170
Views
38
CrossRef citations to date
0
Altmetric
Original

S-Allyl-l-cysteine attenuates cerebral ischemic injury by scavenging peroxynitrite and inhibiting the activity of extracellular signal-regulated kinase

, , , &
Pages 827-835 | Received 20 Dec 2005, Published online: 07 Jul 2009

References

  • Abe K, Yuki S, Kogure K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 1988; 19: 480–485
  • Carney JM. Floyd RAProtection against oxidative damage to CNS by α-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers. J Mol Neurosci 1991; 3: 47–57
  • Floyd RA, Carney JM. Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann Neurol 1992; 32: S22–S27
  • Knuckey NW, Palm D, Primiano M, Epstein MH, Johanson CE. N-Acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats. Stroke 1995; 26: 305–310
  • Kim KM, Chun SB, Koo MS, Chio WJ, Kim TW, Kwon YT, Chung HT, Billiar TR, Kim YM. Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. Free Radic Biol Med 2001; 30: 747–756
  • Ide N, Lau BH. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-κB activation. J Nutr 2001; 131: 1020S–1026S
  • Ide N, Lau BH. Garlic compounds protect vascular endothelial cells from oxidized low density lipoprotein-induced injury. J Pharm Pharmacol 1997; 49: 908–911
  • Lau BHS. Suppression of LDL oxidation by garlic. J Nutr 2001; 131: 985S–988S
  • Numagami Y, Sato S, Ohnishi ST. Attenuation of rat ischemic brain damage by aged garlic extracts: A possible protecting mechanism as antioxidants. Neurochem Int 1996; 29: 135–143
  • Numagami Y, Ohnishi ST. S-Allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia. J Nutr 2001; 131: 1100S–1105S
  • Geng Z, Rong Y, Lau BHS. S-Allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Free Radic Biol Med 1997; 23: 345–350
  • Martinez Munoz C, Post JA, Verkleij AJ, Verrips CT, Boonstra J. The effect of hydrogen peroxide on the cyclin D expression in fibroblasts. Cell Mol Life Sci 2001; 58: 990–996
  • Lander JM, Jocovina AT, Davis RJ, Tauras JM. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. J Biol Chem 1996; 271: 19705–19709
  • Pawate S, Shen Q, Fan F, Bhat NR. Redox regulation of glial inflammatory response to lipopolysaccharide and interfereon-γ. J Neurosci Res 2004; 77: 540–551
  • Schieke SM, Briviba K, Klotz LO, Sies H. Activation pattern of mitogen-activated protein kinases elicited by peroxynitrite: Attenuation by selenite supplementation. FEBS Lett 1999; 448: 301–303
  • Zhang P, Wang YZ, Kagan E, Bonner JC. Peroxynitrite targets the epidermal growth factor receptor, Raf-1, and MEK independently to activate MAPK. J Biol Chem 2000; 275: 22479–22486
  • Stanciu M, Wang Y, Kentor R, Burke N, Watkins S, Kress G, Reynolds I, Klann E, Angiolieri MR, et al. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem 2000; 275: 12200–12206
  • Alessandrini A, Namura S, Moskowitz MA, Bonventre JV. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci USA 1999; 96: 12866–12869
  • Namura S, Lihara K, Takami S, Nanigata I, Kikuchi H, Matshushita K, Moskowitz MA, Bonventre JV, Alessandri A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci USA 2001; 98: 11569–11574
  • Belayev L, Alonso OF, Busto R, Zhao W, Ginsberg MD. Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke 1996; 27: 1616–1622
  • Choi J, Kim W-K. Potentiated glucose-deprivation-induced death of astrocytes after induction of iNOS. J Neurosci Res 1998; 54: 870–875
  • Green SJ, Meltzer MS, Hibbs JBJr, Nacy CA. Activated macrophages destroy intracellular Leishmania major amastigotes by an l-arginine-dependent killing mechanism. J Immunol 1990; 144: 278–283
