–2096.
   PubMed Web of Science ®Google Scholar
• Noris, M., Morigi, M., Donadelli, R., Aiello, S., Foppolo, M., Todeschini, M., Orisio, S., Remuzzi, G. and Remuzzi, A. (1995) "Nitric oxide synthesis by cultured endothelial cells is modulated flow conditions", Circ. Res. 76, 536–543.
   PubMed Web of Science ®Google Scholar
• MacRitchie, A.N., Jun, S.S., Chen, Z., German, Z., Yuhanna, IS., Shernlan, T.S. and Shaul, P.W. (1997) "Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium", Circ. Res. 81, 355–362.
   PubMed Web of Science ®Google Scholar
• Zembowicz, A., Tang, J.-I. and Wu, K.K. (1995) "Transcrip-tional induction of endothelial nitric oxide synthase type DI by lysophosphatidylcholine", J. Biol. Chem. 270, 1706–1710.
   Google Scholar
• Inoue, N., Venema, R.C., Sayegh, H.S., Ohara, Y., Murphy, T.J. and Harrison, D.G. (1995) "Arterioscler. Molecular regulation of the bovine endothelial cell nitric oxide synthase by transfoming growth factor-beta", Thromb. Vasc. Biol. 15, 1255–1261.
   PubMed Web of Science ®Google Scholar
• Guillot, P., Guan, J., Liu, L., Kuivenhoven, J.A., Rosenberg, RD., Sessa, W.C. and Aird, W.C. (1999) "A vascular bed-specific pathway regulates cardiac expression of endothelial nitric oxide synthase", J. Clin. Investig. 103, 799–805.
   PubMedGoogle Scholar
• Dinerman, J.L., Dawson, T.M., Schell, M.J., Snowman, A. and Snyder, S.H. (1994) "Endothelial nitric oxide synthase localized to hippocampal pyramodal cells: implications for synaptic plasticity", Proc. Natl Acad. Sci. USA 91, 4214–4218.
   PubMed Web of Science ®Google Scholar
• Miyahara, K., Kawamoto, T., Sase, K., Yui, Y., Toda, K., Yang, L.-X., Hattori, R., Aoyama, T., Yamamoto, Y., Doi, Y., Ogoshi, S., Hashimoto, K., Kawai, C., Sasayama, S. and Shizuta, Y. (1994) "Cloning and structural characterization of the human endothelial nitric oxide synthase gene", Fur. J. Biochem. 223, 719–726.
   PubMedGoogle Scholar
• Marsden, P.A., Heng, H.H., Scherer, S.W., Stewart, R.J., Hall, A.V., Shi, X.-M., Tsui, L.-C. and Schappert, K.T. (1993) "Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene", J. Biol. Chem. 268, 17478–17488.
   PubMedGoogle Scholar
• Nadaud, S., Bonnardeaux, A., Lathrop, M. and Soubrier, F. (1994) "Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene", Biochem. Biophys. Res. Commun. 198, 1027–1033.
   PubMed Web of Science ®Google Scholar
• Wariishi, S., Miyahara, K., Toda, K., Ogoshi, S., Doi, Y., Ohnishi, S., Mitsui, Y., Yui, Y., Kawai, C. and Shizuta, Y. (1995) "A Sp1 binding site in the GC-rich region is essential for a core promoter activity of the human endothelial nitric oxide synthase gene", Biochem. Biophys. Res. Commun. 216, 729–735.
   PubMedGoogle Scholar
• Zang, R., Min, W. and Sessa, W.C. (1995) "Functional analysis of the human endothelial nitric oxide synthase promoter", J. Biol. Chem. 270, 15320–15326.
   PubMedGoogle Scholar
• Tang, J.-L., Zembowicz, A., Xu, X.-M. and Wu, K.K. (1995) "Role of Spl in transcriptional activation of human nitric oxide synthase type DI gene", Biochem. Biophys. Res. Commun. 213, 673–680.
   PubMedGoogle Scholar
• Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY).
   Google Scholar
• Kobayashi, M., Kondo, M. and Mitsui, Y. (1991) "Establish-ment of human endothelial cell line in a serum-free culture and its application for expression of transfected prepro endothelin gene", Human Cell 4, 296–305.
