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Original Article

Acetaminophen Toxicity in Mice Lacking NADPH Oxidase Activity: Role of Peroxynitrite Formation and Mitochondrial Oxidant Stress

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Pages 1289-1297 | Received 02 Sep 2002, Accepted 23 Feb 2003, Published online: 07 Jul 2009

References

  • Roberts, D.W., Bucci, T.J., Benson, R.W., Warbritton, A.R., McRae, T.A., Pumford, N.R., et al. (1991) "Immunohisto-chemical localization and quantification of the 3-(cystein-S-y1)-acetaminophen protein adduct in acetaminophen hepato-toxicity", Am. J. Pat ho. 138(2), 359–371.
  • Nakae, D., Yoshiji, H., Yamamoto, K., Maruyama, H., Kinugasa, T., Takashima, Y., et al. (1990) "Influence of timing of administration of liposome-encapsulated superoxide dismutase on its prevention of acetaminophen-induced liver cell necrosis in rats", Acta Pathol. Jpn. 40(8), 568–573.
  • Jaeschke, H. (1990) "Glutathione disulfide formation and oxidant stress during acetaminophen- induced hepatotoxicity in mice in vivo: the protective effect of allopurinol", J. Pharmacol. Exp. Ther. 255(3), 935–941.
  • Smith, C.V. and Mitchell, J.R. (1985) "Acetaminophen hepatotoxicity in vivo is not accompanied by oxidant stress", Biochem. Biophys. Res. Commun. 133(1), 329–336.
  • Smith, C.V., Hughes, H., Lauterburg, B.H. and Mitchell, J.R. (1985) "Oxidant stress and hepatic necrosis in rats treated with diquat", J. Pharmacol. Exp. Then 235(1), 172–177.
  • Laskin, DI., Gardner, CR., Price, V.F. and Jollow, D.J. (1995) "Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen", Hepatology 21(4), 1045–1050.
  • Blazka, ME., Germolec, DR., Simeonove, P., Bruccoleri, A., Pennypacker, KR. and Luster, M.I. (1995) "Acetaminophen-induced hepatotoxicity is associated with early changes in NF-kB and NF-1L6 DNA binding activity", J. Inflamm. 47(3), 138–150.
  • Goldin, RD., Ratnayaka, ID., Breach, CS., Brown, IN. and Wickramasinghe, S.N. (1996) "Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity", J. Pathol. 179(4), 432–435.
  • Squadrito, GI. and Pryor, WA. (1998) "Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide", Free Radic. Biol. Med. 25(4-5), 392–403.
  • Hinson, J.A., Pike, S.L., Pumford, N.R. and Mayeux, P.R. (1998) "Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice", Chem. Res. Toxicol. 11(6), 604–607.
  • Hinson, J.A., Michael, S.L., Ault, S.G. and Pumford, N.R. (2000) "Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice", Toxicol. Sci. 53(2), 467–473.
  • Michael, S.L., Pumford, N.R., Mayeux, P.R., Niesman, and Hinson, J.A. (1999) "Pretreatment of mice with macrophage inactivators decreases acetaminophen hepato-toxicity and the formation of reactive oxygen and nitrogen species", Hepatology 30(1), 186–195.
  • Gorlach, A., Brandes, RE, Nguyen, K., Amidi, M., Dehghani, F. and Busse, R. (2000) "A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall", Circ. Res. 87(1), 26–32.
  • Hsich, E., Segal, B.H., Pagano, P.J., Rey, EE., Paigen, B., Deleonardis, J., et al. (2000) "Vascular effects following homozygous disruption of p47(phox): an essential com-ponent of NADPH oxidase", Circulation 101(11), 1234–1236.
  • Dinauer, M.C. (1993) "The respiratory burst oxidase and the molecular genetics of chronic granulomatous disease", Crit. Rev. Clin. Lab. Sci. 30(4), 329–369.
  • Curnutte, J.T. (1993) "Chronic granulomatous disease: the solving of a clinical riddle at the molecular level", Clin. Immunol. Immunopathol. 67((3 pt 2), S2–515.
