Quercetin protects C6 glial cells from oxidative stress induced by tertiary-butylhydroperoxide

References

• Clarke DD, Sokoloff L. Circulation and energy metabolism of brain. Basic neurochemistry: Molecular, cellular and medical aspects, GJ Siegel, BW Agranoff, RW Albers, SK Fisher, MD Uheer. Lippincott-Raven, Philadelphia PA 1999; 637–669
   Google Scholar
• Halliwell B, Gutteridge JMC, Cross CE. Free radicals, anti-oxidants and human diseases: Where are we now?. J Lab Clin Med 1997; 119: 598–620
   Google Scholar
• Diplock AT, Chanleux JL, Crozier WG, Kok FJ, Rice-Evans C, Roberfroid M, Stahl W, Vina-Ribes J. Functional food science and defense against reactive oxygen species. Br J Nutr 1998; 80: s77–s112
   PubMed Web of Science ®Google Scholar
• Halliwell B. Antioxidants and human diseases: A general introduction. Nutr Rev 1997; 55: 544–552
   Web of Science ®Google Scholar
• Coyle JT, Puttfarcken P. Oxidative stress, glutamate and neurodegenerative disorders. Science 1993; 262: 689–700
   PubMed Web of Science ®Google Scholar
• Cooper AJL. Glutathione in the brain: Disorders of glutathione metabolism. The molecular and genetic basis of neurological diseases, RN Rosenberg, SB Prusiner, S DiMauro, RL Barchi, LM Kunk. Butterworth-Heinemann, Boston 1997; 1195–1230
   Google Scholar
• Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 2004; 58: 39–46
   PubMed Web of Science ®Google Scholar
• Desagher S, Glowinski J, Premont J. Astrocytes protect neurons from hydrogen peroxide toxicity. J Neurosci 1996; 16: 2553–2562
   PubMed Web of Science ®Google Scholar
• Mena MA, Casarejos MJ, Carazo A, Paino CL, Yebens JG. Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms. J Neural Transm 1997; 104: 317–328
   PubMed Web of Science ®Google Scholar
• Akerud P, Alberch J, Eketjall S, Wanger J, Arenas E. Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons. J Neurochem 1999; 73: 70–78
   PubMed Web of Science ®Google Scholar
• Abbott NJ. Astrocyte–endothelial interactions and blood–brain barrier permeability. J Anat 2002; 200: 629–638
   PubMed Web of Science ®Google Scholar
• Papadopoulos MC, Loumenis IL, Yuan TY, Giffard RG. Increasing vulnerability of astrocytes to oxidative injury with age despite constant antioxidant defenses. Neuroscience 1998; 82: 915–925
   PubMed Web of Science ®Google Scholar
• Gerlack M, Benshachar D, Riederer P, Youdim MBH. Altered brain metabolism of iron as a cause of neurodegenerative diseases?. J Neurochem 1994; 63: 7095–7104
   Web of Science ®Google Scholar
• Afanas'ev IB, Dorozhko AI, Brodskii AV, Kostyuk VA, Potapovitch AI. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem Pharmacol 1989; 38: 1763–1769
   PubMed Web of Science ®Google Scholar
• Formica JV, Regelson W. Review of the biology of quercetin and related bio-flavonoids. Food Chem Toxicol 1995; 33: 1061–1080
   PubMed Web of Science ®Google Scholar
• Hertog MGL, Hollman PCH, Katan MB, Kromhout D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr Cancer 1993; 20: 21–29
   PubMed Web of Science ®Google Scholar
• Kuhnau J. The flavonoids: A class of semi-essential food components: Their role in human nutrition. Rev Nutr Diet 1976; 24: 117–191
   PubMedGoogle Scholar
• Ishige K, Schubertm D, Sagaram Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 2001; 30: 443–446
   Web of Science ®Google Scholar
• Hertog MGL, Feskens EJM, Hollman PCH, Katan MB, Kromhoutatan MGL. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 1993; 342: 1007–1011
   PubMed Web of Science ®Google Scholar
• Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: Antioxidants and beyond. Am J Clin Nutr 2005; 81: 215S–217S
   PubMed Web of Science ®Google Scholar
• Zhao B. Natural antioxidants for neurodegenerative diseases. Mol Neurobiol 2005; 31: 283–294
   PubMed Web of Science ®Google Scholar
• Vinson JA. Flavonoids in foods as in vitro and in vivo antioxidants. Adv Exp Med Biol 1998; 439: 151–163
   PubMed Web of Science ®Google Scholar
