Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCε signaling pathway

References

• Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124–1136
   PubMed Web of Science ®Google Scholar
• Loubani M, Galinanes M. Pharmacological and ischemic preconditioning of the human myocardium: Mitok(ATP) channels are upstream and p38MAPK is downstream of PKC. BMC Physiol 2002; 2: 10
   PubMedGoogle Scholar
• Armstrong SC, Liu GS, Downey JM, Ganote CE. Potassium channels and preconditioning of isolated rabbit cardiomyocytes: Effects of glyburide and pinacidil. J Mol Cell Cardiol 1995; 27: 1765–1774
   PubMed Web of Science ®Google Scholar
• Wang Y, Ashraf M. Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium. Circ Res 1999; 84: 1156–1165
   PubMed Web of Science ®Google Scholar
• Nakano A, Baines CP, Kim SO, Pelech SL, Downey JM, Cohen MV, Critz SD. Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: Evidence for involvement of p38 MAPK. Circ Res 2000; 86: 144–151
   PubMed Web of Science ®Google Scholar
• Nagarkatti DS, Sha'afi RI. Role of p38 MAP kinase in myocardial stress. J Mol Cell Cardiol 1998; 30: 1651–1664
   PubMed Web of Science ®Google Scholar
• Hedges JC, Dechert MA, Yamboliev IA, Martin JL, Hickey E, Weber LA, Gerthoffer WT. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem 1999; 274: 24211–24219
   PubMed Web of Science ®Google Scholar
• Martin JL, Hickey E, Weber LA, Dillmann WH, Mestril R. Influence of phosphorylation and oligomerization on the protective role of the small heat shock protein 27 in rat adult cardiomyocytes. Gene Expr 1999; 7: 349–355
   PubMed Web of Science ®Google Scholar
• Sugden PH, Clerk A. “Stress-responsive” mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res 1998; 83: 345–352
   PubMed Web of Science ®Google Scholar
• Martin JL, Mestril R, Hilal-Dandan R, Brunton LL, Dillmann WH. Small heat shock proteins and protection against ischemic injury in cardiac myocytes. Circulation 1997; 96: 4343–4348
   PubMed Web of Science ®Google Scholar
• Clerk A, Michael A, Sugden PH. Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein HSP25/27, in neonatal ventricular myocytes. Biochem J 1998; 333((Pt 3))581–589
   PubMed Web of Science ®Google Scholar
• Iguchi S, Iwamura H, Nishizaki M, Hayashi A, Senokuchi K, Kobayashi K, Sakaki K, Hachiya K, Ichioka Y, Kawamura M. Development of a highly cardioselective ultra short-acting beta-blocker ONO-1101. Chem Pharm Bull (Tokyo) 1992; 40: 1462–1469
   PubMed Web of Science ®Google Scholar
• Muraki K, Nakagawa H, Nagano N, Henmi S, Kawasumi H, Nakanishi T, Imaizumi K, Tokuno T, Atsuki K, Imaizumi Y, Watanabe M. Effects of ONO-1101, a novel beta-antagonist, on action potential and membrane currents in cardiac muscle. J Pharmacol Exp Ther 1996; 278: 555–563
   PubMed Web of Science ®Google Scholar
• Kurosawa S, Kanaya N, Niiyama Y, Nakayama M, Fujita S, Namiki A. Landiolol, esmolol and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts. Can J Anaesth 2003; 50: 489–494
   PubMed Web of Science ®Google Scholar
• Yasuda T, Kamiya H, Tanaka Y, Watanabe G. Ultra-short-acting cardioselective beta-blockade attenuates postischemic cardiac dysfunction in the isolated rat heart. Eur J Cardiothorac Surg 2001; 19: 647–652
   PubMed Web of Science ®Google Scholar
• Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature 2002; 415: 206–212
   PubMedGoogle Scholar
• Port JD, Bristow MR. Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure. J Mol Cell Cardiol 2001; 33: 887–905
   PubMed Web of Science ®Google Scholar