  • Choi J, Oh Y, Kim H, Kim H, Ko K, Kim W. Mimosine prevents the death of glucose-deprived immunostimulated astrocytes by scavenging peroxynitrite. Glia 2002; 39: 37–46
  • Choi IY, Lee SJ, Ju C, Nam W, Kim H-C, Ko KH, Kim W-K. Protection by a manganese porphyrin of endogenous peroxynitrite-induced death of glial cells via inhibition of mitochondrial transmembrane potential decrease. Glia 2000; 31: 155–164
  • Kim W-K, Choi YB, Rayudu PV, Das P, Asaad W, Arnelle DR, Stamler JS, Lipton SA. Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO− . Neuron 1999; 24: 461–469
  • Kim W-K, Ko KH. Potentiation of N-methyl-d-aspartate-mediated neurotoxicity by immunostimulated murine microglia. J Neurosci Res 1998; 54: 17–26
  • Ju C, Yoon K, Oh Y, Kim H, Shin C, Ryu J, Ko K, Kim W. Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: Correlation with mitochondrial dysfunction and subsequent cell death. J Neurochem 2000; 74: 1989–1998
  • Sattler R, Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol 2001; 24: 107–129
  • Dugan LL, Choi DW. Excitotoxicity, free radicals, and cell membrane changes. Ann Neurol 1994; 35: S17–S21, (Suppl)
  • Yavuz O, Turkozkan N, Bilgihan A, Dogulu F, Aykol S. The effect of 2-chloro adenosine on lipid peroxide level during experimental cerebral ischemia-reperfusion in gerbils. Free Radic Biol Med 1997; 22: 337–341
  • Ikeda Y, Langn DM. The molecular basis of brain injury and brain edema; the role of oxygen free radicals. Neurosurg 1990; 27: 1–11
  • Ima J, Ide N, Nagae S, Moriguchi T, Matsuura H, Itakura Y. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Med 1994; 60: 417–420
  • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620–1624
  • Ischiropoulos H, Al-Mehdi AB, Fisher AB. Reactive species in ischemic rat lung injury: Contribution of peroxynitrite. Am J Physiol Lung Cell Mol Physiol 1995; 269: L158–L164
  • Fukuyama N, Takizawa S, Ishida H, Hoshiai K, Shinohara Y, Nakazawa H. Peroxynitrite formation in focal cerebral ischemia-reperfusion in rats occurs predominantly in the peri-infarct region. J Cereb Blood Flow Metab 1998; 18: 123–129
  • Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi K, Namura S. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci Lett 2000; 288: 163–166
  • Irving EA, Ray AM, Staton PC. Neuroprotection with the MEK inhibitor U0126 following ischemic injury. J Cereb Blood Flow Metab 2001; 21(Suppl 1)S379
  • Irving EA, Barone FC, Reith AD, Hadingham SJ, Parsons AA. Differential activation of MAPK/ERK and p38/SAPK in neurons and glia following focal cerebral ischaemia in the rat. Mol Brain Res 2000; 77: 65–75
  • Wu D, Ye W, Che X, Yang G. Activation of mitogen activated protein kinase after permanent cerebral artery occlusion in mouse brain. J Cereb Blood Flow Metab 2000; 20: 1320–1330
  • Hu BR, Liu CL, Park DJ. Alteration of MAP kinase pathways after transient forebrain ischemia. J Cereb Blood Flow Metab 2000; 20: 1089–1095
  • Oh-Hashi K, Maruyama W, Yi H, Takahashi T, Naoi M, Isobe K. Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells. Biochem Biophys Res Commun 1999; 263: 504–509
  • Jope RS, Zhang L, Song L. Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC12 cells. Arch Biochem Biophys 2000; 376: 365–370
  • Kodera Y, Suzuki A, Imada O, Kasuga S, Sumioka I, Kanezawa A, Taru N, Fujikawa M, Nagae S, et al. Physical, chemical, and biological properties of S-allylcysteine, an amino acid derived from garlic. J Agric Food Chem 2002; 50: 622–632
  • Yan C-K, Zeng F-D. Pharmacokinetics and tissue distribution of S-allylcysteine in rats. Asian J Drug Metab Pharmacokinet 2004; 5: 61–69

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.