100
Views
11
CrossRef citations to date
0
Altmetric
Original

The effect of a nitroxide antioxidant on ischemia-reperfusion injury in the rat in vivo hind limb model

, , , & , PhD , DMD
Pages 114-123 | Received 31 Jul 2007, Published online: 07 Jul 2009

References

  • Perry MO, Fantini G. Ischemia—profile of an enemy—reperfusion injury of skeletal-muscle. J Vasc Surg 1987; 6: 231–234
  • Belkin M, Lamorte WL, Wright JG, Hobson RW. The role of leukocytes in the patho-physiology of skeletal-muscle ischemic-injury. J Vasc Surg 1989; 10: 14–19
  • Zweier JL. Measurement of superoxide-derived free-radicals in the reperfused heart—evidence for a free-radical mechanism of reperfusion injury. J Biol Chem 1988; 263: 1353–1357
  • Zweier JL, Flaherty JT, Weisfeldt ML. Direct measurement of free-radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci USA 1987; 84: 1404–1407
  • Williams RE, Zweier JL, Flaherty JT. Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts. Circulation 1991; 83: 1006–1014
  • Smith JK, Grisham MB, Granger DN, Korthuis RJ. Free-radical defense-mechanisms and neutrophil infiltration in postischemic skeletal-muscle. Am J Physiol 1989; 256: H789–H793
  • Hardy SC, Homervanniasinkam S, Gough MJ. Effect of free-radical scavenging on skeletal-muscle blood-flow during postischemic reperfusion. Br J Surg 1992; 79: 1289–1292
  • Ward PH, Maldonado M, Vivaldi E. Oxygen-derived free-radicals mediate liver-damage in rats subjected to tourniquet shock. Free Radic Res Comm 1992; 17: 313–325
  • Menger MD, Steiner D, Messmer K. Microvascular ischemia-reperfusion injury in striated-muscle—significance of no reflow. Am J Physiol 1992; 263: H1892–H1900
  • vanderLaan L, Oyen WJG, Verhofstad AAJ, Tan E, terLaak HJ, GabreelsFesten A, Hendriks T, Goris RJA. Soft tissue repair capacity after oxygen-derived free radical-induced damage in one hindlimb of the rat. J Surg Res 1997; 72: 60–69
  • Kingston R, Kearns S, Kelly C, Murray P. Effects of systemic and regional taurine on skeletal muscle function following ischaemia-reperfusion injury. J Orthopaedic Res 2005; 23: 310–314
  • Irie H, Kato T, Ikebe K, Tsuchida T, Oniki Y, Takagi K. Antioxidant effect of MCI-186, a new free-radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model. J Surg Res 2004; 120: 312–319
  • Akbas H, Ozden M, Kanko M, Maral H, Bulbul S, Yavuz S, Ozker E, Berki T. Protective antioxidant effects of carvedilol in a rat model of ischaemia-reperfusion injury. J Int Med Res 2005; 33: 528–536
  • Fantini GA, Yoshioka T. Deferoxamine prevents lipid-peroxidation and attenuates reoxygenation injury in postischemic skeletal-muscle. Am J Physiol 1993; 264: H1953–H1959
  • Carney JM, Floyd RA. Protection against oxidative damage to Cns by alpha-phenyl-tert-butyl nitrone (Pbn) and other spin-trapping agents—a novel series of nonlipid free-radical scavengers. J Molec Neurosci 1991; 3: 47–57
  • McCord JM, Fridovich I. Superoxide dismutase an enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969; 244: 6049–6055
  • Salvemini D, Wang ZQ, Zweier JL, Samouilov A, Macarthur H, Misko TP, Currie MG, Cuzzocrea S, Sikorski JA, Riley DP. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science 1999; 286: 304–306
  • Darr DJ, Yanni S, Pinnell SR. Protection of Chinese-hamster ovary cells from paraquat-mediated cyto-toxicity by a low-molecular weight mimic of superoxide-dismutase (Df-Mn). Free Radic Biol Med 1988; 4: 357–363
  • Willingham WM, Sorenson JRJ. Copper(Ii) ethylenediaminetetraacetate does disproportionate superoxide. Biochem Biophys Res Comm 1988; 150: 252–258
