Advanced search
Publication Cover
Free Radical Research Volume 36, 2002 - Issue 2
Submit an article Journal homepage
153
Views
48
CrossRef citations to date
0
Altmetric
Research Article

Gender Differences in Steady-state Levels of Oxidative Damage to DNA in Healthy Individuals

Anna R. Proteggente Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, Guy's Campus, St Thomas' Street, London SE1 9RT, UK
,
Timothy G. England Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, Guy's Campus, St Thomas' Street, London SE1 9RT, UK
,
Almas Rehman Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, Guy's Campus, St Thomas' Street, London SE1 9RT, UK
,
Catherine A. Rice-Evans Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, Guy's Campus, St Thomas' Street, London SE1 9RT, UK
&
Barry Halliwell Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, Guy's Campus, St Thomas' Street, London SE1 9RT, UK; Department of Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore, Singapore 119260
Pages 157-162 | Published online: 07 Jul 2009

  • Halliwell, B. and Gutteridge, J.M.C. (1999) Free Radicals in Biology and Medicine (Oxford University Press, New York).
  • Ames, B.N., Shigenaga, M.K. and Hagen, T.M. (1993) "Oxidants, antioxidants and the degenerative diseases of aging", Proc. Natl Acad. Sci. United States of America 90, 7915-7922.
  • Poulsen, H.E., Prieme, H. and Loft, S. (1998) "Role of oxidative DNA damage in cancer initiation and promotion", Eur. J. Cancer Prev. 7, 9-16.
  • Wiseman, H., Kaur, H. and Halliwell, B. (1995) "DNA damage and cancer: measurement and mechanism", Cancer Lett. 93, 113-120.
  • Block, G., Patterson, B. and Subar, A. (1992) "Fruit, vegetables and cancer prevention: a review of the epidemiological evidence", Nutr. Cancer 18, 1-29.
  • World Cancer Research Fund and American Institute for Cancer Research (1997) Food Nutrition and the Prevention of Cancer: a Global Perspective (Am. Inst. Cancer Res., Washington).
  • Halliwell, B. (2000) "Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come?", Am. J. Clin. Nutr. 72, 1082-1087.
  • Halliwell, B. (1998) "Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies", Free Radic. Res. 29, 469-486.
  • Welch, R.W., Turley, E., Sweetman, S.F., Kennedy, G., Collins, A.R., Dunne, A., Livingstone, M.B.E., McKenna, P.G., McKelvey-Martin, V.J. and Strain, J.J. (1999) "Dietary antioxidant supplementation and DNA damage in smokers and nonsmokers", Nutr. Cancer 34, 167-172.
  • Noroozi, M., Angerson, W.J. and Lean, M.E.J. (1998) "Effects of flavonoids and Vitamin C on oxidative DNA damage to human lymphocytes", Am. J. Clin. Nutr. 67, 1210-1218.
  • Prieme, H., Loft, S., Nyyssonen, K., Salonen, J.T. and Poulsen, H.E. (1997) "No effect of supplementation with Vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion in smokers", Am. J. Clin. Nutr. 65, 503-507.
  • Collins, A., Cadet, J., Epe, B. and Gedik, C. (1997) "Problems in the measurement of 8-oxoguanine in human DNA", Carcinogenesis 18, 1833-1836, Report of a work-shop, DNA oxidation, held in Aberdeen, UK, 19-21 January, 1997.
  • Lunec, J. (1998) "ESCODD: European Standards Committee on Oxidative DNA Damage", Free Radic. Res. 29, 601-608.
  • ESCODD: European Standards Committee on Oxidative DNA Damage (2000) "Comparison of different methods of measuring 8-oxoguanine as a marker of oxidative DNA damage", Free Radic. Res. 32, 333-341.
  • Rehman, A., Jenner, A. and Halliwell, B. (2000) "Gas chromatography-mass spectrometry analysis of DNA: optimisation of protocols for isolation and analysis of DNA from human blood", Meth. Enzymol. 319, 401-417.
  • Dizdaroglu, M. (1990) "Gas-chromatography massspectrometry of free radical-induced products of pyrimidines and purines in DNA", Meth. Enzymol. 193, 842-857.
  • Jenner, A., England, T.G., Aruoma, O.I. and Halliwell, B. (1998) "Measurement of oxidative DNA damage by gas chromatography-mass spectrometry: the use of ethanethiol to prevent artifactual generation of oxidised DNA bases", Biochem. J. 331, 365-369.
  • Dizdaroglu, M. (1993) "Quantitative determination of oxidative base damage in DNA by stable isotope-dilution mass spectrometry", FEBS Lett. 315, 1-6.
  • Kamiya, H., Miura, H., Murata-Kamiya, N., Ischikawa, H., Sakaguchi, T., Inoue, H., Sasaki, T., Masutani, C., Hanaoka, F., Nishimra, S. and Ohtsuka, E. (1995) "8-Hydroxyadenine (7,8,-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH 3T3 cells", Nucleic Acids Res. 23, 2893-2899.
  • Purmal, A.A., Kow, Y.K. and Wallace, S.S. (1994) "Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro", Nucleic Acids Res. 22, 72-78.
  • Proteggente, A.R., Rehman, A., Halliwell, B. and Rice-Evans, C.A. (2000) "Potential problems of ascorbate and iron supplementation: pro-oxidant effect in vivol", Biochem. Biophys. Res. Commun. 277, 535-540.
  • Collins, A.R., Gedik, C.M., Olmedilla, B., Southern, S. and Bellizzi, M. (1998) "Oxidative DNA damage measured in human lymphocytes: large differences between sexes and between countries, and correlations with heart disease mortality rates", FASEB J. 12, 1397-1400.
  • Chen, L., Bowen, P.E., Berzy, D., Aryee, F., Stacewicz-Sapuntzakis, M. and Riley, R.E. (1999) "Diet modification affects DNA oxidative damage in healthy humans", Free Radic. Biol. & Med. 26, 695-703.
  • Loft, S., Vistisen, K., Ewertz, M., Tjonneland, A., Overvad, K. and Poulsen, H.E. (1992) "Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans--influence of smoking, gender and body mass index", Carcinogenesis 13, 2241-2247.
  • Lodovici, M., Casalini, C., Cariaggi, R., Michelucci, L. and Dolara, P. (2000) "Levels of 8-hydroxyguanine as a marker of DNA damage in human leukocytes", Free Radic. Biol. & Med. 28, 13-17.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.