Aspirin Prevents Apoptosis and NF-κB Activation Induced by H²O² in HeLa Cells

References

• Ghosh, S., May, M.J. and Kopp, E.B. (1998) "NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses", Annu. Rev. Immunol. 16, 225–260.
   PubMed Web of Science ®Google Scholar
• Miyamato, S. and Verma, I.M. (1995) "Rel/NF-kappa B /I kappa B story", Adv. Cancer Res. 66, 255–292.
   PubMed Web of Science ®Google Scholar
• Siebenlist, U., Fransozo, G. and Brown, K. (1994) "Structure, regulation and function of NF-kappa B", Annu. Rev. Cell. Biol. 10, 405–455.
   PubMedGoogle Scholar
• Pahl, H.L. (1999) "Activators and target genes of Rel/NF-kappaB transcription factors", Oncogene 18, 6853–6866.
   PubMed Web of Science ®Google Scholar
• Baeuerle, PA. and Baltimore, D. (1996) "NF-kappa B: ten years after", Cell 87, 10–13.
   Web of Science ®Google Scholar
• Baldwin, A.S. (1996) "The NF-kappa B and I kappa B proteins: new discoveries and insights", Annu. Rev. Immunol. 14, 649–681.
   PubMed Web of Science ®Google Scholar
• Gilmore, T.D. (1999) "The Rel/NF-kappaB signal transduc-tion pathway: introduction", Oncogene 18, 6842–6844.
   PubMed Web of Science ®Google Scholar
• Rothwarf, D.M., Zandi, E., Natoli, G. and Karin, M. (1998) "lKK-gamma is an essential regulatory subunit of the IkappaB kinase complex", Nature 395, 297–300.
   PubMed Web of Science ®Google Scholar
• DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., Zandi, E. and Karin, M. (1997) "A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB", Nature 388, 548–554.
   PubMed Web of Science ®Google Scholar
• Zandi, E., Rothwarf, D.M., Delhase, M., Hayakawa, M. and Karin, M. (1997) "The IkappaB kinase complex (IKK) contains two kinase subunits, lKKalpha and lKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation", Cell 91, 243–252.
   PubMed Web of Science ®Google Scholar
• Nakamura, H., Nakamura, K. and Yodoi, J. (1997) "Redox regulation of cellular activation", Annu. Rev. Immunol. 15, 351–369.
   PubMed Web of Science ®Google Scholar
• Remade, J., Raes, M., Toussaint, 0., Renard, P. and Rao, G. (1995) "Low levels of reactive oxygen species as modulators of cell function", Mutat. Res. 316, 103–122.
   Google Scholar
• Ye, J., Zhang, X. and Shi, X. (2000) "On the role of hydroxyl radical and the effect of tetrandrine on nuclear factor-kappaB activation by phorbo112-myristate 13-acetate", Ann. Clin. Lab. Sci. 30, 65–71.
   PubMed Web of Science ®Google Scholar
• Schreck, R., Rieber, P. and Baeuerle, P.A. (1991) "Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1", EMBO J. 10, 2247–2258.
   PubMed Web of Science ®Google Scholar
• Meyer, M., Schreck, R. and Baeuerle, PA. (1993) "H202 and antioxidants have opposite effects on activation of NF-kappaB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor", EMBO J. 12, 2005–2015.
   PubMed Web of Science ®Google Scholar
• Rahman, I., Gilmour, P.S., Jimenez, L.A. and MacNee, W. (2002) "Oxidative stress and TNF-alpha induce histone acetylation and NF-kappa B /AP-1 activation in alveolar epithelial cells: potential mechanism in gene trans-cription in lung inflammation", Mol. Cell. Biochem. 234–235, 239–248.
   Web of Science ®Google Scholar
• Chang, W.J. and Alvarez-Gonzalez, R. (2001) "The sequence-specific DNA binding of NF-kappa B is reversibly regulated by the automodification reaction of poly (ADP-ribose) polymerase 1", J. Biol. Chem. 276, 47664–47670.
   PubMed Web of Science ®Google Scholar
• Schmidt, K.N., Traendmer, E.B., Meier, B. and Baeuerle, PA. (1995) "Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B", J. Biol. Chem. 270, 27136–27142.
   PubMed Web of Science ®Google Scholar
• Korn, S.H., Wouters, E.F., Vos, N. and Janssen-Heininger, Y.M. (2001) "Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase", J. Biol. Chem. 276, 35693–35700.
   PubMed Web of Science ®Google Scholar
• Kapahi, P, Takahashi, T., Natoli, G., Adams, S.R., Chen, Y., Tsien, R.Y. and Karin, M. (2000) "Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase", J. Biol. Chem. 275, 36062–36066.
   PubMed Web of Science ®Google Scholar
• Schoonbroodt, S., Ferreira, V, Best-Belpomme, M., Boelaert, J.R., Legrand-Poels, S., Korner, M. and Piette, J. (2000) "Crucial role of amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress", J. Immunol. 164, 4292–4300.
   PubMed Web of Science ®Google Scholar
• Kamata, H., Manabe, T., Oka, S., Kamata, K. and Hirata, H. (2002) "Hydrogen peroxide activates I kappa B kinases through phosphorylation of serine residues in the activation loops", FEBS Lett. 519, 231–237.
   PubMed Web of Science ®Google Scholar
• Li, N. and Karin, M. (1999) "Is NF-kappa B the sensor of oxidative stress?", FASEB J. 13, 1137–1143.