  • Krishna MC, Grahame DA, Samuni A, Mitchell JB, Russo A. Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide. Proc Natl Acad Sci USA 1992; 89: 5537–5541
  • Belkin S, Mehlhorn RJ, Hideg K, Hankovsky O, Packer L. Reduction and destruction rates of nitroxide spin probes. Arch Biochem Biophys 1987; 256: 232–243
  • Chen K, Glockner JF, Morse PD, Swartz HM. Effects of oxygen on the metabolism of nitroxide spin labels in cells. Biochemistry 1989; 28: 2496–2501
  • Chen K, Swartz HM. Oxidation of hydroxylamines to nitroxide spin labels in living cells. Biochim Biophys Acta 1988; 970: 270–277
  • Swartz HM. Principles of the metabolism of nitroxides and their implications for spin trapping. Free Radic Res Comm 1990; 9: 399–405
  • Mitchell JB, Degraff W, Kaufman D, Krishna MC, Samuni A, Finkelstein E, Ahn MS, Hahn SM, Gamson J, Russo A. Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide-dismutase mimic, tempol. Arch Biochem Biophy 1991; 289: 62–70
  • Samuni A, Godinger D, Aronovitch J, Russo A, Mitchell JB. Nitroxides block DNA scission and protect cells from oxidative damage. Biochemistry 1991; 30: 555–561
  • Reddan JR, Sevilla MD, Giblin FJ, Padgaonkar V, Dziedzic DC, Leverenz V, Misra IC, Peters JL. The superoxide-dismutase mimic tempol protects cultured rabbit lens epithelial-cells from hydrogen-peroxide insult. Exp Eye Res 1993; 56: 543–554
  • Krishna MC, Degraff W, Tamura S, Gonzalez FJ, Samuni A, Russo A, Mitchell JB. Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin-C in Chinese-hamster V79 cells. Cancer Res 1991; 51: 6622–6628
  • Krishna MC, Halevy RF, Zhang RL, Gutierrez PL, Samuni A. Modulation of streptonigrin cytotoxicity by nitroxide sod mimics. Free Radic Biol Med 1994; 17: 379–388
  • Pogrebniak H, Matthews W, Mitchell J, Russo A, Samuni A, Pass H. Spin trap protection from tumor-necrosis-factor cytotoxicity. J Surg Res 1991; 50: 469–474
  • Hahn SM, Tochner Z, Krishna CM, Glass J, Wilson L, Samuni A, Sprague M, Venzon D, Glatstein E, Mitchell JB, Russo A. Tempol, a stable free-radical, is a novel murine radiation protector. Cancer Res 1992; 52: 1750–1753
  • Metz JM, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM. A phase I study of topical tempol for the prevention of alopecia induced by whole brain radiotherapy. Clin Cancer Res 2004; 10: 6411–6417
  • Cotrim AP, Sowers AL, Lodde BM, Vitolo JM, Kingman A, Russo A, Mitchel JB, Baum BJ. Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin Cancer Res 2005; 11: 7564–7568
  • Anzai K, Ueno M, Yoshida A, Furuse M, Aung W, Nakanishi I, Moritake T, Takeshita K, Ikota N. Comparison of stable nitroxide, 3-substituted 2,2,5,5-tetramethylpyrrolidine-N-oxyls, with respect to protection from radiation, prevention of DNA damage, and distribution in mice. Free Radic Biol Med 2006; 40: 1170–1178
  • Rachmilewitz D, Karmeli F, Okon E, Samuni A. A novel antiulcerogenic stable radical prevents gastric-mucosal lesions in rats. Gut 1994; 35: 1181–1188
  • Karmeli F, Eliakim R, Okon E, Samuni A, Rachmilewitz D. A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. Gut 1995; 37: 386–393
  • Liaw WJ, Chen TH, Lai ZZ, Chen SJ, Chen A, Tzao C, Wu JY, Wut CC. Effects of a membrane-permeable radical scavenger, Tempol, on intraperitoneal sepsis-induced organ injury in rats. Shock 2005; 23: 88–96
  • Yan SX, Hong XY, Hu Y, Liao KH. Tempol, one of nitroxides, is a novel ultraviolet-A1 radiation protector for human dermal fibroblasts. J Dermatol Sci 2005; 37: 137–143
  • Damiani E, Astolfi P, Cionna L, Ippoliti F, Greci L. Synthesis and application of a novel sunscreen-antioxidant. Free Radic Res 2006; 40: 485–494
