In vivo prooxidant state in Werner syndrome (WS): Results from three WS patients and two WS heterozygotes

References

• Chen L, Oshima J. Werner syndrome. J Biomed Biotechnol 2002;2:46–54.
   PubMedGoogle Scholar
• von Kobbe C, Thoma NH, Czyzewski BK, Pavletich NP, Bohr VA. Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem 2003;278:52997–53006.
   Google Scholar
• Imamura 0, Fujita K, Itoh C, Takeda S, Furuichi Y, Matsumoto T. Werner and Bloom helicases are involved in DNA repair in a complementary fashion. Oncogene 2002;21:954–963.
   Google Scholar
• Goto M, Yamabe Y, Shiratori M, Okada M, Kawabe T, Matsumoto T, Sugimoto M, Furuichi Y. Immunological diagnosis of Werner syndrome by down-regulated and truncated gene products. Hum Genet 1999;105:301–307.
   PubMed Web of Science ®Google Scholar
• Poot M, Gollahon KA, Emond MJ, Silber JR, Rabinovitch PS. Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: Implications for the disease phenotype. FASEB J 2002;17: 757–758.
   Google Scholar
• Poot M, Yom JS, Whang SH, Kato JT, Gollahon KA, Rabinovitch PS. Werner syndrome cells are sensitive to DNA cross-linking drugs. FASEB J 2001;15:1224–1226.
   PubMed Web of Science ®Google Scholar
• Nunoshiba T, Demple B. Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide. Cancer Res 1993;53:3250–3252.
   PubMed Web of Science ®Google Scholar
• Pagano G, Manini P, Bagchi D. Oxidative stress-related mechanisms are associated with xenobiotics exerting excess toxicity to Fanconi anemia cells. Environ Health Perspect 2003;111:1699–1703.
   Google Scholar
• Kashino G, Kodama S, Nakayama Y, Suzuki K, Fukase K, Goto M, Watanabe M. Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells. Free Radic Biol Med 2003; 35:438–443.
   Google Scholar
• de Magalhaes JP, Migeot V, Mainfroid V, de Longueville F, Remade J, Toussaint 0. No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H202. Ann NY Acad Sci 2004; 1019:375–378.
   Google Scholar
• von Kobbe C, May A, Grandori C, Bohr VA. Werner syndrome cells escape hydrogen peroxide-induced cell proliferation arrest. FASEB J 2004;18:1970–1972.
   PubMed Web of Science ®Google Scholar
• Nordenson I. Chromosome breaks in Werner's syndrome and their prevention in vitro by radical-scavenging enzymes. Hereditas 1977;87:151–154.
   PubMed Web of Science ®Google Scholar
• Oliver CN, Ahn B-W, Moerman EJ, Goldstein S, Stadtman ER. Age-related changes in oxidized proteins. J Biol Chem 1987;262:5488–5491.
   Google Scholar
• Degan P, Bonassi S, De Caterina M, Korkina LG, Pinto L, Scopacasa F, Zatterale A, Calzone R, Pagano G. In vivo accumulation of 8-hydroxy-2'-deoxyguanosine in DNA corre-lates with release of reactive oxygen species in Fanconi's anaemia families. Carcinogenesis 1995;16: 735–742.
   Google Scholar
• Espinosa-Mansilla A, Durán-Meràs I, Salinas F. High-performance liquid chromatographic-fluorometric determi-nation of glyoxal, methylglyoxal, and diacetyl in urine by prederivatization to pteridinic rings. Anal Biochem 1998;255:263–273.
   PubMed Web of Science ®Google Scholar
• Asensi M, Sastre J, Pallardo FV, Estrela JM, Villa J. High performance liquid chromatography determination of oxidized glutathione in blood. Methods Enzymol 1994;234: 367–371.
   Google Scholar
• Iriyama K, Yoshiura M, Iwamoto T, Ozaki Y. Simultaneous determination of uric and ascorbic acids in human serum by reversed-phase high-performance liquid chromatography with electrochemical detection. Anal Biochem 1984;141: 238–243.
   PubMed Web of Science ®Google Scholar
• Kelly FJ, Rodgers W, Handel J, Smith S, Hall MA. Time course of vitamin E repletion in the preterm infant. Br J Nutr 1990;63:631–638.
   Google Scholar
• Zar JH. Biostatistical analysis. 3rd ed. Upper Saddle River, NJ: Prentice-Hall; 1996.
   Google Scholar
• Floyd RA. The role of 8-hydroguanine in carcinogenesis. Carcinogenesis 1990;9:1447–1450.
   Google Scholar
• Vlassara H, Palace MR. Diabetes and advanced glycation endproducts. J Intern Med 2002;251:87–101.
   PubMed Web of Science ®Google Scholar
• Lou ME. Redox regulation in the lens. Prog Retin Eye Res 2003;22:657–682.
   PubMed Web of Science ®Google Scholar
• Davis T, Singhrao SK, Wyllie FS, Haughton MF, Smith PJ, Wiltshire M, Wynford-Thomas D, Jones CJ, Faragher RG, Kipling D. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms. J Cell Sci 2003; 116:1349–1357.
   Google Scholar
• Grandori C, Wu KJ, Fernandez P, Ngouenet C, Grim J, Clurman BE, Moser MJ, Oshima J, Russell DW, Swisshelm K, Frank S, Amati B, Dalla Favera R, Monnat RJ. Jr. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev 2003;17:1569–1574.
   Google Scholar
• Orren DK, Machwe A, Karmakar P, Piotrowski J, Cooper MP, Bohr VA. A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA. Nucleic Acids Res 2001;29:1926–1934.
   PubMed Web of Science ®Google Scholar
• Pichierri P, Rosselli F, Franchitto A. Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Oncogene 2003;22:1491–1500.
   Google Scholar
• Blander G, Zalle N, Leal JF, Bar-Or RL, Yu CE, Oren M. The Werner syndrome protein contributes to induction of p53 by DNA damage. FASEB J 2000;14: 2138–2140.
   Google Scholar
• Pagano G, Degan P, d'Ischia M, Kelly FJ, Pallardó FV, Zatterale A, Anak SS, Akii:k EE, Beneduce G, Calzone R, De Nicola E, Dunster C, Lloret A, Manini P, Nobili P, Saviano A, Vuttariello E, Warnau M. Gender- and age-related distinctions for the in vivo prooxidant state in Fanconi anaemia patients. Carcinogenesis 2004;25:1899–1909.
   Google Scholar