36
Views
21
CrossRef citations to date
0
Altmetric
Original Article

Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers

&
Pages 497-506 | Received 15 Aug 1999, Published online: 07 Jul 2009

References

  • Thurman R.G., Bunzendahl H., Lemasters J.J. Role of sinusoidal lining cells in hepatic reperfusion injury following cold storage and transplantation. Seminars in Liver Disease 1993; 13: 93–100
  • Chazouilleres O., Calmus Y., Vaubourdolle M., Ballet F. Preservation-induced liver injury. Clinical aspects, mechanisms and therapeutic approaches. Journal of Hepatology 1993; 18: 123–134
  • Dart R.C., Liebler D.C., Sipes I.G. Hepatic injury and lipid peroxidation during hemorrhagic shock and resuscitation. Life Sciences 1993; 53: 1685–1690
  • Zimmerman B.J., Granger D.N. Mechanisms of reperfusion injury. American Journal of Medical Science 1994; 307: 284–292
  • Jaeschke H. Mechanisms of oxidant stress-induced acute tissue injury. Proceedings of the Society for Experimental Biology and Medicine 1995; 209: 104–111
  • Jaeschke H., Farhood A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Americal Journal of Physiology 1991; 260: G355–G362
  • Jaeschke H., Bautista A.P., Spolarics Z., Spitzer J.J. Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Radical Research Communications 1991; 15: 277–284
  • Shiratori Y., Kiriyama H., Fukushi Y., Nagura T., Takada H., Hai K., Kamii K. Modulation of ischemia-reperfusion-induced hepatic injury by Kupffer cells. Digestive Disease and Sciences 1994; 39: 1265–1272
  • Bremer C., Bradford B.U., Hunt K.J., Knecht K.T., Connor H.D., Mason R.P., Thurman R.G. Role of Kupffer cells in the pathogenesis of hepatic reperfusion injury. Americal Journal of Physiology 1994; 267: G630–G636
  • Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). European Journal of Biochemistry 1990; 192: 245–261
  • Lindert K.A., Caldwell-Kenkel J.C., Nukina S., Lemasters J.J., Thurman R.G. Activation of Kupffer cells on reperfusion following hypoxia: particle phagocytosis in low-flow reflow model. Americal Journal of Physiology 1992; 262: G345–G350
  • Caldwell-Kenkel J.C., Currin R.T., Tanaka Y., Thurman R.G., Lemasters J.J. Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Hepatology 1991; 13: 83–95
  • Samarasinghe D.A., Farrell G.C. The central role of sinusoidal endothelial cells in hepatic hypoxia-reoxygenation injury in the rat. Hepatology 1996; 24: 1230–1237
  • Minor T., Isselhard W., Berghaus K. Parenchymal and vascular endothelial cell injury in the hypoxic and reperfused rat liver. Evidence for superoxide anion generation by perfusion with ferricytochrome c. Biomedicine and Pharmacotherapy 1993; 47: 213–218
  • Marotto M.B., Thurman R.G., Lemasters J.J. Early midzonal cell death during low-flow hypoxia in the isolated, perfused rat liver: protection by allopurinol. Hepatology 1988; 8: 585–590
  • Hoglen N.C., Abril B.A., Sauer J.M., Earnest D.L., McCuskey R.S., Lantz R.C., Mobley S.A., Sipes I.G. Modulation of Kupffer cell and peripheral blood monocyte activity by in vivo treatment of rats with all-trans-retinol. Liver 1997; 17: 157–165
  • Scholz R., Hansen W., Thurman R.G. Interaction of mixed-function oxidation with biosynthetic processes. I. Inhibition of gluconegoenesis by aminopyrine in perfused rat liver. European Journal of Biochemistry 1973; 38: 64–72
  • Reinke L.A., Tupper J.S., Smith P.R., Swenny D.J. Diminished pentose cycle flux in perfused liver of ethanol-fed rats. Molecular Pharmacology 1987; 31: 631–637