  • Damiani E, Rosati L, Castagna R, Carloni P, Greci L. Changes in ultraviolet absorbance and hence in protective efficacy against lipid peroxidation of organic sunscreens after UVA irradiation. J Photochem Photobiol B-Biol 2006; 82: 204–213
  • Gelvan D, Saltman P, Powell SR. Cardiac reperfusion damage prevented by a nitroxide free-radical. Proc Natl Acad Sci USA 1991; 88: 4680–4684
  • Goldstein S, Samuni A, Aronovitch Y, Godinger D, Russo A, Mitchell JB. Kinetics of paraquat and copper reactions with nitroxides: the effects of nitroxides on the aerobic and anoxic toxicity of paraquat. Chem Res Toxicol 2002; 15: 686–691
  • LoMonaco M, Milone M, Valente EM, Padua L, Tonali P. Low-rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis. Muscle Nerve 1996; 19: 1523–1529
  • Couet WR, Erickson UG, Tozer TN, Tuck LD, Wesbey GE, Nitecki D, Brasch RC. Pharmacokinetics and metabolic fate of two nitroxides potentially useful as contrast agents for magnetic resonance imaging. Pharm Res 1984; 1984: 203–209
  • Nilsson UA, Carlin G, Bylund-Fellenius AC. The hydroxylamine OXANOH and its reaction product, the nitroxide OXANO. @, act as complementary inhibitors of lipid peroxidation. Chem Biol Interact 1990; 74: 325–342
  • Nilsson UA, Olsson LI, Carlin G, Bylundfellenius AC. Inhibition of lipid-peroxidation by spin labels—relationships between structure and function. J Biol Chem 1989; 264: 11131–11135
  • Dragutan I, Mehlhorn RJ. Modulation of oxidative damage by nitroxide free radicals. Free Radic Res 2007; 41: 303–315
  • Hahn SM, Sullivan FJ, DeLuca AM, Krishna CM, Wersto N, Venzon D, Russo A, Mitchell JB. Evaluation of tempol radioprotection in a murine tumor model. Free Radic Biol Med 1997; 22: 1211–1216
  • Xavier S, Yamada K, Samuni AM, Samuni A, DeGraff W, Krishna MC, Mitchell JB. Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage. Biochim Biophys Acta 2002; 1573: 109–120
  • Matsumoto K, Krishna MC, Mitchell JB. Novel pharmacokinetic measurement using electron paramagnetic resonance spectroscopy and simulation of in vivo decay of various nitroxyl spin probes in mouse blood. J Pharmacol Exp Ther 2004;310:1076–1083. Epub 2004 Apr 1022.
  • Bobko AA, Kirilyuk IA, Grigor'ev IA, Zweier JL, Khramtsov VV. Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione. Free Radic Biol Med 2007;42:404–412. Epub 2006 Nov 2010.
  • Offer T, Samuni A. Nitroxides inhibit peroxyl radical-mediated DNA scission and enzyme inactivation. Free Radic Biol Med 2002; 32: 872–881
  • Zeltcer G, Berenshtein E, Kitrossky N, Chevion M, Samuni A. Time window of nitroxide effect on myocardial ischemic-reperfusion injury potentiated by iron. Free Radic Biol Med 2002; 32: 912–919
  • Carden D, Granger D. Pathophysiology of ischaemia-reperfusion injury. J Pathol 2000; 190: 255–266
  • Dammers R, Wehrens X, oude Egbrink M, Slaaf D, Kurvers H, Ramsay G. Microcirculatory effects of experimental acute limb ischaemia-reperfusion. Br J Surg 2001; 88: 816–824
  • Samuni A, Krishna CM, Riesz P, Finkelstein E, Russo A. A novel metal-free low-molecular weight superoxide-dismutase mimic. J Biol Chem 1988; 263: 17921–17924
  • Rosen GM, Finkelstein E, Rauckman EJ. A method for the detection of superoxide in biological-systems. Arch Biochem Biophys 1982; 215: 367–378
  • Mehlhorn RJ, Swanson CE. Nitroxide-stimulated H2O2 decomposition by peroxidases and pseudoperoxidases. Free Radic Res Comm 1992; 17: 157–175
  • Bowry VW, Ingold KU. Kinetics of nitroxide radical trapping. 2. Structural effects. J Am Chem Soc 1992; 114: 4992–4996

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.