• Nijveldt RJ, van Nood E, van Hoorn EC, Boelens PG, va Norren K, vam Leeuwen PAM. Flavonoids: A review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001; 74: 418–425
   PubMed Web of Science ®Google Scholar
• Filipe P, Lanca V, Silva JN, Morliere P, Santus R, Fernandes A. Flavonoids and urate antioxidant interplay in plasma oxidative stress. Mol Cell Biochem 2001; 221: 79–87
   PubMed Web of Science ®Google Scholar
• Dajas F, Rivera-Megret F, Blasina F, Arredondo F, Abin-Carriquiry JA, Costa G, Echeverry C, Lafon L, Heizen H, Ferreira M, Morquio A. Neuroprotection by flavonoids. Braz J Med Biol Res 2003; 36: 1613–1620
   PubMed Web of Science ®Google Scholar
• Bastianetto SB, Zheng W, Quirion R. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide related to toxicity in cultured hippocampal neurons. Br J Pharmacol 2000; 131: 711–720
   PubMed Web of Science ®Google Scholar
• van Meeteren ME, Hendriks JJA, Dijkstra CD, van Tol AF. Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease. Biochem Pharmacol 2004; 67: 967–975
   PubMed Web of Science ®Google Scholar
• Pfeiffer SE, Herschman HR, Lightbody J, Sato G. Synthesis by a clonal line of rat glial cells of a protein unique to the nervous system. J cell Physiol 1970; 75: 329–339
   PubMed Web of Science ®Google Scholar
• Bissel MG, Rubinstein LJ, Bugnami A, Herman MM. Characterisation of the rat C6 glioma maintained on organ culture system. Production of glial fibrillary acidic protein in the absence of gliofibrillogenesis. Brain Res 1974; 82: 77
   PubMed Web of Science ®Google Scholar
• Babich H, Borefreund E. Applications of the neutral red cytotoxicity assay to in vitro toxicology (Review). Altern Lab Anim 1990; 18: 129–144
   Web of Science ®Google Scholar
• Geetha S, SaiRam M, Singh V, Ilavazhagan G, Sawhney RC. Antioxidant and immunomodulatory properties of Seabuckthorn (Hippophae rhamnoides) — an in vitro study. J Ethnopharmacol 2002; 79: 373–378
   PubMed Web of Science ®Google Scholar
• Tice RR, Andrews PW, Hira IO, Singh NP. The single cell gel (SCG) assay: An electrophoretic technique for the detection of DNA damage in individual cells. Biological and reactive intermediates IV, CM Witmer. Plenum Press, New York 1990; 157–164
   Google Scholar
• Collins AR, Ai-guo M, Duthie SJ. The kinetics of oxidative DNA damage (strand breaks and oxidized pyrimidines) in human cells. Mutat Res 1995; 336: 69–77
   PubMed Web of Science ®Google Scholar
• Van den Berg J, Kuypers F, Qju J, Chiu D, Lubin B, Roelofsen B, Op den Kamp J. The use of cis-parinaric acid to determine lipid peroxidation in human erythrocyte membranes. Comparison of normal and sickle erythrocytes membranes. Biochim Biophys Acta 1988; 944: 29–39
   PubMed Web of Science ®Google Scholar
• Hissin PJ, Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976; 76: 214–226
   PubMed Web of Science ®Google Scholar
• Xiaopeng B, Francis MH, Huang JY, John AC, James WP. Roles of cytoplasmic Ca++ and intracellular Ca++ stores in induction and suppression of apoptosis in S49 cells. Am J Physiol (Cell Physiol 41) 1997; 272: C1241–C1249
   Web of Science ®Google Scholar
• Torel J, Cillard J, Cillard P. Antioxidant activity of flavonoid and reactivity with peroxyl radical. Phytochemistry 1986; 25: 383–385
   Web of Science ®Google Scholar
• Robak J, Gryglewski RL. Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 1988; 37: 837–841
   PubMed Web of Science ®Google Scholar
• Manach A, Mazur A, Scalbert A. Polyphenols and prevention of cardiovascular diseases. Curr Opin Lipidol 2005; 16: 77–84
   PubMed Web of Science ®Google Scholar
• Cherbuni A, Vigna GB, Zuliani G, Ruggiero C, Senin U, Fellin R. Role of antioxidants in atherosclerosis: Epidemiological and clinical update. Curr Pharm Des 2005; 11: 2017–2032
   PubMed Web of Science ®Google Scholar
• Galati G, O'Brien PJ. Potential toxicity of flavonoids and other dietary phenolics: Significance for their chemopreventive and anticancer properties. Free Radic Biol Med 2004; 37: 287–303
   PubMed Web of Science ®Google Scholar
