α-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-κB and AP-1 transcription factors in human neuroblastoma IMR-32 cells

References

• Powell SR. The antioxidant properties of zinc. J Nutr 2000; 130: 1447S–1454S
   PubMed Web of Science ®Google Scholar
• Zago MP, Oteiza PI. The antioxidant properties of zinc: Interactions with iron and antioxidants. Free Radic Biol Med 2001; 31: 266–274
   PubMed Web of Science ®Google Scholar
• Mackenzie GG, Keen CL, Oteiza PI. Zinc status of human IMR-32 neuroblastoma cells influences their susceptibility to iron-induced oxidative stress. Dev Neurosci 2002; 24: 125–133
   PubMedGoogle Scholar
• Oteiza PI, Clegg MS, Zago MP, Keen CL. Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells. Free Radic Biol Med 2000; 28: 1091–1099
   PubMed Web of Science ®Google Scholar
• Oteiza PI, Olin KL, Fraga CG, Keen CL. Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. J Nutr 1995; 125: 823–829
   PubMed Web of Science ®Google Scholar
• Virgili F, Canali R, Figus E, Vignolini F, Nobili F, Mengheri E. Intestinal damage induced by zinc deficiency is associated with enhanced CuZn superoxide dismutase activity in rats: Effect of dexamethasone or thyroxine treatment. Free Radic Biol Med 1999; 26: 1194–1201
   PubMed Web of Science ®Google Scholar
• Ho E, Ames BN. Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc Natl Acad Sci USA 2002; 99: 16770–16775
   PubMed Web of Science ®Google Scholar
• Oteiza PL, Olin KL, Fraga CG, Keen CL. Oxidant defense systems in testes from zinc-deficient rats. Proc Soc Exp Biol Med 1996; 213: 85–91
   PubMed Web of Science ®Google Scholar
• Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999; 18: 6853–6866
   PubMed Web of Science ®Google Scholar
• Ginn-Pease ME, Whisler RL. Redox signals and NF-kappaB activation in T cells. Free Radic Biol Med 1998; 25: 346–361
   PubMed Web of Science ®Google Scholar
• Janssen-Heininger YM, Poynter ME, Baeuerle PA. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med 2000; 28: 1317–1327
   PubMed Web of Science ®Google Scholar
• Li N, Karin M. Is NF-kappaB the sensor of oxidative stress?. FASEB J 1999; 13: 1137–1143
   PubMed Web of Science ®Google Scholar
• Sen CK, Packer L. Antioxidant and redox regulation of gene transcription. FASEB J 1996; 10: 709–720
   PubMed Web of Science ®Google Scholar
• Brennan P, O'Neill LA. Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: Evidence against a universal hypothesis involving oxygen radicals. Biochim Biophys Acta 1995; 1260: 167–175
   PubMed Web of Science ®Google Scholar
• Packer L. alpha-Lipoic acid: A metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury. Drug Metab Rev 1998; 30: 245–275
   PubMed Web of Science ®Google Scholar
• Saliou C, Rihn B, Cillard J, Okamoto T, Packer L. Selective inhibition of NF-kappaB activation by the flavonoid hepatoprotector silymarin in HepG2. Evidence for different activating pathways. FEBS Lett 1998; 440: 8–12
   PubMed Web of Science ®Google Scholar
• Zhang WJ, Frei B. Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells. FASEB J 2001; 15: 2423–2432
   PubMed Web of Science ®Google Scholar
• Azzi A, Gysin R, Kempna P, Ricciarelli R, Villacorta L, Visarius T, Zingg JM. The role of alpha-tocopherol in preventing disease: From epidemiology to molecular events. Mol Aspects Med 2003; 24: 325–336
   PubMed Web of Science ®Google Scholar
• Mackenzie GG, Carrasquedo F, Delfino JM, Keen CL, Fraga CG, Oteiza PI. Epicatechin, catechin, and dimeric procyanidins inhibit PMAinduced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J 2004; 18: 167–169
   PubMed Web of Science ®Google Scholar
• Martindale JL, Holbrook NJ. Cellular response to oxidative stress: Signaling for suicide and survival. J Cell Physiol 2002; 192: 1–15
   PubMed Web of Science ®Google Scholar
• Finkel T. Oxygen radicals and signaling. Curr Opin Cell Biol 1998; 10: 248–253
   PubMed Web of Science ®Google Scholar
• Karin M, Takahashi T, Kapahi P, Delhase M, Chen Y, Makris C, Rothwarf D, Baud V, Natoli G, Guido F, Li N. Oxidative stress and gene expression: The AP-1 and NF-kappaB connections. Biofactors 2001; 15: 87–89
   PubMed Web of Science ®Google Scholar
• Chinenov Y, Kerppola TK. Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity. Oncogene 2001; 20: 2438–2452
   PubMed Web of Science ®Google Scholar
• Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001; 410: 37–40
   PubMed Web of Science ®Google Scholar
• Rahman I, MacNee W. Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches. Free Radic Biol Med 2000; 28: 1405–1420
   PubMed Web of Science ®Google Scholar
• Scortegagna M, Galdzicki Z, Rapoport SI, Hanbauer I. Activator protein-1 DNA binding activation by hydrogen peroxide in neuronal and astrocytic primary cultures of trisomy-16 and diploid mice. Brain Res Mol Brain Res 1999; 73: 144–150
   PubMedGoogle Scholar
• Vollgraf U, Wegner M, Richter-Landsberg C. Activation of AP-1 and nuclear factor-kappaB transcription factors is involved in hydrogen peroxide-induced apoptotic cell death of oligodendrocytes. J Neurochem 1999; 73: 2501–2509
   PubMed Web of Science ®Google Scholar
• Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408: 239–247
   PubMed Web of Science ®Google Scholar
• Hammond CL, Lee TK, Ballatori N. Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes. J Hepatol 2001; 34: 946–954
   PubMed Web of Science ®Google Scholar
• Han D, Handelman G, Marcocci L, Sen CK, Roy S, Kobuchi H, Tritschler HJ, Flohe L, Packer L. Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors 1997; 6: 321–338
   PubMed Web of Science ®Google Scholar
• Roy S, Packer L. Redox regulation of cell functions by alpha-lipoate: Biochemical and molecular aspects. Biofactors 1998; 7: 263–267
   PubMedGoogle Scholar
• Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989; 6: 593–597
   PubMed Web of Science ®Google Scholar
• Zafarullah M, Li WQ, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 2003; 60: 6–20
   PubMed Web of Science ®Google Scholar
• Oteiza PI, Clegg MS, Keen CL. Short-term zinc deficiency affects nuclear factor-kappab nuclear binding activity in rat testes. J Nutr 2001; 131: 21–26
   PubMed Web of Science ®Google Scholar
• Mackenzie GG, Zago MP, Keen CL, Oteiza PI. Low intracellular zinc impairs the translocation of activated NF-kappa B to the nuclei in human neuroblastoma IMR-32 cells. J Biol Chem 2002; 277: 34610–34617
   PubMed Web of Science ®Google Scholar
• Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 1991; 51: 794–798
   PubMed Web of Science ®Google Scholar
• Muller JM, Rupec RA, Baeuerle PA. Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen intermediates. Methods 1997; 11: 301–312
   PubMed Web of Science ®Google Scholar
• Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248–254
   PubMed Web of Science ®Google Scholar
• Spiegelman VS, Stavropoulos P, Latres E, Pagano M, Ronai Z, Slaga TJ, Fuchs SY. Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB. J Biol Chem 2001; 276: 27152–27158
   PubMedGoogle Scholar
• Ho E, Quan N, Tsai YH, Lai W, Bray TM. Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice. Exp Biol Med (Maywood) 2001; 226: 103–111
   PubMed Web of Science ®Google Scholar
• Dringen R. Metabolism and functions of glutathione in brain. Prog Neurobiol 2000; 62: 649–671
   PubMed Web of Science ®Google Scholar
• Dringen R, Gutterer JM, Hirrlinger J. Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. Eur J Biochem 2000; 267: 4912–4916
   PubMedGoogle Scholar
• Dringen R, Hirrlinger J. Glutathione pathways in the brain. Biol Chem 2003; 384: 505–516
   PubMed Web of Science ®Google Scholar
• Schreck R, Albermann K, Baeuerle PA. Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 1992; 17: 221–237
   PubMed Web of Science ®Google Scholar
• Staal FJ, Roederer M, Herzenberg LA. Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. Proc Natl Acad Sci USA 1990; 87: 9943–9947
   PubMed Web of Science ®Google Scholar
• Li J, Quan N, Bray TM. Supplementation of N-acetylcysteine normalizes lipopolysaccharide-induced nuclear factor kappaB activation and proinflammatory cytokine production during early rehabilitation of protein malnourished mice. J Nutr 2002; 132: 3286–3292
   PubMed Web of Science ®Google Scholar
• Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, Manning AM, Andersen JS, Mann M, Mercurio F, Ben-Neriah Y. Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature 1998; 396: 590–594
   PubMed Web of Science ®Google Scholar
• Qu Z, Qing G, Rabson A, Xiao G. Tax deregulation of NFkappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms. J Biol Chem 2004; 279: 44563–44572
   PubMed Web of Science ®Google Scholar