The antioxidant effect of DL-α-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats

References

• Sasaki M., Yoshida M.C., Kagami K., Takeichi N., Kobayashi H., Dempo K., Mori M. Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Letter 1985; 14: 4–6
   Google Scholar
• Yoshida M.C., Masuda R., Sasaki M., Takeichi N., Kobayashi H., Dempo K., Mori M. New mutation causing hereditary hepatitis in the laboratory rats. Journal of Heredity 1987; 78: 361–365
   PubMed Web of Science ®Google Scholar
• Li Y., Togashi Y., Sato S., Emoto T., Kang J-H., Takeichi N., Kobayashi H., Kojima Y., Une Y., Uchino J. Spontaneous hepatic Cu accumulation in Long-Evans cinnamon rats with hereditary hepatitis: a model of Wilson's disease. Journal of Clinical Investigation 1991; 87: 1858–1861
   PubMed Web of Science ®Google Scholar
• Ono T., Abe S., Yoshida M.C. Hereditary low level of plasma ceruloplasmin in LEC rats associated with spontaneous development of hepatitis and liver cancer. Japanese Journal of Cancer Research 1991; 82: 490–492
   PubMedGoogle Scholar
• Wu J., Forbes J.R., Chen H.S., Cox D.W. The LEC rats has a deletion in the Cu transporting ATPase gene homologous to the Wilson disease gene. Nature Genetics 1994; 7: 541–545
   PubMed Web of Science ®Google Scholar
• Thomas G.R., Forbes J.R., Roberts E.A., Walshe J.M., Cox D.W. The Wilson disease gene: spectrum of mutations and their consequences. Nature Genetics 1995; 9: 210–217
   PubMed Web of Science ®Google Scholar
• Togashi Y., Li Y., Kang J.H., Takeichi N., Fujioka Y., Nagasawa K., Kobayashi H. D-penicillamine prevents the development of hepatitis in Long-Evans cinnamon rats with abnormal Cu metabolism. Hepatology 1992; 15: 82–87
   PubMedGoogle Scholar
• Aust S.D., Morehouse L.A., Thomas C.E. Role of metals in oxygen radicals reactions. Free Radical Biology and Medicine 1985; 1: 3–25
   Google Scholar
• Beckman J.K., Borowitz S.M., Green H.I., Burr I.M. Promotion of iron-induced rat liver microsomal lipid peroxidation by Cu. Lipids 1988; 23: 559–563
   PubMed Web of Science ®Google Scholar
• Halliwell B., Gutteridge J.M.C., Cross E. Free radicals, antioxidants and human disease: where are we now?. Journal of Laboratory and Clinical Medicine 1992; 119: 598–620
   PubMed Web of Science ®Google Scholar
• Sokol R.J., Devereaux M.W., Mierau G.W., Hambidge K., Mshikes R.H. Oxidant injury to hepatic mitochondrial lipids in rats with dietary Cu overload. Modification by vitamin E deficiency. Gastroenterology 1990; 99: 1061–1071
   PubMed Web of Science ®Google Scholar
• Yamashita T., Ohshima H., Asanuma T., Inukai N., Miyoshi I., Kasai N., Kon Y., Watanabe T., Sato F., Kuwabara M. The effects of α-phenyl-tert-butyl nitrone (PBN) on Cu induced rat fulminant hepatitis with jaundice. Free Radical Biology and Medicine 1996; 21: 755–761
   PubMedGoogle Scholar
• Reed L.J. Multienzyme complex. Accounts of Chemical Research 1974; 7: 40–46
   Web of Science ®Google Scholar
• Packer L., Witt E.H., Tritschler H.J. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995; 19: 227–250
   PubMed Web of Science ®Google Scholar
• Suzuki Y.J., Tuchiya M., Packer L. Antioxidant activities of dihydrolipoic acid and its structural homologues. Free Radical Research Communications 1993; 18: 115–122
   PubMed Web of Science ®Google Scholar
• Suzuki Y.J., Tuchiya M., Packer L. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Radical Research Communications 1991; 15: 255–263
   PubMed Web of Science ®Google Scholar
• Haenen G.R., Bast A. Scavenging of hypochlorous acid by lipoic acid. Biochemical Pharmacology 1991; 42: 2244–2246
   PubMed Web of Science ®Google Scholar
• Scott B.C., Aruoma O.I., Evans P.J., O'Neill C., van der Vilet A., Cross C.E., Tritschler H.J., Halliwell B. Lipoic and dihydrolipoic acids as antioxidants: A critical evaluation. Free Radical Research 1994; 20: 119–133
