242
Views
49
CrossRef citations to date
0
Altmetric
Original

The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by α-lipoic acid

, , &
Pages 815-823 | Received 20 May 2008, Published online: 07 Jul 2009

References

  • Pinsky MR. Sepsis: a pro- and anti- inflammatory disequilibrium syndrome. Contrib Nephrol 2001; 132: 354–366
  • Szabó C. Pathophysiological roles of nitric oxide in inflammation. Nitric oxide: biology and pathobiology, LJ Ignarro. Academic Press, San Diego 2000; 841–872
  • Crimi E, Sica V, Slutsky AS, Zhang H, Williams-Ignarro S, Ignarro LJ, Napoli C. Role of oxidative stress in experimental sepsis and multisystem organ dysfunction. Free Radic Res 2006; 7: 665–672
  • Boveris A, Cadenas E, Reiter R, Filipowski M, Nakase Y, Chance B. Organ chemiluminescence: noninvasive assay for oxidative radical reactions. Proc Natl Acad Sci USA 1980; 77: 347–351
  • Cadenas E, Sies H. Low-level chemiluminescence as an indicator of singlet molecular oxygen in biological systems. Methods Enzymol 1984; 105: 221–231
  • Cutrin JC, Boveris A, Zingaro B, Corvetti G, Poli G. In situ determination by surface chemiluminescence of temporal relationships between evolving warm ischemia-reperfusion injury in rat liver and phagocyte activation and recruitment. Hepatology 2000; 31: 622–632
  • Evelson P, Gonzalez-Flecha B. Time course and quantitative analysis of the adaptive responses to 85% oxygen in the rat lung and heart. Biochim Biophys Acta 2000; 1523: 209–216
  • Navarro A, Boveris A. Hypoxia exacerbates macrophage mitochondrial damage in endotoxic shock. Am J Physiol Regulat Integ Compar Physiol 2005; 288: R354–R355
  • Boveris A, Alvarez S, Navarro A. The role of mitochondrial nitric oxide synthase in inflammation and septic shock. Free Radic Biol Med 2002; 33: 1186–1193
  • Brealey D, Singer M. Mitochondrial dysfunction in sepsis. Curr Infect Dis Rep 2003; 5: 365–371
  • Boczkowski J, Lisdero CL, Lanone S, Samb A, Carreras MC, Boveris A, Aubier M, Poderoso JJ. Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia. FASEB J 1999; 13: 1637–1646
  • Bernardi P, Petronelli V, DiLisia F, Forte M. A mitochondrial perspective on cell death. Trends Biochem Sci 2001; 26: 112–117
  • Brown GC. Nitric oxide and mitochondria. Frontiers Biosci 2007; 12: 1024–1033
  • Alvarez S, Evelson P. Nitric oxide and oxygen metabolism in inflammatory conditions: sepsis and exposition to polluted ambients. Frontiers Biosci 2007; 12: 964–974
  • Escames G, Leon J, Macias M, Khaldy H, Acuña-Castroviejo D. Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats. FASEB J 2003; 17: 932–934
  • Alvarez S, Boveris A. Nitric oxide metabolism in muscle mitochondria in endotoxic and septic shock. Progress in inflammation research, J Pitzer. Nova Science, New York 2006; 147–164
  • Alvarez S, Boveris A. Mitochondrial nitric oxide metabolism in rat muscle during endotoxemia. Free Radic Biol Med 2004; 35: 1472–1478
  • Alvarez S, Boveris A. Mitochondrial NO in endotoxemia. Proceedings of the XII Biennial Meeting of the Society for Free Radical Research International, S Puntarulo, A Boveris. Medimond SRL, Italy 2004; 133–135
  • Lisdero CL, Carreras MC, Meulemans A, Melani M, Aubier M, Boczkowski J, Poderoso JJ. The mitochondrial interplay of ubiquinol and nitric oxide in endotoxemia. Methods Enzymol 2004; 382: 67–81
  • Hobbs A, Higgs A, Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic agent. Annl Rev Pharmacol Toxicol 1999; 39: 191–220
  • Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med 1995; 19: 227–250
  • Bilska A, Wtodek L. Lipoic acid: the drug of the future?. Pharmacol Rep 2005; 57: 570–577
  • Cadenas E, Boveris A. Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria. Biochem J 1980; 188: 31–37
  • Boveris A, Cadenas E, Reiter R, Filipowski M, Nakase Y, Chance B. Organ chemiluminescence: non-invasive assay for oxidative radical reactions. Proc Natl Acad Sci USA 1980; 77: 347–351