   PubMedGoogle Scholar
• Lee, K.A.W., Zerivitz, K. and Akusjarvi, G. (1994) "Small-scale preparation of nuclear extracts from mammalian cells", In: Celis, J.E., ed, Cell Biology: A Laboratory Handbook (Academic Press, San Diego, CA) vol. 1, pp 668–673.
   Google Scholar
• Dignam, J.D., Lebovitz, R.M. and Roeder, R.G. (1983) "Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei", Nucl. Acids Res. 11, 1475–1489.
   PubMed Web of Science ®Google Scholar
• Chodosh, L.A. (1994) "UV crosslinking of proteins to nucleic acids", In: Ausubel, EM., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. and Struhl, K., eds, Current Protocols in Molecular Biology (Wiley, New York), 12.5. 1–8.
   Google Scholar
• Venema, R.C., Nishida, K., Alexander, R.W., Harrison, D.G. and Murphy, T.J. (1994) "Organization of the bovine gene encoding the endothelial nitric oxide synthase", Biochim. Biophys. Acta 1218, 413–420.
   PubMed Web of Science ®Google Scholar
• Teichert, A.M., Karantzoulis-Fegaras, F., Wang, Y., Mawji, IA., Bei, X., Gnanapandithen, K. and Marsden, RA. (1998) "Characterization of the murine endothelial nitric oxide synthase promoter", Biochim. Biophys. Acta 1443, 352–357.
   PubMed Web of Science ®Google Scholar
• Bossone, S.A., Asselin, C., Patel, A.J. and Marcu, KB. (1992) "MAZ, a zinc finger protein binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termin-ation", Proc. Natl Acad. Sci, USA 89, 7452–7456.
   PubMed Web of Science ®Google Scholar
• Lobanenkov, V.V., Nicolas, R.H., Adler, V.V., Paterson, H., Klenova, EM., Polotskaja, A.V. and Goodwin, G.H. (1990) "A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene", Oncogene 5, 1743–1753.
   PubMed Web of Science ®Google Scholar
• Takimoto, M., Tomonaga, T., Matunis, M., Avigan, M., Dreyfuss, G. and Levens, D. (1993) "Specific binding of heterogenous ribonucleoprotein particule protein K to the human c-myc promoter, in vitro", J. Biol. Chem. 268, 18249–18258.
   PubMed Web of Science ®Google Scholar
• Michelotti, E.F., Tomonaga, T., Krutzsch, H. and Levens, D. (1995) "Cellular nucleic acid binding protein regulates the CT element of the human c-myc protooncogene", J. Biol. Chem. 270, 9494–9499.
   PubMed Web of Science ®Google Scholar
• Law, G.L., Itoh, H., Law, D.J., Mize, G.J., Merchant, J.L. and Morris, DR. (1998) "Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter", J. Biol. Chem. 273, 19955–19964.
   PubMed Web of Science ®Google Scholar
• Merchant, J.L., Iyer, G.R., Taylor, B.R., Kitchen, J.R., Mortensen, ER., Wang, Z., Flintoft, R.J., Michel, J.B. and Bassel-Duby, R. (1996) "ZBP-89, a Kriippel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter", Mol. Cell. Biol. 16, 6644–6653.
   PubMedGoogle Scholar
• Cieslik, K., Zembowicz, A., Tang, J.-L. and Wu, K.K. (1998) "Transcriptional regulation of endothelial nitric-oxide synthase by lysophosphatidylcholine", J. Biol. Chem. 273, 14885–14890.
   PubMedGoogle Scholar
• Karantzaulis-Fegaras, E, Antoniou, H., Lai, S.-L.M., Kulkarni, G., D'Abreo, C., Wong, G.K.T., Miller, T.L., Chan, Y., Atkins, J., Wang, Y. and Marsden, RA. (1999) "Characterization of the human endothelial nitric-oxide synthase promoter", J. Biol. Chem. 274, 3076–3093.
   PubMedGoogle Scholar
• Laumonnier, Y., Nadaud, S., Agrapart, M. and Soubrier, F. (2000) "Characterization of an upstream enhancer region in the promoter of the human endothelial nitric-oxide synthase gene", J. Biol. Chem. 275, 40732–40741.
   PubMedGoogle Scholar