   PubMed Web of Science ®Google Scholar
• Devasagayam T.P., Di Mascio P., Kaiser S., Sies H. Singlet oxygen induced singlet-strand brakes in plasmid pBR322 DNA: The enhancing effect of thiols. Biochimica et Biophysica Acta 1991; 1088: 409–4142
   PubMed Web of Science ®Google Scholar
• Bonomi F., Cerioli A., Pagani S. Molecular aspects of the removal of ferritinboundiron by DL-dihydrolipoate. Biochimica et Biophysica Acta 1989; 994: 180–186
   PubMed Web of Science ®Google Scholar
• Ou P., Tritschler H.J., Wolff S.P. Thioctic (Lipoic) acid: A therapeutic metal-chelating antioxidants?. Biochemical Pharmacology 1995; 50: 123–126
   PubMed Web of Science ®Google Scholar
• Biewenga G.P., Haenen G.R., Bast A. The pharmacology of the antioxidant lipoic acid. General Pharmacology 1997; 29: 315–331
   PubMedGoogle Scholar
• Winterbourn C.C. Oxidative reactions of hemoglobin. Methods in Enzymology 1990; 186: 265–272
   PubMed Web of Science ®Google Scholar
• Paglia D.E., Valentine W.N. Studies on the quantitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 1967; 70: 158–169
   PubMed Web of Science ®Google Scholar
• Beers R.F., Jr., Sizer I.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. Journal of Biological Chemistry 1952; 195: 133–140
   PubMed Web of Science ®Google Scholar
• Carlberg I., Mannervik B. Glutathione reductase. Methods in Enzymology 1985; 113: 484–490
   PubMed Web of Science ®Google Scholar
• Kadiiska M.B., Hanna P.M., Hernandez L., Mason R.P. In vivo evidence of hydroxyl radical formation after acute Cu and ascorbic acid intake: electron spin resonance spin-trapping investigation. Molecular Pharmacology 1992; 42: 723–729
   PubMed Web of Science ®Google Scholar
• Burkitt M., Mason R.P. Direct evidence for in vivo hydroxyl-radical generation in experimental iron overload: an ESR spin-trapping investigation. Proceedings of the National Academy of Sciences of the USA 1991; 88: 9503–9506
   PubMedGoogle Scholar
• Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–685
   PubMed Web of Science ®Google Scholar
• Erdelmeier I., Gerard Monnier D., Yadan J.C., Chaudiere J. Reactions of N-methyl-2-phenylin-dole with malondialdehyde and 4-hydroxyalkenals. Mechanistic aspects of the colorimetric assay of lipid peroxidation. Chemical Research in Toxicology 1998; 11: 1184–1194
   PubMed Web of Science ®Google Scholar
• Kato J., Kobune M., Kohgo Y., Sugawara N., Hisai H., Nakamura T., Sakamaki S., Sawada N., Niitsu Y. Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats. Journal of Clinical Investigation 1996; 98: 923–929
   PubMed Web of Science ®Google Scholar
• Ewing J.F., Maines M.D. Rapid induction of heme oxygenase-1 mRNA and protein by hyperthermia in rat brain: heme oxygenase-2 is not a heat shock protein. Proceedings of the National Academy of Sciences of the USA 1991; 88: 5364–5368
   PubMed Web of Science ®Google Scholar
• Applegate L.A., Lusher P., Tyrrell R.M. Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells. Cancer Research 1991; 51: 974–978
   PubMed Web of Science ®Google Scholar
• Scholich H., Murphy M.E., Sies H. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol. Biochimica et Biophysica Acta 1989; 1001: 256–261
   PubMed Web of Science ®Google Scholar
• Xu D.P., Wells W.W. α-Lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondria. Journal of Bioenergetics and Biomembranes 1996; 28: 77–85
   PubMed Web of Science ®Google Scholar
• Bustamante J., Lodge J.K., Marcocci L., Tritschler H.J., Packer L., Rihn B.H. α-Lipoic acid in liver metabolism and disease. Free Radical Biology and Medicine 1998; 24: 1023–1039
   PubMed Web of Science ®Google Scholar