  • Poderoso JJ, Fernandez S, Carreras MC, Tchercanski D, Acevedo C, Rubio M, Peralta J, Boveris A. Liver oxygen uptake dependence and mitochondrial function in septic rats. Circulatory Shock 1994; 44: 175–182
  • Boveris A, Costa LE, Cadenas E, Poderoso JJ. Regulation of mitochondrial respiration by adenosine diphosphate, oxygen and nitric oxide synthase. Methods Enzymol 1999; 301: 188–198
  • Yonetani T. Cytochrome oxidase: beef heart. Methods Enzymol 1967; 10: 332–335
  • Boveris A, Lores-Arnaiz S, Bustamante J, Alvarez S, Valdez L, Boveris AD, Navarro A. Pharmacological regulation of mitochondrial nitric oxide synthase. Methods Enzymol 2002; 359: 328–339
  • Llesuy S, Evelson P, Gonzalez-Flecha B, Peralta J, Carreras MC, Poderoso JJ, Boveris A. Oxidative stress in muscle and liver of rats with septic syndrome. Free Radic Biol Med 1994; 16: 445–451
  • Gonzalez-Flecha B. Oxidant mechanisms in response to ambient air particles. Molec Aspects Med 2004; 25: 169–182
  • Shiva S, Oh JY, Landar AL, Ulasova E, Venkatraman A, Bailey SM, Darley-Usmar VM. Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cutochrome c oxidase signaling pathway. Free Radic Biol Med 2005; 38: 297–306
  • Navarro A, Torrejón R, Bandez MJ, Lopez-Cepero JM, Boveris A. Mitochondrial function and mitochondria-induced apoptosis in an overestimulated rat ovarian cycle. Am J Physiol Endocrinol Metab 2005; 289: 101–109
  • Palmer JW, Tandler B, Hoppel CL. Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. J Biol Chem 1977; 10: 8731–8739
  • Gustafsson R, Tata JR, Lindberg O, Ernster L. The relationship between the structure and activity of rat skeletal muscle mitochondria after thyroidectomy and thyroid hormone treatment. J Cell Biol 1965; 26: 555–578
  • Müller W. Subsarcolemmal mitochondria and capilarization of soleous muscle fibers in young rats subjected to an endurance training. Cell Tissue Res 1976; 10: 367–389
  • Gujral JS, Hinson JA, Farhood A, Jaeschke H. NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia. Am J Physiol Gastrointest Liver Physiol 2004; 287: 243–252
  • Brandes R, Koddenberg G, Gwinner W, Kim D, Kruse H, Busse R, Mugge A. Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia. Hypertension 1999; 33: 1243–1249
  • Wu F, Tyml K, Wilson JX. iNOS expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells. Cell Physiol 2008; 217: 207–214
  • Vejrazka M, Micek R, Stipek S. Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells. Biochim Biophys Acta 2005; 1722: 143–147
  • Boveris DL, Boveris A. Oxygen delivery to the tissues and mitochondrial respiration. Frontiers Biosci 2007; 12: 1014–1023
  • Boveris A, Valdez L, Alvarez S, Zaobornyj T, Boveris AD, Navarro A. Kidney mitochondrial nitric oxide synthase. Antioxidants Redox Signal 2003; 5: 265–271
  • Antunes F, Cadenas E. The mechanism of cytochrome c oxidase inhibition by nitric oxide. Frontiers Biosci 2007; 12: 975–985
  • Brown GC, Borutaite V. Nitric oxide and mitochondrial respiration in the heart. Cardiovasc Res 2007; 75: 283–290
  • Boveris A, Roldan EJ, Alvarez S. Effect of lipoic acid on short-term ischemia-reperfusion in rat intestine. Biological oxidants and antioxidants, L Packer, E Cadenas. Hippokrates Verlag, Stuttgart 1994; 77–86
  • Smith AR, Shenvi S, Widlansky M, Suh JH, Hagen T. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem 2004; 11: 1135–1146
  • Mythili Y, Sudharsan PT, Selvakumar E, Varalakshmi P. Protective effect of dl-alpha-lipoic acid on cyclophosphamide induced oxidative cardiac injury. Chemico-Biol Interact 2004; 151: 13–19
  • Zhang W-J, Wei H, Hagen T, Frei B. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/AkT signaling pathway. Proc Natl Acad Sci USA 2007; 104: 4077–4082
  • Demarco VG, Scumpia PO, Bosanquet JP, Skimmimg JW. Alpha-lipoic acid inhibits endotoxin-stimulated expression of iNOS and nitric oxide independent of the heat shock response in RAW 264.7 cells. Free Radic Res 2004; 38: 675–682

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.