99
Views
50
CrossRef citations to date
0
Altmetric
Research Article

Carotenoids Induce Apoptosis in the T-lymphoblast Cell Line Jurkat E6.1

, , , &
Pages 791-802 | Published online: 07 Jul 2009

  • Britton, G. (1995) "Structure and properties of carotenoids in relation to function", FASEB J. 9, 1551-1558.
  • Khachik, F., Spangler, CJ. and Smith, J.C. (1997) "Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum", Anal. Chem. 69, 1873-1881.
  • Khachik, E, Beecher, G.R. and Whittaker, N.F. (1986) "Separation, identification, and quantification of the major carotenoid and chlorophyll constituents in extracts of several green vegetables by liquid chromatography", J. Agric. Food Chem. 34, 603-616.
  • Francis, F.J. (2000) "Carotenoids as food colorants", Cereal Foods World 45, 198-203.
  • Mayne, S.T. (1996) "Beta-carotene, carotenoids, and disease prevention in humans", EASES J. 10, 690-701.
  • Christen, W.G., Buring, J.E., Manson, J.E. and Hennekens, C.H. (1999) "Beta-carotene supplementation: a good thing, a bad thing, or nothing?", Curr. Opin. Lipidol. 10, 29-33.
  • Pryor, W.A., Stahl, W. and Rock, C.L. (2000) "Beta carotene: from biochemistry to clinical trials", Nutr. Rev. 58, 39-53.
  • Sharoni, Y. and Levy, J. (1996) "Anticarcinogenic properties of lycopene", In: Kumpulainen, J.T. and Salonen, J.T., eds, Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention (Royal Society of Chemistry, Cambridge), pp 378-385.
  • Carpenter, K.L.H., Hardwick, S.J., Albarani, V. and Mitchinson, M.J. (1999) "Carotenoids inhibit DNA synthesis in human aortic smooth muscle cells", FEBS Lett. 447, 17-20.
  • Bertram, J.S., Pung, A., Churley, M., Kappock, IV, T.J., Wilkins, L.R. and Cooney, R.V. (1991) "Diverse carotenoids protect against chemically induced neoplastic transformation", Carcinogenesis 12, 671-678.
  • Bertram, J.S. (1999) "Carotenoids and gene regulation", Nutr.Rev. 57, 182-191.
  • Means, A.L. and Gudas, L.J. (1995) "The roles of retinoids in vertebrate development", Annu. Rev. Biochem. 64, 201-233.
  • Bendich, A. (1989) "Carotenoids and the immune response", J. Nutr. 119, 112-115.
  • Rogers, M.B. (1997) "Life-and-death decisions influenced by retinoids", Curr. Top. Dev. Biol. 35, 1-46.
  • Palace, V.P., Khaper, N., Qin, G. and Singal, P.K. (1999) "Antioxidant potentials of vitamin A and carotenoids and their relevance to heart disease", Free Radie. Biol. Med. 26, 746-761.
  • Palozza, P. (1998) "Prooxidant actions of carotenoids in biologic systems", Nutr. Rev. 56, 257-265.
  • Edge, R., McGarvey, D.J. and Truscott, T.G. (1997) "The carotenoids as anti-oxidants-a review", J. Photochem. PhotobioI. 41B, 189-200.
  • Young, A.J. and Löwe, G.M. (2001) "Antioxidant and prooxidant properties of carotenoids", Arch. Biochem. Biophys. 385, 20-27.
  • Wyllie, A.H., Kerr, J.F.R. and Currie, A.C. (1980) "Cell death: the significance of apoptosis", Int. Rev. Cytol. 68, 251-305.
  • Kaufmann, S.H. and Gores, G.J. (2000) "Apoptosis in cancer: cause and cure", BioEssays 22, 1007-1017.
  • Hegyi, L., Hardwick, S.J., Siow, R.C.M. and Skepper, J.N. (2001) "Macrophage death and the role of apoptosis in human atherosclerosis", J. Hematotherapy Stem Cell Res. 10, 27-42.
  • Granville, DJ., Carthy, C.M., Hunt, D.W.C. and McManus, B.M. (1998) "Apoptosis: Molecular aspects of cell death and disease", Lab. Investig. 78, 893-913.
  • Handelman, GJ., Van Kujik, F.J.G.M., Chatterjee, A. and Krinsky, N.I. (1991) "Characterization of products formed during the autoxidation of ß-carotene", Free Radie. Biol. Med. 10, 427-437.