• Schafer M, Ponicke K, Heinroth-Hoffmann I, Brodde OE, Piper HM, Schluter KD. Beta-adrenoceptor stimulation attenuates the hypertrophic effect of alpha-adrenoceptor stimulation in adult rat ventricular cardiomyocytes. J Am Coll Cardiol 2001; 37: 300–307
   PubMed Web of Science ®Google Scholar
• Takahashi YST, Hirai T, Takemura S, Minamiyama Y, Sakaguchi M, Suehiro S. Pre-ischemic administration of landiolol prevents ischemia-reperfusion injury in the rat heart. Osaka City Journal 2007, in press
   Google Scholar
• Masanori S, Toshihiko S, Koji H, Hidekazu H, Mitsuharu H, Takanobu A, Takeshi I, Yasuyuki B, Shigefumi S. Orally administered benidipine and manidipine prevent ischemia-reperfusion injury in the rat heart. Circ J 2004; 68: 241–246
   PubMed Web of Science ®Google Scholar
• Hu K, Nattel S. Mechanisms of ischemic preconditioning in rat hearts. Involvement of alpha 1B-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C. Circulation 1995; 92: 2259–2265
   PubMed Web of Science ®Google Scholar
• Wang Y, Ashraf M. Activation of alpha1-adrenergic receptor during Ca2+ pre-conditioning elicits strong protection against Ca2+ overload injury via protein kinase C signaling pathway. J Mol Cell Cardiol 1998; 30: 2423–2435
   PubMed Web of Science ®Google Scholar
• Ohnuma Y, Miura T, Miki T, Tanno M, Kuno A, Tsuchida A, Shimamoto K. Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning. Am J Physiol Heart Circ Physiol 2002; 283: H440–H447
   PubMed Web of Science ®Google Scholar
• Peart J, Willems L, Headrick JP. Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine. Am J Physiol Heart Circ Physiol 2003; 284: H519–H527
   PubMed Web of Science ®Google Scholar
• Wang Y, Hirai K, Ashraf M. Activation of mitochondrial ATP-sensitive K(+) channel for cardiac protection against ischemic injury is dependent on protein kinase C activity. Circ Res 1999; 85: 731–741
   PubMed Web of Science ®Google Scholar
• Kristiansen SB, Henning O, Kharbanda RK, Nielsen-Kudsk JE, Schmidt MR, Redington AN, Nielsen TT, Botker HE. Remote preconditioning reduces ischemic injury in the explanted heart by a KATP channel-dependent mechanism. Am J Physiol Heart Circ Physiol 2005; 288: H1252–H1256
   PubMed Web of Science ®Google Scholar
• Inoue I, Nagase H, Kishi K, Higuti T. ATP-sensitive channel in the mitochondrial inner membrane. Nature 1991; 352: 244–247
   PubMed Web of Science ®Google Scholar
• Gross GJ, Fryer RM. Sarcolemmal versus mitochondrial ATP-sensitive K+ channels and myocardial preconditioning. Circ Res 1999; 84: 973–979
   PubMed Web of Science ®Google Scholar
• Gross GJ, Auchampach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 1992; 70: 223–233
   PubMed Web of Science ®Google Scholar
• Sanada S, Kitakaze M, Papst PJ, Hatanaka K, Asanuma H, Aki T, Shinozaki Y, Ogita H, Node K, Takashima S, Asakura M, Yamada J, Fukushima T, Ogai A, Kuzuya T, Mori H, Terada N, Yoshida K, Hori M. Role of phasic dynamism of p38 mitogen-activated protein kinase activation in ischemic preconditioning of the canine heart. Circ Res 2001; 88: 175–180
   PubMed Web of Science ®Google Scholar
• Arnaud C, Joyeux-Faure M, Bottari S, Godin-Ribuot D, Ribuot C. New insight into the signalling pathways of heat stress-induced myocardial preconditioning: Protein kinase Cepsilon translocation and heat shock protein 27 phosphorylation. Clin Exp Pharmacol Physiol 2004; 31: 129–133
   PubMed Web of Science ®Google Scholar