   PubMed Web of Science ®Google Scholar
• Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R. and Verma, I.M. (1996) "Suppression of TNF-alpha induced apoptosis by NF-kappa B", Science 274, 787–789.
   PubMed Web of Science ®Google Scholar
• Baichwal, V.R. and Baeuerle, PA. (1997) "Activate NF-kappa B or die?", Curr. Biol. 7, R94—R96.
   Web of Science ®Google Scholar
• Liu, Z.G., Hsu, H., Goeddel, D.V. and Karin, M. (1996) "Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappa B activation prevents cell death", Cell 87, 565–576.
   PubMed Web of Science ®Google Scholar
• Rayet, B. and Gélinas, C. (1999) "Aberrant rel/nfkb genes and activity in human cancer", Oncogene 18, 6847–6938.
   Web of Science ®Google Scholar
• Chu, Z.L., McKinsley, TA., Liu, L., Gentry, J.J., Malim, M.H. and Ballard, D.W. (1997) "Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control", Proc. Natl Acad. Sci. USA 94, 10057–10062.
   PubMed Web of Science ®Google Scholar
• Wang, C., Mayo, M., Korneluk, R., Goeddel, DN. and Baldwin, AS. Jr. (1998) "NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c- IAP2 to suppress caspase-8 activation", Science 281, 1680–1683.
   PubMed Web of Science ®Google Scholar
• Guttridge, D.C., Albanese, C., Reuther, J.Y., Pesten, R.G. and Baldwin, AS. Jr. (1999) "NF-kappaB controls cell growth and differentiation through transcriptional regulation of cydin D1", Mol. Cell. Biol. 19, 5785–5799.
   PubMed Web of Science ®Google Scholar
• Lin, K.I., DiDonato, J.A., Hoffmann, A., Hardwick, J.M. and Ratan, R.R. (1998) "Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis", J. Cell. Biol. 141, 1479–1487.
   PubMed Web of Science ®Google Scholar
• Kimura, K. and Gelmann, E.P. (2002) "Propapoptotic effects of NF-kappaB in LNCaP prostate cancer cells lead to serine protease activation", Cell Death Diff. 9, 972–980.
   PubMed Web of Science ®Google Scholar
• Kopp, E. and Ghosh, S. (1994) "Inhibition of NF-kappa B by sodium salicylate and aspirin", Science 265, 956–959.
   PubMed Web of Science ®Google Scholar
• Yin, M-J., Yamamoto, Y. and Gaynor, R.B. (1998) "The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta", Nature 396, 77–80.
   PubMed Web of Science ®Google Scholar
• Grilli, M., Pizzi, M., Memo, M. and Spano, P. (1996) "Neuroprotection by aspirin and sodium salicylate through blockade of NF- kappaB activation", Science 274, 1383–1385.
   PubMed Web of Science ®Google Scholar
• Stark, L.A., Din, F.V., Zwacka, R.M. and Dunlop, M.G. (2001) "Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells", FASEB J. 15, 1273–1275.
   PubMed Web of Science ®Google Scholar
• Ji, C., Amarnath, V, Pietenpol, J.A. and Marnett, L.J. (2001) "4-hydroxynonenal induces apoptosis via caspase-3 acti-vation and cytochrome c release", Chem. Res. Toxicol. 14, 1090–1096.
   PubMed Web of Science ®Google Scholar
• Foglieni, C., Meoni, C. and Davalli, A.M. (2001) "Fluorescent dyes for cell viability: an application on prefixed conditions", Histochem. Cell Biol. 115, 223–229.
   PubMed Web of Science ®Google Scholar
• Natarajan, R., Fisher, B.J., Jones, D.G. and Fowler, IQ, A.A. (2002) "Atypical mechanism of NF-kappaB activation during reoxygenation stress in microvascular endothelium: a role for tyrosine lcinases", Free Radic. Biol. Med. 33, 962–973.
   PubMed Web of Science ®Google Scholar
• Shi, X., Ding, M., Dong, Z., Chen, F., Ye, J., Wang, S., Leonard, S.S., Castranova, V. and Vallyathan, V. (1999) "Antioxidant properties of aspirin: characterization of the ability of aspirin to inhibit silica-induced lipid permddation, DNA damage, NF-kappaB activation, and TNF-alpha production", Mol. Cell. Biochem. 199, 93–102.
   PubMed Web of Science ®Google Scholar
• Kaltschmidt, B., Kaltschmidt, C., Hofmann, T.G., Hehner, S.P., Droge, W. and Schmitz, M.L. (2000) "The pro- or anti-apoptotic function of NF-kappa B is determined by the nature of the apoptotic stimulus", Fur. J. Biochem. 267, 3828–3835.
   Web of Science ®Google Scholar
• Podhaisky, H-P., Abate, A., Polte, T., Oberle, S. and Schroder, H. (1997) "Aspirin protects endothelial cells from oxidative stress—possible synergism with vitamin E", FEBS Lett. 417, 349–351.
   PubMed Web of Science ®Google Scholar
• Dumont, A., Hehner, S.P., Hofmann, T.G., Ueffing, M., Droge, W. and Schmitz, M.L. (1999) "Hydrogen per-oxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-kappa B", Oncogene 18, 747–757.
   PubMed Web of Science ®Google Scholar
• Kamata, H. and Hirata, H. (1999) "Redox regulation of cellular signaling", Cell. Signal. 11, 1–14.
   PubMed Web of Science ®Google Scholar