  • Henry, L.K., Puspitasari-Nienaber, N.L., Jarén-Galân, M., van Breemen, R.B., Catignani, G.L. and Schwartz, S.J. (2000) "Effects of ozone and oxygen on the degradation of carotenoids in an aqueous model system", J. Agric. Food Chem. 48, 5008-5013.
  • Hu, X., White, K.M., Jacobsen, N.E., Mangelsdorf, D.J. and Canfield, L.M. (1998) "Inhibition of growth and cholesterol synthesis in breast cancer cells by oxidation products of ß-carotene", J. Nutr. Biochem. 9, 567-574.
  • Wang, X.D. and Russell, R.M. (1999) "Procarcinogenic and anticarcinogenic effects of beta-carotene", Nutr. Rev. 57, 263-272.
  • Ormerod, M.G. (1990) "Analysis of DNA", In: Ormerod, M.G., ed, Flow Cytometry: A Practical Approach (IRL Press, Oxford), P 75.
  • Laemmli, U.K. (1970) "Cleavage of structural proteins during the assembly of the head of bacteriophage T4", Nature 227, 680-685.
  • Hardwick, S.J., Hegyi, L., Clare, K., Law, N.S., Carpenter, K.L.H., Mitchinson, MJ. and Skepper, J.N. (1996) "Apoptosis in human monocyte-macrophages exposed to oxidised low density lipoprotein", J. Pathol. 179, 294-302.
  • Long, L.H., Clement, M.V. and Halliwell, B. (2000) "Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catecin, and quercetin to commonly used cell culture media", Biochem. Biophys. Res. Commun. 273, 50-53.
  • Clement, M.V., Ramalingam, J., Long, L.H. and Halliwell, B. (2001) "The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide", Antioxid. Redox Signaling 3, 157-163.
  • Sakahira, H., Enari, M., Ohsawa, Y, Uchiyama, Y. and Nagata, S. (1999) "Apoptotic nuclear morphological change without DNA fragmentation", Curr. Biol. 9, 543-546.
  • Susin, S.A., Daugas, E., Ravagnan, L., Samejima, K., Zamzami, N., Loeffler, M., Costantini, P., Ferri, K.F., Irinopoulou, T., Prévost, M.-C, Brothers, G., Mak, T.W., Penninger, J., Earnshaw, W.C. and Kroemer, G. (2000) "Two distinct pathways leading to nuclear apoptosis", J. Exp. Med. 192, 571-579.
  • Mayne, S.T., Cartmel, B., Suva, F, Kirn, C.S., Fallon, B.G., Briskin, K., Zheng, T, Baum, M., Shor-Posner, G. and Goodwin, Jr, W.J. (1999) "Plasma lycopene concentrations in humans are determined by lycopene intake, plasma cholesterol concentrations and selected demographic factors", J. Nutr. 129, 849-854.
  • De Waart, E.G., Schouten, E.G., Stalenhoef, A.F.H. and Kok, FJ. (2001) "Serum carotenoids a-tocopherol and mortality risk in a prospective study among Dutch elderly", Int. J Epidemiol. 30, 136-143.
  • Olmedilla, B., Granado, F., Southon, S., Wright, A.J.A., Blanco, I., Gil-Martinez, E., van den Berg, H., Corridan, B., Roussel, A.-M., Chopra, M. and Thurnham, D.I. (2001) "Serum concentrations of carotenoids and vitamins A E, and C in control subjects from five European countries", Br. J. Nutr. 85, 227-238.
  • Broekmans, W.M.R., Klöpping-Ketelaars, I.A.A., Schuurman, C.R.W.C., Verhagen, H., van den Berg, H., Kok, F.J. and van Poppel, G. (2001) "Fruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humans", J. Nutr. 130, 1578-1583.
  • The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group(1994) "Effect of vitamin-E and beta-carotene on the incidence of lung-cancer and other cancers in male smokers", N. Engl. J. Med. 330, 1029-1035.
  • Meydani, M., Martin, A., Ribayaercado, J.D., Gong, J.X., Blumberg, J.B. and Rusell, R.M. (1994) "Beta-carotene supplementation increases antioxidant capacity of plasma in older women", J. Nutr. 124, 2397-2403.
  • Bendich, A. and Oison, J.A. (1989) "Biological activities of carotenoids", FASEB J. 3, 1927-1932.