  • Bradford B.U., Marotto M., Lemasters J.J., Thurman R.G. New, simple models to evaluate zone-specific damage due to hypoxia in the perfused rat liver: time course and effect of nutritional state. Journal of Pharmacology and Experimental Therapeutics 1986; 236: 263–268
  • Rao P.N., Walsh T.R., Makowka L., Rubin R.S., Weber T., Snyder J.T., Starzl T.E. Purine nucleoside phosphorylase: a new marker for free oxygen radical injury to the endothelial cell. Hepatology 1990; 11: 193–198
  • Bergmeyer H.U., Bernt B. Lactate dehydrogenase: uv assay with pyruvate and NADH. Methods of Enzymatic Analysis, H.U. Bergmeyer. Academic Press, Inc., New York 1974, In
  • Hoffe P.A., May R., Robertson B.C. Purine nucleoside phosphorylase from Salmonella typhimurium and rat liver. Methods of Enzymology 1978; 51: 517–524
  • Lang J.K., Gohil K., Packer L. Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Analytical Biochemistry 1986; 157: 106–116
  • Gores G.J., Kost L.J., LaRusso N.F. The isolated perfused rat liver: conceptual and practical considerations. Hepatology 1986; 6: 511–517
  • Lemasters J.J., Stemkowski C.J., Ji S., Thurman R.G. Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver. Journal of Cell Biology 1983; 97: 778–786
  • Lemasters J.J., Ji S., Thurman R.G. Centrilobular injury following low flow hypoxia in isolated, perfused rat liver. Science 1981; 213: 661–663
  • Ferreira J., Tapia G., Videla L.A. Effects of the Kupffer cell inactivator gadolinium chloride on rat liver oxygen uptake and content of mitochondrial cytochromes. FEBS Letters 1998; 426: 263–265
  • Lettinga K.D., Gutter W., Van Noorden C.J.F., Schellens J.P.M., Frederiks W.M. Early effects of high doses of retinol (vitamin A) on the in situ cellular metabolism in rat liver. Liver 1996; 16: 1–11
  • Younes M., Strubelt O. The involvement of reactive oxygen species in hypoxic injury to rat liver. Research Communications in Chemical Pathology and Pharmacology 1988; 59: 369–381
  • Zhong Z., Lemasters J.J., Thurman R.G. Role of purines and xanthine oxidase in reperfusion injury in perfused liver. Journal of Pharmacology and Experimental Theraputics 1989; 250: 470–475
  • Younes M., Kayser E., Strubelt O. Effect of antioxidants on hypoxia/reoxygenation-induced injury in isolated perfused rat liver. Pharmacology and Toxicology 1992; 71: 278–283
  • Marubayashi S., Dohi K., Ochi K., Kawasaki T. Role of free radicals in ischemic rat liver cell injury: prevention of damage by α-tocopherol administration. Surgery 1986; 99: 181–191
  • Lee S.M., Clemens M.G. Effect of α-tocopherol on hepatic mixed function oxidases in hepatic ischemia/reperfusion. Hepatology 1992; 15: 276–281
  • Kuo J.H., Chen H.W., Chou R.G.R., Lii C.K. Vitamin E protection of cell morphology under oxidative stress is related to cytoskeletal proteins in rat hepatocytes. Archives of Toxicology 1997; 71: 231–237
  • Wanner G.A., Ertel W., Muller P., Hofer Y., Leiderer R., Menger M.D. Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation. Shock 1996; 5: 34–40
  • Wanner G.A., Muller P., Ertel W., Busch C.J., Menger M.D., Messmer K. Differential effect of cyclooxygenase metabolites on proinflammatory cytokine release by Kupffer cells after liver ischemia and reperfusion. American Journal of Surgery 1998; 175: 146–151
  • Gyenes M., de Groot H. Prostanoid release by Kupffer cells upon hypoxia-reoxygenation: role of pHi and Ca+2i. American Journal of Physiology 1993; 264: G535–G540
  • Sakamoto W., Fujie K., Nishihira J., Mino M., Morita I., Murota S.I. Inhibition of PGE2 production in macrophages from vitamin E-treated rats. Prostaglandins Leukotrienes and Essential Fatty Acids 1991; 44: 89–92

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.