• Sanada S, Asanuma H, Tsukamoto O, Minamino T, Node K, Takashima S, Fukushima T, Ogai A, Shinozaki Y, Fujita M, Hirata A, Okuda H, Shimokawa H, Tomoike H, Hori M, Kitakaze M. Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C. Circulation 2004; 110: 51–57
   PubMed Web of Science ®Google Scholar
• Lochner A, Genade S, Tromp E, Podzuweit T, Moolman JA. Ischemic preconditioning and the beta-adrenergic signal transduction pathway. Circulation 1999; 100: 958–966
   PubMed Web of Science ®Google Scholar
• Lange M, Smul TM, Blomeyer CA, Redel A, Klotz KN, Roewer N, Kehl F. Role of the beta1-adrenergic pathway in anesthetic and ischemic preconditioning against myocardial infarction in the rabbit heart in vivo. Anesthesiology 2006; 105: 503–510
   PubMed Web of Science ®Google Scholar
• Iliodromitis EK, Tasouli A, Andreadou I, Bofilis E, Zoga A, Cokkinos P, Kremastinos DT. Intravenous atenolol and esmolol maintain the protective effect of ischemic preconditioning in vivo. Eur J Pharmacol 2004; 499: 163–169
   PubMed Web of Science ®Google Scholar
• Mieno S, Horimoto H, Kishida K, Horimoto S, Sasaki S. Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts. Asian Cardiovasc Thorac Ann 2006; 14: 239–243
   PubMedGoogle Scholar
• Ichihara K, Abiko Y. Effects of diltiazem and propranolol on irreversibility of ischemic cardiac function and metabolism in the isolated perfused rat heart. J Cardiovasc Pharmacol 1983; 5: 745–751
   PubMed Web of Science ®Google Scholar
• Krishnan SC, Antzelevitch C. Sodium channel block produces opposite electrophysiological effects in canine ventricular epicardium and endocardium. Circ Res 1991; 69: 277–291
   PubMed Web of Science ®Google Scholar
• Kramer JH, Mak IT, Freedman AM, Weglicki WB. Propranolol reduces anoxia/reoxygenation-mediated injury of adult myocytes through an anti-radical mechanism. J Mol Cell Cardiol 1991; 23: 1231–1244
   PubMed Web of Science ®Google Scholar
• Temsah RM, Dyck C, Netticadan T, Chapman D, Elimban V, Dhalla NS. Effect of beta-adrenoceptor blockers on sarcoplasmic reticular function and gene expression in the ischemic-reperfused heart. J Pharmacol Exp Ther 2000; 293: 15–23
   PubMed Web of Science ®Google Scholar
• Bessho R, Chambers DJ. Myocardial protection: The efficacy of an ultra-short-acting beta-blocker, esmolol, as a cardioplegic agent. J Thorac Cardiovasc Surg 2001; 122: 993–1003
   PubMed Web of Science ®Google Scholar
• Mehlhorn U. Improved myocardial protection using continuous coronary perfusion with normothermic blood and beta-blockade with esmolol. Thorac Cardiovasc Surg 1997; 45: 224–231
   PubMed Web of Science ®Google Scholar
• Zatta AJ, Kin H, Lee G, Wang N, Jiang R, Lust R, Reeves JG, Mykytenko J, Guyton RA, Zhao ZQ, Vinten-Johansen J. Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling. Cardiovasc Res 2006; 70: 315–324
   PubMed Web of Science ®Google Scholar
• Philipp S, Yang XM, Cui L, Davis AM, Downey JM, Cohen MV. Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade. Cardiovasc Res 2006; 70: 308–314
   PubMed Web of Science ®Google Scholar
• Mehlhorn U, Sauer H, Kuhn-Regnier F, Sudkamp M, Dhein S, Eberhardt F, Grond S, Horst M, Hekmat K, Geissler HJ, Warters RD, Allen SJ, Rainer de Vivie E. Myocardial beta-blockade as an alternative to cardioplegic arrest during coronary artery surgery. Cardiovasc Surg 1999; 7: 549–557
   PubMedGoogle Scholar
• Yabe K, Ishishita H, Tanonaka K, Takeo S. Pharmacologic preconditioning induced by beta-adrenergic stimulation is mediated by activation of protein kinase C. J Cardiovasc Pharmacol 1998; 32: 962–968
   PubMed Web of Science ®Google Scholar