  • Schmitz, H.H., Poor, C.L., Gugger, E.T. and Erdman, Jr., J.W. (1993) "Analysis of carotenoids in human and animal tissues", Methods Enzymol. 214, 102-116.
  • Halliwell, B., Zhao, K. and Whiteman, M. (2000) "The gastrointestinal tract: a major site of antioxidant action?", Free Radie. Res. 33, 819-830.
  • Iftikhar, S., Lietz, H., Mobarhan, S. and Frommel, TO. (1996) "In vitro beta-carotene toxicity for human colon cancer cells", Nutr. Cancer 25, 221-230.
  • Palozza, P., Calviello, G., Serini, S., Maggiano, N., Lanza, P., Ranelletti, F.O. and Bartoli, G.M. (2001) "ß-Carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells", Free Radie. Biol. Med. 30, 1000-1007.
  • Muto, Y, Fujii, J., Shidoji, Y, Moriwaki, H., Kawaguchi, T. and Noda, T. (1995) "Growth-retardation in human cervical dysplasia-derived cell lines by beta-carotene through downregulation of epidermal growth-factor receptor", Am. J. Clin. Nutr. 62, S1535-S1540.
  • Palozza, P., Maggiano, N., Calviello, G., Lanza, P., Piccioni, E., Ranelletti, EO. and Bartoli, G.M. (1998) "Canthaxanthin induces apoptosis in human cancer cell lines", Carcinogenesis 19, 373-376.
  • Sumantran, V.N., Zhang, R., Lee, D.S. and Wicha, M.S. (2000) "Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid", Cancer Epidemiol. Biomark. Prev. 9, 257-263.
  • Müller, K., Carpenter, K.L.H., Freeman, M.A. and Mitchinson, MJ. (1999) "Antioxidant BO-653 and human macrophagemediated LDL oxidation", free Radie. Res. 30, 59-71.
  • Napoli, J.L. (2000) "Retinoic acid: its biosynthesis and metabolism", Prog. Nucleic Acid Res. MoI. Biol. 63, 139-188.
  • Rogers, M.B. (1997) "Life-and-death decisions influenced by retinoids", Curr. Top. Dev. Biol. 35, 1-46.
  • Konta, T., Xu, Q., Furusu, A., Nakayama, K. and Kitamura, M. (2001) "Selective roles of retinoic acid receptor and retinoid X receptor in the suppression of apoptosis by all-trans-retinoic acid", J. Biol. Chem. 276, 12697-12701.
  • Zhang, D., Holmes, W.F., Wu, S., Soprano, D.R. and Soprano, K.J. (2000) "Retinoids and ovarian cancer", J. Cell. Physiol. 185, 1-20.
  • Hansen, L.A., Sigman, C.C., Andreola, F., Ross, S.A., Kelloff, GJ. and De Luca, L.M. (2000) "Retinoids in chemoprevention and differentiation therapy", Carcinogenesis Zl, 1271-1279.
  • Giovannucci, E., Ascherio, A., Rimm, E.B., Stampfer, M.J., Colditz, G.A. and Willett, W.C. (1995) "Intake of carotenoids and retinol in relation to the risk of prostate cancer", J. Natl Cancer Inst. 87, 1767-1776.
  • Narisawa, T., Fukaura, Y, Hasebe, M., Ito, M., Aizawa, R., Murakoshi, M., Uemura, S., Khachik, E and Nishino, H. (1996) "Inhibitory effects of natural carotenoids a carotene, ßcarotene, lycopene and lutein on colonie aberrant crypt foci formation in rats", Cancer Lett. 107, 137-142.
  • Nikawa, T., Schulz, W.A., van den Brink, C.E., Hanusch, M., van der Saag, P., Stahl, W. and Sies, H. (1995) "Efficacy of alltrans-b-carotene, canthaxanthin, and all-tnms-, 9-cis and 4-oxoretinoic acids in inducing differentiation of an F9 embryonal carcinoma RARß-lacZ receptor cell line", Arch. Biochem. Biophys. 316, 665-672.
  • Hanusch, M., Stahl, W., Schulz, W.A. and Sies, H. (1995) "Induction of gap junctional communication by 4-oxoretinoic acid generated from its precursor canthaxanthin", Arch. Biochem. Biophys. 317, 423-428.
