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Original Article

Protective effects of fluvastatin against reactive oxygen species induced DNA damage and mutagenesis

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Pages 33-44 | Received 07 Feb 2000, Published online: 07 Jul 2009

References

  • Plosker G.L., Wagstaff A.J. Fluvastatin-a review of its pharmacology and use in the management of hypercholesterolaemia. Drugs 1996; 51: 433–459
  • Suzumura K., Yasuhara M., Tanaka K., Odawara A., Narita H., Suzuki T. An in vitro study of the hydroxyl radical scavenging property of fluvastatin, and HMG-CoA reductase inhibitor. Chemical & Pharmaceutical Bulletin 1999; 47: 1010–1012
  • Suzumura K., Yasuhara M., Narita H. Superoxide anion scavenging properties of fluvastatin and its. Chemical & Pharmaceutical Bulletin 1999; 47: 1477–1480
  • Hussein O., Schlezinger S., Rosenblat M., Keidar S., Aviram M. Reduced susceptibility of low density lipoprotein (LDL) to lipid peroxidation after fluvastatin therapy is associated with the hypocholesterolemic effect of the drug and its binding to the LDL. Atherosclerosis 1997; 128: 11–18
  • Mitani H., Bandoh T., Ishikawa J., Kimura M., Totsuka T., Hayashi S. Inhibitory effects of fluvastatin, a new HMG-CoA reductase inhibitor, on the increase in vascular ACE activity in cholesterol-fed rabbits. British. Journal. of Pharmacology 1996; 119: 1269–1275
  • Leonhardt W., Kurktschiev T., Meissner D., Lattke P., Abletshauser C., Weidinger G., Jaross W., Hanefeld M. Effects of fluvastatin therapy on lipids, antioxidants, oxidation of low density lipoproteins and trace metals. European Journal of Clinical Pharmacology 1997; 53: 65–69
  • Goldstein J.L., Ho Y.K., Brown M.S. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proceedings of the National Academy of Sciences USA 1979; 76: 333–337
  • Suzumura K., Yasuhara M., Tanaka K., Suzuki T. Protective effect of fluvastatin sodium (XU-62-320), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on oxidative modification of human low-density lipoprotein in vitro. Biochemical Pharmacology 1999; 57: 697–703
  • Anderson D., Phillips B.J., Yu T.W., Edwards A.J., Ayesh R., Butterworth K.R. The effect of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with low or high cholesterol levels. Environmental Molecular Mutagenesis 1997; 30: 161–174
  • Araki A. Oxidative stress and diabetes mellitus: a possible role of alpha-dicarbonyl compounds in free radical formation. Nippon Ronen Igakkai Zasshi 1997; 34: 716–720
  • Kaneto H., Fujii J., Myint T., Miyazawa N., Islam K.N., Kawasaki Y., Suzuki K., Nakamura M., Tatsumi H., Yamasaki Y., Taniguchi N. Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction. Biochemical Journal 1996; 320: 855–863
  • Leinonen J., Rantalaiho V., Lehtimaki T., Koivula T., Wirta O., Pasternack A., Alho H. The association between the total antioxidant potential of plasma and the presence of coronary heart disease and renal dysfunction in patients with NIDDM. Free Radical Research 1998; 29: 273–281
  • Jiann G.L., Michael C.M., William R., Kenneth A., Robert D. The use of the single cell electrophoresis assay in detecting DNA single strand breaks in lung cells in vitro. Toxicology and Applied Pharmacology 1996; 141: 195–204
  • Ames B.A. Dietary carcinogens and anticarcinogens. Science 1983; 221: 1256–1264
  • Doi T., Vlassara H., Kirstein M., Yamada Y., Striker G.E., Striker L.J. Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor. Proceedings of the National Academy of Sciences USA 1992; 89: 2873–2877
  • Berlin V., Haseltine W.A. Reduction of adriamycin to a semiquinone-free radical by NADPH cytochrome P-450 reductase produces DNA cleavage in a reaction mediated by molecular oxigen. Journal of Biological Chemistry 1981; 256: 4747–4756
  • Tsuchiya T., Imaeda A., Kiho T., Ukai S. Detoxification of paraquat poisoning: Effects of carbohydrate sulfate, alkylsulfate and alkylsulfonate on active oxygen. Biological & Pharmaceutical Bulletin 1995; 18: 1700–1704
  • Hakura A., Tsutsui Y., Mochida H., Sugihara Y., Mikami T., Sagami F. The mutagenicity of activated oxygen species-generating systems towards Salmonella TA102 and TA104 tester strains. Environmental Mutagen Research 1996; 18: 35–40
  • Maron D.M., Ames B.A. Revised methods for the Salmonella mutagenicity test. Mutation Research 1983; 113: 173–215
  • Nakamura T., Nishi H., Kokusenya Y., Hirota K., Miura Y. Mechanism of antioxidative activity of fluvastatin-determination of the active position. Chemical & Pharmaceutical Bulletin 2000; 48: 235–237
  • Marmett L.T., Hurd H.K., Hollstein M.C., Levin D., Esterbauer E.H., Ames B.N. Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. Mutation Research 1985; 148: 25–34
  • Han J.S. Effects of various chemical compounds on spontaneous and hydrogen peroxide-induced reversion in strain TA104 of Salmonella typhimurium. Mutation Research 1992; 266: 77–84
  • Oudes A.J., Herr C.M., Olsen Y., Fleming J.E. Age-dependent accumulation of advanced glycation end-products in adult Drosophila melanogaster. Mechanisms of Ageing and Development 1998; 100: 221–229
  • Wolffenbuttel B.H., Boulanger C.M., Crijns F.R., Huijberts M.S., Poitevin P., Swennen G.N., Vasan S., Egan J.J., Ulrich P., Cerami A., Levy B.I. Breakers of advanced glycation end products restore large artery properties in experimental diabetes. Proceedings of the National Academy of Sciences USA 1998; 95: 4630–4634
  • Wolff S.P., Dean R.T. Glucose autoxidation and protein modification: the potential role of autoxidative glycosylation in diabetes. Biochemical Journal 1987; 245: 243–250
  • Wolff S.P., Jiang Z.Y., Hunt J.V. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radical Biology & Medicine 1991; 10: 339–352
  • Mullarkey C.J., Edelstein D., Brownlee M. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochemical and Biophysical. Research Communications 1990; 173: 932–939
  • Young I.S., Tate S., Lightbody J.H., McMaster D., Trimble E.R. The effects of desferrioxamine and ascorbate on oxidative stress in the streptozotocin diabetic rat. Free Radical Biology & Medicine 1995; 18: 833–840
  • Martinez B.A., Bosch M.F., Trenor C., Romero F.J. Experimental diabetic neuropathy: role of oxidative stress and mechanisms involved. Biofactors 1998; 8: 41–43

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