• Reljanovic M., Reichel G., Rett K., Lobisch M., Schuette K., Moller W., Tritschler H.J., Mehnert H. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. Free Radical Research 1999; 31: 171–179
   PubMed Web of Science ®Google Scholar
• Hagen T.M., Ingersoll R.T., Lykkesfeldt J., Liu J., Wehr C.M., Vinarsky V., Bartholomew J.C., Ames B.N. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. The FASEB Journal 1999; 13: 411–418
   PubMed Web of Science ®Google Scholar
• Koizumi M., Fujii K., Suzuki K., Inoue T., Gutteridge J.M.C., Taniguchi N. A marked increase in free Cu levels in the plasma and liver of LEC rats: An animal model for Wilson's disease and liver cancer. Free Radical Research 1998; 28: 441–450
   PubMed Web of Science ®Google Scholar
• Forman S.J., Kumar K.S., Redeker A.G., Hochstein P. Hemolytic anemia in Wilson's disease: clinical findings and biochemical mechanisms. American Journal of Hematology 1980; 9: 269–275
   PubMedGoogle Scholar
• Sokol R.J., Twedt D., Mckim J.M., Jr., Devereaux W.M., Karrer F.M., Kam I., VonSteigman G., Narkewicz M.R., Bacon B.R., Britton R.S., Neushwander-Tetri B.A. Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with Cu toxicosis. Gastroenterology 1994; 107: 1788–1798
   PubMed Web of Science ®Google Scholar
• Sternlieb I., Quintana N., Volenberg I., Schilsky M.L. An array of mitochondrial alterations in the hepatocytes of Long-Evans Cinnamon rats. Hepatology 1995; 22: 1782–1787
   PubMedGoogle Scholar
• Ossola J.O., Groppa M.D., Tomaro M.L. Relationship between oxidative stress and heme oxygenase induction by copper sulfate. Archives of Biochemistry and Biophysics 1997; 337: 332–337
   PubMed Web of Science ®Google Scholar
• Sigel H., Prijis B. Stability and structure of binary and ternary complexes of α-lipoate and lipoate derivatives with Mn2+, Cu2+, Zn2+in solution. Archives of Biochemistry and Biophysics 1978; 187: 208–214
   PubMed Web of Science ®Google Scholar
• Sigel H. Die hydrophoben und Metallionen-koordinierenden Eigenschaften von A-Liposäure: ein Beispiel für intramolekulare Gleichgewichte in Metallionen-Komplexen. Angewandte Chemie 1982; 94: 421–432
   Google Scholar
• Gregus Z., Stein A.F., Varga F., Klaassen C.D. Effect of lipoic acid on biliary excretion of glutathione and metals. Toxicology and Applied Pharmacology 1993; 114: 99–96
   Google Scholar
• Sakurai H., Kamada H., Fukudome A., Kito M., Takeshima S., Kimura M., Otaki N., Nakajima K., Kawano K., Hagino T. Copper-metallothionein induction in the liver of LEC rats. Biochemical and Biophysical Research Communications 1992; 185: 548–552
   PubMedGoogle Scholar
• Lutsenko S., Cooper M.J. Localization of the Wilson's disease protein product to mitochondria. Proceedings of the National Academy of Sciences of the USA 1998; 95: 6004–6009
   PubMed Web of Science ®Google Scholar
• Ferreira A.M., Ciriolo M.R., Marcocci L., Rotilio G. Copper(I) transfer into metallothionein mediated by glutathione. Biochemical Journal 1993; 292: 673–676
   PubMed Web of Science ®Google Scholar
• Fernandez C.J.C., Kaplowitz N., Garcia R.C., Colell A., Miranda M., Mari M., Ardite E., Morales A. GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. American Journal of Physiology 1997; 273: G7–G17
   Google Scholar
• Yamada T., Sogawa K., Suzuki Y., Izumi K., Agui T., Matsumoto K. Elevation of the level of lipid peroxidation associated with hepatic injury in LEC mutant rats. Research Communications in Chemical Pathology and Pharmacology 1992; 77: 121–124
   PubMedGoogle Scholar
• Yamamoto H., Hirose K., Hayasaki Y., Masuda M., Kazusaka A., Fujita S. Mechanism of enhanced lipid peroxidation in the liver of Long-Evans cinnamon (LEC) rats. Archives of Toxicology 1999; 73: 457–464
   PubMed Web of Science ®Google Scholar