  • Kim, S.-J., Nara, E., Kobayashi, H., Terao, J. and Nagao, A. (2001) "Formation of cleavage products by autoxidation of lycopene", Lipids 36, 191-199.
  • Stahl, W., von Laar, J., Martin, H.-D., Emmerich, T. and Sies, H. (2000) "Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene", Arch. Biochem. Biophys. 373, 271-274.
  • Jänne, P.A. and Mayer, R.J. (2000) "Chemoprevention of colorectal cancer", N. Engl. J. Med. 342, 1960-1968.
  • Madaan, S., Abel, P.D., Chaudhary, K.S., Stamp, G.W.H. and Lalani, E.N. (2000) "Over-expression of COX-2 in human prostate cancer", J. Pathol. 190, 44A.
  • Subbaramaiah, K., Telang, N., Ramonetti, J.T., Araki, R., DeVito, B., Weksler, B.B. and Dannenberg, A.J. (1996) "Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells", Cancer Res. 56, 4424-4429.
  • Chan, T.A., Morin, P.J., Vogelstein, B. and Kinzler, K.W. (1998) "Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis", Proc. Natl Acad. Sci. USA 95, 681-686.
  • Yao, R., Rioux, N., Castonguay, A. and You, M. (2000) "Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis", Exp. Lung Res. 26, 731-742.
  • Mestre, J.R., Subbaramaiah, K., Sacks, P.G., Schantz, S.P., Tanabe, T., Inoue, H. and Dannenberg, A.J. (1997) "Retinoids suppress phorbol ester-mediated induction of cyclooxygenase-2", Cancer Res. 57, 1081-1085.
  • Mestre, J.R., Subbaramaiah, K., Sacks, EG., Schantz, S.P., Tananbe, T., Inoue, H. and Dannenberg, A.J. (1997) "Retinoids suppress epidermal growth factor-induced transcription of cyclooxygenase-2 in human oral squamous carcinoma cells", Cancer Res. 57, 2890-2895.
  • Cacciola, S.A., Cohen, L.A. and Kashfi, K. (1999) "Lycopene inhibits proliferation and regulates cyclooxygenase-2 gene expression in neoplastic rat mammary epithelial cells", EASES J. 13, A551.
  • Pablos, J., Santiago, B., Carreira, P.E., Galindo, M. and GomezReino, JJ. (1999) "Cyclooxygenase-1 and -2 are expressed in human T cells", Clin. Exp. Immunol. 115, 86-90.
  • Matos, H.R., Di Mascio, P. and Mederos, M.H.G. (2000) "Protective effect of lycopene on lipid peroxidation and oxidative DNA damage in cell culture", Arch. Biochem. Biophys. 383, 56-59.
  • Lowe, G.M., Booth, L.A., Young, A.J. and Bilton, R.F. (1999) "Lycopene and ß-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses", Free Radie. Res. 30, 141-151.
  • Yeh, S.L. and Hu, M.L. (2001) "Induction of oxidative DNA damage in human foreskin fibroblast Hs68 cells by oxidised ß-carotene and lycopene", Free Radie. Res. 35, 203-213.
  • Stivala, L.A., Savio, M., Quarta, S., Scotti, C., Cazzalini, O., Rossi, L., Scovassi, I.A., Pizzala, R., Melli, R., Bianchi, L., Vannini, V. and Prosperi, E. (2000) "The antiproliferative effect of ß-carotene requires p21 """/0P1 jn normal human fibroblasts", Eur. J. Biochem. 267, 2290-2296.
  • Nahum, A., Hirsch, K., Danilenko, M., Watts, C.K.W., Prall, O.W.J., Levy, J. and Sharoni, Y. (2001) "Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cylin D levels and retention of p27klpl in the cyclin E-cdk2 complexes", Oncogene 20, 3428-3436.
  • Liebermann, D.A., Hoffman, B. and Steinman, R.A. (1995) "Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways", Oncogene 11, 199-210.
  • Salgo, M.G., Cueto, R., Winston, G.W. and Pryor, WA. (1999) "Beta carotene and its oxidation products have different effects on microsome mediated binding of benzo[a]pyrene to DNA", Free Radie. Biol. Med. 26, 162-173.
  • Paolini, M., Cantelli-Forti, G., Perocco, P., Pedulli, G.F., AbdelRahman, S.Z. and Legator, M.S. (1999) "Co-carcinogenic effect of ß-carotene", Nature 398, 760-761.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.