• Dajas F, Costa G, Abin-Carriguiry JA, Echeverry C, Martinez-Borges A, Dajas-Bailder F. Antioxidants and cholinergic neuroprotective mechanisms in experimentative Parkinsonism. Funct Neurol 2001; 17: 37–44
   Google Scholar
• Sandstrom B. Induction and rejoining of DNA single strand breaks in relation to cellular growth in human cells exposed to three hydroperoxide at 0°C and 37°C. Free Radic Res Commun 1991; 15: 79–89
   PubMed Web of Science ®Google Scholar
• Aherne SA, O'Brien N. Mechanism of protection by flavonoids, quercetin and rutin against tert-butylhydroperoxide and menadione induced DNA single strand breaks in Caco-2 cells. Free Radic Biol Med 2000; 29: 507514
   Web of Science ®Google Scholar
• Bastianetto SB, Zheng W, Quirion R. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide related to toxicity in cultured hippocampal neurons. Br J Pharmacol 2000; 131: 711–720
   PubMed Web of Science ®Google Scholar
• Sestili P, Guidarelli A, Dacha M, Cantoni O. Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butyl hydroperoxide free radical scavenging versus iron chelating mechanism. Free Radic Biol Med 1998; 25: 196–200
   PubMed Web of Science ®Google Scholar
• Wen-Peng I, Kuo SM. Flavonoid structure affects the inhibition of lipid peroxidation in Caco-2 intestinal cells at physiological concentrations. J Nutr 2003; 133: 2184–2187
   PubMed Web of Science ®Google Scholar
• Ratty AK, Sunamoto J, Das NP. Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1. Biochem Pharmacol 1988; 37: 989–995
   PubMed Web of Science ®Google Scholar
• Makar TK, Nodergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper JL. Vitamin E, ascorbate, glutathione, glutathione disulfide and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: Evidence that astrocytes play an important role in antioxidative processes in the brain. J Neurochem 1994; 62: 45–53
   PubMed Web of Science ®Google Scholar
• Saito Y, Matuyama K, Saido TC, Kawashima S. N23K, a gene transiently up-regulated during neuronal differentiation, encides a precursor protein for a newly identified neuropeptide niciceptin. Biochem Biophys Res Commun 1995; 217: 539–545
   PubMed Web of Science ®Google Scholar
• Sagara Y, Schubert D. The activation of metabotropic glutamate receptors protects neuronal cells from oxidative stress. J Neurosci 1998; 18: 6662–6671
   PubMed Web of Science ®Google Scholar
• Kim MS, Cheong YP, So HS, Lee KM, Kim TY, Oh J, Chung YT, Son Y, Kim BR, Park R. Protective effects of morphine in peroxynitrite-induced apoptosis of primary neonatal astrocytes: Potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase). Biochem Pharmacol 2001; 61: 779–786
   PubMed Web of Science ®Google Scholar
• Di Monte D, Bellomo G, Thor H, Nicotera O, Orrenius S. Menadione induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis. Arch Biochem Biophys 1984; 235: 343–350
   PubMed Web of Science ®Google Scholar
• Nicotera P, McConkey D, Svemsson SA, Bellomo G, Orrenius S. Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress. Toxicology 1988; 52: 55–63
   PubMed Web of Science ®Google Scholar
• Orrenius S, McCabe MJ, Nicotera P. Ca(2+) dependent mechanisms of cytotoxicity and programmed cell death. Toxicol Lett 1992; 64-65: 357–364
   Web of Science ®Google Scholar
• Dobrydneva Y, Williams RL, Blackmore PF. trans-Resveratol inhibits calcium influx in thrombin-stimulated human platelets. Br J Pharmacol 1999; 128: 149–157
   PubMed Web of Science ®Google Scholar
• Wang H, Joseph JA. Structure relationships of quercetin in antagonizing hydrogen peroxide-induced calcium dysregulation in PC12 cells. Free Radic Biol Med 1999; 27: 683–694
   PubMed Web of Science ®Google Scholar
• Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo CL, Theoharides TC. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol 2005; 145: 934–44
   PubMed Web of Science ®Google Scholar
• Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ. Flavonoid permeability across an in situ model of the blood–brain barrier. Free Radic Biol Med 2004; 36: 592–604
   PubMed Web of Science ®Google Scholar