  • Pollock, J.D., Williams, D.A., Gifford, MA., Li, L.L., Du, X., Fisherman, J., et al. (1995) "Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production", Nat. Genet. 9(2), 202–209.
  • Kirk, E.A., Dinauer, M.C., Rosen, H., Chait, A., Heinecke, J.W. and LeBoeuf, R.C. (2000) "Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice", Arterioscler. Thromb. Vasc. Biol. 20(6), 1529–1535.
  • Mitchell, J.R., Jollow, D.J., Potter, W.Z., Gillette, J.R. and Brodie, B.B. (1973) "Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione", J. Pharmacol. Exp. Then 187(1), 211–217.
  • Knight, T.R., Kurtz, A., Bajt, M.L., Hinson, J.A. and Jaeschke, H. (2001) "Vascular and hepatocellular peroxy-nitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress", Toxicol. Sci. 62(2), 212–220.
  • Winwood, P.J. and Arthur, M.J. (1993) "Kupffer cells: their activation and role in animal models of liver injury and human liver disease", Semin. Liver Dis. 13(1), 50–59.
  • Badwey, J.A. and Karnovsky, M.L. (1980) "Active oxygen species and the functions of phagocytic leukocytes", Annu. Rev. Biochem. 49, 695–726.
  • Morgenstern, D.E., Gifford, M.A., Li, L.L., Doerschuk, C.M. and Dinauer, M.C. (1997) "Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus", J. Exp. Med. 185(2), 207–218.
  • Harada, H., Hines, IN., Hoffman, J.M., Gao, B., Flores, S., McCord, J.M. and Grisham, M.B. (2002) "Role of NADPH oxidase-derived superoxide in reduced size liver ischemia and reperfusion injury in mice", Hepatology 36(4), 175A.
  • Esterline, R.L., Ray, S.D. and Ji, S. (1989) "Reversible and irreversible inhibition of hepatic mitochondrial respirtion by acetaminophen and its toxic metabolite, N-acetyl-p-benzo-quinoneimine (NAPQI)", Biochem. Pharmacol. 38(14), 2387–2390.
  • Pumford, N.R., Hinson, J.A., Benson, R.W. and Roberts, D.W. (1990) "Immunoblot analysis of protein containing 3-(cystein-S-yl)acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice", Toxicol. Appl. Pharmacol. 104(3), 521–532.
  • DeLeve, L.D., Wang, X., Kaplowitz, N., Shulman, H.M., Bart, J.A. and van der Hoek, A. (1997) "Sinusoidal endothelial cells as a target for acetaminophen toxicity Direct action versus requirement for hepatocyte activation in different mouse strains", Biochem. Pharmacol. 53(9), 1339–1345.
  • Steinberg, P., Lafranconi, W.M., Wolf, C.R., Waxman, D.J., Oesch, F. and Friedberg, T. (1987) "Xenobiotic metabolising enzymes are not restricted to parenchymal cells in rat liver", Mol. Pharmacol. 32(4), 463–470.
  • Steinberg, P., Schlemper, B., Molitor, E., Platt, K.L., Seidel, A. and Oesch, F. (1990) "Rat liver endothelial and Kupffer cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and aflatoxin B1", Environ. Health Perspect. 88, 71–76.
  • Deaciuc, IV, D'Souza, N.B., Sarphie, T.G., Schmidt, J., Hill, D.B. and McClain, C.J. (1999) "Effects of exogenous super-oxide anion and nitric oxide on the scavenging function and electron microscopic appearance of the sinusoidal endo-thelium in the isolated, perfused rat liver", J. Hepatol. 30(2), 213–221.
  • Lawson, J.A., Farhood, A., Hopper, R.D., Bajt, M.L. and Jaeschke, H. (2000) "The hepatic inflammatory response after acetaminophen overdose: role of neutrophils", Toxicol. Sci. 54(2), 509–516.
  • Suh, Y.A., Arnold, R.S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., et al. (1999) "Cell transformation by the superoxide-generating mddase Mox 1", Nature 401(6748), 79–82.
  • Arbiser, J.L., Petros, J., Klafter, R., Govindarajan, B., McLaughlin, E.R., Brown, L.F., et al. (2002) "Reactive oxygen generated by Nox 1 triggers the angiogenic switch", Proc. Natl Acad. Sci. USA 99(2), 715–720.

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